Review
Cell Biology
Nasim Kheshtchin, Jamshid Hadjati
Summary: Hypoxia, a common characteristic of solid tumors, contributes to different aspects of tumor progression and limits the efficacy of immunotherapies. Developing new immunotherapy strategies involving therapeutic targeting of HIF-1 molecules associated with hypoxia may enhance the clinical effectiveness of immunotherapy. Targeting hypoxia presents a potential opportunity to improve the clinical benefit of cancer immunotherapy.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Oncology
Leah Davis, Matthias Recktenwald, Evan Hutt, Schuyler Fuller, Madison Briggs, Arnav Goel, Nichole Daringer
Summary: Hypoxia, or inadequate oxygen supply, is a characteristic of the tumor microenvironment and is associated with a poor prognosis and resistance to therapy. HIF-alpha, specifically the HIF-1 alpha and HIF-2 alpha subunits, play a crucial role in mediating the transcription of important proteins involved in tumor progression. While HIF-1 alpha has been extensively studied, the role of HIF-2 alpha is often overlooked. HIF-2 alpha can enhance the aggressive behavior of tumors, promoting metastasis, tissue remodeling, angiogenesis, and the upregulation of cancer stem cell factors. This review highlights the structure, function, hypoxic response, and roles of HIF-2 alpha in cancer progression, as well as discussing current therapeutic strategies and future directions.
Article
Cell Biology
Xin Zhang, Kexin Wang, Xingbo Feng, Jian Wang, Yali Chu, Chunmeng Jia, Qingsi He, Cheng Chen
Summary: The study revealed that HIF1 alpha R282 is methylated by PRMT3, which is essential for its stability and oncogenic function. Using MPG-peptide to inhibit HIF1 alpha expression offers a new therapeutic strategy for colorectal cancer resistant to anti-angiogenesis therapy.
CELL DEATH & DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Jan Korbecki, Donata Siminska, Magdalena Gassowska-Dobrowolska, Joanna Listos, Izabela Gutowska, Dariusz Chlubek, Irena Baranowska-Bosiacka
Summary: This paper discusses the mechanisms and effects of chronic low-grade inflammation caused by chronic hypoxia and cycling hypoxia in malignant tumors, as well as their impact on the tumor microenvironment and cell recruitment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Yanming Xu, Ying Li, Xiaodong Yang, Dehua Lu, Yuanyuan Zheng, Jingyun Tan, Wenhua Li, Qi Chen, Yajie Liu, Jing Gao, Shubin Wang
Summary: This study found that the tumor microenvironment is hypoxia, which can induce the expression of hypoxia inducible factor-1a (HIF-1a) and mediate tumor chemoresistance, leading to poor prognosis for cancer patients. A cost-effective and practical HIF-1a inhibitor, plasma-activated medium (PAM), was investigated in colorectal cancer (CRC) in vitro and in vivo. PAM was able to reduce HIF-1a expression induced by hypoxia, enhancing the chemosensitivity of oxaliplatin (OXA) in CRC cells and inhibiting cell proliferation and tumor growth. Mechanistically, PAM might exert synergistic antitumor activity by inhibiting the MAPK pathway.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Review
Oncology
Diana Gaete, Diego Rodriguez, Deepika Watts, Sundary Sormendi, Triantafyllos Chavakis, Ben Wielockx
Summary: Solid tumors often face hypoxic environments, leading to activation of HIFs and subsequent regulation by PHDs to counteract internal stress. PHDs have the potential to be a therapeutic target in anti-tumor treatments.
Review
Oncology
Bich Phuong Bui, Phuong Linh Nguyen, Kyeong Lee, Jungsook Cho
Summary: This review discusses the crucial role of hypoxia-inducible factor-1 (HIF-1) in tumor biology, particularly in hypoxic environments. Despite numerous identified HIF-1 inhibitors as potential therapeutic agents for various cancers, none of them have been successfully translated into clinically available cancer treatments. The review summarizes the roles of the HIF-1 pathway in tumor proliferation, angiogenesis, metastasis, drug resistance, and cancer-related pain. Additionally, it highlights the current status of HIF-1 inhibitors in clinical trials and their future perspectives. HIF-1 inhibitors may be promising combinational therapeutic interventions to improve the efficacy of current cancer treatments and reduce drug resistance and cancer-related pain.
