Article
Pharmacology & Pharmacy
Weiping Li, Zhe Zhang, Jiawen Li, Jun Mu, Meng Sun, Xue Wu, Xiaochen Niu, Yang Yang, Huanle Yan, Xiaoling Xu, Chengxu Xue, Lu Qian, Ye Tian
Summary: This study aimed to investigate the protective effects of silibinin against cerebral ischemia-reperfusion injury in neuroblastoma N2a cells, as well as the mechanisms involved. The results showed that silibinin significantly reduced cell death, apoptotic rate, LDH, and ROS generation, and inhibited mitochondrial dysfunction and oxidative stress. However, the protective effects of silibinin were weakened when GAS6 was silenced.
Article
Biochemistry & Molecular Biology
Sophie Moulin, Amandine Thomas, Stefan Wagner, Michael Arzt, Herve Dubouchaud, Frederic Lamarche, Sophie Bouyon, Guillaume Vial, Diane Godin-Ribuot, Jean-Louis Pepin, Claire Arnaud, Elise Belaidi
Summary: This study found that IH-induced ER stress, MAM alterations, and mitochondrial dysfunction were mediated by HIF-1, ultimately leading to cardiomyocyte apoptosis. This suggests that modulation of HIF-1 may help mitigate the adverse effects of sleep-disordered breathing on the heart.
Article
Medicine, Research & Experimental
Xiao-Bing Lv, Qing-Hui Niu, Min Zhang, Li Feng, Jia Feng
Summary: The microRNA miR-30a-5p plays a significant role in cardiomyocyte apoptosis, with potential regulation of E2F3. Downregulation of miR-30a-5p attenuates the impact of hypoxia/reoxygenation on H9c2 cardiomyocytes by targeting E2F3.
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Genetics & Heredity
Nan Niu, Hui Li, Xiancai Du, Chan Wang, Junliang Li, Jihui Yang, Cheng Liu, Songhao Yang, Yazhou Zhu, Wei Zhao
Summary: This study found that NRF-1 and HIF-1α are important anti-apoptotic molecules in cardiomyocytes under hypoxia, although their regulatory mechanisms differ. NRF-1 exerts its anti-apoptotic effect by negatively regulating the expression of HIF-1α.
Article
Biochemistry & Molecular Biology
Rui Teixeira da Silva, Ivo F. Machado, Joao S. Teodoro, Arnau Panisello-Rosello, Joan Rosello-Catafau, Anabela P. Rolo, Carlos M. Palmeira
Summary: PEG35 preconditioning effectively ameliorates hepatic hypoxia/reoxygenation injury through the enhancement of autophagy and mitochondrial quality control.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Yan Wang, Hongying Zhou, Jin Wu, Shanshan Ye
Summary: This study demonstrated that MG53 overexpression inhibited inflammation response and apoptosis in cardiomyocytes under hypoxia/reoxygenation. SIRT7 inhibited the succinylation of MG53 at K130, while KAT3B promoted succinylation. The posttranslational modification of MG53 influenced its protein levels and ubiquitination, thus affecting cardiomyocyte injury.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Cell Biology
Jingyi Wen, Dan Wang, Lichun Cheng, Di Wu, Lulu Qiu, Miao Li, Yu Xie, Si Wu, Yan Jiang, Hansheng Bai, Bing Xu, Huiyi Lv
Summary: This study found that subjecting H9c2 cells to the AnaeroPack system for 10 hours of hypoxia followed by 6 hours of reoxygenation resulted in the highest apoptosis rate and damage, with deformed, small, and visibly round cells. This H/R injury model proved to be practical and repeatable.
