Article
Medicine, Research & Experimental
Moamen Adel Mashaly, Ibrahim Ghalib Saleh, Ahmed Amine Ashour, Ahmed Mohamed Mansour
Summary: This study evaluates the safety of quercetin and investigates its effects in normal and lipopolysaccharide-primed livers. It also examines the influence of mild inflammation/fever on quercetin effects.
Article
Chemistry, Multidisciplinary
Kazi Nadim Hossain, Md. Shafiqul Islam, Sheikh Hasibur Rahman, Subroto Sarker, Milon Mondal, Mohammad Asikur Rahman, Sadeq K. Alhag, Laila A. Al-Shuraym, Othman A. Alghamdi, Muhammad Torequl Islam, Ammar AL-Farga, Mohamed El-Shazly, Md. Jahir Alam, Heba A. S. El-Nashar
Summary: This study investigated the antioxidant, anti-inflammatory, and hepatoprotective activities of Wissadula periplocifolia. The results showed that it has strong antioxidant, anti-inflammatory, and hepatoprotective effects.
Article
Biochemistry & Molecular Biology
Linlin Qu, Rongzhan Fu, Xiaoxuan Ma, Daidi Fan
Summary: Ginsenoside Rk3 shows promising therapeutic potential in protecting against APAP-induced acute liver injury by reducing hepatotoxicity, inhibiting liver inflammation and oxidative stress, and promoting continuous activation of autophagy.
Article
Biochemistry & Molecular Biology
Sina Mahdavifard, Zahra Shahi
Summary: This study demonstrates that nicotinamide treatment can effectively correct the liver histopathological and biochemical changes caused by lead toxicity. It reduces oxidative stress and inflammation markers while increasing antioxidant markers.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Sohail Hussain, Mohammad Ashafaq, Saeed Alshahrani, Ibrahim A. M. Bokar, Rahimullah Siddiqui, Mohammad Intakhab Alam, Manal Mohamed Elhassan Taha, Yosif Almoshari, Saad S. Alqahtani, Rayan A. Ahmed, Abdulmajeed M. Jali, Marwa Qadri
Summary: This study found that curcumin-incorporated nano-lipid carrier (Cur-NLC) has potential hepatoprotective activity against cypermethrin (Cyp) toxicity in adult male rats. The administration of Cur-NLC improved liver toxicity caused by Cyp, as evidenced by decreased serum liver markers, increased antioxidative parameters, decreased expression of inflammatory cytokines and apoptosis, and reduced histopathological changes.
Article
Medicine, Research & Experimental
Michael A. Fawzy, Gehad Nasr, Fares E. M. Ali, Moustafa Fathy
Summary: This study aimed to investigate the regulatory effects of quercetin (QU) on selected phosphodiesterase inhibitors against alpha-naphthyl isothiocyanate (ANIT)-induced acute intrahepatic cholestasis. The combination treatment of QU with sildenafil (Sild) or pentoxifylline (PTX) showed promising hepatoprotective effects and anti-cholestatic properties in improving ANIT-induced liver injury.
Article
Biochemistry & Molecular Biology
Lubna A. H. Mansour, Gehad E. Elshopakey, Fatma M. Abdelhamid, Talat A. Albukhari, Samah J. Almehmadi, Bassem Refaat, Mohamed El-Boshy, Engy F. Risha
Summary: Naringenin (NRG), a naturally occurring flavonoid found in citrus species and tomatoes, has various biological activities including antioxidant, antitumor, antiviral, antibacterial, anti-inflammatory, antiadipogenic, and cardioprotective effects. This study investigated the protective role of NRG against liver and brain toxicity induced by lead acetate in rats. The findings suggest that NRG has potential hepato- and neuroprotective effects against lead acetate toxicity.
Article
Biochemistry & Molecular Biology
Sahar Rafiee, Ali Nouri, Esfandiar Heidarian
Summary: This study examined the effect of rutin on paraquat-induced liver toxicity. The results showed that treatment with rutin can reduce the levels of various markers associated with liver toxicity.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Pharmacology & Pharmacy
Hamid Ali, Azra Jahan, Samrana Samrana, Abid Ali, Safdar Ali, Nurul Kabir, Amjad Ali, Riaz Ullah, Ramzi A. Mothana, Bibi Nazia Murtaza, Muhammad Kalim
Summary: The study found that pomegranate has hepatoprotective effects, reducing liver damage and oxidative stress caused by carbon tetrachloride, decreasing inflammation, and reducing fat accumulation in hepatocytes.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Veronica F. Salau, Ochuko L. Erukainure, Kolawole A. Olofinsan, Recardia L. S. Schoeman, Motlalepula G. Matsabisa
Summary: The study investigated the hepatoprotective effect of Lippia javanica herbal tea in Fe2+-mediated hepatic oxidative injury. Results showed that the infusion has strong antioxidant activity and hepatoprotective effects. It increased the levels of reduced glutathione, non-protein thiol, superoxide dismutase, and catalase, while reducing hepatic malondialdehyde levels and several enzyme activities. The infusion contains phytoconstituents such as phenolic compounds, tannins, phenolic glycosides, and terpenoids. Molecular docking analysis revealed the potential binding affinity of dihydroroseoside and obacunone with antioxidant enzymes. Overall, the study highlights the potential therapeutic use of L. javanica herbal tea in oxidative stress-related liver diseases.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shohreh Taziki, Faramarz Gholamzadeh, Rozhin Hosseini
Summary: Liver disorders are a leading cause of death worldwide. Isotretinoin, used for acne treatment, has been found to potentially cause hepatotoxicity. This study investigated the mechanism of isotretinoin-induced hepatotoxicity and the protective role of taurine. The results showed that oral administration of isotretinoin caused hepatotoxicity in rats, as evidenced by increased levels of ALT, AST, and MDA, and decreased GSH in liver tissue. However, taurine administration significantly prevented this hepatotoxicity.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Pharmacology & Pharmacy
Nema A. Mohamed, Mohamed A. M. Hashem, Abdullah M. Alzahrani, Ashraf M. Abdel-Moneim, Heba M. Abdou
