Article
Nutrition & Dietetics
Wei Xiong, Rongzi Li, Boying Li, Xifan Wang, Huihui Wang, Yanan Sun, Xiaoyu Wang, Yixuan Li, Fazheng Ren
Summary: Memory impairment is a characteristic of brain aging, and enhancing neurogenesis is a potential method for mitigating it. Nobiletin (NOB), a natural flavonoid derived from citrus peels, was found to attenuate memory impairment and restore hippocampal neurogenesis in aging mice. Furthermore, NOB inhibited inflammation and improved viability and differential ability of cells. Overall, NOB is a potential candidate for improving brain function by enhancing neurogenesis.
Article
Nutrition & Dietetics
Marta Portero-Tresserra, Neus Galofre-Lopez, Elisabet Pallares, Claudia Gimenez-Montes, Carlos Barcia, Roser Granero, Divka Rojic-Becker, Anna Vale-Martinez, Margarita Marti-Nicolovius, Gemma Guillazo-Blanch
Summary: Age-related changes in the brain significantly impact hippocampal structure and function, leading to cognitive impairments such as deteriorating spatial object recognition (SOR) memory. Both intrinsic factors like neuroinflammation and lifestyle factors like diet can influence aging-related brain function and cognitive performance. This study aimed to evaluate the effects of caloric restriction (CR) on SOR memory, hippocampal neuron loss, neurogenesis, and inflammation in aged male rats. The results showed that CR attenuated the decline in SOR memory, hippocampal neuron loss, and microglial activation associated with aging, while also reducing neurogenesis in the dentate gyrus.
Article
Immunology
Jiangong Wang, Bin Liu, Fengjiao Sun, Yong Xu, Haiyun Luan, Meizi Yang, Chaoyun Wang, Tiantian Zhang, Zhenyu Zhou, Haijing Yan
Summary: This study found that inhibition of H3R reduced microglia activity and promoted a shift from pro-inflammatory M1 phenotype to anti-inflammatory M2 phenotype in microglia, thereby attenuating lipopolysaccharide-induced neuroinflammation in mice. Additionally, inhibition of H3R rescued the impairments of neurogenesis and cognitive function caused by neuroinflammation. Mechanistically, the neuroprotective effects of H3R inhibition were mediated by histamine-dependent activation of H2R and reinforcement of CREB-CBP interaction, which led to increased release of anti-inflammatory cytokines and brain-derived neurotrophic factor, as well as decreased release of pro-inflammatory cytokines.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Cristina Cachan-Vega, Ignacio Vega-Naredo, Yaiza Potes, Juan Carlos Bermejo-Millo, Adrian Rubio-Gonzalez, Claudia Garcia-Gonzalez, Eduardo Antuna, Manuel Bermudez, Jose Gutierrez-Rodriguez, Jose Antonio Boga, Ana Coto-Montes, Beatriz Caballero
Summary: This study evaluated the effects of chronic melatonin treatment on neurodegeneration and hippocampal neurogenesis in aged and neurodegenerative brains. The findings suggest that melatonin can decrease neurodegenerative processes and improve the functionality of adult hippocampal neurogenesis.
Article
Biochemistry & Molecular Biology
Tracy A. Bedrosian, Judith Houtman, Juan Sebastian Eguiguren, Saeed Ghassemzadeh, Nicole Rund, Nicole M. Novaresi, Lauren Hu, Sarah L. Parylak, Ahmet M. Denli, Lynne Randolph-Moore, Takashi Namba, Fred H. Gage, Tomohisa Toda
Summary: The age-dependent decline of lamin B1 in adult neural stem/progenitor cells is associated with alterations in adult hippocampal neurogenesis and anxiety-like behavior in mice, indicating a role in stem cell aging and mood regulation.
Article
Cell Biology
Peng Chen, ZhiLei Guo, Benhong Zhou
Summary: Alzheimer's disease is a common form of dementia that significantly impacts the quality of life for the elderly. Hippocampal dysfunction plays a pivotal role in neurodegeneration in Alzheimer's patients and understanding the impact of neurogenesis on aging and cognitive deficits is crucial for advancing research in this field.
AGEING RESEARCH REVIEWS
(2023)
Article
Food Science & Technology
Ji Yeon Hong, Jae-Jun Ban, Qing-Ling Quan, Ji-Eun Eom, Hee Soon Shin, Jin Ho Chung
Summary: Tomato and lemon extracts can reduce cellular oxidative stress and increase neurogenesis, while the mixture of the two shows synergistic effects in anti-oxidation and hippocampal neurogenesis.
Review
Multidisciplinary Sciences
Runrui Zhang, Hongxin Quan, Yinfeng Wang, Fucheng Luo
Summary: Neurogenesis is the process of generating neurons from neural stem cells, which occurs in both embryonic and adult stages with distinct characteristics. Dysfunction in either stage can have negative effects on neural development, cognition, and can lead to neurological disorders. Non-human primates, particularly monkeys, serve as valuable models due to their closer neural resemblance to humans, but there are potential impacts and limitations of using non-human primate models in physiological and pathological neurogenesis research.
