Review
Biochemistry & Molecular Biology
Sree Samanvitha Kuppa, Hyung Keun Kim, Ju Yeon Kang, Seok Cheol Lee, Jong Keun Seon
Summary: Osteoarthritis is a low-grade inflammatory disorder of the joints, but there are limited treatment options currently available. This article explores the use of mesenchymal stem cells and their secreted factors for intervention in osteoarthritis, with a focus on the polarization of macrophages to reduce inflammation and symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Zhansong Tian, Fanchun Zeng, Chunrong Zhao, Shiwu Dong
Summary: Post-trauma osteoarthritis (PTOA) is a common joint disease characterized by cartilage degeneration, with inflammation playing a crucial role. Regulation of inflammatory cells differentiation could be a potential therapeutic strategy for alleviating the condition.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Youyi Liu, Xiading Zhang, Yiwei Hu, Mingzhu Kang, Yibo Wu, Yuan Wang, Chao Deng
Summary: Emerging evidence suggests that human placenta-derived mesenchymal stem cells (HPL-MSCs) play a role in immune regulation and may improve inflammation through regulating macrophage polarization. Mechanistically, HPL-MSCs attenuate the NF-kappa B signaling pathway, resulting in reduced inflammation levels. This study highlights the potential of HPL-MSCs as a novel target for the treatment of inflammation-related diseases.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Immunology
Yin Yuan, Shuo Ni, Aoxiang Zhuge, Lanjuan Li, Bo Li
Summary: A study found that adipose-derived mesenchymal stem cells (ADMSCs) can alleviate ulcerative colitis (UC) by reducing the infiltration of pro-inflammatory macrophages (M1 macrophages) and reprogramming the glycolytic pathway. Additionally, the secretion of succinate by M1 macrophages triggers ADMSCs to secrete PGE2, which can shift macrophages from the pro-inflammatory phenotype to the anti-inflammatory phenotype. This research demonstrates the immunomodulatory effect of ADMSCs and provides a new perspective for UC therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ken Woo, So Young Park, Andrew Padalhin, Hyun Seok Ryu, Celine DG. Abueva
Summary: This study investigated the effect of photobiomodulation (PBM) treatment on tonsil-derived mesenchymal stem cells (TMSCs) and its interaction with RAW 264.7 macrophage cells. The results showed that PBM priming improved the therapeutic efficacy of TMSCs and supported M2 macrophage polarization. Based on these findings, PBM can enhance the therapeutic efficacy of TMSCs for potential applications in oral mucositis and wound healing.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2023)
Article
Cell & Tissue Engineering
Bing Dong, Chao Wang, Jing Zhang, Jinrong Zhang, Yinuo Gu, Xiaoping Guo, Xu Zuo, He Pan, Alan Chen-Yu Hsu, Guoqiang Wang, Fang Wang
Summary: In this study, it was found that exosomes derived from human umbilical cord mesenchymal stem cells can ameliorate severe, steroid-resistant asthma by modulating macrophage polarization through inhibition of TRAF1.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Neurosciences
Cheng Li, Xiaoxiao Li, Zhen Shi, Panfeng Wu, Jinfei Fu, Juyu Tang, Liming Qing
Summary: Our study reveals that LPS preconditioned mesenchymal stem cell-derived exosomes (LPS pre-Exos) can promote functional recovery and repair in peripheral nerve injury by accelerating axon regeneration and remyelination, as well as enhancing macrophage polarization. TSG-6, highly enriched in LPS pre-Exos, serves as a critical mediator in inducing the regulatory effects by inhibiting NF-κB and NLRP3 signaling pathways.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Cell Biology
Hongjing Ren, Mengchang Liu, Yueda Jihu, Huizhen Zeng, Chong Yao, Hong Yan
Summary: This study aimed to investigate the effect of hypoxia on the anti-inflammatory effect of adipose-derived mesenchymal stem cells (AMSCs) in vitro and its possible mechanism. The AMSCs were cultured under 3% O-2 hypoxic environment, while a 21% O-2 normoxic environment was used as the control. The results showed that under hypoxia, the AMSCs had better viability, downregulated the expression of inflammatory factors, alleviated macrophage inflammation, and activated the PI3K/AKT/HIF-1a pathway.
