Article
Multidisciplinary Sciences
J. F. Dewald-Kaufmann, T. Wuestenberg, B. B. Barton, S. Goerigk, M. A. Reinhard, R. Musil, J. Werle, P. Falkai, A. Jobst, F. Padberg
Summary: Social rejection and exclusion are major stressors that threaten mental and physical health. The study found that during partial social exclusion, there was an immediate increase in ball passes to the excluding player followed by a return of behavior to baseline, which may suggest overlapping principles of cooperation in this paradigm.
SCIENTIFIC REPORTS
(2021)
Review
Psychology, Multidisciplinary
John A. Terrizzi, Richard S. Pond, Trevor C. J. Shannon, Zachary K. Koopman, Jessica C. Reich
Summary: This article explores how disgust, an emotion associated with avoidance and social withdrawal, acts as an important precursor to social rejection. It argues that disgust influences social rejection through three avenues: first, by promoting stigmatization, especially of individuals displaying cues of infectious diseases; second, by generating cultural variants that promote disease avoidance and conservative values, resulting in reduced social interaction; and third, by inducing shame when the self is perceived as a source of contamination, leading to withdrawal from social interaction.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Clinical Neurology
V Brinker, J. Dewald-Kaufmann, F. Padberg, M. A. Reinhard
Summary: Both social exclusion and loneliness can lead to hostile behaviors, including aggression. This study found that imagining a social exclusion scenario led to aggressive reactions towards the excluding person, as measured by the amount of hot sauce allocated. Loneliness was also found to be associated with increased aggressive tendencies. The cognitive and emotional processes underlying the relationship between social exclusion, loneliness, and aggression should be investigated in future research.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Eugene Zubkov, Olga Abramova, Yana Zorkina, Aleksandra Ochneva, Valeria Ushakova, Anna Morozova, Olga Gurina, Alexander Majouga, Vladimir Chekhonin
Summary: This study compared the effects of clomipramine and four neuropeptides in an acute stress model, and found that intranasal administration of neuropeptide Y could be a promising compound for the treatment of stress disorders.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Aubrey M. Kelly, Ashley W. Seifert
Summary: VP and OT, two nonapeptides, play critical roles in modulating physiology and social behaviors across vertebrates, showing relatively strong evolutionary conservation in distributions. The distribution of VP and OT neurons in Acomys cahirinus, a gregarious rodent species, was examined, revealing both similarities and sex differences in neuronal populations compared to other rodents. These findings provide foundational knowledge for studying nonapeptide-mediated behavior in social rodents.
Article
Psychiatry
Matthias A. Reinhard, Frank Padberg, Julia Dewald-Kaufmann, Torsten Wuestenberg, Stephan Goerigk, Barbara B. Barton, Adima Zuelch, Lisa Brandl, Hannah Windmueller, Fabiana Fernandes, Andre R. Brunoni, Richard Musil, Andrea Jobst
Summary: This study confirms that patients with Borderline Personality Disorder (BPD) exhibit greater aversive reactions and a tendency for reduced oxytocin levels in response to social exclusion. They also engage in less interaction with the excluder. These preliminary behavioral findings support the notion of altered oxytocin regulation and reduced social cooperation capacity in BPD.
JOURNAL OF PERSONALITY DISORDERS
(2022)
Article
Psychology, Clinical
Suhao Peng, Dan Tao, Bin Xuan
Summary: Two studies found that social rejection and ostracism have different effects on cognitive effort avoidance. Study 1 showed that individuals who experienced social rejection exhibited impaired response accuracy and increased cognitive effort avoidance. Study 2 showed that ostracism affected response speed and accuracy, but not cognitive effort avoidance. These findings highlight the differential effects of social rejection and ostracism on cognitive effort.
PSYCHOLOGY RESEARCH AND BEHAVIOR MANAGEMENT
(2023)
Review
Neurosciences
Angel Baudon, Etienne Clauss Creusot, Ferdinand Althammer, Christian P. Schaaf, Alexandre Charlet
Summary: The neuropeptide oxytocin has been studied for its effects on physiology, neuronal circuits, and behaviors, particularly sociality. Recent studies have shown the existence and importance of astroglial oxytocin receptors in various brain regions. The role of astrocytic oxytocin receptors in neuromodulation and integrated brain functions still needs further investigation.
