Article
Medicine, Research & Experimental
Jenny T. Mao, Bingye Xue, Qing-Yi Lu, Laurie Lundmark, Windie Burns, Jieping Yang, Ru-Po Lee, Joseph Glass, Clifford Qualls, Larry Massie
Summary: This study aims to investigate the antineoplastic effects of Grape seed procyanidin extract (GSE) and milk thistle silymarin extract (MTE) against lung cancer. The results showed that the combination of GSE and MTE could enhance their anticancer effects without toxicity. Furthermore, GSE and MTE were found to upregulate miR-663a and FHIT genes in lung cancer cell lines, further enhancing their anticancer properties.
Article
Oncology
Lauren C. Chartier, Gordon S. Howarth, Debbie Trinder, Suzanne Mashtoub
Summary: The study investigated the combination of Emu oil and grape seed extract in a model of colitis-associated colorectal cancer, showing that the combination improved clinical indicators and reduced colonic tumors, suggesting potential in managing ulcerative colitis and colorectal cancer.
Article
Multidisciplinary Sciences
Chaozhong Peng, Xiao Li, Zhixue Ye, Wenqing Wu
Summary: The study showed that Rab1A is significantly upregulated in CRC tissues and correlated with tumor size, lymph node metastasis, and TNM stage; Rab1A promotes CRC cell proliferation and migration by regulating Gli1; Rab1A also activates mTOR signaling in CRC cells.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Yu-qing Zhang, Jun Li, Xiao-juan Huang, Cai-xia Yang, Chao Wu, Zai-lei Yang, De-qiang Li
Summary: This study developed an eco-friendly food packaging material using regenerated cellulose films with the addition of grape seed extract (GSE) and polyethylene glycol 200 (PEG). The composite film showed improved mechanical properties, water contact angle, UV-blocking properties, and exhibited color changes under different pH conditions. Furthermore, the addition of GSE delayed the decomposition and biodegradation of strawberries. This research demonstrates the potential of regenerated cellulose film as a color sensor in food packaging.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Medicine, Research & Experimental
Jiaoyang Ning, Yi Luo, Liu Chen, Gang Xiao, Guilong Tanzhu, Rongrong Zhou
Summary: This article provides an overview of the expression patterns and prognostic significance of circRNAs in lung cancer, and summarizes the clinical relevance of circRNAs in lung cancer metastasis. Furthermore, it focuses on the roles of circRNAs in each step of lung cancer metastasis, demonstrating their dual functionality as both facilitators and inhibitors of metastatic processes. Due to their potential, circRNAs hold promise as novel biomarkers and therapeutic targets for lung cancer metastasis.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Pharmacology & Pharmacy
Adriana G. Quiroz-Reyes, Jose F. Islas, Paulina Delgado-Gonzalez, Hector Franco-Villarreal, Elsa N. Garza-Trevino
Summary: Metastasis is the process of tumor dissemination and is the primary cause of cancer-related deaths. Traditional cancer therapy focuses on preventing metastasis, while new therapies target cancer stem cells as potential orchestrators of metastasis.
Article
Food Science & Technology
Ivana Loncarevic, Jovana Petrovic, Nemanja Teslic, Ivana Nikolic, Nikola Maravic, Biljana Pajin, Branimir Pavlic
Summary: This study aimed to use grape pomace, a by-product of wine production rich in polyphenols, to make enriched cocoa spread. The formulation was modified by substituting refined sunflower oil with cold-pressed grape seed oil. The addition of grape seed extract encapsulated on maltodextrins further increased the polyphenols and flavonoids content. The sensory characteristics of the enriched spreads were positively affected by the encapsulates, reducing the grape seed oil aroma and sweetness.
Article
Pharmacology & Pharmacy
Weiyu Wang, Shengyao Ma, Zhenyu Ding, Yang Yang, Huaijie Wang, Kunning Yang, Xiaoshan Cai, Hanyue Li, Zhiqin Gao, Meihua Qu
Summary: XPC expression levels in lung adenocarcinoma have been found to influence patients' prognosis and inhibit tumor invasion and metastasis by regulating the stemness of lung cancer cells.
