Article
Neurosciences
Saren H. Seeley, Jessica R. Andrews-Hanna, John J. B. Allen, Mary-Frances O'Connor
Summary: This study explores the relationship between prolonged grief symptoms and functional brain network connectivity, and finds that higher ICG scores are associated with lower connectivity. Additionally, intranasal oxytocin increases functional connectivity in a specific brain circuit, but ICG scores do not moderate the effects of oxytocin. In dynamic connectivity states, higher ICG scores are associated with longer time of positive correlations among default, frontoparietal, and cingulo-opercular networks. These findings provide preliminary evidence that prolonged grief symptoms in older adults are related to both static and time-varying functional network connectivity, specifically involving a default network-salience-related circuit sensitive to oxytocin.
HUMAN BRAIN MAPPING
(2023)
Review
Nursing
Maria Nunez-Nunez, Manuel Murillo-Izquierdo, Marisa Moya-Martin, Malvina Hoxha, M. Teresa Quesada Perez, Fernando Oltra-Hostalet, Hector Alonso-Ramos, Jaime Cordero-Ramos, Jose Barrera-Cabeza, Pilar Retamar-Gentil, Santiago Sandoval Fernandez-del-Castillo
Summary: This review updates and summarizes the evidence on the Y-site compatibility of antibacterial agents administered as prolonged infusions in ICUs, providing useful and reliable information for patient safety in nursing practice.
NURSING IN CRITICAL CARE
(2022)
Review
Biochemistry & Molecular Biology
Kenji Ohba
Summary: Inappropriate secretion of thyroid-stimulating hormone (IST) and syndrome of IST (SITSH) are clinical conditions characterized by elevated levels of free thyroxine and triiodothyronine along with detectable thyroid-stimulating hormone (TSH). While IST is associated with resistance to thyroid hormone beta caused by gene mutations, recent evidence suggests potential involvement of various factors such as hysteresis in the hypothalamus-pituitary-thyroid axis (HPT-axis), methodological interference, and postoperative Cushing's syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Substance Abuse
L. K. Galbo, A. T. Davenport, P. M. Epperly, J. B. Daunais, B. T. Stinson, P. W. Czoty
Summary: This study investigated the relationship between social dominance hierarchy and ethanol consumption in nonhuman primates. While lower social status was associated with higher ethanol intakes during induction, the differences between dominant and subordinate monkeys became more pronounced when ethanol availability was increased to 22 hours per day. Factors unique to the conditions of induction may have obscured any influence of social rank, indicating that unrestricted access to ethanol is necessary to observe the effects of social rank on ethanol consumption.
Article
Agriculture, Dairy & Animal Science
M. A. Crookenden, J. R. Roche, A. Heiser, B. Kuhn-Sherlock, C. D. Higham, C. V. C. Phyn, S-A Turner
Summary: One-time administration of Imrestor increased neutrophil numbers and function in dairy cows during the first 14 days postpartum. Using a lower dose rate of Imrestor or a single dose on the day of calving may be sufficient to improve neutrophil function in grazing dairy cows. Further large-scale field studies are needed to determine the impact of lower dose rates or the timing of immunological responses on animal health during early lactation.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Multidisciplinary Sciences
Carlos E. P. Leonardi, Rodrigo A. Carrasco, Fernanda C. F. Dias, Eric M. Zwiefelhofer, Gregg P. Adams, Jaswant Singh
Summary: Kisspeptin modulates GnRH secretion and peripheral administration of kisspeptin can induce LH release and ovulation. The experiments demonstrate that iv administration of kisspeptin can activate GnRH neurons and pre-treatment with a GnRH receptor blocker alters kisspeptin-induced LH release and ovulation. The results support the hypothesis that peripheral kisspeptin may release pre-synthesized GnRH from the nerve terminals outside the blood-brain barrier.
Article
Immunology
Jiaxi Wang, Meng Zhang, Hairong Lyu, Ruiting Guo, Xia Xiao, Xue Bai, Yedi Pu, Juanxia Meng, Qing Li, Ting Yuan, Wenyi Lu, Mingfeng Zhao
Summary: This study investigated the clinical data of patients with relapsed refractory B-ALL treated with CD19 CAR-T cells. It found that low-dose prednisone is a beneficial and tolerable therapy for persistent hematologic toxicity, and it can also alleviate recurrence when administered again after stopping the medication.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Amr Negm, Azza Sedky, Hany Elsawy
Summary: This study confirms the anti-inflammatory and anti-metastatic potentials of capric acid and calcitriol in individual exposure in human colon cancer cell lines. These effects are likely achieved through the inhibition of COX-2 mediators and NF-kappa B transcription factor, as well as the reciprocal regulation of MMP-2 and MMP-9 signaling pathways. The activation of COX-2 and NF-kappa B via disruption of the cellular outer matrix could be considered as a novel molecular target for colorectal cancer therapy.