Article
Biochemistry & Molecular Biology
Michelle Holthaus, Nivethiha Santhakumar, Thorsten Wahlers, Adnana Paunel-Goerguelue
Summary: The preconditioning of mesenchymal stem cells (MSCs) can enhance their regenerative and immunomodulatory capabilities and exert anti-inflammatory effects by influencing the phenotype and polarization state of macrophages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell & Tissue Engineering
Yaqi Zhang, Xi Le, Shuo Zheng, Ke Zhang, Jing He, Mengting Liu, Chengshu Tu, Wei Rao, Hongyuan Du, Yu Ouyang, Changyong Li, Dongcheng Wu
Summary: This study demonstrates that MSCs derived from human umbilical cords can protect renal function in rats with diabetic nephropathy by altering macrophage phenotype. UC-MSCs-derived miR-146a-5p promotes the anti-inflammatory phenotype of macrophages by inhibiting the TRAF6/STAT1 signaling pathway and effectively improves renal function.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Immunology
Xia Cai, Yang Shi, Yue Dai, Fang Wang, Xuepeng Chen, Xiaojun Li
Summary: Baicalin enhances efferocytosis by promoting macrophage engulfment of apoptotic PMNs, inhibiting reactive oxygen species production, and regulating macrophage polarization, thus promoting resolution of inflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Peiyao Zhang, Panfeng Wu, Umar Zeb Khan, Zekun Zhou, Xinlei Sui, Cheng Li, Kangkang Dong, Yongjun Liu, Liming Qing, Juyu Tang
Summary: LPS pre-exosomes can switch macrophage polarization and enhance inflammation resolution. These exosomes show improved potential for immunotherapy in prolonging graft survival. The NF-κB/NLRP3/procaspase-1/IL-1β signaling pathway plays a key role in LPS pre-exosome-mediated regulation of macrophage polarization. Inhibiting NF-κB in BMDMs can abolish the LPS-induced inflammatory pathway activation and M1 macrophage polarization, while increasing the proportion of M2 cells.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Cell & Tissue Engineering
Zhi-Hui Li, Jun-Feng Chen, Jing Zhang, Zi-Ying Lei, Li-Li Wu, Shi-Bo Meng, Jia-Lei Wang, Jing Xiong, Deng-Na Lin, Jun-Yi Wang, Zhi-Liang Gao, Bing-Liang Lin
Summary: This study found that mesenchymal stem cell (MSC) treatment can improve the condition of acute-on-chronic liver failure (ACLF) by promoting M2 macrophage polarization and increasing the expression of Mertk in macrophages to alleviate inflammatory injury.
Article
Medicine, General & Internal
Yu Ning, Peisen Huang, Guihao Chen, Yuyan Xiong, Zhaoting Gong, Chunxiao Wu, Junyan Xu, Wenyang Jiang, Xiaosong Li, Ruijie Tang, Lili Zhang, Mengjin Hu, Jing Xu, Jun Xu, Haiyan Qian, Chen Jin, Yuejin Yang
Summary: This study found that MSCATV-EV, derived from ATV-treated MSCs, has a good cardiac repair effect on acute myocardial infarction. The results showed that MSCATV-EV alleviated inflammation in the infarct region by regulating macrophage polarization. Additionally, the study identified the miR-139-3p/Stat1 pathway as the mechanism underlying the promotion of macrophage polarization by MSCATV-EV.
