Article
Physiology
Arezoo Daryadel, Betul Haykir, Catharina J. Kung, Milica Bugarski, Carla Bettoni, Udo Schnitzbauer, Nati Hernando, Andrew M. Hall, Carsten A. Wagner
Summary: This study aims to clarify the role of various phosphate-regulatory mechanisms in the acute regulation of renal phosphate transporters. The results show that acute intake of phosphate leads to downregulation of renal phosphate transporters, even in the absence of parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23) signaling. When FGF23 signaling is blocked, PTH partially contributes to the regulation of phosphate transporters. Inositol hexakisphosphate kinases (IP6-kinases), known as intracellular phosphate sensors in yeast and bacteria, are not involved in this process. Additionally, acute phosphate intake does not affect the levels of PTHrp and dopamine.
Article
Nutrition & Dietetics
Maria Victoria Pendon-Ruiz De Mier, Noemi Vergara, Cristian Rodelo-Haad, Maria Dolores Lopez-Zamorano, Cristina Membrives-Gonzalez, Rodrigo Lopez-Baltanis, Juan Rafael Munoz-Castaneda, Francisco Caravaca, Alejandro Martin-Malo, Arnold J. Felsenfeld, Eugenio J. De la Torre, Sagrario Soriano, Rafael Santamaria, Mariano Rodriguez
Summary: The study aimed to investigate the role of the P/UUN ratio in identifying patients with high inorganic phosphate intake, and found that the ratio can serve as a marker for inorganic phosphate intake. Patients with the highest P/UUN ratio were found to have a higher intake of inorganic phosphate.
Review
Biochemistry & Molecular Biology
Linto Thomas, Jessica A. Dominguez Rieg, Timo Rieg
Summary: Hyperphosphatemia is associated with cardiovascular complications and its management includes oral Pi binders and dietary restrictions. However, these options may be inadequate for patients with chronic kidney disease (CKD). Recent studies propose the inhibition of renal Na+/Pi cotransporter 2a (Npt2a), responsible for most P-i reabsorption, as a potential treatment option. Npt2a inhibitors have been developed and shown to increase urinary P-i excretion and decrease plasma P-i and PTH levels, but their effects on FGF23 are unclear.
BIOCHEMICAL SOCIETY TRANSACTIONS
(2022)
Article
Chemistry, Multidisciplinary
Qian-Qian Chen, Chun-Li Hu, Jin Chen, Yi-Lin Li, Bing-Xuan Li, Jiang-Gao Mao
Summary: An organic-inorganic hybrid polyiodate with a novel branched polyiodate chain structure has been successfully synthesized. This compound exhibits excellent Second-Harmonic-Generation (SHG) performance and a high laser-induced-damage-threshold (LIDT) under laser radiation, showing promising potential for applications.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Cell Biology
Wenqiong Luo, Yixuan Jiang, Zumu Yi, Yingying Wu, Ping Gong, Yi Xiong
Summary: The study found that 1,25D can promote bone metabolism under diabetes-induced conditions by regulating the FOXO1/FGF23 signaling pathway, leading to improved bone health and reduced bone loss in diabetic individuals.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Orthopedics
Y. Dong, P. Wang, M. Zhang, L. Xiao, Y. Yang, B. Wang, Y. Liu, Z. Dai, J. Zheng
Summary: Proteomic analysis revealed the crucial role of protein phosphorylation in the pathogenesis of osteoarthritis (OA). Phosphoproteomics identified BRAF as a potential regulator in OA development through the ERK signaling pathway. Immunohistochemistry showed increased expression of BRAF in human OA cartilage, and inhibition of BRAF alleviated cartilage degradation in an OA mouse model by activating the downstream ERK pathway.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Polymer Science
Yao Lu, Xuna Jin, Xiang Li, Minpeng Liu, Baolei Liu, Xiaodan Zeng, Jie Chen, Zhigang Liu, Shihua Yu, Yucheng Xu
Summary: Superparamagnetic Fe3O4 particles were synthesized by solvothermal method, and a layer of dense silica sol polymer was coated on the surface prepared by sol-gel technique; then La(OH)(3) deposited on the surface of silica sol polymer by controlled in situ growth technology. These materials showed excellent adsorption capacity for phosphate removal, with a high removal rate, high sorption capacity, and good selectivity in the presence of competing ions. Moreover, the Fe3O4@La(OH)(3) particles demonstrated fast separability, easy reusability, and high stability.
