Article
Endocrinology & Metabolism
Georgia Colleluori, Lina Aguirre, Nicola Napoli, Clifford Qualls, Dennis T. Villareal, Reina Armamento-Villareal
Summary: The study found that hypogonadal men with T2D showed significant improvements in bone mass and density after 18 months of testosterone therapy, while those without T2D did not show significant changes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Medicine, General & Internal
Kazuyoshi Shigehara, Kouji Izumi, Yoshifumi Kadono, Atsushi Mizokami
Summary: Bone fracture due to osteoporosis is a significant issue for elderly men, and testosterone replacement therapy has shown benefits in improving bone mineral density in symptomatic hypogonadal men with osteopenia.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Emily A. Rosenberg, Petra Buzkova, Howard A. Fink, John A. Robbins, Molly M. Shores, Alvin M. Matsumoto, Kenneth J. Mukamal
Summary: In older men, DHT was inversely associated with hip fracture risk while SHBG was positively associated with hip fracture risk, and testosterone was not associated. Testosterone and DHT were positively associated with lean body mass in individual models.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Endocrinology & Metabolism
J. A. Cauley, S. S. Ellenberg, A. V. Schwartz, K. E. Ensrud, T. M. Keaveny, P. J. Snyder
Summary: The study found that TBS is not clinically useful in monitoring the 1-year effect of testosterone treatment on bone structure in older hypogonadal men.
OSTEOPOROSIS INTERNATIONAL
(2021)
Review
Endocrinology & Metabolism
Y. Zhang, Z. Tian, S. Ye, Q. Mu, X. Wang, S. Ren, X. Hou, W. Yu, J. Guo
Summary: The study found that individuals with Down syndrome have significantly lower bone mineral density in total body and different regions (hip, lumbar spine, and femoral neck) compared to controls. It also showed a decreasing trend in lumbar spine volumetric bone mineral density and an elevated femoral neck volumetric bone mineral density in Down syndrome individuals versus controls.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Geriatrics & Gerontology
Shalender Bhasin, Venkatesh Krishnan, Thomas W. Storer, Mitchell Steiner, Adrian S. Dobs
Summary: Testosterone, other androgens, and nonsteroidal SARMs are being developed as therapies to treat functional limitations associated with aging and chronic diseases. They have shown anabolic effects on muscle mass and strength in various populations. Testosterone treatment also has positive effects on bone health, sexual function, and depressive symptoms. However, the cardiovascular and prostate safety of testosterone still needs further investigation. Future studies should focus on translating muscle gains into functional improvements through combined administration with exercise.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Pediatrics
Francisco Sanchez Ferrer, Ernesto Cortes Castell, Francisco Carratala Marco, Mercedes Juste Ruiz, Jose Antonio Quesada Rico, Ana Pilar Nso Roca
Summary: Childhood obesity is a public health issue that can have long-term consequences. This study of 553 children over 10 years found that weight status influences bone mineral content, with BMC and BMD being highest in the normal-weight and overweight groups. Waist circumference was negatively correlated with bone mineralization.
Article
Urology & Nephrology
Yasmine Salah Naga, Ola Atef Sharaki, Eman Zaki Azzam, Eman Mohamed Mostafa Farag, Montasser Mohamed Hussein Zeid
Summary: The study aimed to investigate the correlation between serum free testosterone levels and bone mineral density (BMD) in kidney transplant recipients. The results showed a significant positive correlation between serum free testosterone levels and lumbar spine BMD, but no significant correlation with forearm and hip BMD.
Article
Medicine, General & Internal
Ahmed S. A. Soliman, Mohamed W. Abukhatwah, Naglaa M. Kamal, Enas M. M. Sweed, Abdullah M. Alelyani, Sami D. Althobaiti, Mazen A. Alzaedi, Amany M. El-Rebigi, Nehad T. Besher, Omar M. W. Abukhatwah, Abdullah O. Alharbi, Wesam E. Afifi
Summary: Long-term glucocorticoid therapy in children with INS leads to lower bone mineral density and a higher prevalence of osteopenia and osteoporosis.
Review
Endocrinology & Metabolism
Mingwei Hu, Yifan Zhang, Jianjun Guo, Cuicui Guo, Xue Yang, Xue Ma, Hao Xu, Shuai Xiang
Summary: This study evaluated the changes in bone mineral density and bone turnover markers after denosumab and romosozumab therapies in patients with osteoporosis. The results showed that the romosozumab group exhibited greater changes in lumbar BMD and bone turnover markers at 3 months of treatment, while changes in BMD of total hip and femoral neck were relatively delayed. From 6 to 12 months of treatment, romosozumab showed greater changes in bone mineral density and markers of bone turnover.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Barbara Stachowska, Jowita Halupczok-Zyla, Justyna Kuliczkowska-Plaksej, Joanna Syrycka, Marek Bolanowski
Summary: Patients with active Cushing's syndrome show altered bone microstructure with decreased TBS, leading to a higher risk of hip and major osteoporotic fractures. TBS appears to be a valuable tool for assessing fracture risk in endogenous hypercortisolism.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Oliver Christian Rabe, Matilde Winther-Jensen, Kristine Hojgaard Allin, Ole Lander Svendsen
Summary: The study showed that patients with diabetes and Charcot foot have a higher risk of fractures and osteoporosis compared to patients with diabetes without Charcot foot.
Article
Health Care Sciences & Services
Chih-Hsuan Wung, Cheng-Yin Chung, Pei-Yu Wu, Jiun-Chi Huang, Yi-Chun Tsai, Szu-Chia Chen, Yi-Wen Chiu, Jer-Ming Chang
Summary: This study investigated the associations between metabolic syndrome (MetS) and its components with bone mineral density (BMD) T-score among hemodialysis (HD) patients, as well as the relationships between obesity-related indices and BMD T-score in HD patients with and without MetS. Positive associations were found between MetS and its five components with BMD T-score, and some obesity-related indices were associated with BMD T-score only in patients with MetS.MetS, abdominal obesity, hypertriglyceridemia, and low HDL-cholesterol were linked to a reduced risk of osteoporosis among HD patients. Additionally, BMI, WHtR, AVI, and BRI played important roles in predicting the risk of osteoporosis among HD patients with MetS.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Endocrinology & Metabolism
Jakob Starup-Linde, Marie Juul Ornstrup, Thomas Nordstrom Kjaer, Simon Lykkeboe, Aase Handberg, Soren Gregersen, Torben Harslof, Steen Bonlokke Pedersen, Peter Vestergaard, Bente Lomholt Langdahl
Summary: This study compared bone structure, bone density, and bone turnover markers between non-diabetic overweight men with MetS and overweight men with T1D or T2D. The results showed lower bone turnover in men with T2D, but no clinically significant differences in bone density or structure.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Sungwook Kang, Chan-Hee Park, Hyunwoo Jung, Subum Lee, Yu-Sun Min, Chul-Hyun Kim, Mingoo Cho, Gu-Hee Jung, Dong-Hee Kim, Kyoung-Tae Kim, Jong-Moon Hwang
Summary: This study investigated the difference in physiological loading on the spine between osteoporotic and normal spines during three different motions using finite element modelling. The results showed higher stress on the nucleus pulposus, annulus fibrosus, and cortical bones in the osteoporosis group compared to the normal group. These findings may contribute to the understanding of discogenic pain and degeneration.
SCIENTIFIC REPORTS
(2022)
