Antidepressant drugs as a complementary therapeutic strategy in cancer

Targeting Metabolic Remodeling in Glioblastoma Multiforme

(2015)   Oncotarget

Age-dependent stimulatory effect of desipramine and fluoxetine pretreatment on metastasis formation by B16F10 melanoma in male C57BL/6 mice

(2014) Marta Kubera et al.   Pharmacological Reports

Alternative Pathways of Cancer Cell Death by Rottlerin: Apoptosis versus Autophagy

(2012) Claudia Torricelli et al.   Evidence-based Complementary and Alternative Medicine

Fluoxetine inhibits NF-κB signaling in intestinal epithelial cells and ameliorates experimental colitis and colitis-associated colon cancer in mice

(2011) Seong-Joon Koh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The effect of tricyclic antidepressants on cutaneous melanoma cell lines and primary cell cultures

(2011) Katharine A. Parker et al.   ANTI-CANCER DRUGS

Tumor necrosis factor-α induces epithelial–mesenchymal transition of renal cell carcinoma cells via a nuclear factor kappa B-independent mechanism

(2011) Sheng-Tang Wu et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Bax-derived membrane-active peptides act as potent and direct inducers of apoptosis in cancer cells

(2011) J. G. Valero et al.   JOURNAL OF CELL SCIENCE

Deep sequencing of gastric carcinoma reveals somatic mutations relevant to personalized medicine

(2011) Joanna D Holbrook et al.   Journal of Translational Medicine

The Tricyclic Antidepressant Amitriptyline Inhibits D-Cyclin Transactivation and Induces Myeloma Cell Apoptosis by Inhibiting Histone Deacetylases: In Vitro and In Silico Evidence

(2011) X. Mao et al.   MOLECULAR PHARMACOLOGY

Role of oxidative stress and DNA damage in human carcinogenesis

(2011) Thomas B. Kryston et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Inflammation meets cancer, with NF-κB as the matchmaker

(2011) Yinon Ben-Neriah et al.   NATURE IMMUNOLOGY

Mitochondrial Metabolism Inhibitors for Cancer Therapy

(2011) Emma E. Ramsay et al.   PHARMACEUTICAL RESEARCH

Antidepressants and Breast and Ovarian Cancer Risk: A Review of the Literature and Researchers' Financial Associations with Industry

(2011) Lisa Cosgrove et al.   PLoS One

Fluoxetine inhibits the extracellular signal regulated kinase pathway and suppresses growth of cancer cells

(2010) Andrzej Stepulak et al.   CANCER BIOLOGY & THERAPY

Antioxidant activity of fluoxetine: Studies in mice melanoma model

(2010) Margarita Kirkova et al.   CELL BIOCHEMISTRY AND FUNCTION

Autophagy regulation by p53

(2010) Maria Chiara Maiuri et al.   CURRENT OPINION IN CELL BIOLOGY

Redox metabolism and malignancy

(2010) Christina L Grek et al.   CURRENT OPINION IN PHARMACOLOGY

Oxidative stress, inflammation, and cancer: How are they linked?

(2010) Simone Reuter et al.   FREE RADICAL BIOLOGY AND MEDICINE

The antidepressants maprotiline and fluoxetine induce Type II autophagic cell death in drug-resistant Burkitt's lymphoma

(2010) Suzanne M. Cloonan et al.   INTERNATIONAL JOURNAL OF CANCER

Targeting monoamine oxidase A in advanced prostate cancer

(2010) Vincent Flamand et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Desipramine induces apoptosis in rat glioma cells via endoplasmic reticulum stress-dependent CHOP pathway

(2010) Jian Ma et al.   JOURNAL OF NEURO-ONCOLOGY

The causes of cancer revisited: “Mitochondrial malignancy” and ROS-induced oncogenic transformation – Why mitochondria are targets for cancer therapy

(2010) Stephen J. Ralph et al.   MOLECULAR ASPECTS OF MEDICINE

Lipids, Mitochondria and Cell Death: Implications in Neuro-oncology

(2010) Alison Colquhoun   MOLECULAR NEUROBIOLOGY

The Role of Mitochondria in Glioma Pathophysiology

(2010) Bartlomiej B. Ordys et al.   MOLECULAR NEUROBIOLOGY

Moclobemide exerts anti-inflammatory effect in lipopolysaccharide-activated primary mixed glial cell culture

(2010) A. M. Bielecka et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

The Effects of Antidepressants on Mitochondrial Function in a Model Cell System and Isolated Mitochondria

(2010) W. Abdel-Razaq et al.   NEUROCHEMICAL RESEARCH

Use of antidepressants and NSAIDs in relation to mortality in long-term breast cancer survivors

(2010) Karen J. Wernli et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Antidepressant hyperforin up-regulates VEGF in CNS tumour cells

(2010) Evelyne Tassone et al.   PHARMACOLOGICAL RESEARCH

Do antidepressants reduce the effectiveness of tamoxifen?†

(2010) William Breitbart   PSYCHO-ONCOLOGY

Tricyclic Antidepressants and Non-Hodgkin Lymphoma

(2009) Susanne Oksbjerg Dalton et al.   EPIDEMIOLOGY

Mechanisms of Hyperforin as an anti-angiogenic angioprevention agent

(2009) Girieca Lorusso et al.   EUROPEAN JOURNAL OF CANCER

Autophagy in tumour suppression and promotion

(2009) Andreas Brech et al.   Molecular Oncology

Autophagy: Basic Principles and Relevance to Disease

(2008) Mondira Kundu et al.   Annual Review of Pathology-Mechanisms of Disease

Fluoxetine mediates G0/G1 arrest by inducing functional inhibition of cyclin dependent kinase subunit (CKS)1

(2008) Anand Krishnan et al.   BIOCHEMICAL PHARMACOLOGY

Life, death and burial: multifaceted impact of autophagy

(2008) Lorenzo Galluzzi et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Oxidative stress, DNA methylation and carcinogenesis

(2008) Rodrigo Franco et al.   CANCER LETTERS

HDAC expression and clinical prognosis in human malignancies

(2008) Wilko Weichert   CANCER LETTERS

To kill a tumor cell: the potential of proapoptotic receptor agonists

(2008) Avi Ashkenazi et al.   JOURNAL OF CLINICAL INVESTIGATION

Increased Risk of Both Ulcerative Colitis and Crohn’s Disease in a Population Suffering from COPD

(2008) Anders Ekbom et al.   LUNG

The antidepressant sertraline downregulates Akt and has activity against melanoma cells

(2008) Kalpana K. Reddy et al.   Pigment Cell & Melanoma Research

Approaches to mitochondrially mediated cancer therapy

(2007) Geoffrey J. Pilkington et al.   SEMINARS IN CANCER BIOLOGY