Article
Biochemistry & Molecular Biology
Raul Lopez-Fernandez-Sobrino, Jorge R. Soliz-Rueda, Javier Avila-Roman, Anna Arola-Arnal, Manuel Suarez, Begona Muguerza, Francisca Isabel Bravo
Summary: The study found that wine lees powder has antihypertensive effects related to flavanols, anthocyanins, and endothelial factors, reducing blood pressure by affecting NO and prostacyclin production. Additionally, the antihypertensive effect of wine lees powder is mediated by SIRT1, leading to increased expression of eNos and Sirt1 genes.
Article
Nutrition & Dietetics
Shumpei Fujie, Natsuki Hasegawa, Naoki Horii, Kenichiro Inoue, Masataka Uchida, Motoyuki Iemitsu
Summary: The study found that chronic Chlorella intake combined with aerobic exercise training can enhance endothelial vasorelaxation in aged mice by increasing arterial NO production.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2021)
Article
Physiology
Jessica Lavier, Manon Beaumann, Steeve Menetrey, Karima Bouzourene, Nathalie Rosenblatt-Velin, Vincent Pialoux, Lucia Mazzolai, Anne-Christine Peyter, Maxime Pellegrin, Gregoire P. Millet
Summary: Hypoxic high-intensity exercise increases NO bioavailability and improves vascular function, showing promising potential for cardiovascular disease prevention.
Article
Pharmacology & Pharmacy
Jiaojiao Wang, Zhiping Liu, Jing Lu, Jiami Zou, Weile Ye, Hong Li, Si Gao, Peiqing Liu
Summary: This study found that SIRT6 regulates endothelial function by modulating the activity of NOS3. SIRT6 activates NOS3 through deacetylation and facilitates its interaction with calmodulin, leading to increased nitric oxide generation.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jae Min Cho, Seul-Ki Park, Oh Sung Kwon, D. Taylor La Salle, James Cerbie, Caitlin C. Fermoyle, David Morgan, Ashley Nelson, Amber Bledsoe, Leena P. Bharath, Megan Tandar, Satya P. Kunapuli, Russell S. Richardson, Pon Velayutham Anandh Babu, Sohom Mookherjee, Bellamkonda K. Kishore, Fei Wang, Tianxin Yang, Sihem Boudina, Joel D. Trinity, J. David Symons
Summary: This study explores the importance of endothelial cell autophagy in maintaining vascular homeostasis and its role in nitric oxide generation. The findings suggest that autophagy is necessary for glycolysis-dependent purinergic signaling to eNOS, and impaired autophagy leads to arterial dysfunction. The activation of P2Y(1)-Rs improves arterial function in cases of compromised autophagy.
CARDIOVASCULAR RESEARCH
(2022)
Article
Cell Biology
Niroz Abu-Saleh, Hiba Yaseen, Safa Kinaneh, Mogher Khamaisi, Zaid Abassi
Summary: The study found that the combination of hyperglycemia and hyperlipidemia could lead to endothelial dysfunction, increase production of endothelin-1, decrease both total endothelial NO synthase and NRF2 activity, activate the endothelin system and attenuate the nitric oxide system.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Physiology
Agnaldo Bruno Chies, Maria Angelica Spadella, Priscila Ramos de Oliveira, Raquel Fantin Domeniconi, Talita de Mello Santos, Roseli Peres Moreira, Carla B. Rosales, Dulce Elena Casarini, Luis Gabriel Navar
Summary: This study found that NO reduces Ang II responses in femoral veins of 2K1C hypertensive rats, while exercise mobilizes vasodilator prostanoids to maintain controlled Ang II responses in the veins.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Lin Zhang, Chenfei Li, Liting Yang, Gabriel Komla Adzika, Jeremiah Ong'achwa Machuki, Mingjin Shi, Qi Sun, Hong Sun
Summary: The study aimed to investigate the impact of estrogen deficiency during catecholamine stress on vasomotor function, as well as to utilize estrogen replacement therapy to mitigate the adverse effects of stress on aortic vessels. The results showed that estrogen prevented excessive weight gain during stress, while upregulating eNOS activities and decreasing ET-1 expressions to facilitate vasomotor functions. Overall, estrogen treatments during stress preserved vasomotor functions by preventing excessive intima-media thickening and collagen depositions in the aortic vascular walls.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, Research & Experimental
Zinnet Sevval Aksoyalp, Cahit Nacitarhan, Ozan Erbasan
Summary: The study showed that vorapaxar caused endothelial dysfunction by disrupting nitric oxide and endothelium-derived hyperpolarizing factor-dependent relaxation mechanisms, while parmodulin-2 did not cause endothelial damage. Parmodulin-2 may be a better option than vorapaxar in treating cardiovascular diseases.