Review
Biochemistry & Molecular Biology
Alfonso Rodriguez-Gil, Estrella Carrillo-Cruz, Cristina Marrero-Cepeda, Guillermo Rodriguez, Jose A. Perez-Simon
Summary: Vitamin D plays a dual role in the immune system and tumor cells, potentially decreasing graft-versus-host disease and relapse rates.
Review
Medicine, Research & Experimental
Amine Souissi, Monoem Haddad, Ismail Dergaa, Helmi Ben Saad, Karim Chamari
Summary: Cardiovascular drift, characterized by decreasing mean arterial pressure and stroke volume along with an increase in heart rate during prolonged exercise, remains a debated phenomenon with two proposed mechanisms involving blood volume displacement and sympathetic nervous activity. Due to the diversity of circumstances, it is challenging to pinpoint a single factor contributing to cardiovascular drift. This review focuses on exploring the understanding of cardiovascular drift through nitric oxide and force-frequency relationship, suggesting that it may serve as a protective strategy under certain conditions during intense and prolonged myocardial contractions.
Article
Biochemistry & Molecular Biology
Asghar Ghasemi, Hamideh Afzali, Sajad Jeddi
Summary: This study found that nitrite can stimulate insulin secretion in Type 2 diabetic rats, and the underlying mechanism may be related to increased gene expression of proteins involved in glucose sensing, calcium sensing, and exocytosis of insulin vesicles.
BIOMEDICAL JOURNAL
(2022)
Article
Medicine, Research & Experimental
Jieun Won, Danbi Lee, Yu-Gyeong Lee, Seon-Hwa Hong, Jee Hyun Kim, Youn-Jung Kang
Summary: Most embryos fail to produce live offspring in the IVF-ET procedure, but there is a lack of research on this problem. G-CSF is used clinically to improve embryo implantation rates, but there is no standardized protocol for its use. In this study, intrauterine administration of G-CSF showed significant effects on endometrial receptivity and embryo implantation in mice.
Article
Endocrinology & Metabolism
Sine W. Jorgensen, Line Hjort, Linn Gillberg, Louise Justesen, Sten Madsbad, Charlotte Brons, Allan A. Vaag
Summary: This study found that 36-hour prolonged fasting compared to 12-hour overnight fasting led to a slight decrease in first-phase insulin secretion in healthy young males, but with opposite changes in hepatic versus whole body insulin action. Reduced insulin secretion during prolonged fasting may represent a healthy response to improved hepatic insulin action, challenging the physiological understanding of insulin secretion disposition indices not considering organ-specific insulin action.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Medicine, Research & Experimental
Chiu-Li Yeh, Jin-Ming Wu, Kuen-Yuan Chen, Ming-Hsun Wu, Po-Jen Yang, Po-Chu Lee, Po -Da Chen, Sung-Ling Yeh, Ming-Tsan Lin
Summary: This study investigated the effects of enteral cholecalciferol and/or intravenous calcitriol administration on immune cell subsets, the renin-angiotensin system, and acute lung injury in obese mice. The results suggest that calcitriol administration has a stronger impact on immune cell balance and anti-inflammatory pathways in the lungs, while both forms of vitamin D attenuate sepsis-induced lung injury in obese animals.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Agriculture, Dairy & Animal Science
Edyta Kowalczuk-Vasilev, Marian Flis, Agata Bielak, Renata Klebaniuk, Dariusz Gugala, Miroslaw Karpinski, Grzegorz Rytlewski, Eugeniusz R. Grela
Summary: This study examines the combined effect of replacing inorganic salts with glycine chelates and adding calcitriol and L-carnitine on the reproductive traits, blood lipid and mineral profile, and mineral and fatty acid profile of pheasant egg yolk. The results show that the proposed nutritional supplementation improves the number and quality of laid eggs, as well as the absorption and bioavailability of minerals in the blood and egg yolk. The yolk also has a higher proportion of polyunsaturated fatty acids and a favorable ratio of omega-3 to omega-6 fatty acids. Therefore, this nutritional strategy has potential for increasing poultry's nutritional reserves and improving their reproduction.