Article
Cell Biology
Nina Martino, Ramon Bossardi Ramos, Dareen Chuy, Lindsay Tomaszek, Alejandro P. Adam
Summary: Increased levels of sIL-6Ra during inflammatory responses activate IL-6 signaling in endothelial cells, leading to endothelial activation. These findings have implications for understanding acute endotheliopathy.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Oncology
Andrew W. Chung, Anthony J. Kozielski, Wei Qian, Jianying Zhou, Ann C. Anselme, Alfred A. Chan, Ping-Ying Pan, Delphine J. Lee, Jenny C. Chang
Summary: Triple-negative breast cancer (TNBC) patients with mesenchymal stem-like (MSL) subtype have poor response to chemotherapy, while patients with basal-like 1 (BL1) subtype show the best clinical response. Docetaxel activates the MAPK pathway in MSL TNBCs, leading to the release of IL-6 through an IL-1A mediated cascade. Treatment with the humanized IL-6R antibody tocilizumab delays tumor progression in MSL TNBCs.
Article
Multidisciplinary Sciences
Annelies Vennekens, Emma Laporte, Florian Hermans, Benoit Cox, Elodie Modave, Adrian Janiszewski, Charlotte Nys, Hiroto Kobayashi, Bert Malengier-Devlies, Joel Chappell, Patrick Matthys, Marie-Isabelle Garcia, Vincent Pasque, Diether Lambrechts, Hugo Vankelecom
Summary: The study identifies IL-6 as a pituitary stem cell activator upon local damage, with the competence quenched at aging. In aging pituitary, cells exhibit elevated basal IL-6 levels and an inflammatory state, inhibiting the activation response to IL-6. Interestingly, in vitro stem cell activation by IL-6 was observed in organoid culture not only from young but also from aging pituitary.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Endocrinology & Metabolism
Emma Laporte, Silke De Vriendt, Julie Hoekx, Hugo Vankelecom
Summary: Interleukin-6 (IL-6) is important for stem cell activation in the pituitary, but dispensable for normal development and homeostasis. However, IL-6 is needed for the acute stem cell response to local damage in the pituitary.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Elham Beyranvand Nejad, Camilla Labrie, Tetje C. van der Sluis, Suzanne van Duikeren, Kees L. M. C. Franken, Rueshandra Roosenhoff, Ramon Arens, Thorbald van Hall, Sjoerd H. van der Burg
Summary: Elevated serum levels of IL-6 are associated with poor prognosis and chemotherapy resistance in various cancers, with unknown underlying mechanisms. This study demonstrated that tumor-produced IL-6 confers resistance to cisplatin and therapeutic vaccination, affecting the function of myeloid cells. However, combination therapies can overcome IL-6-mediated resistance, providing direction for more effective cancer treatments.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Geriatrics & Gerontology
Lina Ma, Lolita S. Nidadavolu, Huanle Yang, Jackie Langdon, Reyhan Westbrook, Benjamin M. W. Tsui, Taek-Soo Lee, Jared Hinson, Shizhang Ling, Ruth Marx-Rattner, Yuqiong Wu, Tu Nguyen, Jessica Tan, Mohammed Khadeer, Ruin Moaddel, Anne Le, Jeremy D. Walston, Peter M. Abadir
Summary: Selective knockdown of IL-6 in a frail mouse with chronic inflammation can reverse some changes associated with chronic inflammation, but it also leads to higher mortality.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Cell Biology
Qi Chen, Nan Gao, Fu-Shin Yu
Summary: IL-36 cytokines have different roles in mediating immune and inflammatory response. This study showed that IL-36R signaling plays a role in corneal epithelial wound healing and IL-36R deficiency accelerates the healing process. The expression of certain proinflammatory cytokines and antimicrobial peptides were affected by IL-36R deficiency. IL-36Ra could be a potential therapeutic agent for wound healing and ulcer reduction.
Article
Oncology
Paula Roberta Aguiar Pastrez, Ana Margarida Barbosa, Vania Sammartino Mariano, Rhafaela Lima Causin, Antonio Gil Castro, Egidio Torrado, Adhemar Longatto-Filho
Summary: Esophageal squamous cell carcinoma (ESCC) is a rapidly progressing cancer with high mortality rates. In this study, we investigated the levels of inflammatory cytokines in ESCC patients and healthy individuals. We found increased levels of IL-1 beta, IL-6, IL-8, and IL-10 in ESCC patients. Among these cytokines, IL-8 was identified as an independent prognostic factor for ESCC. Additionally, patients with low IL-6, IL-8, TNM I/II, or those who underwent surgery had a higher overall survival rate. Our findings suggest IL-8 as a potential biomarker for ESCC.
