期刊
EVOLUTION
卷 65, 期 6, 页码 1559-1571出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1558-5646.2011.01237.x
关键词
Drift load; genetic drift; models; molecular evolution; natural selection
资金
- European Research Council [232971 PopPhyl]
- Fundacao para a Ciencia e Tecnologia (Portugal) [SFRH/BD/38132/2007]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/38132/2007] Funding Source: FCT
One of the assumptions underlying many theoretical predictions in evolutionary biology concerns the distribution of the fitness effect of mutations. Approximations to this distribution have been derived using various theoretical approaches, of which Fisher's geometrical model is among the most popular ones. Two key concepts in this model are complexity and pleiotropy. Recent studies have proposed different methods for estimating how complexity varies across species, but their results have been contradictory. Here, we show that contradictory results are to be expected when the assumption of universal pleiotropy is violated. We develop a model in which the two key parameters are the total number of traits and the mean number of traits affected by a single mutation. We derive approximations for the distribution of the fitness effect of mutations when populations are either well-adapted or away from the optimum. We also consider drift load in a well-adapted population and show that it is independent of the distribution of the fitness effect of mutations. We show that mutation accumulation experiments can only measure the effect of the mean number of traits affected by mutations, whereas drift load only provides information about the total number of traits. We discuss the plausibility of the model.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据