Review
Biochemistry & Molecular Biology
Fiona M. Docherty, Lori Sussel
Summary: This article reviews endogenous mechanisms of beta cell regeneration in steady state, stress, and disease; efforts to stimulate endogenous regeneration and transdifferentiation; and exogenous methods of beta cell generation and transplantation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Mahe Quest, Paul Rinnert, Linus Hahner, Andreas Nieder
Summary: This study found that carrion crows possess both exogenous and endogenous attention mechanisms, indicating a substantial attentional capacity and robust cognitive control over attention allocation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Eleni Kyriakou, Gkikas Magiorkinis
Summary: In humans, retroviruses, including human endogenous retroviruses (HERVs) and exogenous retroviruses (HTLV and HIV), play complex roles in symbiosis and disease. This review explores the interactions between these groups, the influence of exogenous retrovirus infection on HERV expression, the impact of HERVs on the pathogenicity of HTLV and HIV, and the potential antiviral protection provided by HERVs.
TRENDS IN MICROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Xinqiang Liang, Yanping Tang, Mekhrdod S. Kurboniyon, Danni Luo, Guiwan Tu, Pengle Xia, Shufang Ning, Litu Zhang, Chen Wang
Summary: By synthesizing a three-dimensional nanostructure and regulating enzymatic activity, efficient ROS generation and antioxidant depletion can be achieved for effective ROS-mediated tumor therapy.
FRONTIERS IN PHARMACOLOGY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Charles H. Cannon
Summary: This study highlights the formation of a set of closely related tree species in the Mascarene Islands that actively exchange genes, instead of evolving as completely independent species. The findings provide valuable insights into diversification and emphasize the importance of considering the entire network of potentially interfertile species.
Article
Chemistry, Multidisciplinary
Miaoxia Liu, Gerardo Salinas, Jing Yu, Antoine Cornet, Haidong Li, Alexander Kuhn, Neso Sojic
Summary: Multimodal imaging is a powerful approach that integrates multiple optical modalities in a single device, with potential applications in various fields. In this study, we developed wireless multimodal light-emitting chemical systems by coupling two light sources based on different physical principles. The results provide a novel alternative for designing autonomous hybrid systems with multimodal and multicolor optical readouts for complex bio-chemical systems.
Article
Chemistry, Multidisciplinary
Miaoxia Liu, Gerardo Salinas, Jing Yu, Antoine Cornet, Haidong Li, Alexander Kuhn, Neso Sojic
Summary: In this study, we developed a wireless multimodal light-emitting chemical device by combining two light sources based on different physical principles. This device integrates optical imaging and electrochemical reactions, providing a novel approach for complex bio-chemical systems.
Review
Engineering, Biomedical
Hui Huang, Zeyu Wang, Liang Chen, Hong Yu, Yu Chen
Summary: Catalytic therapy has shown promise in enhancing therapeutic efficacy and reducing side effects by converting less toxic or nontoxic endogenous substances into highly toxic reactive species to induce cell death. This review summarizes the recent advances in the development and use of catalytic biomaterials and nanomedicines in various biomedical applications. The study focuses on the use of endogenous activators and exogenous stimuli to improve treatment efficacy, and discusses the biosafety and biocompatibility of these materials. The challenges and future opportunities for catalytic biomaterials and nanomedicines are also highlighted.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Izabela Korczowska-Lacka, Bartosz Slowikowski, Thomas Piekut, Mikolaj Hurla, Natalia Banaszek, Oliwia Szymanowicz, Pawel P. Jagodzinski, Wojciech Kozubski, Agnieszka Permoda-Pachuta, Jolanta Dorszewska
Summary: In diseases of the central nervous system, oxidative stress load commonly exceeds the body's antioxidant capacity. Endogenous antioxidants such as enzymes and exogenous antioxidants like vitamins and polyphenols play a significant role in preventing oxidative damage. However, the clinical efficacy and effectiveness of these antioxidants in neurological diseases need further research and definition.