Article
Cell & Tissue Engineering
Siyuan Tian, Xia Zhou, Miao Zhang, Lina Cui, Bo Li, Yansheng Liu, Rui Su, Keshuai Sun, Yinan Hu, Fangfang Yang, Guoyun Xuan, Shuoyi Ma, Xiaohong Zheng, Xinmin Zhou, Changcun Guo, Yulong Shang, Jingbo Wang, Ying Han
Summary: This study found that mesenchymal stem cells (MSCs) protect against liver fibrosis by delivering miR-148a through their secreted exosomes (MSC-EXOs) to regulate intrahepatic macrophage functions. This finding provides a potential therapeutic target for liver fibrosis.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Oncology
Zhaofeng Liang, Wenhao Guo, Shikun Fang, Yue Zhang, Ling Lu, Wenrong Xu, Hui Qian
Summary: circRNAs, with their covalently closed loop structure, high stability, tissue specificity, and functional diversity, have been identified as potential biomarkers for bladder cancer. They have been shown to function in regulating gene transcription, acting as miRNA sponges, and encoding proteins.
FRONTIERS IN ONCOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Xu Zhang, Hongbo Zhang, Jianmei Gu, Jiayin Zhang, Hui Shi, Hui Qian, Dongqing Wang, Wenrong Xu, Jianming Pan, Helder A. Santos
Summary: Extracellular vesicles (EVs) have shown great potential as a cell-free strategy for cancer therapy, with the ability to be modified and engineered to enhance their therapeutic efficiency and safety. Recent advances have focused on strategies to scale up production, improve cargo-loading, and enhance tumor-targeting of engineered EVs.
ADVANCED MATERIALS
(2021)
Review
Engineering, Biomedical
Peipei Wu, Bin Zhang, Dickson Kofi Wiredu Ocansey, Wenrong Xu, Hui Qian
Summary: Extracellular vesicles play a crucial role in disease treatment and diagnosis, with engineered design enhancing their therapeutic capability and diagnostic imaging potential.
Article
Cell Biology
Xinye Han, Peipei Wu, Linli Li, Hassan Mohamud Sahal, Cheng Ji, Jiahui Zhang, Yi Wang, Qichen Wang, Hui Qian, Hui Shi, Wenrong Xu
Summary: DF-Ex can reverse the damage caused by high glucose in HUVECs and accelerate diabetic cutaneous wound healing; DF-Ex exerts its effects by activating the Akt/beta-catenin pathway; This research provides a new treatment strategy for diabetic cutaneous wound healing.
Article
Cell Biology
Yan Wang, Huiting Wang, Ruiqi Zheng, Peipei Wu, Zixuan Sun, Jingyan Chen, Leilei Zhang, Chenxiao Zhang, Hui Qian, Jiajia Jiang, Wenrong Xu
Summary: In this study, circ-ITCH was found to suppress GC metastasis by acting as a sponge for miR-199a-5p and increasing Klotho expression, providing potential biomarkers and targets for the diagnosis and therapy of GC.
Article
Biochemistry & Molecular Biology
Qingli Bie, Hui Song, Xinke Chen, Xiao Yang, Shuo Shi, Lihua Zhang, Rou Zhao, Li Wei, Baogui Zhang, Huabao Xiong, Bin Zhang
Summary: The IL-17B/IL-17RB signaling cascade promotes self-renewal and tumorigenesis of CSCs by inducing Beclin-1 ubiquitination. IL-17RB expression is upregulated in gastric cancer (GC) tissues, correlating with cancer cell differentiation. The study suggests IL-17B as a potential therapeutic target for cancer treatment.
Review
Cell & Tissue Engineering
Qian Jin, Peipei Wu, Xinru Zhou, Hui Qian, Wenrong Xu
Summary: Exosomes, small extracellular vesicles secreted by cells, play crucial roles in intercellular communication in the CNS, contributing to CNS development and homeostasis as well as potentially influencing the progression of neurological disorders. Additionally, exosomes may serve as diagnostic biomarkers and therapeutic tools for these disorders, showing promise in the field of neurological research.
