Review
Cell Biology
Yin Shi, Han-Ming Shen, Vidya Gopalakrishnan, Nancy Gordon
Summary: Autophagy is a highly conserved catabolic process that protects cells from harm and allows survival under stress conditions. The regulation of autophagy is complex, involving various signaling pathways including AMPK and mTOR. Understanding these regulatory mechanisms can lead to the discovery of new therapeutic targets.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Reproductive Biology
Naiara Z. Saraiva, Clara S. Oliveira, Nathalia N. C. Almeida, Marivaldo R. Figueiro, Carolina C. R. Quintao, Joaquim M. Garcia
Summary: This study investigated the epigenetic changes resulting from the use of histone deacetylase inhibitors in the maturation of bovine oocytes and subsequent embryo development. The results showed that the treatment with histone deacetylase inhibitors promoted the development of bovine oocytes and had a positive impact on embryo development.
Article
Cell Biology
Maria Likhatcheva, Roben G. Gieling, James A. L. Brown, Constantinos Demonacos, Kaye J. Williams
Summary: Genotoxic stress can activate the ATM kinase, with potential involvement of Suv39H1 and Tip60 in ATM activation under hypoxic conditions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Horticulture
Chao Gong, Huihui Su, Zhenxing Li, Peiting Mai, Baojuan Sun, Zhiliang Li, Zhou Heng, Xiaowan Xu, Songguang Yang, Tao Li
Summary: Our study revealed that histone acetylation mediated by histone deacetylases (HDACs) plays a critical role in the resistance of tomato to bacterial wilt (BW). Most defense-related genes were up-regulated in resistant cultivar, while down-regulated in susceptible cultivar, and silencing of HDACs genes led to a decrease in disease incidence in susceptible cultivar. Under R. solanacearum infection, histone H3 and H4 acetylation levels of defense-related genes were increased, especially in the resistant cultivar.
SCIENTIA HORTICULTURAE
(2021)
Review
Biochemistry & Molecular Biology
Goutham Narayanan Subramanian, Abrey Jie Yeo, Magtouf Hnaidi Gatei, David John Coman, Martin Francis Lavin
Summary: The ATM protein kinase has diverse functions in the cell, including protecting DNA, maintaining cellular homeostasis, and safeguarding against external and internal damage.
Review
Immunology
Yudan Cui, Jingshan Cai, Wenxin Wang, Shengjun Wang
Summary: HDACIs are antitumor drugs that enhance gene transcription via epigenetic regulation, with cytotoxic properties against tumor cells. The effects of HDACIs on immunocytes in the tumor microenvironment, specifically MDSCs, are still not fully understood.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Zun-Yan Zhou, Ji-Yuan Yang, Cheng-Ze Shao, Fei Luo, Wei Du
Summary: By regulating the expression of E2F-1 and ATM, the resistance of human nasopharyngeal carcinoma cells to cisplatin can be reversed.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Review
Genetics & Heredity
Motohiro Yamauchi
Summary: Chromosome rearrangements are structural variations in chromosomes and are associated with a variety of human diseases. Ataxia-telangiectasia (A-T) is an autosomal recessive disorder characterized by chromosome rearrangements at the cellular level, particularly in T lymphocytes. The defective gene in A-T is ataxia-telangiectasia mutated (ATM), which plays a central role in cellular response to DNA damage, including suppressing chromosome rearrangements.
Article
Biochemistry & Molecular Biology
Zhendong Cao, Krista A. Budinich, Hua Huang, Diqiu Ren, Bin Lu, Zhen Zhang, Qingzhou Chen, Yeqiao Zhou, Yu-Han Huang, Fatemeh Alikarami, Molly C. Kingsley, Alexandra K. Lenard, Aoi Wakabayashi, Eugene Khandros, Will Bailis, Jun Qi, Martin P. Carroll, Gerd A. Blobel, Robert B. Faryabi, Kathrin M. Bernt, Shelley L. Berger, Junwei Shi
Summary: The study identified ZMYND8 as a crucial factor for AML proliferation by directly activating IRF8 and interacting with MYC. ZMYND8 interacts with BRD4 through its chromatin reader cassette, facilitating chromatin occupancy and leukemic growth.
