Article
Environmental Sciences
Naveed Rauf, Ayesha Nawaz, Hizb Ullah, Rahim Ullah, Ghulam Nabi, Asad Ullah, Fazal Wahab, Sarwat Jahan, Junfen Fu
Summary: Vitamin C, E, and their nanoparticles have been found to effectively mitigate cisplatin-induced reproductive toxicity, restoring testicular function and improving tissue structure.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Neurosciences
Masoud Hosseinzadeh, Amir Alizadeh, Parnian Heydari, Marzieh Kafami, Mahmoud Hosseini, Farimah Beheshti, Narges Marefati, Moustafa Ghanbarabadi
Summary: This study aimed to assess the effects of vitamin E injection on cisplatin-induced cognitive impairment in rats. The results showed that vitamin E could reverse the memory impairment caused by cisplatin, possibly through affecting the hippocampal oxidative status.
ACTA NEUROPSYCHIATRICA
(2021)
Article
Multidisciplinary Sciences
Rong Du, Xi Cheng, Jingjing Ji, Yang Lu, Yuanyuan Xie, Weina Wang, Yanhua Xu, Yuquan Zhang
Summary: This study aimed to investigate the association between ferroptosis and premature ovarian insufficiency (POI) caused by cisplatin (CDDP) and the potential therapeutic effect of vitamin E (VE). The results showed that CDDP induced ovarian tissue fibrosis and follicle development disorders along with impaired ovarian function, while VE could reverse these reproductive toxicities. Furthermore, molecular experiments revealed that ferroptosis-related molecules ACSl4, ALOX15, SLC7A11, and GPX4 were differentially expressed, suggesting their involvement in the mechanism of POI.
SCIENTIFIC REPORTS
(2023)
Review
Nutrition & Dietetics
Eloy Bejarano, Jasper Weinberg, Madison Clark, Allen Taylor, Sheldon Rowan, Elizabeth A. Whitcomb
Summary: Age is a significant risk factor for cataracts, and proper regulation of oxidative stress is crucial for maintaining lens clarity. The lens contains high levels of antioxidants, such as ascorbate and glutathione, which help the lens stay clear, especially in young individuals. This study summarizes the functional and genetic evidence supporting the hypothesis that impaired oxidative stress regulation leads to redox dysregulation and cataracts. The roles of endogenous antioxidant glutathione and exogenous antioxidant vitamin C/ascorbate, as well as the transcription factor NRF2 in cataract development, are discussed.
Review
Food Science & Technology
Xin-Yu Li, Lei Meng, Liang Shen, Hong-Fang Ji
Summary: Vitamin C (VC), vitamin E (VE), and beta-carotene (beta C) are dietary antioxidants that can enhance the body's antioxidant capacity. Their effects on the gut microbiota were reviewed in this article, with 19 studies included. VC, VE, and beta C can modulate the composition and activity of the gut microbiota, improve intestinal barrier function, and support the normal function of the immune system, providing health benefits to the host. Future studies should further investigate the antioxidant activity of vitamins on the gut microbiota and explore the causal relationships between vitamin regulation of the gut microbiota and host health.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Martin Alcala, Victoria E. Bolado, Isabel Sanchez-Vera, Sonia Clapes, Francisco Dasi, Guillermo Saez, Esther Carrera, Fabiola Alvarez-Gallego, Mary R. Loeken, Marta Viana
Summary: Studies on rats and cell cultures have shown that obesity depletes maternal glutathione, reducing the antioxidant capacity in embryos, which can lead to malformations. Vitamin E supplementation can prevent this process and protect against birth defects.
Article
Biochemistry & Molecular Biology
Arpita Basu, Jeannette Crew, Jeffrey L. Ebersole, Jefferson W. Kinney, Arnold M. Salazar, Petar Planinic, James M. Alexander
Summary: The study showed that a dietary intervention including whole blueberries and soluble fiber during pregnancy can significantly increase maternal serum glutathione and antioxidant capacity, decrease malondialdehyde levels, and reduce adipocyte dysfunction and insulin resistance biomarkers.
Article
Plant Sciences
Anka Cebulj, Andreja Vanzo, Joze Hladnik, Damijana Kastelec, Urska Vrhovsek
Summary: Selecting a non-browning cultivar is one of the most effective ways to prevent browning of apple and apple products. The Slovenian cultivar 'Majda' stands out for its high acidity, low phenol content, and high reduced glutathione content, contributing to its non-browning characteristics.
