Article
Oncology
Emese Zsiros, Jason Ricciuti, Steven Gallo, Deanna Argentieri, Kristopher Attwood, Wenyan Ji, Alan Hutson, Paul Visco, Devon Coffey, Grazyna Riebandt, Jaron Mark, Aaron Varghese, Suzanne M. Hess, Thomas Furlani, Andrew Fabiano, Mark Hennon, Sai Yendamuri, Eric C. Kauffman, Kimberly E. Wooten, Wesley L. Hicks, Jessica Young, Kazuaki Takabe, Kunle Odunsi, Amy A. Case, Brahm H. Segal, Candace S. Johnson, Boris Kuvshinoff, Steven Nurkin, Gyorgy Paragh, Oscar de Leon-Casasola
Summary: Restricting the prescription of opioids to 3 or fewer days after surgery can effectively manage postsurgical acute pain and reduce the risk of chronic opioid use in surgical patients.
Article
Neurosciences
Ulrike Bingel, Katja Wiech, Christoph Ritter, Vishvarani Wanigasekera, Roisin Ni Mhuircheartaigh, Michael C. Lee, Markus Ploner, Irene Tracey
Summary: This study investigates the functional connectivity of the hippocampus during nocebo-induced hyperalgesia. The results show an increase in connectivity between the hippocampus and brain regions involved in the processing of pain perception, which is correlated with an increase in anxiety. Additionally, the connectivity between the hippocampus and amygdala is negatively correlated with pain intensity.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Zahra Rostamipoor, Masoomeh Nazemi-Rafi, Amirhossein Mirafzal, Shahab Ilka, Masumeh Hosseininasab
Summary: Oral clonidine significantly reduced pain and the need for morphine in opioid-dependent patients with orthopaedic fractures.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Surgery
Teryn A. Holeman, Michael J. Buys, Kimberlee Bayless, Zachary Anderson, Julie Hales, Benjamin S. Brooke
Summary: This study aimed to evaluate the impact of complete opioid tapering after surgery on pain intensity and pain interference. The study found significant improvement in pain intensity and interference among patients who completely tapered off opioids after surgery, especially among those undergoing orthopedic procedures early after surgical discharge.
Article
Neurosciences
Nathan M. Sharfman, Leslie K. Kelley, Maria E. Secci, Nicholas W. Gilpin
Summary: Chronic inflammatory pain is a significant subset of chronic pain diagnoses, affecting a large number of individuals and incurring substantial economic costs. Studies suggest that melanocortin 4 receptors (MC4Rs) may play a role in pain signaling and pain-like behaviors, particularly in the central amygdala (CeA). However, the exact role of MC4Rs in chronic inflammatory pain in males and females is not fully understood.
Review
Clinical Neurology
Javier Martinez-Calderon, Mar Flores-Cortes, Jose Miguel Morales-Asencio, Alejandro Luque-Suarez
Summary: The study identified an association between pain catastrophizing and opioid misuse in people with chronic musculoskeletal pain, but there were inconsistent results regarding the association between pain catastrophizing and opioid use as well as dose. The overall certainty of the evidence was judged to be very low for all outcome measures, indicating caution should be taken when interpreting these results.
Article
Anesthesiology
Josh Bleicher, Benjamin Sands Brooke, Kimberlee Bayless, Zachary Anderson, Julie Beckstrom, Chong Zhang, Angela P. Presson, Lyen C. Huang, Michael Jacob Buys
Summary: Understanding the patterns of postoperative opioid use among different populations is important for developing opioid stewardship programs. This retrospective study investigated opioid prescribing, use, and pain after general surgery procedures for patients at a veterans administration hospital. The results showed that both non-opioid users and chronic opioid users required very few opioids after surgery, and chronic opioid users quickly returned to their baseline opioid use. There was no difference in pain recovery between the two groups. The study suggests that opioid prescribing guidelines should consider including chronic opioid therapy patients and recommend a more conservative approach.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2022)
Article
Medicine, General & Internal
Elizabeth M. Magnan, Daniel J. Tancredi, Guibo Xing, Alicia Agnoli, Anthony Jerant, Joshua J. Fenton
Summary: Opioid tapering is associated with increased emergency department visits and hospitalizations, decreased primary care visits, and reduced medication adherence in patients on long-term opioid therapy. These findings highlight the unintended negative consequences of tapering and should be considered by policy makers and clinicians.
