Article
Chemistry, Analytical
Hui Liu, Si-Yu Wang, Jin-Hao Zhu, Jin-Di Xu, Shan-Shan Zhou, Ming Kong, Qian Mao, Song-Li Li, He Zhu
Summary: This study evaluated the impact of sulfur-fumigated ginseng on the overall quality of Si-Jun-Zi decoction (SJZD) using metabolomics and glycomics strategies. The results showed that sulfur-fumigated ginseng altered the composition and quality of SJZD, particularly the non-saccharides and saccharide components.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Oncology
Kun Wang, Yuhan Ding, Chang Xu, Mengdi Hao, Huimin Li, Lei Ding
Summary: In this study, the expression profile of Cldn-7 in inflammatory bowel disease and colitis-associated colorectal cancer was analyzed. Knockout of Cldn-7 gene resulted in intestinal abnormalities, increased susceptibility to colitis and colorectal cancer, disrupted epithelial barrier integrity, and promoted inflammatory cascade, leading to malignant transformation. These findings suggest a key role of Cldn-7 in maintaining intestinal homeostasis and preventing inflammatory bowel disease and consequent colorectal cancer.
Article
Pharmacology & Pharmacy
Yin Zhang, Yi-Chao Fang, Li-Xun Cui, Yue-Tong Jiang, Yu-Sha Luo, Wen Zhang, De-Xun Yu, Jun Wen, Ting-Ting Zhou
Summary: This study analyzed the brain metabolic profile of depressed rats and identified differential metabolites and metabolic pathways related to the antidepressant effect of Zhi-zi-chi decoction. The levels of reactive oxygen species and antioxidant enzymes in the brain were also measured. The results indicate that Zhi-zi-chi decoction has a potential antidepressant effect associated with reversing the imbalance of glutathione and oxidative stress.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Xueyuan Wu, Shu Fu, Miao Jiang, Jing Wang, Huaqiao Tang, Chunlin Fang, Wen Li, Chaomei Fu
Summary: The study demonstrated that SXD significantly reduced DSS-induced colon damage, with the middle dose of 2.6 g/kg showing the best effect. SXD effectively ameliorated DSS-induced UC in mice by inhibiting oxidative stress, protecting the mucosal barrier, inhibiting the TLR4-MyD88-NF-kappa B signaling pathway, and regulating the intestinal flora.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Xueyuan Wu, Shu Fu, Miao Jiang, Jing Wang, Huaqiao Tang, Chunlin Fang, Wen Li, Chaomei Fu
Summary: The study found that Sanhuang Xiexin decoction (SXD) has a therapeutic effect in a mouse model of ulcerative colitis. SXD can alleviate colon damage, reduce inflammatory markers, inhibit oxidative stress, protect the mucosal barrier, and regulate intestinal flora.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Chemistry, Applied
Maiquan Li, Mingzhi Zhu, Wei Quan, Weisu Huang, Xia Liu, Can Zhang, Baiyi Lu, Xing Xiao, Zhonghua Liu
Summary: Acteoside, the main active component in Osmanthus fragrans flower, has high antiaging effect but low absorption rate. Our study confirmed its ability to palliate cognitive impairment by reducing oxidative stress, alleviating intestinal inflammation, restoring intestinal mucosal barrier, rebuilding gut microbiome structure, and upregulating gut microbiome metabolites. Furthermore, antibiotic treatment revealed the essential role of gut microbiota in the attenuation of cognitive impairment of acteoside. Overall, acteoside intake is a promising nutritional intervention for prevention of neurodegenerative diseases.
Article
Cell Biology
Lisa Perruzza, Francesco Strati, Matteo Raneri, Hai Li, Giorgio Gargari, Tanja Rezzonico-Jost, Martina Palatella, Ivo Kwee, Diego Morone, Frauke Seehusen, Paolo Sonego, Claudio Donati, Pietro Franceschi, Andrew J. Macpherson, Simone Guglielmetti, Victor Greiff, Fabio Grassi
Summary: This study demonstrates that hydrolysis of extracellular ATP by apyrase results in amplification of the SIgA repertoire, influencing the distribution of bacteria and gene expression in the intestinal epithelium in mice. Apyrase-induced SIgA improves intestinal homeostasis, attenuating barrier impairment and susceptibility to infection.
