期刊
EXPERIMENTAL BIOLOGY AND MEDICINE
卷 237, 期 5, 页码 585-592出版社
ROYAL SOC MEDICINE PRESS LTD
DOI: 10.1258/ebm.2012.011362
关键词
mesenchymal stem cell; Schistosoma japonicum; praziquantel; fibrosis
资金
- Major Research Plan of the National Natural Science Foundation of China [91129718]
- National Natural Science Foundation of China [81071421, 81000181, 31140063]
- Foundation of the Jiangsu Province for transfer of scientific and technological achievements [BA2009124]
- Jiangsu Province's Scientific and Technological Supporting Program [BE2010703]
- Jiangsu Province Doctoral Innovation Fund [CX10B_281Z]
- Natural Science Foundation of the Jiangsu Province for high schools [09KJB320001]
- Sci-tech Innovation Team and Talents of Jiangsu University [2008-018-02]
Mesenchymal stem cells (MSCs) have gained popularity for their potential as seed cells to treat various human diseases, including pathogenic infections. Schistosoma japonicum (S. japonicum) infection is characterized by formation of parasite egg granulomas and host liver fibrosis. MSCs have been proposed as useful treatments of S. japonicum infection, but the efficacy and underlying mechanisms remain unknown. Herein, we report that MSCs were able to ameliorate S. japonicum-induced liver injury in vivo and this effect was enhanced by combining MSCs with conventional drug praziquantel (PZQ). Kunming strains of mice were infected with S. japonicum and treated with vehicle, MSCs, PZQ or PZQ MSCs. MSC treatment not only prolonged the survival time of infected mice but reduced egg granuloma diameter and decreased the concentrations of serum transforming growth factor-beta 1 and hyaluronic acid. MSC treatment also inhibited collagen deposition and reduced the expression of collagen type 3, alpha-smooth muscle actin and vimentin in infected mouse liver tissues. Collectively, our findings suggest that MSC treatment represents a novel therapeutic approach for S. japonicum-induced liver injury and fibrosis.
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