Article
Biochemical Research Methods
Tianyao Zhu, Jason P. Gallivan, Daniel M. Wolpert, J. Randall Flanagan
Summary: This study examines the interaction between bias and noise in motor errors. The findings suggest that adaptation can compensate for bias and selecting less noisy regions of the environment can reduce noise. However, adaptation to bias limits the ability to select less noisy movements.
PLOS COMPUTATIONAL BIOLOGY
(2023)
Article
Biology
Guy Avraham, Jordan A. Taylor, Assaf Breska, Richard B. Ivry, Samuel D. McDougle
Summary: This study examines the relevance of associative learning concepts for sensorimotor adaptation and provides evidence for the existence of associative learning effects in sensorimotor adaptation tasks. The findings suggest a potential integration of different cerebellar-dependent learning paradigms within a common theoretical framework.
Article
Neurosciences
Ryosuke O. Tachibana, Dahyun Lee, Kazuki Kai, Satoshi Kojima
Summary: This study investigates the neural substrates underlying motor memory consolidation in birdsong, and finds that consolidation of learned vocal changes occurs during the daytime, and is strongly correlated with the amount of learning.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Mona Spaeth, Ingrid Aichert, Dagmar Timmann, Andres O. Ceballos-Baumann, Edith Wagner-Sonntag, Wolfram Ziegler
Summary: This article explores the role of cerebellar and basal ganglia dysfunctions in unintentional adaptation to speech rhythm and articulation rate of a second speaker. The findings suggest that continuous auditory-motor adaptation takes place in interactive language use and the plasticity of auditory-motor representations of speech persists throughout life.
Article
Geriatrics & Gerontology
Vineeth Radhakrishnan, Cecile Gallea, Romain Valabregue, Syam Krishnan, Chandrasekharan Kesavadas, Bejoy Thomas, Praveen James, Ramshekhar Menon, Asha Kishore
Summary: This study validated the structural connectivity within the cerebellum-basal ganglia reciprocal network in a larger dataset of human subjects across a wider age range. It found age-related neurodegeneration in the subcortical cerebello-basal ganglia tracts and their association with different cognitive functions. These findings have significant implications for understanding neurodevelopmental and neurodegenerative diseases.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Clinical Neurology
Hemani Ticku, Neel Fotedar, Jorge Juncos, Stewart A. Factor, Aasef G. Shaikh
Summary: Ocular oscillations play a critical role in diagnosing neurodegenerative disorders. In patients with progressive supranuclear palsy, vertical jerky eye oscillations were observed, which were eliminated by head stabilization. These oscillations were interpreted as pseudonystagmus caused by the vestibulo-ocular reflex in response to involuntary subtle jerky head oscillations.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Computer Science, Artificial Intelligence
Jhielson M. Pimentel, Renan C. Moioli, Mariana F. P. De Araujo, Patricia A. Vargas
Summary: This work presents a neurorobotics model that integrates the cerebellum and basal ganglia to coordinate movements in a humanoid robot. The model is capable of predicting and adjusting the robot's hand motion in real time, making it an important tool for brain studies and robot motor control.
INTERNATIONAL JOURNAL OF NEURAL SYSTEMS
(2023)
Article
Neurosciences
Jinnan Gong, Sisi Jiang, Zhiliang Li, Haonan Pei, Qifu Li, Dezhong Yao, Cheng Luo
Summary: This study utilized diffusion and functional MRI to investigate the pathoglytic changes in the basal ganglia-thalamocortical and cerebellum-thalamocortical pathways in people with idiopathic generalized epilepsy (IGE). The findings revealed connectivity changes with perception and cognition systems and identified abnormal integration of sensorimotor and visual information in IGE. Aberrant functional and structural integration of cerebellum, basal ganglia, and thalamus were linked to cognitive impairment and epileptic activities in IGE.
HUMAN BRAIN MAPPING
(2021)
Article
Anatomy & Morphology
Gianpaolo Antonio Basile, Marina Quartu, Salvatore Bertino, Maria Pina Serra, Marcello Trucas, Marianna Boi, Roberto Demontis, Alessia Bramanti, Giuseppe Pio Anastasi, Demetrio Milardi, Rosella Ciurleo, Alberto Cacciola
Summary: This study successfully reconstructed the fiber bundles of the human subthalamic area and created a large-scale normative population atlas using an optimized tractography protocol. This atlas is of great significance in both clinical anatomy and functional neurosurgery, as it improves our understanding of the complex morphology of this important brain region.
