Article
Biochemistry & Molecular Biology
Hyun Hee Jang, Youngsook Son, Gabee Park, Ki-Sook Park
Summary: This study demonstrates that bone marrow-derived mesenchymal stem cells (MSCs) have vasculogenic properties. Different populations of MSCs vary in angiogenic factor expression and vasculogenic properties. The vasculogenic MSCs (vMSCs), distinct from endothelial progenitor cells (EPCs), may contribute to neovascularization and could be a promising cellular therapy for cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Developmental Biology
Minkyoung Lee, Charles Betz, Jianmin Yin, Ilkka Paatero, Niels Schellinx, Adam N. Carte, Christopher W. Wilson, Weilan Ye, Markus Affolter, Heinz-Georg Belting
Summary: Rasip1 plays essential roles during blood vessel formation by regulating various cellular behaviors such as cell pairing, tricellular junction stability, and apical membrane organization. Loss of Rasip1 function results in defects in sprouting angiogenesis, anastomosis, and lumen formation, highlighting the importance of Rasip1 in maintaining proper multicellular organization and junction formation during vascular development.
Article
Biochemistry & Molecular Biology
Michael G. McCoy, Daniel Perez-Cremades, Nathan Belkin, Wenhui Peng, Bofang Zhang, Jingshu Chen, Madhur Sachan, A. K. M. Khyrul Wara, Rulin Zhuang, Henry S. Cheng, Mark W. Feinberg
Summary: This study demonstrates that a 4-miRNA cassette can reprogram vascular smooth muscle cells into endothelial cells, and these induced cells exhibit high similarity to native endothelial cells. Injected induced cells even restore blood flow faster than conventional endothelial cells in a mouse model, suggesting the potential of this approach for vascular disease therapy.
Review
Physiology
Weijin Nan, Yuxi He, Shurong Wang, Yan Zhang
Summary: VE-cadherin is an endothelium-specific adhesion protein found in the junctions between endothelial cells. It is crucial for maintaining the homogeneity of endothelial cells and plays important roles in vascular development, permeability, and tumor angiogenesis.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Ke Ma, Sitong Liu, Hongyue Liang, Guan Wang, Tianyu Wang, Shuya Luo, Kuan Gao, Hui Wang, Mei Liu, Lichuan Bai, Qinghuan Xiao
Summary: This study reveals a novel mechanism of cholesterol-mediated TMEM16A inhibition, by which cholesterol reduces TMEM16A expression via DNMT1-mediated methylation and directly inhibits channel activities. TMEM16A channel inhibition promotes endothelial cell angiogenesis.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Isabel Vidal, Elena Fernandez-Florido, Ana Dacil Marrero, Laura Castilla, Ana R. Quesada, Beatriz Martinez-Poveda, Miguel Angel Medina
Summary: The potential of dimethyl itaconate as an anti-angiogenic compound was evaluated in this study, and the results indicate that it interferes with multiple key steps of the angiogenic process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Peripheral Vascular Disease
Sara Petrillo, F. De Giorgio, F. Bertino, F. Garello, V Bitonto, D. L. Longo, S. Mercurio, G. Ammirata, A. L. Allocco, V Fiorito, D. Chiabrando, F. Altruda, E. Terreno, P. Provero, L. Munaron, T. Genova, A. Novoa, A. R. Carlos, S. Cardoso, M. Mallo, M. P. Soares, E. Tolosano
Summary: The Feline Leukemia Virus Subgroup C Receptor 1a (FLVCR1a) is highly expressed in angiogenic endothelial cells (ECs) and has a critical role in developmental and pathological angiogenesis. Deficiency of FLVCR1a leads to abnormal vascular networks in multiple models, including defective vessel formation in zebrafish embryos, reduced retinal vasculature expansion and EC proliferation in mice, and disorganized and dysfunctional tumor blood vessels. These findings suggest FLVCR1a as a potential therapeutic target for diseases characterized by aberrant neovascularization.