Article
Immunology
Ying Yin, Xiao-zhao Liu, Ximiao He, Li-quan Zhou
Summary: The study suggests that coronavirus infections can lead to increased retrotransposon expression, potentially causing genome instability and more severe symptoms, especially in cancer patients and the elderly. Additionally, the interaction between coronaviruses and retrotransposons may result in viral fragment invasion of the human genome, leading to more severe disease outcomes.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Nannan Su, Wenxuan Zhen, Heng Zhang, Lingyi Xu, Yitian Jin, Xiaoying Chen, Cheng Zhao, Qinrui Wang, Xinyan Wang, Shaowei Li, Han Wen, Wei Yang, Jiangtao Guo, Fan Yang
Summary: This study reports the presence of an endogenous cholesterol molecule inside the TRPV2 receptor, which antagonizes ligand activation and is removed by methyl-beta-cyclodextrin. Additionally, the study shows that estradiol can enhance TRPV2 activation. These findings provide a structural basis for understanding the regulation of TRPV2.
NATURE CHEMICAL BIOLOGY
(2023)
Article
Engineering, Biomedical
Yu Zhang, Qiang Li, Meng Ding, Weijun Xiu, Jingyang Shan, Lihui Yuwen, Dongliang Yang, Xuejiao Song, Guangwen Yang, Xiaodan Su, Yongbin Mou, Zhaogang Teng, Heng Dong
Summary: Ti3C2 MXene-based nanoplatforms (MXP) with high-efficiency near-infrared photothermal conversion and immunocompetent loading capacity are prepared to form endogenous/exogenous nanovaccines. This study provides a two-pronged strategy for improving immunogenicity and killing tumor cells to achieve a favorable outcome in tumor patients.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Neurosciences
Antonio Fernandez, Sara Okun, Marisa Carrasco
Summary: Covert attention, both endogenous and exogenous, improves performance by enhancing gain in all orientations without changing tuning width. In the spatial frequency dimension, endogenous attention enhances gain both above and below target frequency, whereas exogenous attention only enhances gain above. Exogenous attention also shifts peak sensitivity to frequencies above target, while endogenous attention does not.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
G. Tamburello, G. Chiodini, G. Ciotoli, M. Procesi, D. Rouwet, L. Sandri, N. Carbonara, C. Masciantonio
Summary: This study digitized and analyzed a dataset of thermal springs worldwide compiled by Gerald Ashley Waring in 1965. Using a machine learning approach, data from 6000 geothermal areas were analyzed and confirmed the dominant role of terrestrial heat flow, topography, volcanism, and extensional tectonics in the formation of thermal springs.
NATURE COMMUNICATIONS
(2022)
Review
Cell Biology
Bryan J. Mathis, Hideyuki Kato, Yuji Hiramatsu
Summary: Nrf2 is a key regulator of the antioxidant response and detoxification of xenobiotics. However, excessive upregulation of Nrf2 may lead to cardiomyopathy, and miRNA involvement adds complexity to this mechanism. Extensive research has been done on exogenous compounds that regulate Nrf2 and their potential to promote cardiomyopathy, as well as their comparison to exercise-induced factors.