Article
Genetics & Heredity
Sarah R. Poll, Renan Martin, Elizabeth Wohler, Elizabeth S. Partan, Elizabeth Walek, Shaima Salman, Daniel Groepper, Lisa Kratz, Mirlene Cernach, Reynaldo Jesus-Garcia, Chad Haldeman-Englert, Yoon Jae Choi, Carol D. Morris, Bernard Cohen, Julie Hoover-Fong, David Valle, Gregg L. Semenza, Nara L. M. Sobreira
Summary: Ollier disease and Maffucci Syndrome are rare disorders characterized by multiple enchondromas and have a high risk of developing malignancies. Variants in HIF1A, VHL, and IDH1 genes have been found to be significantly associated with these disorders. Functional studies are needed to confirm the role of these genetic variants in the development of phenotypic abnormalities in individuals with Ollier disease and Maffucci Syndrome.
Article
Biochemistry & Molecular Biology
Xiangqi Meng, Jingxuan Peng, Xiaoshan Xie, Fenghai Yu, Wencong Wang, Qihao Pan, Huilin Jin, Xiaoling Huang, Hongyan Yu, Shengrong Li, Dianying Feng, Qingxin Liu, Lekun Fang, Mong-Hong Lee
Summary: This study reveals that the highly expressed long non-coding RNA LVBU in colorectal cancer cells promotes tumor growth and development by regulating the BCL6-p53 signaling pathway, which in turn affects urea cycle and polyamine synthesis.
Review
Cell Biology
Minghui Zhang, Yu Zhang, Yubo Ding, Jialu Huang, Jingwei Yao, Zhuoyi Xie, Yufan Lv, Jianhong Zuo
Summary: This review examines the regulatory roles of HIF-1 alpha and lncRNAs in the EMT process of tumor cells and their relationship with tumorigenesis, and summarizes current drugs that inhibit tumor progression by modulating HIF-1 alpha.
Article
Pharmacology & Pharmacy
Aranka Brockmueller, Sosmitha Girisa, Mahzad Motallebi, Ajaikumar B. Kunnumakkara, Mehdi Shakibaei
Summary: A study found that Calebin A (CA), a compound derived from turmeric, inhibits colorectal cancer (CRC) cell migration by modulating the NF-kappa B pathway through the inhibition of HIF-1 alpha. CA suppressed the proliferation and migration of CRC cells, reduced the expression of metastatic factors, and induced apoptosis through inhibition of HIF-1 alpha. This research has important implications for cancer therapy.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yijie Wang, Xiong Liu, Min Wang, Yu Wang, Shuo Wang, Lai Jin, Min Liu, Jun Zhou, Yan Chen
Summary: This study reveals that UBE3B is an E3 ligase for HIF-2 & alpha; and its depletion inhibits breast cancer progression. UBE3B physically interacts with HIF-2 & alpha; and promotes its polyubiquitination, thereby inhibiting its degradation. UBE3B depletion also inhibits breast cancer cell proliferation, migration, and invasion, and suppresses tumor growth and metastasis.
Article
Biochemistry & Molecular Biology
Yijie Wang, Xiong Liu, Min Liu, Yu Wang, Shuo Wang, Lai Jin, Min Liu, Jun Zhou, Yan Chen
Summary: It has been found that UBE3B acts as an E3 ligase for HIF-2 alpha, promoting its polyubiquitination and inhibiting its degradation, which plays a crucial role in breast cancer growth and metastasis.
Article
Medicine, General & Internal
Zhou Lan, Ke-Long Zou, Hao Cui, Hao Chen, Yu-Yue Zhao, Guang-Tao Yu
Summary: Hypoxia in solid tumors affects tumor therapy, but targeting the hypoxic tumor microenvironment shows promise. In this study, a drug carrier was developed to alleviate hypoxia and inhibit the growth of oral squamous cell carcinoma (OSCC).
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Engineering, Biomedical
Xijuan Yao, Shuting Lu, Cheng Feng, Ruiyang Suo, Hang Li, Yi Zhang, Qi Chen, Jian Lu, Bo Wu, Jinhe Guo
Summary: This study proposes a new strategy to overcome the resistance of esophageal cancer to 125I brachytherapy. By co-encapsulating catalase and a HIF-1 inhibitor into liposomes, researchers were able to generate oxygen and reduce the expression of hypoxia-related proteins, improving the radiosensitivity of brachytherapy and leading to the eradication of esophageal cancer.