PROGRESS IN NEUROBIOLOGY
(2022)
Article
Psychology, Multidisciplinary
Jiyoung Park, Joshua Woolley, Wendy Berry Mendes
Summary: This study examined the role of oxytocin in modulating reactions to social acceptance or rejection during interracial interactions. The results showed that black participants who received intranasal oxytocin displayed more positive cardiovascular responses, cooperative behavior, and perceived their partner to have more favorable attitudes after receiving positive social feedback from a white stranger.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Neurosciences
Sina Radke, Kathrin Jankowiak, Sanne Tops, Ted Abel, Ute Habel, Birgit Derntl
Summary: The study found that social rejection leads to a lower willingness to cooperate with others, and increased brain activity when receiving negative feedback. Intranasal oxytocin did not seem to alter responses to social rejection.
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
(2021)
Review
Behavioral Sciences
Julia S. Krimberg, Francisco S. Lumertz, Rodrigo Orso, Thiago W. Viola, Rosa Maria M. de Almeida
Summary: Social isolation stress is associated with negative developmental outcomes and may be related to the oxytocinergic system. Decreased OXTR levels are associated with behavioral alterations such as increased aggression and anxiety-like behavior, hyperactivity, and diminished social behaviors and memory. Administration of synthetic oxytocin or its agonists can partially decrease these behavioral alterations.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Clinical Neurology
Hidenori Yamasue, Masaki Kojima, Hitoshi Kuwabara, Miho Kuroda, Kaori Matsumoto, Chieko Kanai, Naoko Inada, Keiho Owada, Keiko Ochi, Nobutaka Ono, Seico Benner, Tomoyasu Wakuda, Yosuke Kameno, Jun Inoue, Taeko Harada, Kenji Tsuchiya, Kazuo Umemura, Aya Yamauchi, Nanayo Ogawa, Itaru Kushima, Norio Ozaki, Satoshi Suyama, Takuya Saito, Yukari Uemura, Junko Hamada, Yukiko Kano, Nami Honda, Saya Kikuchi, Moe Seto, Hiroaki Tomita, Noriko Miyoshi, Megumi Matsumoto, Yuko Kawaguchi, Koji Kanai, Manabu Ikeda, Itta Nakamura, Shuichi Isomura, Yoji Hirano, Toshiaki Onitsuka, Hirotaka Kosaka, Takashi Okada
Summary: Intranasal oxytocin has the potential to be a novel therapy for autism spectrum disorder, but the efficacy of repeated administrations is inconsistent. This study tested the effect of TTA-121, a new formulation of intranasal oxytocin with improved bioavailability, on the core symptoms of autism spectrum disorder and determined the dose-response relationship. The findings showed that TTA-121 at a dose of 6 U per day significantly improved the reciprocity score, indicating potential benefits for individuals with autism spectrum disorder.
Article
Communication
Sarah Lutz, Christiane M. Buettner, Dominik Neumann
Summary: This study investigates the psychological and behavioral responses to social exclusion on social media, specifically when users are not included in others' posts. Two experiments were conducted, distinguishing between self-exclusion (voluntarily not participating in the displayed activity) and other-exclusion (not being invited to the activity). Exclusion, for both reasons, was associated with threatened needs and impaired emotional responses compared to inclusion. As expected, these effects were more pronounced for other-exclusion. Coping behaviors also differed, with self-excluded users engaging in more prosocial behavior while those excluded by others exhibited more withdrawal behavior. The effectiveness of different coping behaviors in restoring needs and regulating emotions varied depending on self- versus other-exclusion.
Article
Psychology, Multidisciplinary
Stefan Doric
Summary: This study aimed to test the impact of social exclusion on cooperation in the Trust Game and found that social exclusion did not diminish participants' ability to analyze social cues and their willingness to cooperate.
Article
Psychology, Biological
Susanne Henningsson, Siri Leknes, Martin Asperholm, Marie Eikemo, Lars Westberg
Summary: The study found no evidence to support the idea that intranasal oxytocin can improve first impressions of an opposite-sex stranger, with some Bayesian support against this hypothesis. However, there was an observed sex- and context-dependent drug effect on post-ostracism mood ratings, suggesting that individual variation and social context can interact with the effects of intranasal oxytocin. Further research is needed to determine if oxytocin can improve first impressions in humans under different conditions.
