Article
Physiology
Ryuhei Sano, Yukihito Ishii, Masao Yamanaka, Yuzo Yasui, Yusuke Kemmochi, Fuko Kuroki, Miki Sugimoto, Sumiaki Fukuda, Tomohiko Sasase, Katsuhiro Miyajima, Dai Nakae, Takeshi Ohta
Summary: The study investigated glomerular changes and pharmacological effects of dapagliflozin on renal lesions in SDT fatty rats. The results suggest that dapagliflozin not only improved hyperglycemia, but also ameliorated glomerular hyperfiltration and tubule lesions in SDT fatty rats.
PHYSIOLOGICAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Yuichi Shinozaki, Yuko Katayama, Fuminari Yamaguchi, Tomohisa Suzuki, Kana Watanabe, Kinuko Uno, Takahiro Tsutsui, Miki Sugimoto, Masami Shinohara, Katsuhiro Miyajima, Takeshi Ohta
Summary: By using the SDT fatty rat model treated with 0.3% salt loading and unilateral nephrectomy, it is possible to evaluate therapeutic agents for the treatment of hypertensive DKD based on the suppression of GFR decline.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Thiri Wai Linn, Anongporn Kobroob, Metas Ngernjan, Doungporn Amornlerdpison, Narissara Lailerd, Orawan Wongmekiat
Summary: The study found that long-term supplementation of crocodile oil did not improve the development of diabetic nephropathy in spontaneously diabetic Torii rats, but instead exacerbated kidney and mitochondrial dysfunction caused by diabetes. This may be due to the imbalanced omega-6: omega-3 ratio in crocodile oil.
Article
Toxicology
Soon Hui Teoh, Katsuhiro Miyajima, Yuichi Shinozaki, Masami Shinohara, Keiichi Ohata, Francois Briand, Rika Morimoto, Yuka Nakamura, Kinuko Uno, Noriko Kemuriyama, Dai Nakae, Takeshi Ohta, Tatsuya Maekawa
Summary: Type 2 diabetes mellitus is a global health concern with a growing number of patients, and excessive salt consumption is considered a major cause of diseases like hypertension. Excessive sodium chloride supplementation in male SDT fatty rats showed significant changes in various parameters, while the effects were less pronounced in female SDT fatty rats. Urinary L-FABP levels may serve as a useful biomarker for detecting kidney damage.
JOURNAL OF TOXICOLOGICAL SCIENCES
(2021)
Article
Oncology
Tiago Bordeira Gaspar, Tito Teles Jesus, Maria Teresa Azevedo, Sofia Macedo, Mariana Alves Soares, Rui Sousa Martins, Ruben Leite, Lia Rodrigues, Daniela Ferreira Rodrigues, Luis Cardoso, Ines Borges, Sule Canberk, Fatima Gartner, Leandro Miranda-Alves, Jose Manuel Lopes, Paula Soares, Joao Vinagre
Summary: ATRX mutations can lead to pancreatic neuroendocrine tumors (PanNETs) in humans and may also predispose individuals to inflammation aging. In this study, the additional non-tumorigenic effects of Atrx deletion in mice were explored, and it was found that Atrx loss resulted in obesity, diabetes, glucose intolerance, and increased pancreatic adiposity. The study also identified the role of Atrx in endocrine dysfunction and the potential of an Atrx genetically engineered mouse model for metabolic studies.
Article
Endocrinology & Metabolism
Xiang Gao, Junsheng He, Anming Zhu, Kang Xie, Kaixuan Yan, Xue Jiang, Ying Xu, Qin Li, Aimin Xu, Dewei Ye, Jiao Guo
Summary: The review discusses the criteria for an ideal animal model of GDM, the limitations of current models, and potential strategies for developing better models. Current leading strategy involves insulin insufficiency due to pancreatic beta-cell death, but these models have limitations in mimicking the natural history of GDM and its metabolic complications. Emerging evidence suggests genetic modifications in pregnancy-related hormones may contribute to increased susceptibility to GDM.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2021)
Article
Medicine, General & Internal
Si-Wen Dang, Lei Gao, Yu-Jun Li, Ruo Zhang, Jing Xu
Summary: Non-obese MAFLD has unique metabolic characteristics and correlations with diabetic retinopathy and diabetic peripheral neuropathy.
