Article
Multidisciplinary Sciences
Joshua M. Borin, Sarit Avrani, Jeffrey E. Barrick, Katherine L. Petrie, Justin R. Meyer
Summary: Training bacteriophages on target hosts before therapy can prolong suppression of antibiotic-resistant bacteria by delaying the evolution of resistance. Evolution of resistance to trained phages is more costly and requires multiple mutations, making them more effective in combating resistance. Transfer of genetic information from host genomes through recombination can enhance phage fitness and improve treatment outcomes, highlighting the potential of training in phage therapy development.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Microbiology
Nannan Wu, Tongyu Zhu
Summary: Nosocomial infections are a significant healthcare burden globally, exacerbated by antimicrobial resistance. Utilizing bacteriophages from an expanding library offers a promising alternative for tackling AMR bacteria and provides a database for monitoring and treatment of hospital-acquired infections.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Microbiology
Greater Kayode Oyejobi, Xiaoxu Zhang, Dongyan Xiong, Faith Ogolla, Heng Xue, Hongping Wei
Summary: Phage treatment shows potential for bacterial infections, but bacterial resistance to phage is a challenge. Research on phage resistance and coevolutionary dynamics between phage and bacteria is crucial for successful phage therapy.
CRITICAL REVIEWS IN MICROBIOLOGY
(2023)
Article
Virology
Mianzhi Wang, Jingyi Wei, Lei Jiang, Li Jiang, Junxuan Zhang, Xiaolu He, Yiwen Ren, Zixuan Wang, Yongxue Sun, Zhiqiang Wang
Summary: Antibiotic-resistant bacteria pose a threat to antibiotic therapies, and phage therapy has emerged as an alternative. This study successfully trained a phage to reduce bacterial resistance and improve treatment outcomes. The results showed improved clinical outcomes and reduced bacterial load with phage treatment, and the use of a phage cocktail delayed the emergence of resistance.
Article
Respiratory System
Marco Cafora, Marc Chanson, Anna Pistocchi
Summary: Cystic fibrosis (CF) is a common life-threatening genetic disorder in Caucasians caused by mutations in the CFTR gene. CFTR dysfunction affects mucus- and sweat-producing epithelia, leading to various organ complications. The disease is associated with microbiota dysbiosis and abnormal epithelial homeostasis. New strategies are needed to combat bacterial infections and restore epithelial homeostasis in CF patients, and alternative cutting-edge approaches to modulator therapy are promising.
JOURNAL OF CYSTIC FIBROSIS
(2023)
Article
Immunology
John S. Bradley, Hamza Hajama, Kathryn Akong, Mary Jordan, Dayna Stout, Ryan S. Rowe, Douglas J. Conrad, Sara Hingtgen, Anca M. Segall
Summary: Cystic fibrosis (CF) is a genetic disease characterized by chronic lung infection, often caused by antibiotic-resistant pathogens. Bacteriophages can be used in conjunction with antibiotics to provide targeted treatment for CF.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)
Article
Nutrition & Dietetics
Herve Lobbes, Stephane Durupt, Sabine Mainbourg, Bruno Pereira, Raphaele Nove-Josserand, Isabelle Durieu, Quitterie Reynaud
Summary: Iron deficiency prevalence in adult patients with cystic fibrosis is 44.2%, and it is significantly associated with female gender, younger age, lower body mass index, and Pseudomonas aeruginosa colonization.
Article
Microbiology
Grazyna Majkowska-Skrobek, Pawel Markwitz, Ewelina Sosnowska, Cedric Lood, Rob Lavigne, Zuzanna Drulis-Kawa
Summary: The study found that resistance of Klebsiella pneumoniae to bacteriophages mainly comes from modifications to the receptor, which can be manifested through mutations or changes in exopolysaccharides. The loss or modification of capsules in K. pneumoniae does not significantly affect its fitness or antibiotic resistance, but driving bacteria to expel multidrug resistance clusters.