Article
Genetics & Heredity
Ana Valencia, Candelaria Vergara, Chloe L. Thio, Nicolas Vince, Venceslas Douillard, Alba Grifoni, Andrea L. Cox, Eric O. Johnson, Alex H. Kral, James J. Goedert, Alessandra Mangia, Valeria Piazzolla, Shruti H. Mehta, Gregory D. Kirk, Arthur Y. Kim, Georg M. Lauer, Raymond T. Chung, Jennifer C. Price, Salim Khakoo, Laurent Alric, Matthew E. Cramp, Sharyne M. Donfield, Brian R. Edlin, Michael P. Busch, Graeme Alexander, Hugo R. Rosen, Edward L. Murphy, Genevieve L. Wojcik, Mary Carrington, Pierre-Antoine Gourraud, Alessandro Sette, David L. Thomas, Priya Duggal, Continue Ignore
Summary: Spontaneous clearance of acute hepatitis C virus (HCV) infection is associated with specific amino acids in HLA-DQ beta 1. Fine-mapping the MHCII region revealed these key amino acids, explaining the allelic and SNP associations with HCV outcomes. This understanding could contribute to the design of vaccines promoting spontaneous clearance of HCV infection.
AMERICAN JOURNAL OF HUMAN GENETICS
(2022)
Article
Infectious Diseases
Massimo Andreoni, Nicola Coppola, Antonio Craxi, Stefano Fagiuoli, Ivan Gardini, Alessandra Mangia, Felice Alfonso Nava, Patrizio Pasqualetti
Summary: The study findings suggest that tolerability is considered the most important feature of suitable treatment by hospital clinicians and SerD HCPs, and timely treatment initiation is crucial for the success of the strategy. Drug addiction services patients prefer a complete Meet-Test-Treat pathway within their habitual care center.
BMC INFECTIOUS DISEASES
(2022)
Article
Gastroenterology & Hepatology
Guiseppe Indolfi, Deirdre Kelly, Gabriella Nebbia, Raffaele Iorio, Anna Mania, Vania Giacomet, Leszek Szenborn, Jiang Shao, Mun Sang Yue, Chia-Hsiang Hsueh, Bandita Parhy, Kathryn Kersey, Alessandra Mangia, Malgorzata Pawlowska, Sanjay Bansal
Summary: Sofosbuvir-velpatasvir-voxilaprevir is a highly effective and well-tolerated pangenotypic regimen for treating chronic HCV infection in adolescents aged 12 to 17 years.
Article
Virology
Silvia Rosati, Alexander Wong, Vito Di Marco, Paco Perez-Hernandez, Guilherme Macedo, Christian Brixko, Roberto Ranieri, Francesca Campanale, Annalisa Bascia, Conrado Fernandez-Rodriguez, Victor de Ledinghen, Ivana Maida, Elisabetta Teti, Alessandra Mangia, Kim Vanstraelen, Candido Hernandez, Michael Mertens, Ioanna Ntalla, Heribert Ramroth, Elena Jimenez
Summary: Prison populations are at high risk of HCV infection, but treatment is complicated by social issues. This study analyzed data from Europe and Canada and found that a simple and effective sofosbuvir/velpatasvir treatment achieved high cure rates in prison settings.
Letter
Gastroenterology & Hepatology
Nahum Mendez-Sanchez, Elisabetta Bugianesi, Robert G. Gish, Frank Lammert, Herbert Tilg, Mindie H. Nguyen, Shiv K. Sarin, Nuria Fabrellas, Shira Zelber-Sagi, Jian-Gao Fan, Gamal Shiha, Giovanni Targher, Ming-Hua Zheng, Wah-Kheong Chan, Shlomo Vinker, Takumi Kawaguchi, Laurent Castera, Yusuf Yilmaz, Marko Korenjak, C. Wendy Spearman, Mehmet Ungan, Melissa Palmer, Mortada El-Shabrawi, Hans-Juergen Gruss, Jean-Francois Dufour, Anil Dhawan, Heiner Wedemeyer, Jacob George, Luca Valenti, Yasser Fouad, Manuel Romero-Gomez, Mohammed Eslam
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Alessandra Mangia, Nicola Serra, Giovanna Cocomazzi, Vincenzo Giambra, Stefano Antinucci, Alberto Maiorana, Francesco Giuliani, Emanuele Montomoli, Paolo Cantaloni, Alessandro Manenti, Valeria Piazzolla
Summary: For naive individuals, low IgG titers are relatively long-lasting. Only a third of naive subjects maintain neutralizing responses. After specific stimulation, a very limited number of naive were unable to produce IFN-gamma. The results of breakthrough infections suggest that simultaneous neutralizing antibody titers < 20, binding antibody levels/ml < 200, and IFN-gamma < 1,000 mIU/ml in subjects older than 58 may identify at-risk groups.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Alessandra Mangia, Annarita Valeria Piazzolla, Maria Maddalena Squillante, Giovanna Cocomazzi, Vanna Maria Valori, Massimiliano Copetti, Paola Parente, Vito Attino, Maria Guido
Summary: Non-alcoholic fatty liver disease (NAFLD) can progress to severe liver fibrosis and cirrhosis. The presence of portal inflammation, high triglycerides levels, advanced fibrosis at baseline, and the duration of follow-up are predictors of disease progression in NAFLD patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Health Care Sciences & Services
Stefano Fagiuoli, Pierluigi Toniutto, Nicola Coppola, Domenica Daniela Ancona, Margherita Andretta, Fausto Bartolini, Fulvio Ferrante, Alessandro Lupi, Stefano Palcic, Francesca Vittoria Rizzi, Davide Re, Gema Alvarez Nieto, Candido Hernandez, Francesca Frigerio, Valentina Perrone, Luca Degli Esposti, Alessandra Mangia
Summary: This study investigates the impact of polymedication and aging on the prevalence of drug-drug interactions (DDIs) in HCV patients treated with SOF/VEL or GLE/PIB. The study finds that SOF/VEL patients are older and have more comorbidities and polypharmacy compared to GLE/PIB patients. The simultaneous use of multiple medications can lead to DDIs and increase treatment risks.