CELL BIOLOGY INTERNATIONAL
(2021)
Review
Plant Sciences
Jose Leon, Mari Cruz Castillo, Beatriz Gayubas
Summary: Plants are highly adaptable to changing adverse environmental conditions, particularly in response to oxygen levels which have significant impacts on growth and development. The transition from hypoxia to reoxygenation can lead to cell damage due to oxidative stress, and further research is needed to understand this process. Studying molecular events related to gene expression regulation during hypoxia and reoxygenation will be crucial for improving agricultural biotechnology in the context of global climate change.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Endocrinology & Metabolism
Min Zhai, Feng Bai
Summary: This study suggests that 1,8-Cineole can protect cardiomyocytes from H/R-induced cell injury, and its mechanism may be associated with the AMPK/NLRP3 signaling pathway.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Biochemistry & Molecular Biology
Gurdeep Marwarha, Oystein Rosand, Nathan Scrimgeour, Katrine Hordnes Slagsvold, Morten Andre Hoydal
Summary: This study reveals a Janus role of miR-210 in regulating apoptotic cell death of cardiomyocytes under hypoxia-reoxygenation stress. Specifically, miR-210 mitigates apoptotic cell death under hypoxia but exacerbates it during cellular reoxygenation. The underlying cellular mechanisms responsible for this dual effect of miR-210 on apoptotic cell death are also elucidated.
Article
Biochemistry & Molecular Biology
Vijaya Lakshmi Bodiga, Praveen Kumar Vemuri, Madhukar Rao Kudle, Sreedhar Bodiga
Summary: The study revealed that polyphenols from Terminalia bellirica fruit can enhance zinc uptake, improve intracellular zinc levels, and attenuate cardiomyoblasts apoptosis after hypoxia/reoxygenation injury, with EGCG showing the most potent effect.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Endocrinology & Metabolism
Rasmus Stenlid, Sara Y. Cerenius, Quan Wen, Banu Kucukemre Aydin, Hannes Manell, Azazul Chowdhury, Hjalti Kristinsson, Iris Ciba, Erik S. Gjessing, Katharina Moerwald, Julian Gomahr, Verena Heu, Daniel Weghuber, Anders Forslund, Peter Bergsten
Summary: Weekly injections of 2 mg exenatide extended release maintain endogenous total GLP-1 levels and lower circulating DPP-4 levels. This provides supportive evidence for the use of exenatide in the treatment of pediatric obesity.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Xiaofeng Deng, Yongqing Liu, Zesheng Xu, Zichao Wang
Summary: NRON knockdown alleviates cardiomyocyte apoptosis and improves cardiac function in AMI, suggesting NRON as a potential therapeutic target.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Juan Pang, Jia Nuo Feng, Wenhua Ling, Tianru Jin
Summary: GLP-1 receptor agonists (GLP-1RAs) have been developed as therapeutic agents for type 2 diabetes (T2D) since 2005. GLP-1R is expressed not only in pancreatic islets but also in other organs, especially the lung. The controversy surrounding extra-pancreatic GLP-1R expression still needs to be resolved, and more reliable GLP-1R antibodies should be utilized for further research. The anti-inflammatory features of GLP-1RAs have shown promising results, but whether these features are directly mediated by GLP-1R expressed in immune cells remains controversial.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Cell Biology
Xiaoyu Guo, Ting Hong, Shen Zhang, Yazhong Wei, Haizhen Jin, Qing Miao, Kai Wang, Miao Zhou, Chong Wang, Bin He
Summary: IL-13 plays an important role in protecting septic cardiomyocytes by improving mitochondrial function and morphology. The results suggest that IL-13 could be a potential promising target for SIC treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Guanglei Chang, Jian Liu, Shu Qin, Youqin Jiang, Peng Zhang, Hui Yu, Kai Lu, Nan Zhang, Li Cao, Ying Wang, Yong Li, Dongying Zhang