BIOLOGICAL PSYCHOLOGY
(2021)
Article
Rehabilitation
Elizabeth Stratton, Nick Glozier, Alix Woolard, Vicki Gibbs, Eleni A. Demetriou, Kelsie A. Boulton, Ian Hickie, Elizabeth Pellicano, Adam J. Guastella
Summary: The employment rates for autistic individuals are low, and mental health symptoms and disabilities are associated with vocational functioning. The association between anxiety and stress with vocational outcomes is attenuated in a multivariable model. Depression and disabilities are independent factors associated with vocational outcomes.
DISABILITY AND REHABILITATION
(2023)
Article
Psychiatry
Claudia Bruno, Alys Havard, Malcolm B. Gillies, David Coghill, Jonathan Brett, Adam J. Guastella, Sallie-Anne Pearson, Helga Zoega
Summary: In Australia, there has been an increasing use of attention deficit hyperactivity disorder medication, especially among young females. However, treatment rates are still lower than the estimated prevalence of the disorder. Poor long-term treatment persistence in adolescents may require improved clinical monitoring.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Adam J. Guastella, Kelsie A. Boulton, Andrew J. O. Whitehouse, Yun Ju Song, Rinku Thapa, Simon G. Gregory, Izabella Pokorski, Joanna Granich, Marilena M. DeMayo, Zahava Ambarchi, John Wray, Emma E. Thomas, Ian B. Hickie
Summary: Although oxytocin plays a crucial role in mammalian social development, its effectiveness as a medication to enhance human social development remains unclear. This study found that administering oxytocin to children with autism between the ages of 3 and 5 showed some indication of improvement in social responsiveness. However, there was no evidence of benefit in the overall sample or in the younger age group.
MOLECULAR PSYCHIATRY
(2023)
Review
Psychiatry
Ana Cecilia Bispo-Torres, Rita Lucena, Ivo Cesar Tavares-Rodrigues, Judah L. Barouh, Daniel H. Lins-Silva, Ingrid Dorea-Bandeira, Lucca S. Souza, Daniela Faria-Guimara, Arthur Tolentino, Angela Miranda-Scippa, Daniel F. Hermens, Aline S. Sampaio, Lucas C. Quarantini, Nick Glozier, Ian B. Hickie, Igor D. Bandeira
Summary: Parents and siblings of children on the autism spectrum often experience significant distress, with depressive symptoms being the most frequently reported condition. Mothers of children on the spectrum have a higher prevalence of depressive symptoms compared to mothers of children with atypical development. It is important to investigate the psychopathological symptoms of relatives in order to facilitate their treatment.
PSYCHIATRY RESEARCH
(2023)
Article
Psychiatry
Catherine M. McHugh, Nicholas Ho, Frank Iorfino, Jacob J. Crouse, Alissa Nichles, Natalia Zmicerevska, Elizabeth Scott, Nick Glozier, Ian B. Hickie
Summary: This study examines the application of machine learning in predicting self-harm behavior and finds that a history of self-harm and clinical symptoms are the most important predictive factors.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2023)
Article
Psychiatry
Caroline X. Gao, Kate M. Filia, Gillinder Bedi, Jana M. Menssink, Ellie Brown, Debra J. Rickwood, Alexandra G. Parker, Sarah E. Hetrick, Helen Herrman, Ian Hickie, Nic Telford, Patrick D. McGorry, Sue M. Cotton
Summary: This study aims to elucidate patterns of substance use among young people seeking mental health treatment. 1107 youth were recruited from five primary mental health services in Australia. The findings highlight the importance of screening for substance use in youth mental healthcare settings and the opportunity for early intervention.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2023)
Article
Education, Special
Claudia S. Y. Ong, Iliana Magiati, Murray T. Maybery, Jacqui Rodgers, Mirko Uljarevic, Gail A. Alvares
Summary: Anxiety commonly co-occurs in autism. Little is known about how intolerance of uncertainty (IU) is experienced in young children on the autism spectrum. This study investigated parental perspectives of children's experiences of uncertainty.
