Article
Biochemistry & Molecular Biology
Sha Zhang, Jinjie Li, Xiaoyang Shi, Xiaomeng Tan, Quanjin Si
Summary: This study found that naringenin can promote beige adipose thermogenesis and browning through interactions with gut microbiota. The research revealed the anti-obesity mechanism of naringenin, which prevents obesity caused by high fat diet through increasing energy expenditure.
Review
Biochemistry & Molecular Biology
Pei-Chi Chan, Po-Shiuan Hsieh
Summary: This review focuses on the role and regulatory mechanism of BAT in DIT and whether these mechanisms are applicable to human health and diseases. BAT is considered an important organ in the process of counter-regulating energy intake and lipid accumulation through DIT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Alba Sabate-Perez, Montserrat Romero, Paula Sanchez-Fernandez-de-Landa, Stefania Carobbio, Michail Mouratidis, David Sala, Pablo Engel, Josep A. Villena, Sam Virtue, Antonio Vidal-Puig, Manuel Palacin, Xavier Testar, Antonio Zorzano
Summary: The study reveals a novel molecular mechanism by which TP53INP2 regulates PPARG activity and brown adipogenesis through autophagy, and demonstrates the importance of TP53INP2 in maintaining thermogenic capacity and preventing lipid accumulation in brown adipose tissue. These findings provide insights into the therapeutic strategies against obesity and its metabolic complications.
Review
Biology
Jan Nedergaard, Gabriella von Essen, Barbara Cannon
Summary: This article discusses whether a decrease in UCP1 activity could cause obesity in humans. Studies in mice suggest that the absence of UCP1 leads to obesity. It is still unknown if similar mechanisms exist in humans.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Food Science & Technology
Mingzhu Yan, Suwei Jin, Zhi Wang, Tianji Xia, Yongguang Liu, Qi Chang
Summary: Limonin, a compound found in citrus fruits, has been found to effectively combat obesity by reducing fat mass and body weight gain, and improving fatty liver and hyperlipidemia caused by a high-fat diet. It also promotes the browning of white adipose tissues and prevents the whitening of brown adipose tissue in mice. These effects are associated with the activation of PGC-1 alpha pathway. Overall, limonin shows great potential for regulating energy balance and treating obesity.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biochemistry & Molecular Biology
Camilla Rangel-Azevedo, Daiana Araujo Santana-Oliveira, Carolline Santos Miranda, Fabiane Ferreira Martins, Carlos Alberto Mandarim-de-Lacerda, Vanessa Souza-Mello
Summary: Chronic obesity damages the structure and function of brown adipose tissue (BAT). This study evaluated the effects of a high-fat diet on energy expenditure, thermogenesis, and whitening of BAT. The results showed that the high-fat diet caused whitening of BAT and decreased energy expenditure.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Endocrinology & Metabolism
Vanessa M. Lima, Jianming Liu, Bruna B. Brandao, Caroline A. Lino, Camila S. Balbino Silva, Marcio A. C. Ribeiro, Tiago E. Oliveira, Caroline C. Real, Daniele de Paula Faria, Carly Cederquist, Zhan-Peng Huang, Xiaoyun Hu, Maria Luiza Barreto-Chaves, Julio C. B. Ferreira, William T. Festuccia, Marcelo A. Mori, C. Ronald Kahn, Da-Zhi Wang, Gabriela P. Diniz
Summary: miR-22 plays a role in white, beige, and brown adipocyte differentiation. Deletion of miR-22 reduces white adipocyte differentiation, increases BAT activity, and enhances resistance in HFD-fed mice.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Biology
Ruth Karlina, Dominik Lutter, Viktorian Miok, David Fischer, Irem Altun, Theresa Schoettl, Kenji Schorpp, Andreas Israel, Cheryl Cero, James W. Johnson, Ingrid Kapser-Fischer, Anika Boettcher, Susanne Keipert, Annette Feuchtinger, Elisabeth Graf, Tim Strom, Axel Walch, Heiko Lickert, Thomas Walzthoeni, Matthias Heinig, Fabian J. Theis, Cristina Garcia-Caceres, Aaron M. Cypess, Siegfried Ussar
Summary: Brown adipose tissue (BAT) plays a crucial role in body weight regulation and glucose homeostasis. Studies have revealed the presence of different subtypes of brown adipocytes within BAT, indicating potentially distinct functional properties depending on cellular composition.
