Article
Pharmacology & Pharmacy
Jin-Sung Park, Euna Kwon, Yun-Soon Kim, Sang-Moo Kim, Dae-Sun Kim, Ja-June Jang, Jun-Won Yun, Byeong-Cheol Kang
Summary: Acer tegmentosum Maxim., known as Manchurian stripe maple, has been traditionally used in folk medicine for its remedial effects. Experimental evidence shows its pharmacological efficacies such as neuroprotective, hepatoprotective, antioxidant, and anti-inflammatory activities, gaining popularity as a health supplement. The study shows that ATWE is safe for systemic toxicity and genotoxicity at tested doses, providing a guideline for safe use in humans.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Veterinary Sciences
Shu-Fang Wan, Quan-Jun Wang, Yong-Biao Guan
Summary: The subacute toxicity studies in rats and beagles demonstrated the safety of Jintiange capsule at doses 66.7 times and 33.3 times the recommended dose, respectively. No apparent overall toxicities including haematotoxicities, hepatotoxicities, and renal toxicities were observed.
VETERINARY MEDICINE AND SCIENCE
(2022)
Article
Environmental Sciences
Touseef Rehan, Anum Tahir, Aneesa Sultan, Khulood Fahad Alabbosh, Shahid Waseem, Mazhar Ul-Islam, Khalid Ali Khan, Essam H. Ibrahim, Muhammad Wajid Ullah, Nasrullah Shah
Summary: This study aimed to mitigate the haematotoxic effects induced by benzene by loading methanolic extracts from Ocimum basilicum, Rosemarinus officinalis, and Thymus vulgaris onto silica nanobeads (SNBs) for targeted delivery in rats.
Article
Medicine, Legal
Chunxia Liu, Ji Liu, Yanhua Zheng, Jingjing Qu, Wenxiang Yang, Xiaoqiao Tang, Hong Bai, Bolin Fan
Summary: This study evaluated the subchronic oral toxicity of rhubarb extract in rats. It was found that doses of 0.65 g/kg BW/day did not cause any toxic related changes, while doses of 1.62 g/kg BW or higher resulted in significant increases in relative organ weight and pathological changes in the kidney. The study concluded that the No Observed Adverse Effect Level (NOAEL) of rhubarb extract in rats is 0.65 g/kg BW/day.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wenyi Li, Chunyan Yang, Xue Mei, Rong Huang, Shipeng Zhang, Yuanyuan Tang, Qiuhong Dong, Chunyang Zhou
Summary: The study found that Allium cepa extract (ACE) reduced levels of total cholesterol, triglycerides, LDL-C, and MDA, while increasing HDL levels and SOD activity in hyperlipidemic rats. ACE also improved liver and aortic arch pathology, as well as increased LDL receptor expression in the liver. These findings suggest that ACE may be a potential non-statin lipid-lowering agent for hyperlipidemia.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Xiaoli Fan, Hengzhi Song, Xiaotian Xu, Xi Lu, Yuhui Wang, Xiaoqun Duan
Summary: The toxicity of sodium p-hydroxybenzoate was evaluated in rats through 90-day repeated oral toxicity experiments according to OECD guidelines. The results showed no adverse effects were observed below a dose of 250 mg/kg body weight per day.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Agricultural Engineering
Haiyue Ji, Bingyue Yang, Yiyao Jing, Yao Luo, Bo Li, Yonggang Yan, Gang Zhang, Fan Zhao, Bangqing Wang, Liang Peng, Benxiang Hu
Summary: In this study, hairy root cultures of Polygala tenuifolia Willd. were established using four strains of Rhizobium rhizogenes. The active ingredients in the hairy roots were detected using HPLC. It was found that polygalacic acid and senegenin can promote the biomass and synthesis of active ingredients in the hairy root cultures. The results suggest that P. tenuifolia hairy root cultures can be used for the production of active constituents in pharmaceutical and nutraceutical fields.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Toxicology
Sasi Kumar Murugan, Bharathi Bethapudi, Amara Nageswara Rao, Joseph Joshua Allan, Deepak Mundkinajeddu, Prashanth D'Souza
Summary: This study evaluated the safety of AP-Bio (R), a standardized extract of Andrographis paniculata, in Sprague Dawley rats. The results showed that AP-Bio (R) did not cause any treatment-related toxicity or mortality in both acute and sub-chronic toxicity studies. The study concluded that AP-Bio (R) is safe for rats at higher pharmacological doses.