BRAIN STRUCTURE & FUNCTION
(2022)
Review
Behavioral Sciences
Jonathan J. Cannon, Aniruddh D. Patel
Summary: This study proposes that beat anticipation relies on action-like processes in the brain, orchestrated by neural time-keeping activity in the supplementary motor area (SMA) and the dorsal striatum. By synthesizing recent advances in cognitive science and motor neuroscience, the framework provides testable predictions for future research.
TRENDS IN COGNITIVE SCIENCES
(2021)
Review
Clinical Neurology
Pattamon Panyakaew, Hyder A. Jinnah, Aasef G. Shaikh
Summary: Dystonia and tremor often coexist, either sharing biological mechanisms or as comorbid conditions. This paper compares and identifies the differences and limitations between two definitions of dystonic tremor, and discusses methods to separate tremor subtypes in dystonia based on objective measures and single neuron physiology analyses.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Neurosciences
Yoshiko Kojima, Paul J. May
Summary: The basal ganglia have been found to influence error-based motor learning, particularly in eye movement adaptation, by enhancing the error signal, suggesting a previously unrecognized function of the basal ganglia.
Review
Neurosciences
James M. Shine
Summary: The human brain is a complex system, with the thalamus playing a crucial role in balancing integration and differentiation. Different thalamocortical connections may influence different information processing modes.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Clinical Neurology
Sinem Balta Beylergil, Mikkel Petersen, Palak Gupta, Mohamed Elkasaby, Camilla Kilbane, Aasef G. Shaikh
Summary: The study found that Parkinson's disease affects motion perception in both the visual and vestibular domains, with a more severe impact on vestibular perception compared to visual perception, depending on the severity of the disease.
MOVEMENT DISORDERS
(2021)
Article
Biochemistry & Molecular Biology
Lidio Lima de Albuquerque, Milan Pantovic, Mitchell Clingo, Katherine Fischer, Sharon Jalene, Merrill Landers, Zoltan Mari, Brach Poston
Summary: Parkinson's disease is a neurodegenerative disorder that impairs motor function. Transcranial direct current stimulation (c-tDCS) has been shown to improve motor skills. However, this study found that a single session of c-tDCS did not enhance motor skill acquisition or transfer in patients with Parkinson's disease.
Article
Neurosciences
Peng Yuan, Vincent Koppelmans, Patricia Reuter-Lorenz, Yiri De Dios, Nichole Gadd, Roy Riascos, Igor Kofman, Jacob Bloomberg, Ajitkumar Mulavara, Rachael D. Seidler
JOURNAL OF NEUROPHYSIOLOGY
(2018)
Article
Geriatrics & Gerontology
Roxana G. Burciu, Rachael D. Seidler, Priyank Shukla, Mike A. Nalls, Andrew B. Singleton, Michael S. Okun, David E. Vaillancourt
NEUROBIOLOGY OF AGING
(2018)
Article
Geriatrics & Gerontology
Kathleen E. Hupfeld, David E. Vaillancourt, Rachael D. Seidler
NEUROBIOLOGY OF AGING
(2018)
Article
Clinical Neurology
Nathaniel S. Miller, Kelvin L. Chou, Nicolaas I. Bohnen, Martijn L. T. M. Mueller, Rachael D. Seidler
PARKINSONISM & RELATED DISORDERS
(2018)
Article
Clinical Neurology
Marit F. L. Ruitenberg, Tina Wu, Bruno B. Averbeck, Kelvin L. Chou, Vincent Koppelmans, Rachael D. Seidler
FRONTIERS IN NEUROLOGY
(2018)
Article
Clinical Neurology
Roy F. Riascos, Arash Kamali, Reza Hakimelahi, Benson Mwangi, Pejman Rabiei, Rachael D. Seidler, Barzin B. Behzad, Zafer Keser, Larry A. Kramer, Khader M. Hasan
JOURNAL OF NEUROIMAGING
(2019)
Article
Neurosciences
Brian Greeley, Rachael D. Seidler