Article
Nutrition & Dietetics
Min Cheol Chang, Sang Gyu Kwak, Soyoung Kwak
Summary: The meta-analysis found that high intake of vitamin E significantly reduced the risk of Parkinson's disease, while vitamin C intake did not show a significant protective effect. Further studies are needed to explore the exact mechanisms of vitamin E transportation and regulation in the central nervous system.
CLINICAL NUTRITION
(2021)
Review
Infectious Diseases
Giulia Patti, Carmen Pellegrino, Aurelia Ricciardi, Roberta Novara, Sergio Cotugno, Roberta Papagni, Giacomo Guido, Valentina Totaro, Giuseppina De Iaco, Federica Romanelli, Stefania Stolfa, Maria Letizia Minardi, Luigi Ronga, Ilenia Fato, Rossana Lattanzio, Davide Fiore Bavaro, Gina Gualano, Loredana Sarmati, Annalisa Saracino, Fabrizio Palmieri, Francesco Di Gennaro
Summary: Supplementation with multiple micronutrients, including zinc, may be more beneficial in TB compared to vitamin A alone. Vitamin C at high concentrations sterilizes drug-resistant TB cultures and prevents the emergence of drug persisters; Vitamin D suppresses mycobacterium replication in vitro, while VE shows a promising role in TB management due to its connection with oxidative balance.
Article
Horticulture
Rana Panahi Tajaragh, Farzad Rasouli, Mousa Torabi Giglou, Seyed Morteza Zahedi, Mohammad Bagher Hassanpouraghdam, Mohammad Ali Aazami, Anna Adamkova, Jiri Mlcek
Summary: The use of mannitol and PEG under in vitro conditions to evaluate and screen cucurbit genotypes has shown significant effects on various physiological parameters.
Review
Fisheries
Abdel-Fattah M. El-Sayed, Marisol Izquierdo
Summary: Vitamin E plays a crucial role in farmed fish, providing antioxidant protection, improving immune response and growth performance, reducing muscle degeneration and atherosclerosis risk, enhancing reproductive efficiency and product quality. Consideration should be given to the interaction of VE with vitamin C and selenium, as well as lipid content in feed when supplementing VE.
REVIEWS IN AQUACULTURE
(2022)
Article
Psychology, Biological
Parinaz Matinfar, Maghsoud Peeri, Mohammad Ali Azarbayjani
Summary: The study found that swimming exercise can reduce anxiety symptoms in patients with type 2 diabetes, as well as alleviate insulin resistance and brain oxidative stress.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Pharmacology & Pharmacy
Chiman Salehi, Monireh Seiiedy, Hamid Soraya, Farzaneh Fazli, Morteza Ghasemnejad-Berenji
Summary: The study demonstrated that the use of bisoprolol and vitamin E can protect against cerebral ischemia/reperfusion injury, reduce neuronal cell death, and improve cognitive function.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tansel Sapmaz, Ebru Kale, Mahmud Esad Pence, Kubra Sevgin, Muhammetnur Tekayev, Sude Topkaraoglu, Gulfem Basol, Muserref Banu Yilmaz, Ekrem Sapmaz, Oktay Irkorucu
Summary: The objective of this study was to assess the impact of Vitamin E and Vitamin C on markers of the oxidant-antioxidant system, ovarian follicle reserves, and the surface epithelium in autologous intraperitoneal ovarian transplantation conducted in rats. The study showed that Vit E and Vit C preserved the ovarian follicle reserve and had a protective effect on the antioxidant system in autologous intraperitoneal ovarian transplantation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Editorial Material
Biochemistry & Molecular Biology
Luciano Saso, Hande Gurer-Orhan, Visnja Stepanic
Article
Pharmacology & Pharmacy
Ege Arzuk, Fuat Karakus, Hilmi Orhan
Summary: The study suggests that clozapine-induced cardiotoxicity may be caused by the activation of cardiac mitochondria. Mitochondria in cardiac tissue contain CYP enzymes that can catalyze the formation of reactive metabolites from clozapine. Clozapine significantly reduces mitochondrial oxygen consumption rate, providing an explanation for its adverse effects on the heart.