JOURNAL OF APPLIED TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Christine M. Madla, Yujia Qin, Francesca K. H. Gavins, Jing Liu, Liu Dou, Mine Orlu, Sudaxshina Murdan, Yang Mai, Abdul W. Basit
Summary: The study demonstrates that Wistar and Sprague Dawley rats have differences in gastrointestinal factors that influence oral drug absorption, particularly in relation to the expression of P-glycoprotein (P-gp). Significant sex differences in P-gp expression were observed in Wistar rats, while Sprague Dawley rats showed no sex differences. In light of these findings, Wistar rats may be a better pre-clinical animal model for studying oral drug absorption of P-gp substrates in both male and female subjects.
Article
Multidisciplinary Sciences
Wenxiang Yang, Ji Liu, Yanhua Zheng, Jingjing Qu, Xiaoqiao Tang, Hong Bai, Chunxia Liu, Bolin Fan
Summary: This study evaluated the safety of rhubarb extract and found that rats exposed to the extract developed gastrointestinal symptoms, decreased body weight, increased food consumption, and showed alterations in urine parameters. Additionally, signs of kidney damage were observed in the rats.
Article
Microbiology
Tracey Bear, Nicole Roy, Julie Dalziel, Chrissie Butts, Jane Coad, Wayne Young, Shanthi G. Parkar, Duncan Hedderley, Hannah Dinnan, Sheridan Martell, Susanne Middlemiss-Kraak, Pramod Gopal
Summary: The relationship between microbiota profile and stress exposure is still unclear. A rat model of unpredictable chronic mild stress (UCMS) was used to investigate this relationship. Female Sprague Dawley rats showed atypical behaviors following UCMS, but no depressive-like behaviors were observed. The relative abundance of taxa from the Clostridiales order and Desulfovibrionaceae family correlated with anxiety-like behaviors and plasma cytokine concentrations, suggesting the brain-to-gut influence of mild anxiety with a microbiota profile that may involve inflammatory pathways.
Article
Biochemistry & Molecular Biology
Kokila Vani Perumal, Nor Liyana Ja'afar, Che Norma Mat Taib, Nurul Husna Shafie, Hasnah Bahari
Summary: This study investigated the anti-obesity effects of Elateriospermum tapos shell extract on obesity-induced rats, showing positive outcomes in reducing body weight, improving lipid profiles, decreasing triglyceride accumulation, and enhancing histopathology analysis. The highest dose of 200 mg/kg exhibited the most effective results compared to lower doses.
Article
Pharmacology & Pharmacy
Aiman Nadhirah Zul Aznal, Nurul Aqmar Mohamad Nor Hazalin, Zurina Hassan, Noorul Hamizah Mat, Nelson Jeng-Yeou Chear, Lay Kek Teh, Mohd Zaki Salleh, Farah Wahida Suhaimi
Summary: This study evaluated the effects of Mitragynine and lyophilised kratom decoction (LKD) on adolescent rats. The results showed that Mitragynine and LKD caused deficits in social behavior and reference memory, which may be associated with changes in brain metabolite profiles.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Edwin K. Jackson, Elizabeth V. Menshikova, Vladimir B. Ritov, Delbert G. Gillespie, Zaichuan Mi
Summary: This study investigates the biosynthesis pathway of 8-aminoguanine and finds that both pathway 1 and pathway 2 contribute to its formation. The increased level of 8-aminoguanine in Dahl rats is associated with the increased production of 8-nitroguanosine.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Veterinary Sciences
Songqing Liu, Xin Deng, Zheng Li, Wenjing Zhou, Gang Wang, Jiasui Zhan, Binhong Hu
Summary: Cadmium exposure disrupts the balance between blood and intestinal flora, leading to an increase in specific gut and blood microbiota. Cd exposure also causes the translocation of certain bacteria from the gut into the blood. Additionally, Cd exposure is associated with changes in serum metabolites.
FRONTIERS IN VETERINARY SCIENCE
(2023)