NATIONAL SCIENCE REVIEW
(2023)
Article
Biochemistry & Molecular Biology
Kyu Ri Hahn, Woosuk Kim, Hyo Young Jung, Hyun Jung Kwon, Dae Won Kim, In Koo Hwang, Yeo Sung Yoon
Summary: Feeding mice a diet enriched with cuprizone can induce demyelination in the corpus callosum and increase neural progenitor cells in the dentate gyrus. This damage is more pronounced in young adult mice and may be associated with changes in BDNF and pCREB levels.
NEUROCHEMICAL RESEARCH
(2022)
Article
Behavioral Sciences
Nicole L. Reitz, Polliana T. Nunes, Lisa M. Savage
Summary: Adolescent intermittent ethanol exposure in rats can lead to damage in the critical circuit for learning and memory, resulting in spatial behavior impairments during aging. There are differences in cognitive impairments among rats of different sexes and ages, especially in tasks related to ethanol exposure.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Immunology
Paula Sanchez-Molina, Beatriz Almolda, Lydia Gimenez-Llort, Berta Gonzalez, Bernardo Castellano
Summary: This study found that chronic overexpression of IL-10 by astrocytes can lead to a decrease in hippocampal neurogenesis and impair hippocampal-dependent spatial learning and memory processes. The changes in microglial cells are similar to those observed in normal aging.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Review
Immunology
Shaoyi Fang, Zhibin Wu, Yali Guo, Wenjun Zhu, Chunmiao Wan, Naijun Yuan, Jianbei Chen, Wenzhi Hao, Xiaowei Mo, Xiaofang Guo, Lili Fan, Xiaojuan Li, Jiaxu Chen
Summary: This review explores the roles of adult hippocampal neurogenesis and microglia in the etiology of depression, and discusses the mechanisms by which microglia regulate adult hippocampal neurogenesis in depression and potential drugs for improving neurogenesis.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Alejandro Romero, Jose Angel Morales-Garcia, Eva Ramos
Summary: Neurodegeneration affects various cell types and the potential of neural stem cells to generate new neuronal populations may be a relevant factor in fighting neurodegeneration and aging. Recent evidence suggests that melatonin may modulate adult hippocampal neurogenesis. Preclinical studies have shown that melatonin can enhance molecular and signaling pathways involved in neurogenesis. This article summarizes the current knowledge and highlights the therapeutic potential of melatonin in neurodegeneration.
NEURAL REGENERATION RESEARCH
(2023)
Article
Multidisciplinary Sciences
Raquel Montalban-Loro, Glenda Lassi, Anna Lozano-Urena, Ana Perez-Villalba, Esteban Jimenez-Villalba, Marika Charalambous, Giorgio Vallortigara, Alexa E. Horner, Lisa M. Saksida, Timothy J. Bussey, Jose Luis Trejo, Valter Tucci, Anne C. Ferguson-Smith, Sacri R. Ferron
Summary: The study discovered that Delta-like homolog 1 is expressed biallelically in the adult brain, specifically in the hippocampus, and plays a crucial role in adult neurogenesis. Reduction in Dlk1 levels triggers specific cognitive abnormalities that affect discriminating differences in environmental stimuli, highlighting the importance of selective absence of imprinting in this neurogenic niche.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
Evgeny M. Amelchenko, Dmitri V. Bezriadnov, Olga A. Chekhov, Konstantin V. Anokhin, Alexander A. Lazutkin, Grigori Enikolopov
Summary: Aging is associated with impairments in learning, memory, and cognitive flexibility, as well as a gradual decline in hippocampal neurogenesis. In this study, 6- and 14-month-old mice were tested in learning and memory tasks and their levels of preceding and current neurogenesis were determined. The older mice showed less efficiency in modified versions of the Morris water maze that required a reassessment of previous experience, but their performance improved after additional training. Analysis of neurogenesis levels in the hippocampal dentate gyrus revealed a significant correlation with cognitive flexibility tasks. These findings highlight the importance of hippocampal neurogenesis in supporting cognitive function in aging.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Engineering, Biomedical
Yukinobu Goto, Yuji Hiramatsu, Naohide Ageyama, Shoko Sato, Bryan J. Mathis, Shinsuke Kitazawa, Muneaki Matsubara, Hiroaki Sakamoto, Yukio Sato
JOURNAL OF ARTIFICIAL ORGANS