ENVIRONMENTAL MICROBIOLOGY
(2021)
Review
Medicine, General & Internal
Thomas Radtke, Sherie Smith, Sarah J. Nevitt, Helge Hebestreit, Susi Kriemler
Summary: This review examines the effects of physical activity interventions on exercise capacity, lung function, and health-related quality of life in people with cystic fibrosis. The results suggest that physical activity interventions may improve exercise capacity, but their effects on lung function and quality of life are uncertain.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Article
Respiratory System
Beverley C. Millar, John E. Moore
Summary: The study demonstrates that domestic steam disinfection using baby bottle disinfection devices can effectively eradicate bacteria and pathogens from contaminated utensils, offering a relatively inexpensive, simple, versatile, and widely available technology. CF households that already have baby bottle disinfection devices can easily utilize them to disinfect crockery and cutlery, enhancing sibling safety.
JOURNAL OF CYSTIC FIBROSIS
(2021)
Article
Endocrinology & Metabolism
Sabina Galiniak, Rafal Podgorski, Marta Rachel, Artur Mazur
Summary: Cystic fibrosis (CF) is the most common genetically determined disease caused by a mutation in the CF transmembrane conductance regulator protein gene. This study found significantly reduced serum levels of ghrelin and ASP in CF patients, but no difference in PYY and alpha-MSH levels compared to healthy subjects. Ghrelin was negatively correlated with age, body mass index, and C-reactive protein, while PYY was negatively associated with age in CF patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Nacyra Assad-Garcia, Roshan D'Souza, Rachel Buzzeo, Arti Tripathi, Lauren M. Oldfield, Sanjay Vashee, Derrick E. Fouts, Martha Vives
Summary: This study presents a new and efficient DNA transformation method for Staphylococcus aureus to boot-up purified phage genomic DNA and synthetic phage genomes. This method is a powerful tool for the rapid development of engineered therapeutic phages and phage cocktails against Gram-positive pathogens.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Medicine, Research & Experimental
Pranita D. Tamma, Maria Souli, Michael Billard, Joseph Campbell, Douglas Conrad, Damon W. Ellison, Beth Evans, Scott R. Evans, Kerryl E. Greenwood-Quaintance, Andrey A. Filippov, Holly S. Geres, Toshimitsu Hamasaki, Lauren Komarow, Mikeljon P. Nikolich, Thomas P. Lodise, Seema U. Nayak, Carmelle Norice-Tra, Robin Patel, David Pride, Janie Russell, Daria Van Tyne, Henry F. Chambers, Vance G. FowlerJr, Robert T. Schooley
Summary: This study is a double-blind placebo-controlled trial investigating both the activity of phages in reducing P. aeruginosa colony counts and the safety of phage therapy.
Article
Medicine, General & Internal
Owen William Tomlinson, Zoe L. Saynor, Daniel Stevens, Joe Antoun, Don S. Urquhart, Craig Anthony Williams
Summary: This study investigated exercise testing and training practices for people with cystic fibrosis (pwCF) in the UK. The results showed that the majority of CF clinics now offer exercise testing and training advice, but efforts are still needed to standardize exercise practices, especially regarding field testing and the translation of test results into personalized training programs for pwCF.
Article
Pediatrics
Samya Salah, Nisreen Rumman, Amal Nassar, Maher Khdour, Hussein Hallak
Summary: This study assessed the clinical characteristics and outcomes of cystic fibrosis in Palestine by evaluating the quality of life of participants. The results showed that the quality of life, health status, and longevity of cystic fibrosis patients in Palestine were significantly lower than those in other countries.