THERAPEUTICS AND CLINICAL RISK MANAGEMENT
(2023)
Editorial Material
Cell Biology
Alessandra Mangia
Article
Cell Biology
Alessandra Mangia, Maria Maddalena Squillante, Filippo Fraticelli, Maria Chiara Cavorsi, Giulia Paroni, Lucia Zaffarano, Annarita Valeria Piazzolla
Summary: This study evaluated the impact of baseline viremia on the natural history of HDV infection. The results demonstrated that HDV RNA levels may help identify a subgroup of patients with slower progression of liver disease.
Article
Health Care Sciences & Services
Felice Alfonso Nava, Alessandra Mangia, Marco Riglietta, Lorenzo Somaini, Francesco Giuseppe Foschi, Ernesto Claar, Ivana Maida, Claudio Ucciferri, Francesca Frigerio, Candido Hernandez, Melania Dovizio, Valentina Perrone, Luca Degli Esposti, Massimo Puoti
Summary: This study aimed to analyze the characteristics and clinical features of Hepatitis C virus (HCV) infected people who use drugs (PWUDs) in Italy, with a focus on comorbidity profile, treatment with direct-acting antiviral agents (DAAs), and resource consumption. The study found that HCV-positive individuals were older, had more comorbidities, and had higher rates of drug prescriptions and hospitalizations. Untreated patients with DAAs had more severe comorbidities. These findings provide insights for improving healthcare interventions for HCV-infected PWUDs.
THERAPEUTICS AND CLINICAL RISK MANAGEMENT
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Steven L. Flamm, Graham R. Foster, Marc Bourliere, Stefan Zeuzem, Curtis Cooper, Henry Lik Yuen Chan, Shyam Kottilil, Mark S. Sulkowski, Bruce Kreter, Linda Chen, Renee-Claude Mercier, Kyle P. Hammond, Candido Hernandez, Alessandra Mangia
Meeting Abstract
Gastroenterology & Hepatology
Frank Tacke, Juan Turnes, Andreas Hintz, Stefano Fagiuoli, Antoni Sicras-Mainar, Tim Umland, Luca Degli Esposti, Ramon Morillo Verdugo, Antonio Garcia Herola, Mehtap Guendogdu, Marinela Mendez, Gema Alvarez Nieto, Kim Vanstraelen, Candido Hernandez, Alessandra Mangia
JOURNAL OF HEPATOLOGY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Alessandra Mangia, Stefano Fagiuoli, Vito Di Marco, Stephen Shafran, Mandana Khalili, Scott Milligan, George Papatheodoridis, Denis Ouzan, Silvia Rosati, Alnoor Ramji, Elisabetta Teti, Montserrat Garcia-Retortillo, Francisco Andres Perez Hernandez, Alexander Wong, Chris Fraser, Sergio Rodriguez-Tajes, Elena Jimenez Mutiloa, Luis Enrique Morano Amado, Joss O'Loan, Francesca Campanale, Guilherme Macedo, Michele Milella, Christian Brixko, Maria Buti, Maria Guerra Veloz, Roberto Ranieri, Sergio Borgia, Annalisa Bascia, Conrado Manuel Fernandez Rodriguez, Brian Conway, Victor de Ledinghen, Mary Fenech, Pablo Ryan, Ivana Maida, Alexandra Martins, Stacey Scherbakovsky, Ioanna Ntalla, Candido Hernandez, Kim Vanstraelen, Juan Turnes
JOURNAL OF HEPATOLOGY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Alessandra Mangia, Valeria Piazzolla, Maria Squillante, Giovanna Cocomazzi, Vito Ciciriello, Vincenzo Giambra, Nicola Serra
JOURNAL OF HEPATOLOGY
(2022)