RESEARCH IN AUTISM SPECTRUM DISORDERS
(2023)
Article
Pediatrics
Jacob J. Crouse, Haley M. LaMonica, Yun Ju Christine Song, Kelsie A. Boulton, Cathrin Rohleder, Marilena M. DeMayo, Chloe E. Wilson, Victoria Loblay, Gabrielle Hindmarsh, Tina Stratigos, Michael Krausz, Nathanael Foo, Melissa Teo, Andrew Hunter, Adam J. Guastella, Richard B. Banati, Jakelin Troy, Ian B. Hickie
Summary: Recent years have witnessed significant advancements in understanding early childhood development and the dissemination of health information through digital technologies. The development of a new parenting app called "Thrive by Five" aims to provide evidence-based information and collective actions to caregivers globally, with the potential for improved outcomes in children. This ongoing global project incorporates a scientific framework, including domains to organize content, targeted neurobiological systems, anthropological and cultural considerations, and collaboration with experts in various fields.
JMIR PEDIATRICS AND PARENTING
(2023)
Article
Psychiatry
Adam Skinner, Jo-An Occhipinti, Yun Ju Christine Song, Elizabeth M. Scott, Ian B. Hickie
Summary: This study evaluates the potential impact of the 'Safeguards' initiative on mental health-related emergency department presentation rates for children and adolescents. The results show that 25 Child and Adolescent Acute Response Teams are projected to significantly reduce emergency presentations and re-presentations. However, full and timely implementation of the initiative is crucial for realizing its potential effectiveness.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Penelope A. Lind, Dan J. Siskind, Ian B. Hickie, Lucia Colodro-Conde, Simone Cross, Richard Parker, Nicholas G. Martin, Sarah E. Medland
Summary: The Australian Genetics of Bipolar Disorder Study is a nationwide cohort of adults with bipolar disorder, aiming to investigate the genetic risk, symptom severity, and prevalence, as well as treatment response, medication side effects, and healthcare usage patterns in this population. 6682 participants were recruited through media campaigns, prescription-based mail-outs, and the Australian Genetics of Depression Study. The results indicate a high prevalence of comorbidities and adverse drug reactions among adults with bipolar disorder in the general Australian population.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
William Capon, Ian B. Hickie, Masoud Fetanat, Mathew Varidel, Haley M. LaMonica, Ante Prodan, Sarah Piper, Tracey A. Davenport, Sarah Mughal, Jai L. Shah, Elizabeth M. Scott, Frank Iorfino
Summary: This study aimed to understand the clinical needs of young people aged 12-25 presenting to primary youth mental health services through multidimensional assessments. Three different illness stages were identified, highlighting the importance of multidimensional assessments for determining appropriate service pathways and care options.
COMPREHENSIVE PSYCHIATRY
(2023)
Article
Psychiatry
M. J. C. Formica, M. Fuller-Tyszkiewicz, I. Hickie, L. Olive, S. J. Wood, R. Purcell, A. R. Yung, L. J. Phillips, B. Nelson, C. Pantelis, P. D. Mcgorry, J. A. Hartmann
Summary: This study aimed to investigate the relationship between self-reported sleep disturbance and the development of attenuated psychotic symptoms (APS), while adjusting for anxiety and depressive symptoms. The results showed that self-reported sleep disturbance had both direct and indirect predictive relationships with APS domains, with anxiety and depressive symptoms mediating some of these relationships.
SCHIZOPHRENIA RESEARCH
(2023)
Article
Health Care Sciences & Services
Min K. Chong, Ian B. Hickie, Shane P. Cross, Sarah McKenna, Mathew Varidel, William Capon, Tracey A. Davenport, Haley M. LaMonica, Vilas Sawrikar, Adam Guastella, Sharon L. Naismith, Elizabeth M. Scott, Frank Iorfino
Summary: This study aimed to validate a digital algorithm for accurately differentiating young people at lower and higher risk of developing mental disorders. The results showed a high concordance between the digital algorithm and expert ratings in clinical staging. The algorithm demonstrated high accuracy and could be used as a decision support tool for stratifying care and demand management in youth mental health services.
JMIR FORMATIVE RESEARCH
(2023)
Article
Pediatrics
Alyssa Clare Milton, Zelalem Mengesha, Kristin Ballesteros, Tom McClean, Saskia Hartog, Lucie Bray-Rudkin, Cathy Ngo, Ian Hickie
Summary: Outside school hours care (OSHC) is the fastest-growing childhood education sector in Australia. This study pilot-tested the Connect, Promote, and Protect Program (CP3) and conducted formative and process evaluations. The evaluations showed that the CP3 had high program engagement, appropriateness, and acceptability, and supported children's well-being and development.
JMIR PEDIATRICS AND PARENTING
(2023)