Article
Evolutionary Biology
Joshua P. Jahner, Daniel Gibson, Chava L. Weitzman, Erik J. Blomberg, James S. Sedinger, Thomas L. Parchman
BMC EVOLUTIONARY BIOLOGY
(2016)
Article
Biodiversity Conservation
Joseph S. Wilson, Joshua P. Jahner, Matthew L. Forister
ENVIRONMENTAL CONSERVATION
(2016)
Article
Biodiversity Conservation
Joseph S. Wilson, Joshua P. Jahner, Lisa Starley, Carmelle L. Calvin, Harold Ikerd, Terry Griswold
JOURNAL OF INSECT CONSERVATION
(2016)
Article
Plant Sciences
Andrea E. Glassmire, Christopher S. Jeffrey, Matthew L. Forister, Thomas L. Parchman, Chris C. Nice, Joshua P. Jahner, Joseph S. Wilson, Thomas R. Walla, Lora A. Richards, Angela M. Smilanich, Michael D. Leonard, Colin R. Morrison, Wilmer Simbana, Luis A. Salagaje, Craig D. Dodson, Jim S. Miller, Eric J. Tepe, Santiago Villamarin-Cortez, Lee A. Dyer
Article
Ecology
Joshua P. Jahner, Matthew L. Forister, Thomas L. Parchman, Angela M. Smilanich, James S. Miller, Joseph S. Wilson, Thomas R. Walla, Eric J. Tepe, Lora A. Richards, Mario Alberto Quijano-Abril, Andrea E. Glassmire, Lee A. Dyer
Article
Multidisciplinary Sciences
Carrie L. Branch, Joshua P. Jahner, Dovid Y. Kozlovsky, Thomas L. Parchman, Vladimir V. Pravosudov
ROYAL SOCIETY OPEN SCIENCE
(2017)
Review
Forestry
Thomas L. Parchman, Joshua P. Jahner, Kathryn A. Uckele, Lanie M. Galland, Andrew J. Eckert
TREE GENETICS & GENOMES
(2018)
Article
Multidisciplinary Sciences
Kevin J. Badik, Joshua P. Jahner, Joseph S. Wilson
ROYAL SOCIETY OPEN SCIENCE
(2018)
Review
Chemistry, Multidisciplinary
Lee A. Dyer, Casey S. Philbin, Kaitlin M. Ochsenrider, Lora A. Richards, Tara J. Massad, Angela M. Smilanich, Matthew L. Forister, Thomas L. Parchman, Lanie M. Calland, Paul J. Hurtado, Anne E. Espeset, Andrea E. Classmire, Joshua C. Harrison, Carmen Mo, Su'ad Yoon, Nicholas A. Pardikes, Nadya D. Muchoney, Joshua P. Jahner, Heather L. Slinn, Oren Shelef, Craig D. Dodson, Massuo J. Kato, Lydia F. Yamaguchi, Christopher S. Jeffrey
NATURE REVIEWS CHEMISTRY
(2018)
Article
Evolutionary Biology
Joshua P. Jahner, Marjorie D. Matocq, Jason L. Malaney, Mike Cox, Peregrine Wolff, Mitchell A. Gritts, Thomas L. Parchman
EVOLUTIONARY APPLICATIONS
(2019)
Article
Ecology
Thomas L. Parchman, Pim Edelaar, Kathryn Uckele, Eduardo T. Mezquida, Daniel Alonso, Joshua P. Jahner, Ron W. Summers, Craig W. Benkman
JOURNAL OF EVOLUTIONARY BIOLOGY
(2018)
Article
Multidisciplinary Sciences
Joshua G. Harrison, Zachariah Gompert, James A. Fordyce, C. Alex Buerkle, Rachel Grinstead, Joshua P. Jahner, Scott Mikel, Christopher C. Nice, Aldrin Santamaria, Matthew L. Forister
Article
Biochemistry & Molecular Biology
Joshua P. Jahner, Thomas L. Parchman, Marjorie D. Matocq
Summary: Analysis of genetic data from two ecologically distinct mammals in a hybrid zone in southern California shows that hybrids are rare and consist mostly of F-1 individuals and multigenerational backcrosses. More than half of loci show elevated introgression from one genetic background to the other, although introgression is not associated with measures of divergence and loci with extreme divergence values are not near detoxification enzymes related to woodrat dietary specialization.
Article
Ecology
Kelly B. Klingler, Joshua P. Jahner, Thomas L. Parchman, Chris Ray, Mary M. Peacock
Summary: The study found that pika populations in Nevada exhibit low genetic diversity compared to populations in California and the Rocky Mountains, indicating substantial genetic drift. The genetic differentiation in the region is influenced by geography, elevation, and climate variables, which may interact with anthropogenic climate change to further impact population extinctions in the Great Basin and Sierra Nevada.
BMC ECOLOGY AND EVOLUTION
(2021)
Article
Evolutionary Biology
Andrea E. Glassmire, Joshua P. Jahner, Kevin J. Badik, Matthew L. Forister, Angela M. Smilanich, Lee A. Dyer, Joseph S. Wilson
IDEAS IN ECOLOGY AND EVOLUTION
(2017)