期刊
EXPERIMENTAL BIOLOGY AND MEDICINE
卷 235, 期 5, 页码 547-560出版社
SAGE PUBLICATIONS LTD
DOI: 10.1258/ebm.2009.009249
关键词
nuclear receptors; alcoholic liver disease; retinoid x receptor alpha; peroxisome proliferator-activated receptors; ethanol; lipogenic transcription factors
资金
- NIH [CA 53596, AA14147]
- NATIONAL CANCER INSTITUTE [R29CA053596, R01CA053596] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM [R01AA014147] Funding Source: NIH RePORTER
Ethanol consumption causes fatty liver, which can lead to inflammation, fibrosis, cirrhosis and even liver cancer. The molecular mechanisms by which ethanol exerts its damaging effects are extensively studied, but not fully understood. It is now evident that nuclear receptors (NRs), including retinoid x receptor a and peroxisome proliferator-activated receptors, play key roles in the regulation of lipid homeostasis and inflammation during the pathogenesis of alcoholic liver disease (ALD). Given their pivotal roles in physiological processes, NRs represent potential therapeutic targets for the treatment and prevention of numerous metabolic and lipid-related diseases including ALD. This review summarizes the factors that contribute to ALD and the molecular mechanisms of ALD with a focus on the role of NRs.
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