Summary: The study demonstrated that Spirulina platensis (SP) has a protective effect against carbon tetrachloride-induced liver toxicity in rats by enhancing antioxidant defense mechanisms, inhibiting inflammatory cytokines, and anti-proliferative effects to prevent liver damage.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2021)
Review
Chemistry, Medicinal
Raquel Bridi, Gilsane Lino von Poser, Gabriela de Carvalho Meirelles
Summary: Liver disease rates are increasing, posing as a serious public health problem. The chief factors for developing hepatic disorders include the indiscriminate use of drugs, rich fat diet, high consumption of alcoholic beverages, viral infections and lipid peroxidative products. Due to the lack of reliable hepatoprotective drugs with high adverse reaction incidence and/or lack of efficacy, liver diseases are commonly treated with medicinal plants. Iridoids, particularly those with bitter taste, are believed to be good remedies for liver disease and have been demonstrated to have hepatoprotective effects in various studies.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Iman O. Sherif
Summary: The study demonstrated the hepatoprotective effect of Arj against CP-induced hepatotoxicity in rats through its antioxidant, anti-inflammatory, and antiapoptotic activities, improving liver function and histopathology while suppressing oxidative stress, inflammation, and apoptosis in hepatic tissue.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Infectious Diseases
Samy M. El-Megharbel, Safa H. Qahl, Fatima S. Alaryani, Reham Z. Hamza
Summary: This study investigated the coordination character of the antibiotic ceftriaxone drug and prepared its complexes with magnesium, copper, zinc, iron, and selenium. The complexes exhibited different modes of chelation and geometric shapes. The antibacterial activity of the complexes was tested, and promising outcomes were observed. Additionally, the administration of CFX metal complexes showed potential in preventing liver injury in rats.
Article
Nutrition & Dietetics
Samira Salem, Essaid Leghouchi, Rachid Soulimani, Jaouad Bouayed
Summary: The study found that Parmelia caperata (PC) showed better anti-edematous activity compared to Lobaria pulmonaria (LP) in a mouse carrageenan-induced inflammatory model, while also significantly improving the endogenous antioxidant status of the liver.
INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH
(2021)
Article
Environmental Sciences
Imen Dridi, Rachid Soulimani, Jaouad Bouayed
Summary: The study found that male offspring mice exposed to contaminated European eels during pregnancy and lactation exhibited depression-like behavior at different stages of life, with increased immobility in behavioral tests and elevated antioxidant enzyme activity in the hippocampus in middle-aged animals. This suggests a chronic depressive phenotype in offspring exposed to pollutants, with limited oxidative metabolism disturbances in their brains at middle age.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Zeyneb Chouit, Dounia Djellal, Souhila Haddad, Mourad Hanfer, Messaoud Hachemi, Zhoura Lakroun, Smail Chafaa, Hamadi Fetoui, Mohamed Kebieche, Rachid Soulimani
Summary: The study found that chronic exposure to cadmium may cause changes in neurobehavioral and cognitive abilities in rats, affect mitochondrial function in the brain, increase oxidative stress, and enhance the apoptosis signaling pathway.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Virology
Jaouad Bouayed, Torsten Bohn
Summary: The interaction between humans and SARS-CoV-2 can lead to various outcomes, including changes in human behavior that may facilitate the virus transmission. Some individuals infected with COVID-19 have displayed odd and irresponsible behaviors, potentially aiding in the spread of the virus.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Editorial Material
Immunology
Jaouad Bouayed, Torsten Bohn
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Immunology
Jaouad Bouayed, Feng Q. Hefeng, Mahesh S. Desai, Bin Zhou, Tsuriel Rashi, Rachid Soulimani, Torsten Bohn
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Letter
Virology
Jaouad Bouayed, Torsten Bohn
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Nutrition & Dietetics
Rachid Soulimani, Amadou Dicko, Elie Baudelaire, Jaouad Bouayed
Summary: Rosa canina, Salix alba, Scrophularia nodosa, and Hedera helix have anti-inflammatory effects on LPS-stimulated peripheral blood mononuclear cells. Fine powders with superfine particle sizes have stronger inhibitory effects on inflammatory factors produced by cells, and they contain higher concentrations of phenolic compounds.
INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH
(2023)
Article
Virology
Guillaume Schmitt, Sary Labdouni, Rachid Soulimani, Catherine Delamare, Jaouad Bouayed
Summary: The hormonal and physiological changes during pregnancy make pregnant women more vulnerable to COVID-19. A retrospective study found vitamin D deficiency in COVID-19-positive pregnant women, with more severe deficiency in those with mild symptoms. Additionally, pregnant women with COVID-19 showed lower levels of oxidative stress markers, which may explain the milder course of the disease.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Editorial Material
Immunology
Jaouad Bouayed
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Biochemistry & Molecular Biology
Amal Lassoued, Noureddine Khalloufi, Wiem Saidani, Abdelhafidh Khazri, Neziha Ghanem-Boughanmi, Jaouad Bouayed, Mossadok Ben-Attia
Summary: Freshwater salinisation is a threat to the survival of freshwater species. This study investigated the effects of increased water salinity on the bivalve Unio ravoisieri. High salt concentration was found to significantly disrupt oxidative metabolism and increase neurotoxicity in the organism. The findings suggest that cat activity could be used as a sensitive marker to evaluate the impact of freshwater salinisation on freshwater species.
CHEMISTRY AND ECOLOGY
(2023)