Article
Medicine, Research & Experimental
Feng Zhu, Chi Yuan, Xu Zhang, Zhi Wang, Qiushu Wang, Hegui Wang
Summary: The downregulation of AKAP5 worsened cardiomyocyte remodeling after H/R, possibly by anchoring CaN to form a complex that activates NFATc3 dephosphorylation and expression of hypertrophy-related proteins.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Medicine, Research & Experimental
Chao Cheng, Dong-Ling Xu, Xiao-Bo Liu, Shao-Jie Bi, Juan Zhang
Summary: This study reveals that overexpression of miR-145-5p inhibits H/R-induced cardiomyocyte apoptosis by targeting ROCK1.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Medicine, Research & Experimental
Zhongbai Zhang, Xueting Qin, Zhenghui Wang, Yanchun Li, Fei Chen, Rundu Chen, Chuang Li, Wencheng Zhang, Mei Zhang
Summary: OMT pretreatment showed positive effects on H9c2 cardiomyocytes exposed to H/R injury by reducing oxidative stress, decreasing apoptosis, and modulating the PI3K/Akt signaling pathway. This suggests that OMT may be a potential therapeutic candidate for myocardial ischemia/reperfusion injury.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Medicine, Research & Experimental
Yingcun Liu, Yuqing Fu, Xin Xue, Gang Tang, Liangyi Si
Summary: This study revealed that BRD2 protects cardiomyocytes from hypoxia-reoxygenation damage by activating the Nrf2/HO-1 signaling pathway, providing potential therapeutic targets for minimizing myocardial ischemia-reperfusion (I/R) injury.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Medicine, Research & Experimental
Qiu Qian, Yingxiang Xie
Summary: Propofol can counteract cardiomyocyte H/R injury by upregulating NR4A2 and inhibiting miR-449a, thereby promoting cell viability and proliferation and inhibiting cell apoptosis.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Oncology
Binghui Song, Dongmei Wei, Gang Yin, Xiaoguang Song, Shuqing Wang, Shanshan Jia, Jidong Zhang, Longhu Li, Xiaofei Wu
Summary: This study revealed the association between dysregulation of ANRIL and myocardial infarction risk, with ANRIL positively regulating SIRT1 expression and reducing H/R-induced cardiomyocyte injury through sponging miR-181a. These findings suggest the ANRIL/miR-181a/SIRT1 axis as a potential therapeutic target for reducing MI/R injury.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Pharmacology & Pharmacy
Haiping Ma, Yongjie Li, Tianliang Hou, Jing Li, Long Yang, Hai Guo, Lili Li, Mingxiu Xin, Zhongcheng Gong
Summary: This study demonstrated that sevoflurane post-conditioning (SPostC) has a protective effect on cardiomyocyte hypoxia/reoxygenation injury under low glucose conditions, but this effect is abolished under high glucose conditions. Regulating the HIF-1 alpha/MIF/AMPK signaling pathway can restore the cardioprotective effect of SPostC under hyperglycemia.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Zhengri Lu, Mengen Deng, Genshan Ma, Lijuan Chen
Summary: This study aimed to investigate the role and mechanisms of TRIM38 in myocardial ischemia/reperfusion (I/R) injury. The results showed that TRIM38 expression can alleviate inflammatory responses and oxidative stress, inhibit apoptosis, and attenuate cellular injury by suppressing the TAK1/NF-kappa B pathway activity.
Review
Behavioral Sciences
Maryam Naseh, Jafar Vatanparast, Ali Rafati, Mahnaz Bayat, Masoud Haghani
Summary: FTY720, as an agonist of S1P receptor, exerts neuroprotective effects in ischemic stroke patients through three mechanisms: functional antagonistic, functional agonistic, and receptor-independent mechanisms.
BRAIN AND BEHAVIOR
(2021)
Article
Medicine, Research & Experimental
Zhengbing Lv, Xiaojia Luo, Biying Hong, Qiran Ye, Jianxiong Liu, Yongmei Hu
Summary: This study aimed to explore new targets for the treatment of myocardial ischemia-reperfusion injury (MIRI) and determine their underlying mechanism of action. Experimental results showed that the expression of CBL was upregulated in patients with ischemic cardiomyopathy and H/R-induced cells, and knocking down CBL promoted cell proliferation and antioxidant capacity while inhibiting apoptosis. This effect may be mediated through the regulation of GRB2 expression.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Plant Sciences
Qian Zhang, Yuan-Ye Dang, Xiu Luo, Ji-Jun Fu, Zhi-Cong Zou, Xue-Jing Jia, Guo-Dong Zheng, Chu-Wen Li
Summary: Kazinol B (KB), an isoprenylated flavan derived from Broussonetia kazinoki Sieb. (Moraceae) root, has protective effects on hypoxia and reoxygenation-induced cardiac injury in H9c2 rat cardiac myoblasts, and its mechanism involves modulating the AKT and AMPK-mediated Nrf2 induction.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Immunology
Fatma Zehra Okus, Zehra Busra Azizoglu, Halit Canatan, Ahmet Eken
Summary: In this study, the effects of different S1P analogues on human Th17 and Treg cell differentiation, cytokine production, and IL-23-mediated signaling were investigated. The results showed that all three S1P analogues directly inhibited Th17 cell differentiation and promoted Treg cell differentiation. They also suppressed IL-23-mediated signaling. Additionally, they inhibited the expression of Dectin-1 in dendritic cells and the production of cytokines induced by curdlan.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Z. Dogan, S. Durmus, D. D. Ergun, R. Gelisgen, H. Uzun
Summary: This study evaluated the effectiveness of ranolazine on hypoxia-inducible factor-1 alpha (HIF-1 alpha) and oxidative stress in H9c2 cardiomyocyte cells. The results showed that ranolazine can protect cardiomyocytes from oxidative damage induced by methotrexate (MTX) by reducing oxidative stress and increasing antioxidant capacity markers. The antioxidant properties of ranolazine may contribute to these protective effects.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Gerhild van Echten-Deckert
Summary: Lipids are essential components of the CNS, and sphingolipids, a type of lipid, are highly concentrated in the brain. Sphingosine 1-phosphate (S1P), derived from membrane sphingolipids, has complex effects on the brain, which can be both beneficial and detrimental. However, the role of S1P in brain development and various brain pathologies is still controversial.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Biotechnology & Applied Microbiology
Li Wang, Shaowei Wang, Tong Jia, Xiaojia Sun, Zhen Xing, Hui Liu, Jie Yao, Yanlin Chen
Summary: Myocardial hypoxia/reoxygenation (H/R) injury is a common pathological change in patients with acute myocardial infarction undergoing reperfusion therapy. Dexmedetomidine (DEX) has been found to substantially improve ischemia-mediated cell damage. In this study, we explored the role and mechanism of DEX in ameliorating myocardial H/R injury. Our data showed that DEX treatment notably impeded myocardial apoptosis and inflammation, enhanced cardiomyocyte viability, and improved H/R-mediated myocardial injury by up-regulating Sirt1 through accelerating TET1 and mediating demethylation of the Sirt1 promoter.