STEM CELLS INTERNATIONAL
(2021)
Article
Oncology
Hui Shi, Yaoxiang Sun, Hongru Ruan, Cheng Ji, Jiahui Zhang, Peipei Wu, Linli Li, Chihan Huang, Yuanwang Jia, Xu Zhang, Wenrong Xu, Jiajia Jiang, Hui Qian
Summary: The study found that the anti-cancer drug DIM at therapeutic concentrations upregulated the expression of tumor-related factors in GC-MSCs and promoted the proliferation, invasion, and migration of gastric cancer cells, leading to tumor growth. This mechanism provides a new insight into anti-cancer drug resistance and suggests the need to adjust the chemotherapy regimen to minimize the side effects of drugs on targeted TME cells.
FRONTIERS IN ONCOLOGY
(2021)
Review
Medicine, Research & Experimental
Xueting Li, Shuo Shi, Dehuai Jing, Xinjian Li, Bin Zhang, Qingli Bie
Summary: This review summarizes the role of exosomes from different cell sources in the pathogenesis of diabetic complications and explores potential therapeutic targets.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Review
Oncology
Jing Liang, Shouqi Wang, Guowei Zhang, Baoyu He, Qingli Bie, Bin Zhang
Summary: Studying the differences, heterogeneity, and interaction of tumor-specific endothelial cells (TECs) with the tumor microenvironment is crucial for developing specific anti-tumor angiogenesis therapies.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Baoyu He, Hongli Pan, Fengque Zheng, Saiqiong Chen, Qingli Bie, Jinghe Cao, Rou Zhao, Jing Liang, Li Wei, Jianchao Zeng, Hui Li, Xing Cui, Yixuan Ding, Wei Chao, Tiantian Xiang, Yuhe Cheng, Gui Qiu, Shishun Huang, Libo Tang, Jiansheng Chang, Delan Luo, Jie Yang, Bin Zhang
Summary: In this study, a metabolism-related lncRNA, LINC00930, was identified and found to be upregulated and associated with tumorigenesis, metastasis, and poor prognosis in nasopharyngeal carcinoma (NPC). Functionally, LINC00930 promoted glycolysis activity and cell proliferation. Mechanistically, LINC00930 regulated the expression of PFKFB3 through epigenetic modifications. Clinically, targeting LINC00930 and PFKFB3 in combination with radiotherapy induced tumor regression.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Review
Oncology
Ling Zhang, Yi Liu, Rou Zhou, Baoyu He, Wenjun Wang, Bin Zhang
Summary: CypD is an enzyme distributed in mitochondria that regulates mitochondrial function by controlling the opening of the mitochondrial permeability transition pore and interacting with other binding partners. Recent studies have shown that CypD has a dual role in tumors, promoting tumor cell glycolysis while potentially influencing tumor cell survival, invasion, and drug resistance.
FRONTIERS IN ONCOLOGY
(2022)
Review
Pharmacology & Pharmacy
Benshuai You, Yang Yang, Zixuan Zhou, Yongmin Yan, Leilei Zhang, Jianhua Jin, Hui Qian
Summary: EVs have shown cardioprotective effects in heart disease by activating beneficial signaling pathways. Engineering approaches have been developed to improve the therapeutic efficiency of EVs, but further optimization is needed to achieve better cardiac repair outcomes.
Review
Pharmacology & Pharmacy
Fengtian Sun, Yuntong Sun, Feng Wu, Wenrong Xu, Hui Qian
Summary: This review introduces the novel cell-free strategy of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) and their applications in the treatment of diabetes mellitus (DM) and diabetic complications. The major characteristics of MSC-EVs are summarized, and the recent advances in the use of engineered MSC-EVs for treating hyperglycemia-induced tissue damage are discussed. Additionally, the potential applications of engineered MSC-EVs in the therapy of DM-related diseases are presented, and the opportunities and challenges for clinical translation of MSC-EVs, particularly engineered MSC-EVs, are evaluated.