Article
Medicine, Research & Experimental
Seyyed Mohammad Reza Hashemnia, Reza Meshkani, Fahimeh Zamani-Garmsiri, Maryam Shabani, Maryam Tajabadi-Ebrahimi, Iraj Ragerdi Kashani, Seyed Davar Siadat, Samaneh Mohassel Azadi, Solaleh Emamgholipour
Summary: New evidence suggests that B. coagulans can be a promising alternative for treating metabolic disorders. However, its effects on obesity-induced adipose tissue inflammation are still unknown.
Article
Immunology
Johannes Hoch, Niklas Burkhard, Shanshan Zhang, Marina Rieder, Timoteo Marchini, Vincent Geest, Krystin Krauel, Timm Zahn, Nicolas Schommer, Muataz Ali Hamad, Carolina Bauer, Nadine Gauchel, Daniela Stallmann, Claus Normann, Dennis Wolf, Ruediger Eberhard Scharf, Daniel Duerschmied, Nancy Schanze
Summary: This study found that deficiency of the serotonin transporter (SERT) is associated with metabolic derangements in mice. High-fat diet feeding in SERT-deficient mice resulted in enhanced insulin resistance, liver steatosis, and adipose tissue inflammation. These findings suggest that SERT deficiency may contribute to altered inflammatory processes.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Medicinal
Yea-Jin Park, Tae-Young Gil, Bo-Ram Jin, Yun-Yeop Cha, Hyo-Jin An
Summary: This study aimed to investigate the effect of APO on the reduction of weight gain and obesity-induced adipose tissue inflammation. The results showed that APO-treated mice had a significantly lower white adipose tissue mass index compared to orlistat-treated mice. APO also reduced the expression of inflammatory markers and improved local inflammatory response in adipose tissue. These findings provide a foundation for further research on the use of APO as a therapeutic agent for obesity-induced inflammatory diseases.
PHYTOTHERAPY RESEARCH
(2023)
Article
Nutrition & Dietetics
Yu Wang, Xuyang Gao, Xiaoyou Chen, Qiang Li, Xinrui Li, Junxing Zhao
Summary: Sea buckthorn powder intake has a preventive effect on high-fat diet-induced obesity, reducing body weight, fat mass, and circulating lipid levels, and improving insulin sensitivity. Additionally, it alleviates hepatic steatosis and lipid accumulation, exhibits anti-inflammatory capacity in white adipose tissue, promotes thermogenesis in brown adipose tissue, and induces beige adipocyte formation.
Article
Genetics & Heredity
Zhe Wang, Ming Zhu, Meng Wang, Yihui Gao, Cong Zhang, Shangyun Liu, Shen Qu, Zhongmin Liu, Chao Zhang
Summary: Histone modifications can activate or suppress genes related to lipogenesis, energy metabolism, and inflammation. Certain genes activated under high-fat diet conditions may be associated with inflammation and energy metabolism.
FRONTIERS IN GENETICS
(2021)
Article
Pharmacology & Pharmacy
Jessica Latorre, Aina Lluch, Francisco J. Ortega, Aleix Gavalda-Navarro, Ferran Comas, Samantha Moron-Ros, Amaia Rodriguez, Sara Becerril, Francesc Villarroya, Gema Fruhbeck, Wifredo Ricart, Marta Giralt, Jose Manuel Fernandez-Real, Jose Maria Moreno-Navarrete
Summary: The study found that lysozyme is highly expressed in adipose tissue of obese individuals, associated with chronic inflammation, adipose tissue inflammation, and metabolic disturbances. Knocking down the lysozyme gene in experimental models improved adipose tissue inflammation and reduced weight gain.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Vanessa M. Lima, Jianming Liu, Bruna B. Brandao, Caroline A. Lino, Camila S. Balbino Silva, Marcio A. C. Ribeiro, Tiago E. Oliveira, Caroline C. Real, Daniele de Paula Faria, Carly Cederquist, Zhan-Peng Huang, Xiaoyun Hu, Maria Luiza Barreto-Chaves, Julio C. B. Ferreira, William T. Festuccia, Marcelo A. Mori, C. Ronald Kahn, Da-Zhi Wang, Gabriela P. Diniz
Summary: miR-22 plays a role in white, beige, and brown adipocyte differentiation. Deletion of miR-22 reduces white adipocyte differentiation, increases BAT activity, and enhances resistance in HFD-fed mice.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Biochemistry & Molecular Biology
Sha Zhang, Jinjie Li, Xiaoyang Shi, Xiaomeng Tan, Quanjin Si
Summary: This study found that naringenin can promote beige adipose thermogenesis and browning through interactions with gut microbiota. The research revealed the anti-obesity mechanism of naringenin, which prevents obesity caused by high fat diet through increasing energy expenditure.
