期刊
EXPERIMENTAL AND MOLECULAR MEDICINE
卷 41, 期 8, 页码 584-591出版社
NATURE PUBLISHING GROUP
DOI: 10.3858/emm.2009.41.8.064
关键词
cell migration inhibition; chemotaxis, leukocyte; interleukin-1 beta; lysophosphatidylglycerol; phagocytes; receptors, formyl peptide
资金
- Dong-A University
In this study, we observed that lysophosphatidylglycerol (LPG) completely inhibited a formyl peptide receptor like-1 (FPRL1) agonist (MMK-1)-stimulated chemotactic migration in human phagocytes, such as neutrophils and monocytes. LPG also dramatically inhibited IL-1 beta production by another FPRL1 agonist serum amyloid A (SAA) in human phagocytes. However, LPG itself induced intracellular calcium increase and superoxide anion production in human phagocytes. Keeping in mind that phagocytes migration and IL-1 beta production by FPRL1 are important for the induction of inflammatory response, our data suggest that LPG can be regarded as a useful material for the modulation of inflammatory response induced by FPRL1 activation.
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