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2018)
Article
Oncology
Peng Zhang, Chunxiao Hu, Yongyong Li, Ying Wang, Lei Gao, Kai Lu, Guanglei Chang, Yong Li, Shu Qin, Dongying Zhang
EXPERIMENTAL CELL RESEARCH
(2018)
Review
Pharmacology & Pharmacy
Ya Luo, Kai Lu, Gang Liu, Jing Wang, Irakoze Laurent, Xiaoli Zhou
CLINICAL DRUG INVESTIGATION
(2018)
Article
Medicine, Research & Experimental
Dan Jiang, Min Sun, Linna You, Kai Lu, Lei Gao, Chunxiao Hu, Shiyong Wu, Guanglei Chang, Hongmei Tao, Dongying Zhang
Article
Cell Biology
Dan Jiang, Ying Wang, Guanglei Chang, Qin Duan, Linna You, Min Sun, Chunxiao Hu, Lei Gao, Shiyong Wu, Hongmei Tao, Kai Lu, Dongying Zhang
Article
Medicine, Research & Experimental
Kai Lu, Yue Zhao, Jia Chen, Dayi Hu, Hua Xiao
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2020)
Article
Geriatrics & Gerontology
Jia Chen, Kai Lu, Hong Chen, Ning Hu, Jie Chen, Xi Liang, Jian Qin, Wei Huang
CLINICAL INTERVENTIONS IN AGING
(2020)
Article
Cell Biology
Meixia Zhang, Hechuan Wang, Xiaowen Wang, Mengjun Bie, Kai Lu, Hua Xiao
Article
Medicine, General & Internal
Jia Chen, Liuyue Xu, Quan He, Shouling Wu, Dayi Hu, Kai Lu
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2020)
Article
Medicine, General & Internal
Liuyue Xu, Qian Dong, Yaoying Long, Xiaoqiong Tang, Nan Zhang, Kai Lu
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2020)
Article
Cardiac & Cardiovascular Systems
Meixia Zhang, Hechuan Wang, Mengjun Bie, Xiaowen Wang, Kai Lu, Hua Xiao
Summary: The study demonstrated that CAV1 expression decreased with atrial fibrosis aggravation, leading to increased incidence of AF. Depletion of CAV1 induced excessive extracellular matrix deposition by activating STAT3 and transforming growth factor-beta 1/SMAD2 signaling pathways, worsened by angiotensin II stimulation but improved by CSD peptide.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hechuan Wang, Yiqi Chen, Shuting Zhao, Xiaowen Wang, Kai Lu, Hua Xiao
Summary: Sox9 plays a role in the regulation of fibrosis in the atria and may be downstream of TGF-beta 1. In rat atrial fibroblasts, Sox9 is promoted by TGF-beta 1, affecting the alpha-SMA protein level and cell migration ability. These findings offer a new perspective for treating atrial fibrosis during AF.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Nursing
Nan Zhang, Xiao-Qiong Tang, Kai Lu, Qian Dong, Ling-Na Kong, Tian-Tian Jiang, Liu-Yue Xu
Summary: The study investigated the relationship between illness uncertainty, self-perceived burden, and quality of life in patients with chronic myeloid leukaemia. It found a negative association between illness uncertainty and self-perceived burden with quality of life, and self-perceived burden partially mediated the relationship between illness uncertainty and quality of life, accounting for 22.9% of the total effect.
JOURNAL OF CLINICAL NURSING
(2022)
Article
Medicine, General & Internal
Zheng Qin, Kai Lu, Tiantian Jiang, Mei Wang, Yue Weng, Xiaoqiong Tang, Yu Zhao
Summary: This study explores the potential association between body composition parameters and the incidence of sarcopenia in patients with acute myeloid leukemia (AML) after chemotherapy. The study finds a significant increase in the prevalence of sarcopenia after chemotherapy, with a decrease in skeletal muscle mass, fat-free mass, and soft lean mass. The study also identifies a correlation between mid-arm muscle circumference and intracellular water with sarcopenia.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Letter
Medicine, General & Internal
Liuyue Xu, Qian Dong, Nan Zhang, Kai Lu, Xiaoqiong Tang
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2021)