Article
Biochemistry & Molecular Biology
Yu Yu, Wenjing Yang, Anthony J. Bilotta, Xiaojing Zhao, Yingzi Cong, Yanqing Li
Summary: The study found that host-derived L-lactate can promote intestinal epithelial cell (IEC) migration by increasing mitochondrial ATP production in IEC, aiding in promoting intestinal wound healing. Additionally, administering mice with L-lactate can suppress colitis induced by dextran sulfate sodium.
Article
Pharmacology & Pharmacy
Xianghui Wen, Yu Lou, Siyue Song, Zhixing He, Juan Chen, Zhijun Xie, Xiaowei Shi, Chengping Wen, Tiejuan Shao
Summary: Qu-zhuo-tong-bi decoction (QZTBD) is an effective traditional Chinese medicine for treating gout, which can reduce uric acid levels and alleviate arthritis symptoms. Research shows that QZTBD works by promoting butyrate-producing bacteria and SCFAs, restoring intestinal barrier function, among other mechanisms.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Physiology
Lingli Ren, Zhengwei Zhang, Wenjing Zhao, Bing Zhao, Xi Chen, Yongxiang Wang, Zhong Chen, Juan Ye, Yang Yang, Peng Cao
Summary: In this study, we found that QCWZD can prevent the occurrence of intestinal tumors by regulating the composition of intestinal microbiota, improving the function of the intestinal barrier, and inhibiting GSDME mediated pyroptosis.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Plant Sciences
Lin Ma, Xin Zhao, Tao Liu, Yu Wang, Jiabao Wang, Lu Kong, Qianru Zhao, Yuru Chen, Lu Chen, Han Zhang
Summary: This study investigated the potential mechanisms of Xuanfei Baidu decoction (XFBD) in treating intestinal disorders associated with COVID-19. The results showed that XFBD attenuated inflammation, remodeled intestinal immunity, and improved intestinal flora, providing a potential therapeutic approach for COVID-19 patients with intestinal symptoms.
Article
Microbiology
Zherui Liu, Yinyin Li, Chen Li, Guanglin Lei, Lin Zhou, Xiangling Chen, Xiaodong Jia, Yinying Lu
Summary: This study found that patients with hepatocellular carcinoma (HCC) had decreased diversity of the gut mycobiome and increased abundance of Candida albicans compared to patients with liver cirrhosis. The colonization of C. albicans in animal models promoted tumor growth and affected plasma metabolome. Furthermore, the expression of NLRP6 in the intestine was increased in the presence of C. albicans. However, C. albicans colonization had no effect on tumor growth in mice lacking NLRP6.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Oncology
Si Qin, Lan-Yue Zhang, Hao-Bin Zhang, Si-Man Shi, Xin Zhou, Zhen-Yu Lu, Yi-Xue Duan, Wen-Bin Huang, Ju Wen
Summary: This study used the Chinese medicine formula Si-Jun-Zi decoction as the research object and employed methods such as data mining and bioinformatics to investigate the characteristics and mechanism of the decoction. Network pharmacology was used to analyze the relationships between the effective compounds of the decoction and specific targets and pathways related to cutaneous squamous cell carcinoma (cSCC). Multiple candidate compounds with multi-target activity were identified.
TRANSLATIONAL CANCER RESEARCH
(2022)
Article
Immunology
Hongyu Zhao, Rufeng Chen, Dongxue Zheng, Feng Xiong, Fan Jia, Jinyuan Liu, Lili Zhang, Nana Zhang, Shiqin Zhu, Yongmei Liu, Linhua Zhao, Xinmin Liu
Summary: This study analyzed the characteristics of the intestinal microbiota in patients with PCOS-IR and explored the mechanism of modified Banxia Xiexin Decoction in treating PCOS-IR. The results showed that PCOS-IR model had an imbalance of intestinal microbiota and Genus Clostridium_sensu_stricto_1 might be the pivotal pathogenic bacteria. Modified Banxia Xiexin Decoction can improve PCOS-IR by regulating the balance of intestinal microbiota.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Lijuan Wang, Ning Zhang, Dianwen Han, Peng Su, Bing Chen, Wenjing Zhao, Ying Liu, Hanwen Zhang, Guohong Hu, Qifeng Yang
Summary: The study revealed that MTDH expression in colonic lamina propria macrophages is correlated with the severity of inflammatory colitis. MTDH-/- mice were protected against DSS-induced colitis, but adoptive transfer of MTDH wild-type monocytes partially restored susceptibility. TLR stimulation induced MTDH expression and absence of MTDH suppressed inflammatory cytokine production by macrophages.
JOURNAL OF CROHNS & COLITIS
(2021)