期刊
EXPERIMENTAL BIOLOGY AND MEDICINE
卷 233, 期 12, 页码 1537-1545出版社
SAGE PUBLICATIONS LTD
DOI: 10.3181/0805-RM-164
关键词
osteopontin (OPN); gastric cancer; curcumin; apoptosis; Akt
资金
- National Natural science Foundation of China [30370307, 30400239, 30570915]
- Program for New Century Excellent Talents in Xiamen University
Osteopontin (OPN) is a secreted, integrin-binding matrix phosphorylated glycoprotein that is overexpressed in many advanced cancers. However, the functional mechanisms by which OPN contributes to gastric cancer development are poorly understood. Here, we report that curcumin inhibited the growth of SGC7901 cell and induced apoptosis in a concentration- and time-dependent manner, while the acquired expression of OPN in SGC7901 cells dramatically promoted cell survival under serum depletion and prevented curcumin-induced apoptosis. Furthermore, PI3-K inhibitor LY294002 attenuated OPN-mediated Akt activation. Moreover, inhibiting the binding of OPN to alpha(v)beta(3) integrins reduced activation of Akt. Taken together, these results demonstrate that the pro-survival and anti-apoptosis activities of OPN in gastric cancer cells are mediated in part through PI3-K/Akt pathway via alpha(v)beta(3) integrins. Exp Biol Med 233: 1537-1545, 2008
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