Article
Oncology
Jingyu Xun, Hideo Ohtsuka, Katsuya Hirose, Daisuke Douchi, Shun Nakayama, Masaharu Ishida, Takayuki Miura, Kyohei Ariake, Masamichi Mizuma, Kei Nakagawa, Takanori Morikawa, Toru Furukawa, Michiaki Unno
Summary: This study reveals the impact of ATM expression on the prognosis of pancreatic cancer patients. Loss of ATM expression enhances tumor development, suppresses apoptosis, and reduces sensitivity to gemcitabine. Additionally, loss of phosphorylated ATM is associated with poor prognosis in pancreatic cancer patients.
Article
Cell Biology
Zhihui Liu, Weiguo Wang, Yuhan Xia, Yuan Gao, Zhisong Wang, Mingyang Li, Giorgio Antonio Presicce, Liyou An, Fuliang Du
Summary: This study reveals the changes in the epigenetic modification pattern of H4K20me3 during fertilization and somatic cell nuclear transfer (NT). The results show that there are differences in the H4K20me3 pattern between fertilized embryos, NT embryos, and parthenogenetic activation (PA) embryos. H4K20me3 is only present in the maternal pronuclei of fertilized embryos. The intensity of H4K20me3 is significantly lower in fertilized embryos compared to NT and PA embryos. Knockdown of Suv4-20h2 improves the development and cloning efficiency of NT embryos by upregulating reprogramming factors and ZGA-related factors.
CELL PROLIFERATION
(2023)
Article
Multidisciplinary Sciences
Agnieszka Pierzynska-Mach, Alberto Diaspro, Francesca Cella Zanacchi
Summary: This study used single-molecule localization microscopy (SMLM) to analyze the nanoscale organization of DEK protein. It found differences in cluster features of DEK protein in different breast cell types and showed that the nanoscale organization of DEK clusters remains stable regardless of protein overexpression or chromatin compaction changes.
Review
Oncology
Rihan Hai, Liuer He, Guang Shu, Gang Yin
Summary: Epigenetic dysregulation, specifically through histone post-translational modifications, plays a crucial role in tumour pathogenesis. Histone deacetylases and histone acetyltransferases are pivotal epigenetic modulators that regulate the transcription of oncogenes and tumour suppressor genes, influencing a host of pathological processes in cancer development.
FRONTIERS IN ONCOLOGY
(2021)
Article
Physiology
Rachel Warren, Andrew M. Dylag, Molly Behan, William Domm, Min Yee, Margot Mayer-Proschel, Luis Martinez-Sobrido, Michael A. O'Reilly
Summary: Children and young adults with mutant forms of the ATM gene, which is involved in DNA damage signaling and mitochondrial homeostasis, suffer from respiratory infections, immune deficiencies, and obstructive airways disease associated with disorganized airway epithelium. A study on mice showed that ATM is required for the regeneration of injured airway epithelium after influenza virus infection. Mice lacking ATM exhibited increased airway resistance and reduced lung compliance during infection, and their lungs developed an abnormal proximal airway epithelium containing cells lacking expression of the immunomodulatory protein Scgb1a1. Restoration of Scgb1a1 expression in the airways required ATM and failure to efficiently restore it may contribute to the respiratory diseases seen in individuals with ataxia telangiectasia.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2022)
Article
Cell Biology
Aifang Cheng, Kai-Hei Tse, Hei-Man Chow, Yunqiao Gan, Xuan Song, Fulin Ma, Yi Xuan Yvonne Qian, Weiyi She, Karl Herrup
Summary: ATM protein is associated with cellular organelles such as synaptic vesicles, endosomes, and lysosomes, with its deficiency impacting autophagy and lysosomal function in neurons. This disruption leads to impaired neuronal functions including synaptic maintenance, neuronal survival, and glucose uptake.