Article
Multidisciplinary Sciences
Dan Wang, Zong-Xiang Li, Dong-Mou Jiang, Yan-Zhong Liu, Xin Wang, Yi-Ping Liu
Summary: The study aimed to observe the effect of magnesium ion on vascular function in rats after long-term exhaustive exercise. The results showed that the smooth muscle layer of the blood vessels in the exhaustive exercise group became thicker, the cell arrangement was disordered, and the integrity of endothelial cells was destroyed. The levels of IL-1 beta, TNF-alpha, MDA, and ROS in the serum of the exhaustive exercise group were significantly higher compared to the control group, while the level of NO was significantly decreased. The vasomotor function of rats after exhaustion exercise can be significantly improved by magnesium ion.
Article
Cardiac & Cardiovascular Systems
Lyndsey E. DuBose, Cemal Ozemek, Tyler Wick, Vanessa Richardson, Kerry L. Hildreth, Kerrie L. Moreau
Summary: Endothelial function is reduced in postmenopausal women due to BH4 deficiency and oxidative stress, leading to reduced NO bioavailability. Acute intravenous VITC or oral BH4 supplementation can increase FMD, but cannot fully restore it. Co-administration of VITC and BH4 does not restore FMD in menopausal women, indicating the involvement of additional mechanisms.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Andrei C. Sposito, Ikaro Breder, Alexandre A. S. Soares, Sheila T. Kimura-Medorima, Daniel B. Munhoz, Riobaldo M. R. Cintra, Isabella Bonilha, Daniela C. Oliveira, Jessica Cunha Breder, Pamela Cavalcante, Camila Moreira, Filipe A. Moura, Jose Carlos de Lima-Junior, Helison R. P. do Carmo, Joaquim Barreto, Wilson Nadruz, Luiz Sergio F. Carvalho, Thiago Quinaglia
Summary: The study showed that dapagliflozin may improve cardiovascular function in diabetic patients. Specifically, it was found that dapagliflozin improved flow-mediated dilation capability after 1 minute of rest, compared to glibenclamide.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Kaitlin A. Freeberg, Daniel H. Craighead, Thomas C. Heinbockel, Matthew J. Rossman, Rachel A. Jackman, Lindsey R. Jankowski, Katelyn R. Ludwig, Michel Chonchol, E. Fiona Bailey, Douglas R. Seals
Summary: High-resistance inspiratory muscle strength training (IMST) may improve cerebrovascular and cognitive function in midlife/older adults with above-normal blood pressure, a population at risk for future cognitive decline and dementia.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Medicine, Research & Experimental
Jun -Ha Hwang, Woong Heo, Jung Il Park, Kyung Min Kim, Ho Taek Oh, Gi Don Yoo, Jeekeon Park, Somin Shin, Youjin Do, Mi Gyeong Jeong, Eun Sook Hwang, Jeong-Ho Hong
Summary: Endothelial TAZ is involved in the production of nitric oxide (NO) and inhibits damage-induced liver fibrosis. It regulates NO production by transcriptional regulation of Nos3. Loss of TAZ leads to capillarization of liver sinusoidal endothelial cells and a decrease in NO concentration, accelerating liver fibrosis.
Review
Cell Biology
Meng Li, Yanqing Wu, Lei Ye
Summary: This review summarizes the metabolic and signaling pathways of amino acids in endothelial cells, discussing the importance of amino acid homeostasis in endothelial cell and vascular homeostasis, as well as the challenges and future research directions.
