期刊
EXPERIMENTAL AND MOLECULAR MEDICINE
卷 41, 期 3, 页码 208-216出版社
NATURE PUBLISHING GROUP
DOI: 10.3858/emm.2009.41.3.024
关键词
adipokine; B-cell maturation antigen; obesity; rosiglitazone; TNFRSF13C protein, human; TNFSF13B protein, human; transmembrane activator and CAML Interactor protein
资金
- Korean Government [KRF-2007-521-C00300]
B cell activation factor (BAFF) is a novel member of the TNF ligand superfamily, mainly produced by myeloid cells. BAFF has been shown to participate in B-cell survival and B- and T-cell maturation. BAFF expression in adipocytes has been recently demonstrated. In the current study, we verified that BAFF expression is increased during adipocyte differentiation. BAFF expression was augmented by TNF-alpha treatment and was decreased by rosiglitazone treatment. BAFF secretion in lean and in ob/ob mice sera were compared and smaller amount of BAFF was secreted in ob/ob mice. mRNA and protein expression were different between epididymal and visceral adipose tissue. BAFF expression was also increased in ob/ob mouse adipose tissue. We sought to identify known BAFF receptors (BAFF-R, BCMA, and TACl) in adipocytes, and determined that all three were present and upregulated during adipocyte differentiation. However, the expression of TACl was distinct from that of BAFF-R and BCMA under TNF-alpha and BAFF ligand treatment. BAFF-R and BCMA expression levels were upregulated under pro-inflammatory conditions, but TACl was reduced. Conversely, BAFF-R and BCMA expression levels were downregulated by rosiglitazone treatment, but TACl was increased. Taken together, our results suggest that BAFF may be a new adipokine, representing a link between obesity and inflammation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据