期刊
EXPERIMENTAL BIOLOGY AND MEDICINE
卷 239, 期 11, 页码 1531-1540出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/1535370214525302
关键词
Asthma; obesity; primary care; phenotypes
资金
- Agency for Healthcare Research and Quality (AHRQ) [R18HS19946-G1]
The effects of obesity on asthma diagnosis, control, and exacerbation severity are increasingly recognized; however, the underlying pathophysiology of this association is poorly understood. Mainstream clinical practice has yet to adopt aggressive management of obesity as a modifiable risk factor in asthma care, as is the case with a risk factor like tobacco or allergen exposure. This review summarizes existing data that support the pathophysiologic mechanisms underlying the association between obesity and asthma, as well as the current and future state of treatment for the obese patient with asthma. Our review suggests that evidence of chronic inflammatory response linking obesity and asthma indicates a need to address obesity during asthma management, possibly using patient-centered approaches such as shared decision making. There is a need for research to better understand the mechanisms of asthma in the obese patient and to develop new therapies specifically targeted to this unique patient population.
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