Article
Chemistry, Physical
Kaikai Zheng, Li Xiang, Chou Huang, Yan Wang, Haichuan Zhang, Ji Li
Summary: In this study, an inexpensive fiber material was developed for the removal and recovery of phosphate from wastewater. The material showed excellent adsorption performance and anti-interference ability, leading to successful phosphate removal in real wastewater treatment.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Orthopedics
M. Y. Ansari, K. Novak, T. M. Haqqi
Summary: This study found that ERK1/2 plays a key role in DRP1-mediated mitochondrial fission and apoptosis in IL-1b-stimulated chondrocytes. DRP1 induces IL-1b-induced mitochondrial network fragmentation and chondrocyte apoptosis by regulating its expression and activity. Inhibiting DRP1 activity can block IL-1b-induced mitochondrial damage and apoptosis.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Chemistry, Physical
Yuexiang Li, Ruijie Tong, Wenzhen Zhang, Shaoqin Peng
Summary: Phosphate-intercalated Ni-Ni(OH)2/NiOOH electrode shows improved oxygen evolution reaction (OER) activity and long-term stability, providing a strategy to develop efficient and stable OER materials.
JOURNAL OF CATALYSIS
(2022)
Article
Chemistry, Physical
Lu Gong, Zhenying Yao, Chunmei Zhu, Xin Lian, Bai He, Long Qu, Wei Xiong, Bo Yu
Summary: In this study, porous Mg(OH)(2) nanowires were synthesized via a hydrothermal conversion method for the removal of phosphate from water. These nanowires exhibited good adsorption performance for phosphate, following pseudo-second-order kinetics, and showed minimal interference from coexisting ions. They demonstrated excellent recycling capabilities as well.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Plant Sciences
Yan Wang, Hong Wu, Bin-Jie Gui, Jian Liu, Gen-Xiang Rong, Ran Deng, Yan-Hong Bu, Heng Zhang
Summary: The study found that geniposide can inhibit angiogenesis in rheumatoid arthritis and alleviate disease progression. The research also revealed the important role of SphK1, VEGF/VEGFR2, and S1P/S1PR1 signaling pathways in the effect of geniposide on synovial angiogenesis.
Article
Cell Biology
Zuoqing Zhou, Su'an Tang, Xiaoyu Nie, Yiqun Zhang, Delong Li, Yang Zhao, Yumei Cao, Jianwen Yin, Tianyu Chen, Guangfeng Ruan, Zhaohua Zhu, Xiaochun Bai, Weiyu Han, Changhai Ding
Summary: This study demonstrates that osteoarthritic IPFP-derived fat-conditioned medium can induce ECM degradation in chondrocytes and cartilage explants, activate multiple signaling pathways, and ultimately lead to cartilage degradation and inflammation via the p38MAPK and ERK1/2 pathways. IL-1 beta and TNF-alpha play key roles in this process. Modulating the effects of IPFP on cartilage may be a promising strategy for knee osteoarthritis intervention.
INFLAMMATION RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Ziqi Chen, Fuming Li, Jian Han, Zhihua Yang, Shilie Pan, Miriding Mutailipu
Summary: Selective organic-inorganic transformation is an important and challenging process. In this study, a new hydroxyfluorooxoborate Cs[B3O3F2(OH)(2)] was synthesized by replacing organic cations with Cs atoms. Theoretical analysis confirmed the effects of different components on the optical properties of the structure.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Mingyao Hong, Dongchun Chen, Weiya Zhu, Guanjie Li, Xianggui Zhou, Weishan Li, Youhao Liao
Summary: To improve the safety of Li-ion battery, researchers have developed a flame-retardant separator by co-coating inorganic/organic composites of Mg(OH)2/TPP onto polyethylene (PE) separator. The MT31/PE flame-retardant separator shows better flame-retardant property, superior compatibility with lithium anode, and higher electrochemical performance.
SOLID STATE IONICS
(2023)