Review
Neurosciences
Rocio Salceda
Summary: This review discusses the function of glycine in the development of the central nervous system (CNS) and provides evidence of its regulation of morphogenetic events through transporters and receptors. Glycinergic activity plays a crucial role in balancing excitatory and inhibitory signals during development.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Chemistry, Medicinal
Su Bin Hwang, Hyeon Ju Park, Bog-Hieu Lee
Summary: This study demonstrated the potential of fish-derived collagen hydrolysate (CH) extracted from Mozambique tilapia scales to improve hair and skin health. In vitro and in vivo experiments showed that CH can alleviate oxidative stress, promote hair growth, enhance hair quality, improve skin health, and reduce inflammation. Fish-derived CH offers a cost-effective and bioavailable option for improving hair and skin health.
Article
Biochemistry & Molecular Biology
K. Sivaraman, C. Shanthi
Summary: This study evaluated the therapeutic effects of purified hydrolysate fraction of fish skin collagen from Clarias batrachus and Pangasius pangasius in inflammatory bowel disease. The results showed that the hydrolysate fraction could counter TNF-alpha induced barrier dysfunction and improve clinical signs of colitis in mice.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Soo-Il Kim, Sin-Hye Park, Woojin Na, Yong Chul Shin, Moon-Sik Oh, Young Eun Sim, Yulong Zheng, Ae Hyang Kim, Il-Jun Kang, Young-Hee Kang
Summary: Pangasius hypophthalmus fish skin collagen hydrolysates (fsCH) can retard postmenopausal osteoporosis by inhibiting bone loss and enhancing bone density.
Article
Agriculture, Multidisciplinary
Jun-Hui Cheng, Wen-Xiao Zhao, Hai-Yan Cao, Zhen Wang, Yan Wang, Qi Sheng, Yin Chen, Peng Wang, Xiu-Lan Chen, Yu-Zhong Zhang
Summary: Collagen oligopeptides are widely used in various industries for their high bioactivities and bioavailability. A4095, the most abundant S8 protease secreted by Anoxybacillus caldiproteolyticus 1A02591, was characterized as a collagenolytic protease that can produce collagen oligopeptides by preferentially hydrolyzing the Y-Gly peptide bonds in denatured bovine bone collagen.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biotechnology & Applied Microbiology
Jerrell Felim, Chun-Kai Chen, David Tsou, Hsiang-Ping Kuo, Zwe-Ling Kong
Summary: Marine collagen has potential therapeutic effects for treating osteoarthritis. Collagen and glycine can inhibit the production of proinflammatory cytokines, attenuating cartilage degradation, while collagen peptides promote cartilage regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Neurosciences
Steffen Fricke, Magnus Harnau, Florian Hetsch, Haoran Liu, Julia Leonhard, Anna Eylmann, Pina Knauff, Han Sun, Marcus Semtner, Jochen C. Meier
Summary: High concentrations of cesium can have adverse effects on neuronal physiology, prompting the FDA to issue a warning. It has been found that cesium activates glycine receptors, and further investigation revealed the binding profiles of cesium and potassium to these receptors through experiments and simulations.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Review
Neurosciences
Victoria P. San Martin, Anggelo Sazo, Elias Utreras, Gustavo Moraga-Cid, Gonzalo E. Yevenes
Summary: Pharmacological intervention of glycine receptors can restore inhibitory function and exert anti-nociceptive effects on chronic pain. However, the roles of individual subunits of glycine receptors in chronic pain are not well defined.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Environmental Sciences
Bugra Ocak
Summary: The study extracted collagen hydrolysate (CH) from leather industry waste and used it to prepare biodegradable films with chitosan nanoparticles (CNPs) of varying concentrations, showing improved mechanical and water barrier properties. The incorporation of CNPs into CH-based films provides a promising alternative to non-biodegradable plastics.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Christopher L. Cioffi
Summary: The dysfunction of glycinergic neurotransmission in the spinal cord dorsal horn contributes to pathological pain, and enhancing this neurotransmission is proposed as a potential novel analgesic approach. Inhibitors of glycine transporters, especially GlyT1 and GlyT2, show promise as a new class of analgesics with broad efficacy in preclinical pain models. The development of GlyT inhibitors into safe and effective pain treatments presents key challenges but offers potential as a non-opioid analgesic with a differentiated mechanism of action.