Article
Multidisciplinary Sciences
Ho-Soo Lee, Zhonghui Lin, Sunyoung Chae, Young-Suk Yoo, Byung-Gyu Kim, Youngsoo Lee, Jared L. Johnson, You-Sun Kim, Lewis C. Cantley, Chang-Woo Lee, Hongtao Yu, Hyeseong Cho
NATURE COMMUNICATIONS
(2018)
Article
Biochemistry & Molecular Biology
Jae-Hoon Ji, Sunwoo Min, Sunyoung Chae, Geun-Hyoung Ha, Yonghyeon Kim, Yeon-Ji Park, Chang-Woo Lee, Hyeseong Cho
NUCLEIC ACIDS RESEARCH
(2019)
Article
Multidisciplinary Sciences
Geun-Hyoung Ha, Jae-Hoon Ji, Sunyoung Chae, Jihyun Park, Suhyeon Kim, Jin-Kwan Lee, Yonghyeon Kim, Sunwoo Min, Jeong-Min Park, Tae-Hong Kang, Ho Lee, Hyeseong Cho, Chang-Woo Lee
NATURE COMMUNICATIONS
(2019)
Article
Cell Biology
Young-Suk Yoo, Yeon-Ji Park, Ho-Soo Lee, Nguyen Thi Kim Oanh, Mi-Young Cho, June Heo, Eun-Seo Lee, Hyeseon Cho, Yong-Yea Park, Hyeseong Cho
CELL DEATH & DISEASE
(2019)
Article
Cell Biology
Ho Sun Jung, Gene Uenishi, Mi Ae Park, Peng Liu, Kran Suknuntha, Matthew Raymond, Yoon Jung Choi, James A. Thomson, Irene M. Ong, Igor I. Slukvin
Summary: The research findings suggest that SOX17 is a key regulator in linking arterial and HOXA programs in hemogenic endothelium (HE) in humans, playing a crucial role in the specification of HE with robust lympho-myeloid potential. This understanding may contribute to better programming of hematopoietic stem cell fate from human pluripotent stem cells.
Article
Biochemistry & Molecular Biology
Sunwoo Min, Ho-Soo Lee, Jae-Hoon Ji, Yungyeong Heo, Yonghyeon Kim, Sunyoung Chae, Yong Won Choi, Ho-Chul Kang, Makoto Nakanishi, Hyeseong Cho
Summary: This study demonstrates that histone H2A acetylation at K118 is enriched in transcriptionally active regions, and the RSF1-HDAC1 complex is involved in deacetylating H2A(X)-K118 under DNA damage conditions, affecting DNA repair and transcriptional repression.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Cell & Tissue Engineering
Saritha S. D'Souza, Akhilesh Kumar, Jason Weinfurter, Mi Ae Park, John Maufort, Lihong Tao, HyunJun Kang, Samuel T. Dettle, Thaddeus Golos, James A. Thomson, Matthew R. Reynolds, Igor Slukvin
Summary: This study successfully targeted the CCR5 locus using CRISPR-Cas9 technology, resulting in HIV-resistant human T cells. The edited cells did not affect hematopoietic and T cell differentiation, and were unable to support replication of CCR5-tropic simian immunodeficiency viruses. This provides a platform for further exploration of AIDS therapies using gene-edited iPSCs in a nonhuman primate model.
Article
Biotechnology & Applied Microbiology
Rachel Rui Xia Lim, Mi Ae Park, Long Hui Wong, Sumanto Haldar, Kevin Junliang Lim, Niranjan Nagarajan, Christiani Jeyakumar Henry, Yuan Rong Jiang, Oleg Vladimirovich Moskvin
Summary: This study found that the beneficial effects of dietary intervention on blood lipid profile are associated with an upregulation of the Clostridia class in the gut microbiota. During the dietary intervention, the relative abundance of a single species - Clostridium genus - significantly increased, and oils with high concentration of omega-3 PUFA showed faster and more robust responses in the intestinal microbiota.