FRONTIERS IN PHARMACOLOGY
(2021)
Editorial Material
Medicine, General & Internal
Paolo Calzari, Silvia Vaienti, Gianluca Nazzaro
Summary: The extract of Polypodium leucotomos plays a vital role in preventing skin cancers and photoaging, and it can be effective when taken orally or applied topically. Its mechanisms include antioxidant, photoprotective, antimutagenic, anti-inflammatory, and immunoregulatory effects. In addition, it has potential uses in non-neoplastic diseases such as pigmentary disorders, photosensitivity, and atopic dermatitis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Gowhar Rashid, Nihad Ashraf Khan, Deena Elsori, Andleeb Rehman, Haleema Tanzeelah, Haleema Ahmad, Humaira Maryam, Amaan Rais, Mohd Salik Usmani, Asaad Ma Babker, Mohammad Azhar Kamal, Wael Hafez
Summary: Colorectal cancer is caused by mutations in large intestinal epithelial cells and can be detected early through biomarkers such as KRAS and ctDNA/cfDNA. While colonoscopy is the most common invasive method for diagnosing CRC, non-invasive techniques like molecular analysis of breath, urine, blood, and stool can also be used for early detection. NSAIDs have been found to have a chemopreventive impact on CRC by inhibiting cyclooxygenase enzymes and causing apoptosis in CRC cells. This review paper explores the diversity of biomarkers and detection techniques for CRC, as well as the role of NSAIDs in chemoprevention.
FRONTIERS IN MEDICINE
(2023)
Article
Plant Sciences
Vijay L. Kumar, Sneh Verma, Prasenjit Das
Summary: The methanol extract of air-dried latex of Calotropis procera demonstrated protective effects in a rat model of colorectal cancer, reducing tumor occurrence and promoting apoptosis. This suggests the potential therapeutic application of MeDL in CRC.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Oncology
Junfei Zhang, Yuanxin Du, Yongcai Zhang, Yanan Xu, Yanying Fan, Yan Li
Summary: In this study, the metabonomic profiling of serum samples of lung metastasis mice with colorectal cancer was analyzed using 1H-nuclear magnetic resonance (1H-NMR). The results showed distinct differences between the metastatic mice and control mice based on their metabolic profiles at the serum level. The study also identified several metabolites that were closely associated with the lung metastasis process. Pathway enrichment analysis revealed deregulation of metabolic pathways involved in the lung metastasis process. This study provides potential diagnostic biomarkers for the early diagnosis of lung metastasis in colorectal cancer.
CANCER MANAGEMENT AND RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Sini Li, Yan Qu, Lihui Liu, Xue Zhang, Yan He, Chao Wang, Yufeng Guo, Li Yuan, Zixiao Ma, Hua Bai, Jie Wang
Summary: This study investigated the plasma exosomes' proteomic profiles in patients with lung cancer (LC) who had liver metastasis (LM) or brain metastasis (BM). Differentially expressed exosome-based proteins (DEEPs) were identified in LM and BM, and they were found to be involved in proteomic triggering cascade, ECM-receptor interaction, and the collagen-containing extracellular matrix. Potential biomarkers for the diagnosis of LM and BM were also suggested.