(2019)
Article
Cardiac & Cardiovascular Systems
Naohide Ageyama, Hiroyuki Kurosawa, Ousuke Fujimoto, Tomoya Uehara, Michiaki Hiroe, Yasushi Arano, Toshimichi Yoshida, Yasuhiro Yasutomi, Kyoko Imanaka-Yoshida
INTERNATIONAL HEART JOURNAL
(2019)
Article
Nutrition & Dietetics
Nobutaka Masuoka, Chitose Yoshimine, Marie Hori, Mieko Tanaka, Takashi Asada, Keiichi Abe, Tatsuhiro Hisatsune
Article
Neurosciences
Kung-Chun Kao, Tatsuhiro Hisatsune
EUROPEAN JOURNAL OF NEUROSCIENCE
(2020)
Article
Multidisciplinary Sciences
Keisuke Sakurai, Teppei Shintani, Naohiro Jomura, Takeshi Matsuda, Akira Sumiyoshi, Tatsuhiro Hisatsune
SCIENTIFIC REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Katsutaro Yasuda, Maki Kotaka, Takafumi Toyohara, Shin-Ichi Sueta, Yuko Katakai, Naohide Ageyama, Shinji Uemoto, Kenji Osafune
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Cell Biology
Nobutaka Masuoka, Chenxu Lei, Haowei Li, Noriko Inamura, Shigenobu Shiotani, Nobuya Yanai, Kenichiro Sato, Keisuke Sakurai, Tatsuhiro Hisatsune
Summary: The study found that anserine can protect MCI patients from cognitive decline by suppressing MPO-mediated neuroinflammatory responses. The significant difference in MMSE change scores between the active and placebo arms highlights the protective effect of anserine on cognitive function in elderly individuals with MCI.
Article
Nutrition & Dietetics
Keisuke Sakurai, Chutong Shen, Yuri Ezaki, Noriko Inamura, Yoichi Fukushima, Nobutaka Masuoka, Tatsuhiro Hisatsune
Article
Nutrition & Dietetics
Keisuke Sakurai, Chutong Shen, Izumi Shiraishi, Noriko Inamura, Tatsuhiro Hisatsune
Summary: The study found a significant correlation between cognitive function in elderly individuals and daily consumption of fat, especially in monounsaturated fatty acids and oleic acid. This suggests that the intake of these fats may have a beneficial effect on cognitive decline in community-dwelling Japanese elderly individuals.
Article
Multidisciplinary Sciences
Keisuke Sakurai, Haowei Li, Noriko Inamura, Nobutaka Masuoka, Tatsuhiro Hisatsune
SCIENTIFIC REPORTS
(2020)
Article
Neurosciences
Daisuke Koketsu, Satomi Chiken, Tatsuhiro Hisatsune, Shigehiro Miyachi, Atsushi Nambu
Summary: This study used a photodynamic technique to selectively eliminate the cortico-subthalamo projection in male mice, and found that after elimination, cortically evoked early excitation in the substantia nigra pars reticulata was diminished, while the cortically evoked inhibition and late excitation delivered through the direct and indirect pathways remained unchanged. In addition, locomotor activity was significantly increased after bilateral cortico-subthalamo elimination.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Nutrition & Dietetics
Keisuke Sakurai, Takayuki Toshimitsu, Erika Okada, Saya Anzai, Izumi Shiraishi, Noriko Inamura, Satoru Kobayashi, Toshihiro Sashihara, Tatsuhiro Hisatsune
Summary: This study found that ingestion of Lactiplantibacillus plantarum OLL2712 had protective effects against memory function decline in older adults. Significant improvements in composite memory and visual memory scores were observed in the active group. Additionally, the active group showed a lower abundance ratio of bacteria genera related to inflammation.
Article
Nutrition & Dietetics
Keisuke Sakurai, Erika Okada, Saya Anzai, Risako Tamura, Izumi Shiraishi, Noriko Inamura, Satoru Kobayashi, Mikako Sato, Takashi Matsumoto, Kazuyuki Kudo, Yukihiro Sugawara, Tatsuhiro Hisatsune
Summary: In this study, the dietary patterns of elderly Japanese individuals were classified using cluster analysis, and a high-carbohydrate (HC) dietary pattern and a protein-balanced (PB) dietary pattern were identified. Cognitive function was significantly higher in the PB group than in the HC group. A classification model was created to predict cognitive reservation in community-dwelling older adults based on these dietary patterns.
Article
Veterinary Sciences
Shunya Nakayama, Hiroshi Koie, Chungyu Pai, Yasuyo Ito-Fujishiro, Kiichi Kanayama, Tadashi Sankai, Yasuhiro Yasutomi, Naohide Ageyama
EXPERIMENTAL ANIMALS
(2020)
Article
Veterinary Sciences
Shunya Nakayama, Hiroshi Koie, Miyoko Kato-Tateishi, Chungyu Pai, Yasuyo Ito-Fujishiro, Kiichi Kanayama, Tadashi Sankai, Yasuhiro Yasutomi, Naohide Ageyama
EXPERIMENTAL ANIMALS
(2020)