PEDIATRIC PULMONOLOGY
(2023)
Article
Biology
Marie Vasse, Clara Torres-Barcelo, Michael E. Hochberg
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2015)
Editorial Material
Biochemical Research Methods
Wilbert Sybesma, Jean-Paul Pirnay, Z. Alavidze, R. Aminov, A. Betts, M. Bardiau, L. Bretaudeau, J. Caplin, N. Chanishvili, A. Coffey, I. Cooper, D. De Vos, J. Doskar, V. Friman, N. Hoyle, N. Karanadze, I. Kurtboke, M. Kutateladze, S. McCallin, M. Merabishvili, G. Mgaloblishvili, L. Nadareishvili, N. Nikolaishvili, D. Nizharadze, R. Pantucek, G. Resch, C. Rohde, T. Shulaia, M. Tediashvili, A. Ujmajuridze
BIOTECHNOLOGY JOURNAL
(2016)
Article
Ecology
Alex Betts, Danna R. Gifford, R. Craig MacLean, Kayla C. King
Article
Evolutionary Biology
Clara Torres-Barcelo, Blaise Franzon, Marie Vasse, Michael E. Hochberg
EVOLUTIONARY APPLICATIONS
(2016)
Article
Ecology
Kayla C. King, Michael A. Brockhurst, Olga Vasieva, Steve Paterson, Alex Betts, Suzanne A. Ford, Crystal L. Frost, Malcolm J. Horsburgh, Sam Haldenby, Gregory D. D. Hurst
Editorial Material
Biochemical Research Methods
Wilbert Sybesma, Jean-Paul Pirnay, Z. Alavidze, R. Aminov, A. Betts, M. Bardiau, L. Bretaudeau, J. Caplin, N. Chanishvili, A. Coffey, I. Cooper, D. De Vos, J. Doskar, V. Friman, N. Hoyle, N. Karanadze, I. Kurtboke, M. Kutateladze, S. McCallin, M. Merabishvili, G. Mgaloblishvili, L. Nadareishvili, N. Nikolaishvili, D. Nizharadze, R. Pantucek, G. Resch, C. Rohde, T. Shulaia, M. Tediashvili, A. Ujmajuridze
BIOTECHNOLOGY JOURNAL
(2016)
Article
Multidisciplinary Sciences
Marie Vasse, Robert J. Noble, Andrei R. Akhmetzhanov, Clara Torres-Barcelo, James Gurney, Simon Benateau, Claire Gougat-Barbera, Oliver Kaltz, Michael E. Hochberg
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Biology
Marie Vasse, Hermann Voglmayr, Veronika Mayer, Cecile Gueidan, Maximilian Nepel, Leandro Moreno, Sybren de Hoog, Marc-Andre Selosse, Doyle Mckey, Rumsais Blatrix
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2017)
Review
Virology
Marie Vasse, Sebastien Wielgoss
Article
Multidisciplinary Sciences
Clara Torres-Barcelo, Flor I. Arias-Sanchez, Marie Vasse, Johan Ramsayer, Oliver Kaltz, Michael E. Hochberg
Article
Multidisciplinary Sciences
Alex Betts, Oliver Kaltz, Michael E. Hochberg
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2014)
Article
Cell Biology
William R. Harcombe, William J. Riehl, Ilija Dukovski, Brian R. Granger, Alex Betts, Alex H. Lang, Gracia Bonilla, Amrita Kar, Nicholas Leiby, Pankaj Mehta, Christopher J. Marx, Daniel Segre
Article
Microbiology
Nicola Mayrhofer, Gregory J. Velicer, Kaitlin A. Schaal, Marie Vasse
Summary: The study found that the predatory bacterium Myxococcus xanthus has a repellent effect on the nematode Caenorhabditis elegans, causing it to avoid patches that would normally be attractive. Additionally, the nematode influences the predatory behavior of the bacterium, increasing its swarming rate in response to worm density and prey identity. These findings suggest that nematodes and bacterial predators mutually influence each other's behavior, with potential implications for coevolution within complex microbial food webs.
Article
Microbiology
Clara Torres-Barcelo, James Gurney, Claire Gougat-Barbera, Marie Vasse, Michael E. Hochberg
FEMS MICROBIOLOGY ECOLOGY
(2018)