CELL AND BIOSCIENCE
(2023)
Article
Medicine, Research & Experimental
Friederike Praus, Axel Kuenstner, Thorben Sauer, Michael Kohl, Katharina Kern, Steffen Deichmann, Akos Vegvari, Tobias Keck, Hauke Busch, Jens K. K. Habermann, Timo Gemoll
Summary: This study integrated genomic, transcriptomic, and proteomic analyses to identify significant differences in expression during colorectal cancer progression. The results highlight the importance of tumor heterogeneity and individual differences for clinical studies, and may accelerate the implementation of precision oncology in the future.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Xixi Zhao, Ruofei Tian, Jingyi Zhou, Yanlin Liu
Summary: Food-borne fungi pose significant hazards to food preservation and human health, calling for packaging films with antimicrobial and antioxidant activities. In this study, silver nanoparticles were synthesized from grape seed extracts and coated with chitosan. The results showed that grapes treated with chitosan-coated silver nanoparticles exhibited reduced decay percentage and weight loss, maintained high titratable acidity, and inhibited mold growth during storage.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Alpna Tyagi, Sushil Kumar, Komal Raina, Michael F. Wempe, Paul D. Maroni, Rajesh Agarwal, Chapla Agarwal
MOLECULAR CARCINOGENESIS
(2019)
Article
Microbiology
N. J. Nealon, K. D. Parker, P. Lahaie, H. Ibrahim, A. K. Maurya, K. Raina, E. P. Ryan
BENEFICIAL MICROBES
(2019)
Article
Biochemistry & Molecular Biology
Deepanshi Dhar, Komal Raina, Dileep Kumar, Michael F. Wempe, Stacey M. Bagby, Todd M. Pitts, David J. Orlicky, Chapla Agarwal, Wells A. Messersmith, Rajesh Agarwal
MOLECULAR CARCINOGENESIS
(2020)
Review
Multidisciplinary Sciences
Neha Mishra, Komal Raina, Rajesh Agarwal
Summary: Studying the role of microRNAs in sulfur mustard-induced toxicity helps fill knowledge gaps in this area and serves as diagnostic markers. Further research will aid in devising preventive strategies, diagnostic tools, and therapeutic interventions.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Kristopher D. Parker, Akhilendra K. Maurya, Hend Ibrahim, Sangeeta Rao, Petronella R. Hove, Dileep Kumar, Rama Kant, Bupinder Raina, Rajesh Agarwal, Kristine A. Kuhn, Komal Raina, Elizabeth P. Ryan
Summary: The study demonstrates that modified gut microbiota from humans consuming rice bran can protect mice from colon carcinogenesis, with specific microbial communities associated with colon health. The findings suggest that integrated dietary-FMT intervention strategies could be effective for colorectal cancer control, treatment, and prevention.
Article
Integrative & Complementary Medicine
Dominique Reed, Dileep Kumar, Sushil Kumar, Komal Raina, Reenu Punia, Rama Kant, Laura Saba, Charmion Cruickshank-Quinn, Boris Tabakoff, Nichole Reisdorph, Michael G. Edwards, Michael Wempe, Chapla Agarwal, Rajesh Agarwal
Summary: BMJ intake induced positive changes in metabolism, enhancing glucose homeostasis, vitamin D metabolism and suppressing glycerophospholipid metabolism. In the liver, BMJ modulated PPAR and circadian rhythm signaling, as well as bile acid biosynthesis and glycogen metabolism targets, reducing susceptibility to high-fat diet associated MetS risk factors.
JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE
(2022)
Article
Oncology
Sandeep Paudel, Komal Raina, Vasundhara R. Tiku, Akhilendra Maurya, David J. Orlicky, Zhiying You, Cindy M. Rigby, Gagan Deep, Rama Kant, Bupinder Raina, Chapla Agarwal, Rajesh Agarwal
Summary: This study demonstrated that flavonolignan silibinin can effectively prevent the growth and progression of UVB-induced basal cell carcinoma (BCC). Silibinin can reduce the number and area of BCC lesions, as well as inhibit basal cell proliferation and the expression of related signaling mediators.
Article
Biochemistry & Molecular Biology
Ram R. Prasad, Komal Raina, Neha Mishra, Munendra S. Tomar, Robin Kumar, Amy E. Palmer, Paul Maroni, Rajesh Agarwal
Summary: The expression of zinc transporters is altered during prostate cancer progression, indicating that changes in zinc homeostasis could potentially be an early event in prostate tumorigenesis.