LIFE SCIENCE ALLIANCE
(2021)
Article
Endocrinology & Metabolism
Nazmul Hasan, Naoto Nagata, Jun-ichi Morishige, Md Tarikul Islam, Zheng Jing, Ken-ichi Harada, Michihiro Mieda, Masanori Ono, Hiroshi Fujiwara, Takiko Daikoku, Tomoko Fujiwara, Yoshiko Maida, Tsuguhito Ota, Shigeki Shimba, Shuichi Kaneko, Akio Fujimura, Hitoshi Ando
Summary: This study demonstrates the impact of impaired BAT clock on energy metabolism and obesity development. Disruption of BAT clock helps maintain normal core body temperatures but may lead to reduced energy expenditure and obesity development.
MOLECULAR METABOLISM
(2021)
Article
Endocrinology & Metabolism
Long Cheng, Shuofeng Zhang, Fei Shang, Yibo Ning, Zhiqi Huang, Runcheng He, Jianning Sun, Shifen Dong
Summary: The study found that emodin could reduce body weight and food intake in obese mice, improve glucose tolerance, and decrease blood lipids. Emodin treatment induced beiging of white adipose tissue and increased markers of beige adipocytes in subcutaneous white adipose tissue (scWAT) and brown adipose tissue (BAT). Furthermore, emodin perturbed the lipidomic profiles in scWAT and BAT of obese mice, indicating selective remodeling in tissue lipid content in response to emodin treatment.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Sujoy Ghosh, Chul-Hong Park, Jisu Lee, Nathan Lee, Rui Zhang, Clara Huesing, Dorien Reijnders, Jennifer Sones, Heike Munzberg, Leanne Redman, Ji Suk Chang
Summary: This study demonstrates that maternal cold exposure during pregnancy can influence the gene expression in placental and fetal BAT tissues. The changes in gene expression observed in this study suggest potential effects on fetal brown adipogenesis and placental adaptation to cold stress, warranting further investigation into the implications of these findings.
Article
Plant Sciences
Eun A. Kim, Ju-Hwan Yang, Eun-Hye Byeon, Woong Kim, Dawon Kang, Jaehee Han, Seong-Geun Hong, Deok-Ryong Kim, Sang-Je Park, Jae-Won Huh, Hyeonsook Cheong, Seung-Pil Yun, Dong-Kun Lee
Summary: The study demonstrates that pine needle extract inhibits obesity by increasing hypothalamic POMC neuronal activity and improving physiological conditions after high-fat diet-induced obesity. Additionally, PNE also suppresses lipogenesis in white adipose tissue.
Article
Multidisciplinary Sciences
Shengnan Liu, Siyi Shen, Ying Yan, Chao Sun, Zhiqiang Lu, Hua Feng, Yiruo Ma, Zhili Tang, Jing Yu, Yuting Wu, Balazs Gereben, Petra Mohacsik, Csaba Fekete, Xiaoyun Feng, Feixiang Yuan, Feifan Guo, Cheng Hu, Mengle Shao, Xin Gao, Lin Zhao, Yuying Li, Jingjing Jiang, Hao Ying
Summary: The active form of thyroid hormone, T3, promotes the proliferation of adipocyte progenitor cells in brown adipose tissue, leading to increased thermogenic capacity.
NATURE COMMUNICATIONS
(2022)
Article
Plant Sciences
Ra-Yeong Choi, Mi-Kyung Lee
Summary: The study demonstrated that the Polygonum multiflorum Thunb. hot water extract had an anti-obesity effect in high-fat diet-induced obese mice by suppressing lipogenesis in white adipose tissue, leading to normalization of lipid metabolism in brown adipose tissue.
Article
Endocrinology & Metabolism
Grace Park, John A. Haley, Johnny Le, Su Myung Jung, Timothy P. Fitzgibbons, Ekaterina D. Korobkina, Huawei Li, Shelagh M. Fluharty, Qingbo Chen, Jessica B. Spinelli, Chinmay M. Trivedi, Cholsoon Jang, David A. Guertin
Summary: Adaptive thermogenesis by brown adipose tissue (BAT) plays an important role in dissipating calories as heat and can potentially be used as an anti-obesity target. This study quantified metabolite exchange in BAT and skeletal muscle during cold exposure in mice, revealing unexpected metabolites consumed, released, and shared between organs. Glucose and lactate were found to provide the majority of carbon for adaptive thermogenesis, and cold adaptation triggered different fuel utilization profiles compared to the drug CL316,243. BAT was also found to significantly increase nitrogen uptake during cold adaptation, except for the amino acid glutamine. This study provides valuable insights into the fuel utilization of BAT and its potential implications for future research in this field.