The Critical Role of O2 Provision in the Dynamic Adjustment of Oxidative Phosphorylation

It has been proposed that the adjustment of oxygen uptake (VO2) during the exercise on-transient is controlled intracellularly in young healthy individuals and that insufficient local O-2 delivery plays a rate-limiting role in aging and disease only. This review shows that adequate O-2 provision to the active tissues is critical in the dynamic adjustment of oxidative phosphorylation even in young healthy individuals.