FRONTIERS IN MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Takayuki Maruyama, Terumasa Kobayashi, Yoshio Sugiura, Toshiki Yoneda, Daisuke Ekuni, Manabu Morita
Summary: This study revealed that several miRNAs play an important role in the mechanism of periodontal disease progression induced by obesity.
JOURNAL OF PERIODONTAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Kuishuai Xu, Liang Zhang, Zhongkai Ren, Tianrui Wang, Yingze Zhang, Xia Zhao, Tengbo Yu
Summary: This study established and validated a rat model of rotator cuff tendinopathy to explore the effects of type 2 diabetes on the rotator cuff tendon. The results showed that persistent type 2 diabetes is associated with collagen fiber rupture, extracellular matrix disturbance, and biomechanical decline of the rotator cuff tendon.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Dermatology
Ziye Li, Jing Wei, Song Lu
Summary: This study aimed to examine the relationship between diabetic retinopathy (DR) and diabetic foot ulcers (DFUs) to provide evidence for preventing diabetic complications. A meta-analysis of 11 articles involving 10,208 patients was conducted, revealing that DR significantly increased the risk of DFU occurrence (47.94% vs. 16.38%; OR, 4.13; 95% CI, 2.33-7.33; p < 0.001). These findings emphasize the importance of regular screening for these complications in patients with DR to prevent serious adverse outcomes of diabetes. However, further high-quality studies are needed to validate these conclusions.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Food Science & Technology
Baorui Li, Lei Fu, Ruchia Kojima, Ayaka Yamamoto, Tomoya Ueno, Toshiro Matsui
Summary: The administration of non-absorbable theaflavins improved impaired glucose tolerance and reduced blood glucose levels in diabetic SDT rats, demonstrating anti-diabetic effects. Long-term intake of theaflavins induced increased incretin secretion without affecting dipeptidyl peptidase-IV activity or glucose transporter expression, suggesting a mechanism for their anti-diabetic effects.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Endocrinology & Metabolism
Eunjin Oh, Erika M. McCown, Miwon Ahn, Pablo A. Garcia, Sergio Branciamore, Shanshan Tang, De-Fu Zeng, Bart O. Roep, Debbie C. Thurmond
Summary: STX4 plays a crucial role in regulating human islet beta-cell function, with reduced expression potentially linked to type 1 diabetes. Increasing STX4 expression can improve blood glucose control and promote beta-cell survival in NOD mice.
Article
Biochemistry & Molecular Biology
Ahmad Agil, Miguel Navarro-Alarcon, Fatma Abo Zakaib Ali, Ashraf Albrakati, Diego Salagre, Cristina Campoy, Ehab Kotb Elmahallawy
Summary: The study revealed that melatonin could improve mitochondrial function in brown fat tissue of obese rats, reducing oxidative stress, promoting ATP production, and decreasing susceptibility to apoptosis.
Article
Public, Environmental & Occupational Health
Getachew Zewdu Chekol, Daniel Mengistu, Addisu Waleligne Tadesse
Summary: This study assessed the knowledge of diabetes complications among type-2 diabetic patients in public hospitals of Addis Ababa. The overall knowledge level was found to be 54.9%. Various factors including profession, disease duration, family history, and participation in diabetic counseling were identified to significantly impact the knowledge level. The study recommends emphasizing sustained knowledge about diabetes complications for patients with longer disease duration and improving knowledge among diabetic farmers.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Wei Zhang, Jun Ma, Shan Wang, Tao Huang, Min Xia
Summary: Tranilast plays a crucial role in modulating T2DM-related neuropathic pain, likely through inhibiting hypoxia.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Yuichi Shinozaki, Yuko Katayama, Fuminari Yamaguchi, Tomohisa Suzuki, Kana Watanabe, Kinuko Uno, Takahiro Tsutsui, Miki Sugimoto, Masami Shinohara, Katsuhiro Miyajima, Takeshi Ohta
Summary: By using the SDT fatty rat model treated with 0.3% salt loading and unilateral nephrectomy, it is possible to evaluate therapeutic agents for the treatment of hypertensive DKD based on the suppression of GFR decline.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2022)
Article
Veterinary Sciences
Tatsuya Maekawa, Miki Sugimoto, Shinichi Kume, Takeshi Ohta
Summary: Diabetes mellitus (DM) and obesity are associated with neurodegenerative diseases and psychiatric disorders. This study investigated pathophysiological changes in the brain of female SDT fatty rats with diabetes and obesity. The results showed decreased cell numbers and increased expression of an inflammation-related gene in the brains of SDT fatty rats.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2022)
Article
Reproductive Biology
Shujiao Ma, Xuewen Ji, Ming Cang, Jianguo Wang, Haiquan Yu, Yongbin Liu, Wenguang Zhang, Yiran Wu, Suwen Zhao, Guifang Cao, Bin Tong
Summary: In this study, novel variations in the LEPR gene were identified in Mongolia sheep, and two mutations were significantly associated with litter sizes in Mongolia and Ujimqin ewes. These mutations are predicted to alter the mRNA secondary structure of LEPR. The findings provide potential genetic markers for increasing litter size in sheep.
