期刊
EVOLUTION
卷 66, 期 8, 页码 2427-2438出版社
WILEY
DOI: 10.1111/j.1558-5646.2012.01628.x
关键词
Gamma distribution; log-normal distribution; mitochondrial genome; neutrality index; population genetics
资金
- Biotechnology and Biological Sciences Research Council of the UK
- Biotechnology and Biological Sciences Research Council [BB/G003076/1] Funding Source: researchfish
- BBSRC [BB/G003076/1] Funding Source: UKRI
We explore factors affecting patterns of polymorphism and divergence (as captured by the neutrality index) at mammalian mitochondrial loci. To do this, we develop a population genetic model that incorporates a fraction of neutral amino acid sites, mutational bias, and a probability distribution of selection coefficients against new nonsynonymous mutations. We confirm, by reanalyzing publicly available datasets, that the mitochondrial cyt-b gene shows a broad range of neutrality indices across mammalian taxa, and explore the biological factors that can explain this observation. We find that observed patterns of differences in the neutrality index, polymorphism, and divergence are not caused by differences in mutational bias. They can, however, be explained by a combination of a small fraction of neutral amino acid sites, weak selection acting on most amino acid mutations, and differences in effective population size among taxa.
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