MOLECULAR CARCINOGENESIS
(2022)
Article
Oncology
Kushal Kandhari, Sandeep Paudel, Komal Raina, Chapla Agarwal, Rama Kant, Michael F. Wempe, Cindy O'Bryant, Rajesh Agarwal
Summary: Comparative pre-clinical studies showed that Chinese and Indian bitter melon varieties exhibit comparable efficacy in inhibiting pancreatic cancer cell proliferation, inducing cell death, suppressing tumor growth, and decreasing angiogenesis. The geographical availability of a particular cultivar should not be a limiting factor in selecting a variant for clinical trials.
JOURNAL OF CANCER PREVENTION
(2021)
Article
Biochemistry & Molecular Biology
Komal Raina, Rama Kant, Ram R. Prasad, Kushal Kandhari, Munendra Tomar, Neha Mishra, Robin Kumar, Jennifer T. Fox, Shizuko Sei, Robert H. Shoemaker, Yu Chen, Paul Maroni, Chapla Agarwal, Rajesh Agarwal
Summary: This study compared the pathological and molecular markers of TMPRSS2-ERG fusion and PTEN loss-driven versus non-fusion-driven prostate tumorigenesis in mice. The results showed that both mouse models exhibited growth and progression of prostate intraepithelial lesions to adenocarcinoma stages, although at different rates. The TMPRSS2-ERG. Pten(flox/flox) mice had slower initiation of tumorigenesis but faster progression through different stages, while the Hi-Myc(+/)(-) mice had rapid initiation but slower progression. Additionally, high-grade undifferentiated tumors were observed in the Hi-Myc(+/)(-) mice at advanced stages compared to the fusion-driven TMPRSS2-ERG. Pten(flox/flox) mice.
MOLECULAR CARCINOGENESIS
(2022)
Article
Biochemistry & Molecular Biology
Robin Kumar, Akhilendra K. Maurya, Kristopher D. Parker, Rama Kant, Hend Ibrahim, Md Imtiazul Kabir, Dileep Kumar, Annika M. Weber, Rajesh Agarwal, Kristine A. Kuhn, Elizabeth P. Ryan, Komal Raina
Summary: Dietary rice bran can influence metabolism by modulating gut microbiota, reducing the risk of colorectal cancer. The protective effects of dietary rice bran against colorectal cancer are associated with both microbiota-dependent and independent mechanisms.
MOLECULAR CARCINOGENESIS
(2022)
Article
Oncology
Komal Raina, Kushal Kandhari, Anil K. Jain, Kameswaran Ravichandran, Paul Maroni, Chapla Agarwal, Rajesh Agarwal
Summary: Inositol hexaphosphate (IP6) has stage-specific efficacy in inhibiting prostate cancer growth and progression, arresting tumor grade at earlier stages and preventing the disease from advancing. It also eradicates cancer stem cells in prostate tumors.
Article
Oncology
Annika M. Weber, Hend Ibrahim, Bridget A. Baxter, Robin Kumar, Akhilendra K. Maurya, Dileep Kumar, Rajesh Agarwal, Komal Raina, Elizabeth P. Ryan
Summary: Heat-stabilized rice bran is a nutrient-dense food ingredient with potential colorectal cancer control and prevention properties. This study discovered novel mechanisms by which rice bran metabolism in feces may contribute to its anti-cancer activity. The findings suggest that certain fecal metabolites may serve as dietary biomarkers for colorectal cancer prevention.
Article
Oncology
Komal Raina, Kushal Kandhari, Rama Kant, Ram Raj Prasad, Neha Mishra, Akhilendra K. Maurya, Jennifer T. Fox, Shizuko Sei, Robert H. Shoemaker, Maarten C. Bosland, Paul Maroni, Chapla Agarwal, Rajesh Agarwal
Summary: The use of NSAIDs aspirin and naproxen shows potential usefulness in the prevention of prostate tumorigenesis driven by TMPSS2-ERG fusion genes.
Review
Integrative & Complementary Medicine
Ram Raj Prasad, Sandeep Paudel, Komal Raina, Rajesh Agarwal
JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE
(2020)