Article
Biochemistry & Molecular Biology
Kamil Szopa, Agata Znamirowska-Piotrowska, Katarzyna Szajnar, Malgorzata Pawlos
Summary: This study evaluated the possibility of using collagen and collagen hydrolysate to produce probiotic sheep's milk. The addition of collagen affected the physicochemical, organoleptic and microbiological properties of fermented sheep's milk. The form and dose of collagen had no effect on the growth and survival of probiotic bacteria strains, but resulted in darkening of the milk color and increased sweetness. Collagen hydrolysate addition effectively reduced syneresis in the milk samples.
Article
Biochemistry & Molecular Biology
Ji-Eun Kim, Eun-Young Kwon, Youngji Han
Summary: Collagen peptide and collagen tripeptide are supplementary health foods that have various biological effects. This study found that the supplements increased muscle weight and reduced body fat in aging mice, improving age-associated sarcopenia through different mechanisms.
Review
Biochemistry & Molecular Biology
Karla Aidee Aguayo-Ceron, Fausto Sanchez-Munoz, Rocio Alejandra Gutierrez-Rojas, Lourdes Nallely Acevedo-Villavicencio, Aurora Vanessa Flores-Zarate, Fengyang Huang, Abraham Giacoman-Martinez, Santiago Villafana, Rodrigo Romero-Nava
Summary: Glycine is a non-essential amino acid that has various functions and effects. It binds to specific receptors and transporters in different types of cells throughout the body to exert its effects. Studies have shown that glycine has anti-inflammatory effects, such as reducing pro-inflammatory cytokines and free fatty acid levels, improving insulin response, and mediating other changes. However, the exact mechanism through which glycine acts is still unclear. This review emphasizes the importance of glycine in modulating the expression of nuclear factor kappa B (NF-κB) in various cells to exert its anti-inflammatory effects, and highlights the significance of dietary glycine supplementation in preventing the development of chronic inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Xiumin Chen, Katie A. Wilson, Natascha Schaefer, Lachlan De Hayr, Mark Windsor, Emmanuel Scalais, Germaine van Rijckevorsel, Katrien Stouffs, Carmen Villmann, Megan L. O'Mara, Joseph W. Lynch, Robert J. Harvey
Summary: This study investigates the functional characteristics of four missense variants in the GLRA2 gene associated with ASD or developmental disorders. The results suggest that these variants can result in a loss, gain or alteration of GlyR alpha 2 function, which may lead to changes in brain development, cognition, learning, and memory.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Food Science & Technology
Ivan Cruz-Chamorro, Nuria Alvarez-Sanchez, Ana Isabel Alvarez-Rios, Guillermo Santos-Sanchez, Justo Pedroche, Francisco Millan, Cecilio Carrera Sanchez, Maria Soledad Fernandez-Pachon, Maria Carmen Millan-Linares, Alicia Martinez-Lopez, Patricia Judith Lardone, Ignacio Bejarano, Juan Miguel Guerrero, Antonio Carrillo-Vico
Summary: This study aimed to evaluate the safety and efficacy of a beverage containing Lupinus angustifolius protein hydrolysates (LPHs) on the immune, oxidative, and metabolic status of healthy subjects. The results showed that LPHb ingestion was safe and effective in enhancing the anti-/pro-inflammatory response of PBMCs and improving cellular antioxidant capacity. Additionally, LPHb was found to reduce the LDL-C/HDL-C atherogenic index and serum total cholesterol levels, especially in the male cohort.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)