NPJ BIOFILMS AND MICROBIOMES
(2022)
Article
Biochemistry & Molecular Biology
Nguyen Thi Kim Oanh, Ho-Soo Lee, Yong-Hyun Kim, Sunwoo Min, Yeon-Ji Park, June Heo, Yong-Yea Park, Won-Chung Lim, Hyeseong Cho
Summary: Cells rely on mitochondrial fusion and the DNA damage response (DDR) to maintain genome stability. The fusion of mitochondria is crucial for ATM-mediated DDR signaling and activation of JNK. Fragmented mitochondria impair the formation of BRCA1 and 53BP1 foci, as well as repair processes.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Multidisciplinary Sciences
Seung Han Son, Min Young Kim, Young Su Lim, Hyeon Cheol Jin, June Ho Shin, Jae Kyu Yi, Sungwoo Choi, Mi Ae Park, Ji Hyung Chae, Ho Chul Kang, Young Jin Lee, Vladimir N. Uversky, Chul Geun Kim
Summary: This study uncovers a novel mechanism of CP2c degradation through SUMO1/PSME3/20S proteasome pathway and its significance in cell cycle progression.
Article
Chemistry, Multidisciplinary
Seung Han Son, Min Young Kim, Sungwoo Choi, Ji Sook Kim, Yong Sang Lee, Sangwon Lee, Yeon Ju Lee, Jin Youn Lee, Seol Eui Lee, Young Su Lim, Dae Hyun Ha, Eonju Oh, Young-Bin Won, Chang-Jun Ji, Mi Ae Park, Boram Kim, Kyu Tae Byun, Min Sung Chung, Jaemin Jeong, Dongho Choi, Eun Jung Baek, Eung-Ho Cho, Sang-Bum Kim, A. Reum Je, Hee-Seok Kweon, Hyun Sook Park, Dongsun Park, June Sung Bae, Se Jin Jang, Chae-Ok Yun, Ji Hyung Chae, Jin-Won Lee, Su-Jae Lee, Chan Gil Kim, Ho Chul Kang, Vladimir N. Uversky, Chul Geun Kim
Summary: This study presents a cell-penetrable peptide, ACP52C, that induces apoptosis in cancer cells through transcription activity-independent mechanisms. It dissociates transcription factor CP2c complexes and inhibits TDP2, leading to cancer-specific apoptosis. The study also finds that ACP52C can be sensitized by CASP2 inhibition and derivatives of ACP52C show improved pharmacokinetics and reduced cancer burden.
Review
Biochemistry & Molecular Biology
Sunwoo Min, Jae-Hoon Ji, Yungyeong Heo, Hyeseong Cho
Summary: This article discusses how chromosome regulators coordinate DNA repair at active genes. Researchers have found that DNA double-strand breaks prompt a series of genome-organizing proteins to temporarily shut down the transcription of genes into RNA, and then assist in repairing the broken DNA to restore genomic integrity. A better understanding of the importance of regulating chromosome structure could lead to new therapeutic strategies for diseases such as cancer.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Jenna Kropp Schmidt, Nick Strelchenko, Mi Ae Park, Yun Hee Kim, Katherine D. Mean, Michele L. Schotzko, Hyun Jun Kang, Thaddeus G. Golos, Igor I. Slukvin
SCIENTIFIC REPORTS
(2020)
Article
Biology
Akhilesh Kumar, Saritha S. D'Souza, Gene Uenishi, Mi Ae Park, Jeong Hee Lee, Igor I. Slukvin
Article
Biochemistry & Molecular Biology
Sunwoo Min, Yong Won Choi, Hansol Yun, Sujin Jo, Jae-Hoon Ji, Hyeseong Cho
MOLECULES AND CELLS
(2018)