Article
Biochemistry & Molecular Biology
Joon Seok Lee, Hyun Geun Cho, Jeong Yeop Ryu, Eun Jung Oh, Hyun Mi Kim, Suin Kwak, Seok-Jong Lee, Jongmin Lee, Sang Yub Lee, Seung Huh, Ji Yoon Kim, Ho Yun Chung
Summary: This study analyzed the effects of hypoxia on angiogenesis in arteriovenous malformation (AVM) patients and normal tissues. The results showed that AVM ECs exhibited higher angiogenesis capacity and expression of angiogenesis-related genes under hypoxic conditions. These findings provide a foundation for the development of AVM treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Karolina Kriauciunaite, Agne Pociute, Aida Kausyle, Justina Pajarskiene, Alexei Verkhratsky, Augustas Pivoriunas
Summary: Our study demonstrates that autocrine secretion of bFGF is necessary for the proper barrier function of BCECs, while exogenous bFGF in higher doses suppresses barrier resistance. bFGF exerts a dual regulatory role in the modulation of BCEC barrier function by regulating TEER.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Lucio Diaz-Flores, Ricardo Gutierrez, Maria Pino Garcia, Miriam Gonzalez-Gomez, Lucio Diaz-Flores, Jose Luis Carrasco, Juan Francisco Madrid, Aixa Rodriguez Bello
Summary: Perivascular cells, including pericytes and CD34+ stromal cells/telocytes, play an important role in angiogenesis. The behavior and changes of these cells differ depending on the type of angiogenesis, involving various cell-to-cell interactions and signaling pathways. Perivascular cells and CD34+ stromal cells/telocytes have important functions in vessel development and tissue repair, while their involvement in intussusceptive angiogenesis is limited.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yang Yu, Xuechun Li, Yimei Li, Renyue Wei, Hai Li, Zhonghua Liu, Yu Zhang
Summary: This study establishes a stable iPSC-EC induction system and investigates the regulatory mechanism of endothelial differentiation. The derived piPSC-ECs form microvessel-like structures in vitro and promote blood vessel formation under pathological conditions. The activation of TGF-beta-Smad2/3 signaling promotes mesoderm formation and prevents endothelial differentiation in this model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Gianfranco Matrone, Bo Xia, Kaifu Chen, Martin A. Denvir, Andrew H. Baker, John P. Cooke
Summary: This study identified novel up-regulated genes during endothelial development and highlighted the crucial role of PRDM16 in regulating endothelial cell differentiation and angiogenesis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Oncology
Wenzhe Duan, Shengkai Xia, Mengyi Tang, Manqing Lin, Wenwen Liu, Qi Wang
Summary: Interactions between endothelial cells (ECs) and tumor cells are crucial in brain tumor development. The heterogeneity of ECs and the use of new research models have received increasing attention in brain tumors. Targeting ECs is of particular importance due to the high degree of vascularization in brain tumors.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Review
Oncology
Wenzhe Duan, Shengkai Xia, Mengyi Tang, Manqing Lin, Wenwen Liu, Qi Wang
Summary: Interventions targeting endothelial cells (ECs) have shown promising clinical efficacy in brain tumors due to their high degree of vascularization. This article highlights recent advances in understanding the contributions of ECs to brain tumor development, including interactions with tumor cells, EC heterogeneity, and new research models.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Joman Javadi, Ghazal Heidari-Hamedani, Angelika Schmalzl, Tunde Szatmari, Muzaffer Metintas, Pontus Aspenstrom, Anders Hjerpe, Katalin Dobra
Summary: SDC-1 is a transmembrane proteoglycan that regulates the binding of growth factors and cytokines, impacting angiogenesis. Overexpression of SDC-1 inhibits proliferation, wound healing, and tube formation in endothelial cells in malignant mesothelioma. Silencing SDC-1 affects wound healing but not tube formation.