Article
Biochemistry & Molecular Biology
Olga M. Koper-Lenkiewicz, Kinga Sutkowska, Natalia Wawrusiewicz-Kurylonek, Ewa Kowalewska, Joanna Matowicka-Karna
Summary: Studies have shown that the relationship between SNPs in proinflammatory cytokines genes and susceptibility to developing RA is inconclusive and varies among different ethnic populations. These polymorphisms also have an impact on clinicopathological features of RA and patients' response to treatment. Further research on larger cohorts and diverse populations is needed to elucidate the role of these SNPs in RA patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Hirotaka Hasegawa, Jamie J. Van Gompel, Soliman H. Oushy, Bruce E. Pollock, Michael J. Link, Fredric B. Meyer, Irina Bancos, Dana Erickson, Caroline J. Davidge-Pitts, Jason T. Little, Joon H. Uhm, Amy A. Swanson, Caterina Giannini, Anita Mahajan, John L. Atkinson
Summary: This study reviewed 85 cases of SCO and found that patients had an average age of 56 years, 60% had vision loss, and 73% showed hormonal abnormalities. The tumor was avidly enhancing on MRI images, and GTR had a higher tumor control rate postoperatively, while patients with low Ki67 index had better prognosis.
WORLD NEUROSURGERY
(2021)
Article
Microbiology
Heather Armstrong, Mandana Rahbari, Heekuk Park, David Sharon, Aducio Thiesen, Naomi Hotte, Ning Sun, Hussain Syed, Hiatem Abofayed, Weiwei Wang, Karen Madsen, Eytan Wine, Andrew Mason
Summary: Genetically manipulated mice lacking IL-10 have increased MMTV expression, which may contribute to the development of colitis. Antiviral therapy targeting MMTV reduces colonic MMTV RNA and improves colitis symptoms in these mice.
Article
Health Care Sciences & Services
Magdalena Bizon, Zofia Awizen-Panufnik, Wlodzimierz Sawicki
Summary: Ovarian cancer is difficult to diagnose early due to lack of symptoms, leading to poor prognosis. Inflammation is a key mechanism in this disease. Finding new markers for ovarian cancer is important for clinical use. CA125 and HE4 are commonly used markers, but new ones are still being sought. Inflammatory markers like C-reactive protein, procalcitonin, and interleukin-6 may have potential prognostic roles in diagnosing ovarian cancer.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Oncology
Tsunenori Yamamoto, Ryouichi Tsunedomi, Masao Nakajima, Nobuaki Suzuki, Shin Yoshida, Shinobu Tomochika, Ming Xu, Yuki Nakagami, Hiroto Matsui, Yukio Tokumitsu, Yoshitaro Shindo, Yusaku Watanabe, Michihisa Iida, Shigeru Takeda, Shoichi Hazama, Tsuyoshi Tanabe, Tatsuya Ioka, Yoshinobu Hoshii, Akifumi Kiyota, Hitoshi Takizawa, Yutaka Kawakami, Tomio Ueno, Hiroaki Nagano
Summary: This study investigated the relationship between an immunosuppressive state and patient prognosis in colorectal cancer (CRC) by evaluating the levels of interleukin (IL)-6 in both the systemic and tumor microenvironment. The results showed that elevated serum IL-6 levels were associated with elevated stromal IL-6 levels and a poor prognosis for CRC patients. In addition, tumor-infiltrating immune cells expressing IL-6 were primarily composed of myeloid cells and rarely lymphoid cells.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yuexin Guo, Boya Wang, Tiantian Wang, Lei Gao, Ze-jun Yang, Fei-fei Wang, Hong-wei Shang, Rongxuan Hua, Jing-dong Xu
Summary: This article summarizes the functions of IL-6 in maintaining intestinal homeostasis, explores its relation with the nervous system, and highlights its potential role in Parkinson's disease. It also points out the dual-sided influence of IL-6 on intestinal tumors and inflammation, and how they are achieved through different processes.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Endocrinology & Metabolism
Yi Lu, Yi Wang, Yang Wang, Yu Wu, Yazhuo Huang, Xingtong Liu, Shuo Zhang, Sisi Zhong, Yinwei Li, Bin Li, Jing Sun, Sijie Fang, Huifang Zhou
Summary: This study investigated the immunophenotypes of orbital-infiltrating macrophages and their modulatory effects on orbital fibroblasts (OFs) in Graves' orbitopathy (GO). The results showed the presence of different immunophenotypes of macrophages in GO orbital connective tissues and their promotion effects on OFs through the IL-6/sIL-6R signaling pathway. These findings provide molecular rationale for the potential therapeutic use of blocking sIL-6R in GO.