JOURNAL OF NEUROPHYSIOLOGY
(2019)
Article
Neurosciences
Kaitlin Cassady, Holly Gagnon, Poortata Lalwani, Molly Simmonite, Bradley Foerster, Denise Park, Scott J. Peltier, Myria Petrou, Stephan F. Taylor, Daniel H. Weissman, Rachael D. Seidler, Thad A. Polk
Article
Clinical Neurology
Jessica K. Lee, Vincent Koppelmans, Roy F. Riascos, Khader M. Hasan, Ofer Pasternak, Ajitkumar P. Mulavara, Jacob J. Bloomberg, Rachael D. Seidler
Article
Clinical Neurology
Holly Gagnon, Molly Simmonite, Kaitlin Cassady, Jordan Chamberlain, Erin Freiburger, Poortata Lalwani, Shannon Kelley, Bradley Foerster, Denise C. Park, Myria Petrou, Rachael D. Seidler, Stephan F. Taylor, Daniel H. Weissman, Thad A. Polk
Article
Geriatrics & Gerontology
Jordan D. Chamberlain, Holly Gagnon, Poortata Lalwani, Kaitlin E. Cassady, Molly Simmonite, Rachael D. Seidler, Stephan F. Taylor, Daniel H. Weissman, Denise C. Park, Thad A. Polk
Summary: With aging, there is a decline in neural distinctiveness which may be related to a decrease in GABA levels, leading to less distinct neural activation patterns in the ventral visual cortex of older adults.
NEUROBIOLOGY OF AGING
(2021)
Review
Geriatrics & Gerontology
Tyler Fettrow, Kathleen Hupfeld, Grant Tays, David J. Clark, Patricia A. Reuter-Lorenz, Rachael D. Seidler
Summary: Studies have shown that older adults exhibit increased brain activity when performing cognitive tasks, which may indicate neural dysfunction or neural compensation. Including multiple task difficulty levels in future research can lead to a more advanced understanding of age-related changes in locomotor brain activity and support the development of targeted neural rehabilitation techniques.
NEUROBIOLOGY OF AGING
(2021)
Article
Chemistry, Analytical
Tian Bao, Fatemeh Noohi, Catherine Kinnaird, Wendy J. Carender, Vincent J. Barone, Geeta Peethambaran, Susan L. Whitney, Rachael D. Seidler, Kathleen H. Sienko
Summary: Long-term balance training with vibrotactile sensory augmentation has sustained effects on balance improvement and induces changes in brain activity pattern among community-dwelling healthy older adults.
Article
Neurosciences
Grant D. Tays, Kathleen E. Hupfeld, Heather R. McGregor, Nichole E. Beltran, Igor S. Kofman, Yiri E. De Dios, Edwin R. Mulder, Jacob J. Bloomberg, Ajitkumar P. Mulavara, Scott J. Wood, Rachael D. Seidler
Summary: Altered vestibular signaling and body unloading in microgravity leads to sensory reweighting and adaptation. The effectiveness of daily artificial gravity (AG) for mitigating brain and/or behavioral changes in 60 days of head-down tilt bed rest (HDBR) was examined. Results showed that the AG group exhibited similar behavioral adaptation effects as the control group (CTRLs), but had reduced brain activation in certain areas during the late HDBR phase. These findings suggest that AG may lead to a reduced recruitment of brain activity for motor processes and sensorimotor adaptation.
Article
Neurosciences
Heather R. McGregor, Jessica K. Lee, Edwin R. Mulder, Yiri E. De Dios, Nichole E. Beltran, Scott J. Wood, Jacob J. Bloomberg, Ajitkumar P. Mulavara, Rachael D. Seidler
Summary: The study investigated how artificial gravity (AG) alters resting-state brain functional connectivity changes during head-down tilt bed rest (HDBR), a spaceflight analog. The results showed that AG can change the brain functional connectivity during HDBR and reduce balance and mobility declines. These findings suggest that AG could be an effective countermeasure for the reduced somatosensory stimulation that occurs in microgravity and HDBR.