Article
Physiology
Joshua M. Bock, Erika Iwamoto, Jeffrey G. Horak, Andrew J. Feider, Satoshi Hanada, Darren P. Casey
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2020)
Article
Physiology
William E. Hughes, Nicholas T. Kruse, Kenichi Ueda, Andrew J. Feider, Satoshi Hanada, Joshua M. Bock, Darren P. Casey
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2020)
Article
Physiology
Erika Iwamoto, Brady E. Hanson, Joshua M. Bock, Darren P. Casey
JOURNAL OF APPLIED PHYSIOLOGY
(2020)
Article
Anesthesiology
Kenichi Ueda, David M. Janiczek, Darren P. Casey
Summary: The study found that preoperative measurement of carotid-femoral pulse-wave velocity in patients chronically treated with ACEIs could help identify patients at increased risk of developing hypotension refractory to vasopressors after induction of general anesthesia.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2021)
Article
Cardiac & Cardiovascular Systems
Darren P. Casey, Joshua M. Bock
Summary: Inorganic nitrate supplementation improves conduit artery shear profiles in older adults, but does not significantly affect exercise hyperemia. The study highlights favorable changes in shear patterns with aging, which may reduce the risk of atherosclerotic cardiovascular disease.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Erika Iwamoto, Rintaro Sakamoto, Wakako Tsuchida, Kotomi Yamazaki, Tatsuki Kamoda, Toru Neki, Masaki Katayose, Darren P. Casey
Summary: This study found that shear-mediated dilation of the ICA is higher during the late follicular phase compared to the early follicular phase in premenopausal women. As menopause progresses, shear-mediated dilation decreases. Lower levels of estradiol are associated with reduced shear-mediated dilation of the ICA, regardless of age.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Physiology
Brady E. Hanson, Michael J. Joyner, Darren P. Casey
Summary: This study found that older women have a blunted rapid vasodilatory response to single muscle contractions compared to older men. Sex-related differences in this response were present among older but not young individuals. This indicates that sex plays a role in decreased vasodilation with aging.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Physiology
Joshua M. Bock, Brady E. Hanson, Thomas F. Asama, Andrew J. Feider, Satoshi Hanada, Aric W. Aldrich, Mark Eric Dyken, Darren P. Casey
Summary: This study investigated the effects of acute inorganic nitrate supplementation on blood pressure and cardiopulmonary responses to hypoxia in OSA patients. The results suggest that inorganic nitrate supplementation can attenuate the early-morning rise in systolic blood pressure potentially through suppression of peripheral chemoreflex sensitivity.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Geriatrics & Gerontology
Meredith J. Luttrell, Benjamin R. Mardis, Joshua M. Bock, Erika Iwamoto, Satoshi Hanada, Kenichi Ueda, Andrew J. Feider, Kenzie Temperly, Darren Casey
Summary: The balance of angiogenic factors, including VEGF, and angiostatic factors, like TSP-1 and endostatin, control striated muscle angiogenic responses to exercise training. The effect of age on circulating levels of these factors following exercise is unclear. Older adults showed lower circulating VEGF but higher TSP-1 and endostatin after exercise compared with young adults.
JOURNAL OF AGING AND PHYSICAL ACTIVITY
(2021)
Article
Biochemistry & Molecular Biology
Joshua M. Bock, Kenichi Ueda, Andrew J. Feider, Satoshi Hanada, Darren P. Casey
Summary: Beetroot juice supplementation improves the hyperemic and vasodilatory responses to exercise in patients with T2DM by reducing alpha-adrenergic mediated vasoconstriction in contracting skeletal muscle.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2022)
Article
Peripheral Vascular Disease
Joshua M. Bock, William E. Hughes, Kenichi Ueda, Andrew J. Feider, Satoshi Hanada, Darren P. Casey
Summary: This study found that supplementation with beetroot juice containing inorganic nitrate/nitrite can improve peripheral and central blood pressure as well as AIx in patients with T2DM.
AMERICAN JOURNAL OF HYPERTENSION
(2022)
Article
Cardiac & Cardiovascular Systems
William E. Hughes, David P. Treichler, Kenichi Ueda, Joshua M. Bock, Darren P. Casey
Summary: The study aimed to investigate the effects of eight-weeks of sodium nitrate supplementation on blood pressure indices in patients with peripheral artery disease. The results showed that NaNO3 supplementation reduced the blood pressure responsiveness to sympatho-excitatory stimuli in PAD patients.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Physiology
Brady E. Hanson, Erika Iwamoto, Bryan L. Mouser, Kayla A. Miller, Darren P. Casey
Summary: This study found that acute exposure to hypoxia (both intermittently and continuously) can offset the decline in vascular function after brief inactivity. The potential beneficial effect of hypoxia on peripheral vascular function may be associated with enhanced brachial artery shear in response to the hypoxic challenge.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2022)
Article
Physiology
Joshua M. Bock, Brady E. Hanson, Kayla A. Miller, Nathanael T. Seaberg, Kenichi Ueda, Andrew J. Feider, Satoshi Hanada, Vitor A. Lira, Darren P. Casey
Summary: Patients with type 2 diabetes have poor exercise capacity. However, supplementation of inorganic nitrate/nitrite can improve exercise capacity, including maximal oxygen consumption, maximal workload, and gas exchange threshold.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Physiology
Joshua M. Bock, William E. Hughes, Kenichi Ueda, Andrew J. Feider, Satoshi Hanada, Darren P. Casey
Summary: Microvascular endothelial dysfunction in patients with type 2 diabetes mellitus increases cardiovascular disease mortality. Our study found that glycemic management is associated with acetylcholine-mediated vasodilation in skeletal muscle of these patients, with better vascular function in patients meeting the ADA's therapeutic target for HbA1c.
PHYSIOLOGICAL REPORTS
(2021)