Article
Nutrition & Dietetics
Juliane Weiner, Sebastian Dommel, Claudia Gebhardt, Martha Hanschkow, Yulia Popkova, Kerstin Krause, Nora Kloeting, Matthias Blueher, Juergen Schiller, John T. Heiker
Summary: The study compared the effects of a high-sucrose diet and a high-fat diet on metabolic health in mice. The results showed that the high-fat diet led to more severe obesity, glucose intolerance, and insulin resistance, while the high-sucrose diet resulted in more pronounced hepatic steatosis and inflammation.
FRONTIERS IN NUTRITION
(2023)
Article
Plant Sciences
Eun A. Kim, Ju-Hwan Yang, Eun-Hye Byeon, Woong Kim, Dawon Kang, Jaehee Han, Seong-Geun Hong, Deok-Ryong Kim, Sang-Je Park, Jae-Won Huh, Hyeonsook Cheong, Seung-Pil Yun, Dong-Kun Lee
Summary: The study demonstrates that pine needle extract inhibits obesity by increasing hypothalamic POMC neuronal activity and improving physiological conditions after high-fat diet-induced obesity. Additionally, PNE also suppresses lipogenesis in white adipose tissue.
Article
Food Science & Technology
Caroline Bertoncini-Silva, Priscila Giacomo Fassini, Daniela Carlos, Natalia Aparecida de Paula, Leandra Naira Zambelli Ramalho, Marina Rodrigues Giuliani, italo Sousa Pereira, Jhefferson Barbosa Guimaraes, Vivian Marques Miguel Suen
Summary: After 12 weeks of high-fat diet feeding and oral supplementation with curcumin in mice, it was found that curcumin reduces inflammatory markers and increases anti-inflammatory markers in the liver and white adipose tissue. In the gut, curcumin promotes the growth of beneficial bacteria and reduces harmful bacteria.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Medicine, Research & Experimental
Saeed Daneshyar, Gholamreza Tavoosidana, Mahdi Bahmani, Saeed Shokati Basir, Maryam Delfan, Ismail Laher, Ayoub Saeidi, Urs Granacher, Hassane Zouhal
Summary: This study aims to investigate the combined effects of high-fat diets and exercise training on autophagy in mouse white adipose tissue. The results show that both the high-fat diet and exercise training groups had increased levels of autophagy-related genes and proteins. The combination of high-fat diet and exercise enhances autophagosome formation and modulates lysosomal degradation in white adipose tissue.
Article
Endocrinology & Metabolism
Inka Rapoehn, Ivet Elias, Juliane Weiner, Anna Pujol, Stephanie Kehr, Alexandra Chadt, Hadi Al-Hasani, Ralph Burkhardt, Nora Kloeting, Michael Stumvoll, Fatima Bosch, Peter Kovacs, John T. Heiker, Jana Breitfeld
Summary: Adipose tissue inflammation and insulin resistance are important factors in the development of metabolic diseases resulting from overweight and obesity. The serpin vaspin has compensatory roles in inflammation and insulin resistance. A new transgenic mouse line with human vaspin expression in adipose tissue has been developed, which showed improved metabolic parameters and increased energy expenditure under high-fat diet conditions.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Aline Almeida da Silva, Elisangela Martins da Silva Perez, Ingrid Samantha Tavares de Figueiredo, Nylane Maria Nunes de Alencar, Ana Paula Negreiros Nunes Alves, Fabiano Andre Narciso Fernandes, Renata Prado Vasconcelos, Ariclecio Cunha de Oliveira, Socorro Vanesca Frota Gaban
Summary: This study investigated the effects of virgin coconut oil (VCO) on body weight, white fat depots, and biochemical and morphological parameters in male Swiss mice fed standard (SD) or high-fat (HFD) diets. The results showed that low-dose VCO supplementation did not improve obesity, had no effects on hepatic or renal function, and had beneficial effects on the lipid profile only in animals fed HFD.
Article
Biochemistry & Molecular Biology
Pei-Chi Chan, Chieh-Hua Lu, Hung-Che Chien, Yu-Feng Tian, Po-Shiuan Hsieh
Summary: The study reveals the crucial role of CCL5 in obesity-induced adipose tissue inflammation and insulin resistance, showing that CCL5 gene deletion or tissue-specific deletion of CCL5 through BMT can ameliorate inflammation and impact the distribution of MDSCs and macrophage polarization in adipose tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)