Article
Physiology
Kazuma Kobayashi, Tomohiko Sasase, Tatsuya Maekawa, Yuichi Shinozaki, Ryuhei Sano, Takahisa Yamada, Takeshi Ohta
Summary: Type 2 diabetes is a non-autoimmune metabolic disorder, but there are increasing reports of immune abnormalities in T2D patients. This study suggests that SDT rats may be a useful T2D model involving immune abnormalities, and immune abnormalities in male SDT rats may contribute to the development of diabetes.
PHYSIOLOGICAL RESEARCH
(2022)
Article
Physiology
Mariko Maekawa, Tatsuya Maekawa, Tomohiko Sasase, Kayoko Takagi, Satomi Takeuchi, Mari Kitamoto, Tatsuro Nakagawa, Kaoru Toyoda, Noriko Konishi, Takeshi Ohta, Takahisa Yamada
Summary: This study investigated the pathophysiology of diabetic kidney disease and evaluated the efficacy of long-term administration of the angiotensin-II-receptor antagonist losartan in uninephrectomized db/db mice. The results suggest that these mice are a useful animal model for severe DKD.
PHYSIOLOGICAL RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Feng Long, Ziyi Zhang, Jiayue Chen, Sen Yang, Yuan Tian, Chugang Mei, Wenzhen Zhang, Linsen Zan, Bin Tong, Gong Cheng
Summary: This study explores the role of the BBS2 gene in fat deposition of beef cattle and identifies SNPs associated with meat quality traits. It finds that the expression of BBS2 is negatively correlated with marbling ratios in beef cattle. Knockdown of BBS2 promotes adipogenesis and lipid accumulation in bovine preadipocytes. Several SNPs in the exons of BBS2 are significantly associated with meat quality in Chinese Qinchuan cattle. These findings have implications for improving meat quality and breeding in beef cattle.
Article
Pharmacology & Pharmacy
Yasuka Saigo, Tomohiko Sasase, Kinuko Uno, Yuichi Shinozaki, Tatsuya Maekawa, Ryuhei Sano, Yasufumi Toriniwa, Katsuhiro Miyajima, Takeshi Ohta
Summary: An increasing number of patients worldwide are being diagnosed with nonalcoholic fatty liver disease and nonalcoholic steatohepatitis (NAFLD/NASH) due to the growing prevalence of obesity and metabolic disorders. The incidence of NAFLD is higher in postmenopausal women than in premenopausal women, and the decline in female hormone levels may contribute to the deterioration of metabolism. In this study, a new animal model for NAFLD was investigated using Spontaneously Diabetic Torii (SDT) fatty rats. The results showed that the OVX-SDT fatty rats exhibited NASH with more severe hepatic fibrosis compared to the untreated animals, suggesting that estrogen reduction induced by ovariectomy may enhance lipid synthesis in the liver.
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
(2022)
Article
Microbiology
Zeyi Liang, Jianbo Zhang, Mei Du, Anum Ali Ahmad, Shengyi Wang, Juanshan Zheng, Ghasem Hosseini Salekdeh, Ping Yan, Jianlin Han, Bin Tong, Xuezhi Ding
Summary: This study investigated the bacterial community and associated metabolome in the cecum and colon of Mongolian cattle at different ages after weaning. The results showed the specific development patterns of hindgut microorganisms and the dynamic changes of metabolites. The findings highlighted the importance of microbial and metabolite interactions in enhancing the abiotic stress resistance of Mongolian cattle in a harsh environment.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Xin Guo, Terigele Li, Datong Lu, Takahisa Yamada, Xihe Li, Siqin Bao, Jiasen Liu, Gerelt Borjigin, Ming Cang, Bin Tong
Summary: This study aimed to evaluate the relationship between the expression levels of the CAST gene and the fatty acid (FA) composition in the longissimus thoracis (LL) muscle and to identify novel variants of CAST and perform association analysis with the FA composition in grazing Sonid sheep. The correlation results showed that high expression levels of CAST are correlated with better FA compositions and classes in LL. Four mutations were identified in the CAST gene of Sonid sheep. The association studies showed that these mutations are associated with specific FA compositions and classes in the LL of Sonid sheep, indicating their potential as genetic selection markers for meat quality.