Article
Neurosciences
Matthew Hein, Guangchen Ji, Dalton Tidwell, Preston D'Souza, Takaki Kiritoshi, Vadim Yakhnitsa, Edita Navratilova, Frank Porreca, Volker Neugebauer
Summary: The activation of KOR in the CeA increases activity of amygdala CRF neurons through synaptic disinhibition, leading to averse-affective pain-like behaviors.
Article
Neurosciences
Volker Neugebauer, Peyton Presto, Vadim Yakhnitsa, Nico Antenucci, Brianna Mendoza, Guangchen Ji
Summary: Neuroplasticity in cortico-limbic circuits is important in pain persistence and modulation. The amygdala plays a key role in the emotional dimension of pain, and interactions with prefrontal cortical regions change in pain conditions. Other regions in the limbic system are also involved in pain modulation. The corticolimbic system contains opioids and opioid receptors, and their modulatory effects and potential opposing functions are still not fully understood.
Article
Rehabilitation
Aaron P. Turner, Anne Arewasikporn, Eric J. Hawkins, Pradeep Suri, Stephen P. Burns, Steve L. Leipertz, Jodie K. Haselkorn
Summary: This study aimed to characterize patterns of prescription opioid use in individuals with multiple sclerosis (MS) and identify risk factors associated with chronic use. The results showed a decline in chronic opioid use over the study period, but it remains common among a substantial minority of MS patients. Prior chronic opioid use, history of pain condition, post-traumatic stress disorder, and rural residence were associated with a greater risk of chronic prescription opioid use.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2023)
Article
Pharmacology & Pharmacy
Dara Kusic, Jessica Heil, Stefan Zajic, Andrew Brangan, Oluseun Dairo, Gretchen Smith, Diego Morales-Scheihing, Russell J. Buono, Thomas N. Ferraro, Rachel Haroz, Matthew Salzman, Kaitlan Baston, Elliot Bodofsky, Michael Sabia, Alissa Resch, Laura B. Scheinfeldt
Summary: Pharmacogenetics has the potential to improve opioid medication management. Patient perception data shows that the majority of patients are open to pharmacogenetic testing and believe it can improve their medical care. CYP2D6 PGx testing has the potential to inform chronic pain medication management for patients with significant metabolic differences, but concerns about genetic test result access and genetic discrimination need to be addressed.
Article
Pharmacology & Pharmacy
Deonne Dersch-Mills, Alixe Howlett, Jan Lind, Allison Marchuk, Khorshid Mohammad
Summary: This retrospective chart review aimed to investigate the impact of dexmedetomidine and clonidine on opioid exposure in post-surgical neonates. The implementation of a standardized sedation/analgesia weaning protocol resulted in a reduction in opioid duration and exposure, although the changes were not statistically significant.
Article
Medicine, General & Internal
Benjamin D. Hallowell, Laura C. Chambers, Luke Barre, Nancy Diao, Collette Onyejekwe, Alexandra Banks, Jeffery Bratberg, Heidi Weidele, Samara Viner-Brown, James McDonald
Summary: The study aimed to identify initial diagnoses associated with an elevated risk of chronic prescription opioid use. The results showed that patients with diseases of the musculoskeletal system and connective tissue, diseases of the nervous system, and neoplasms had a higher likelihood of subsequent chronic prescription opioid use. Therefore, interventions and prescribing guidelines should focus on these specific types of diagnoses to reduce inappropriate opioid prescribing.
Article
Health Care Sciences & Services
Alexander D. McCourt, Kayla N. Tormohlen, Ian Schmid, Elizabeth M. Stone, Elizabeth A. Stuart, Corey S. Davis, Mark C. Bicket, Emma E. McGinty
Summary: This study evaluates the effects of state opioid prescribing cap laws on the treatment of chronic pain among patients with chronic pain diagnoses. The findings suggest that these laws do not lead to changes in opioid prescribing, non-opioid medication prescribing, or non-opioid chronic pain procedures.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)