Article
Toxicology
A. T. Aliyev, S. Ozcan-Sezer, A. Akdemir, H. Gurer-Orhan
Summary: Apigenin, a flavonoid, is known to act as an estrogen receptor agonist and inhibit aromatase enzyme. Amentoflavone, a biflavonoid, has been evaluated for its endocrine modulatory effects and antitumor activity in breast cancer cells, showing potential selective cytotoxicity but not a viable alternative to current drugs. Further studies are required to investigate its in vivo effects.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Alev Tascioglu Aliyev, Emiliano Panieri, Visnja Stepanic, Hande Gurer-Orhan, Luciano Saso
Summary: Oxidative stress disrupts the balance between prooxidants and antioxidants, leading to potential biomolecular damage and involvement in various diseases. NRF2, a key regulator of oxidative stress, has potential benefits in the prevention of breast cancer but overactivation may negatively impact cancer therapy. Known oxidative stress modulators like melatonin and polyphenols are suggested to play a role in cancer prevention and treatment through NRF2 activation.
Review
Biochemistry & Molecular Biology
Hilmi Orhan, Fuat Karakus, Ali Erguc
Summary: The biotransformation of exposed chemicals in vivo plays a crucial role in determining toxicity levels, with the liver and microsomes considered the main site for these reactions. Mitochondria, as both initiator and target of toxicity, have been found to metabolize drugs and chemicals, potentially leading to adverse effects on cellular structures and functions.
CURRENT DRUG METABOLISM
(2021)
Review
Biochemistry & Molecular Biology
Elif I. Erguc, Alev Tascioglu-Aliyev, Bita Entezari, Hande Gurer-Orhan
Summary: Endocrine disruptors are exogenous chemicals that interfere with the normal function of endogenous hormones. These chemicals, including pharmaceuticals, phytoestrogens, natural hormones, pesticides, plasticizers, can have potential toxic effects depending on their biotransformation.
CURRENT DRUG METABOLISM
(2021)
Article
Toxicology
Ege Arzuk, Mehmet Tokdemir, Hilmi Orhan
Summary: Mitochondria are the major target of paracetamol-induced hepatotoxicity. This study found that mitochondrial CYPs can catalyze the formation of toxic metabolite NAPQI from paracetamol, leading to the transmission of death signals. However, in the kidneys, there is no correlation between the formation of NAPQI and kidney CYP2E1 activity, suggesting a different toxicity mechanism compared to the liver.
TOXICOLOGY LETTERS
(2022)
Meeting Abstract
Toxicology
S. Midik, K. Atmaca, S. Tay, B. Aladag, A. N. Comu, H. Orhan
TOXICOLOGY LETTERS
(2022)
Meeting Abstract
Toxicology
D. Bozdag, H. Gurer-Orhan, J. Kamstra
TOXICOLOGY LETTERS
(2022)
Article
Endocrinology & Metabolism
Ali Erguec, Fuat Karakus, Ege Arzuk, Neliye Mutlu, Hilmi Orhan
Summary: This study investigated the cytotoxic mechanisms of clozapine, diclofenac, and nifedipine using CHO-K1 cells. It was found that the cytotoxicity of nifedipine and clozapine could be decreased by soft and hard nucleophilic agents, while diclofenac's cytotoxicity was paradoxically increased. Furthermore, oxidative stress and membrane damage were observed in all three drugs, with diclofenac and nifedipine causing mitochondrial membrane damage. These findings suggest that these drugs may exert cytotoxic effects through different mechanisms.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2023)
Meeting Abstract
Toxicology
A. Tascioglu Aliyev, K. Krager, F. LoBianco, K. Ozbilgin, M. Ucoz, N. Aykin-Burns, H. Gurer-Orhan
TOXICOLOGY LETTERS
(2021)
Meeting Abstract
Toxicology
F. Karakus, K. Atmaca, B. Aladag, H. Orhan
TOXICOLOGY LETTERS
(2021)
Meeting Abstract
Toxicology
H. Orhan, F. Karakus, K. Atmaca, B. Aladag
TOXICOLOGY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Hanif Shirinzadeh, Eddy Neuhaus, Elif Ince Erguc, Alev Tascioglu Aliyev, Hande Gurer-Orhan, Sibel Suzen
BIOORGANIC CHEMISTRY
(2020)
Article
Pharmacology & Pharmacy
Hanif Shirinzadeh, Mohammed Ghalia, Alev Tascioglu, Ferial Intissar Adjali, Gulsen Gunesacar, Hande Gurer-Orhan, Sibel Suzen
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2020)