Article
Physiology
Yuichi Shinozaki, Kenji Fukui, Mariko Maekawa, Kaoru Toyoda, Hiromi Yoshiuchi, Koji Inagaki, Kinuko Uno, Katsuhiro Miyajima, Takeshi Ohta
Summary: In patients with diabetic kidney disease (DKD), there is a need for animal models to evaluate renal function decline and assess the efficacy of therapeutic agents. This study developed a DKD animal model using spontaneously hypertensive rat (SHR)/NDmcr-cp (cp/cp) rats with characteristics of obese type 2 diabetes. Unilateral nephrectomy (UNx) in these rats resulted in a decline in creatinine clearance rate (Ccr), glomerular sclerosis, tubular lesions, and tubulointerstitial fibrosis, accompanied by renal anemia. Treatment with losartan-mixed diet suppressed Ccr decline, improved renal anemia and histopathological changes. These findings suggest that UNx-SHR/cp rats can be used as a DKD model for evaluating therapeutic agents.
PHYSIOLOGICAL RESEARCH
(2023)
Article
Reproductive Biology
Yilin Wang, Zhijiao Chi, Shunan Jia, Suwen Zhao, Guifang Cao, Chimgee Purev, Ming Cang, Haiquan Yu, Xihe Li, Siqin Bao, Yongbin Liu, Jianguo Wang, Bin Tong
Summary: Reproductive traits are important in the sheep industry, and the BMP15 gene plays a major role. This study identified 12 novel variants in the BMP15 gene of Mongolia sheep, and found significant associations between certain variants and litter size in Mongolia ewes and Ujimqin ewes. One of the mutations is predicted to affect the tertiary structure of BMP15. These findings may contribute to improving litter size in sheep.
Article
Agriculture, Dairy & Animal Science
Zixuan Cheng, Xihe Li, Siqin Bao, Takahisa Yamada, Guifang Cao, Jianfeng Liu, Aorigele Chen, Bin Tong
Summary: Overexpression of CDC10 in bovine intramuscular preadipocytes and 3T3-L1 cells promotes adipocyte differentiation, while knockdown of CDC10 has the opposite effect. These findings provide new insights into the regulatory role of CDC10 in adipocytes in animals.
Article
Medicine, Research & Experimental
Tatsuya Ishigure, Tomohiko Sasase, Marika Tohma, Kinuko Uno, Yasufumi Toriniwa, Tomoyuki Saito, Yasuka Saigo, Koji Edamura, Katsuhiro Miyajima, Takeshi Ohta
Summary: This study evaluated the relevance of an animal model to human nonalcoholic fatty liver disease (NAFLD) by gene expression analysis. The results showed that a choline-deficient L-amino acid-defined (CDAA) diet-induced NAFLD animal model successfully recaptured key aspects of human pathophysiology, particularly in terms of immune cell functions.
Review
Biochemistry & Molecular Biology
Tomohiko Sasase, Fatchiyah Fatchiyah, Takeshi Ohta
Summary: This review focuses on the various functions of transient receptor potential vanilloid (TRPV) channels, including pain sensing, temperature sensing, and metabolic control. It summarizes the basal properties and pathophysiological contributions of the six TRPV channels and discusses the pharmacological effects of endogenous and exogenous ligands on TRPV channels and related diseases.
GENERAL PHYSIOLOGY AND BIOPHYSICS
(2022)
Article
Agriculture, Dairy & Animal Science
Zixuan Cheng, Cong Sheng, Yaxing Li, Shenyuan Wang, Kaifeng Wu, Jianfeng Liu, Seiki Sasaki, Takahisa Yamada, Su Ya, Huanmin Zhou, Linsen Zan, Bin Tong
Summary: This study investigated the genetic effects of four SNPs on growth and carcass traits in Chinese Qinchuan cattle, as well as compared the allele frequencies among different cattle populations. The results suggest that these SNPs could be used as molecular markers for growth-related traits in Chinese Qinchuan cattle.
ANNALS OF ANIMAL SCIENCE
(2022)
