Article
Infectious Diseases
Mohamed F. Ghaly, Zahraa M. Nasr, Amira I. Abousaty, Hanan G. Seadawy, Mohamed A. A. Shaheen, Sarah Albogami, Mohammad M. Al-Sanea, Mahmoud M. Bendary
Summary: The study found a high prevalence rate of Salmonella in meat products, with most isolates being multidrug-resistant but susceptible to cefotaxime. Out of 13 plant extracts, cinnamon oil and paprika water extract showed antimicrobial activity and synergistic effect with cefotaxime. Therefore, cinnamon oil is recommended as a food additive to combat resistant foodborne pathogens.
Review
Integrative & Complementary Medicine
Jeremy Y. Ng, Vanessa Kishimoto
Summary: This study found that only one third of eligible MS clinical practice guidelines included CAM recommendations. The quality and content of these recommendations varied, with some CPGs being useful for patients and healthcare professionals as a basis for discussing CAM therapies in MS treatment.
COMPLEMENTARY THERAPIES IN MEDICINE
(2021)
Article
Agriculture, Dairy & Animal Science
Anna Bergh, Irene Lund, Anna Bostrom, Heli Hyytiainen, Kjell Asplund
Summary: This study reviewed the scientific literature of 24 different complementary and alternative veterinary medicine (CAVM) therapies used in cats, dogs, and horses, and found that there is insufficient scientific documentation to draw clear conclusions about their clinical effect. The research assessed 42 eligible publications representing nine different CAVM therapies, with varying levels of bias and reported treatment effects. Further research is needed to better understand the efficacy of these CAVM therapies.
Review
Public, Environmental & Occupational Health
Fei-Yi Zhao, Peijie Xu, Gerard A. A. Kennedy, Russell Conduit, Wen-Jing Zhang, Yan-Mei Wang, Qiang-Qiang Fu, Zhen Zheng
Summary: This systematic review aimed to identify and summarize the CAM recommendations associated with insomnia treatment and care from existing comprehensive clinical practice guidelines (CPGs). The findings showed that existing guidelines lack clear recommendations for the use of CAM therapies for insomnia management, and there is a lack of high-quality evidence and multidisciplinary consultation in CPG development. More well-designed studies and interdisciplinary collaboration are urgently needed.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Environmental Sciences
Agnieszka Dawczak-Debicka, Joanna Kufel-Grabowska, Mikolaj Bartoszkiewicz, Adrian Perdyan, Jacek Jassem
Summary: This article reviews the most common unconventional therapies used by cancer patients, highlighting the fear of cancer and limited trust in physicians as important factors leading to their choice of these therapies. Trust and good communication are essential for achieving truthful collaboration between physicians and patients.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Jennifer H. Martin, Joanne Patel
Summary: Complementary and alternative medicine (CAM) includes a variety of therapies that are not commonly used in conventional medicine. In Australia, about two thirds of the population use CAM, but only around half of them discuss it with their doctors. These therapies are often used by patients with life-limiting illness who experience high symptom burden. However, many of these therapies lack demonstrated efficacy for the conditions and symptoms they are used for. There have also been reports of toxicity, adverse effects, batch irregularities, and interactions with other therapies for some CAM products, depending on how they are sold. This, along with the lack of standardization and interchangeability between brands, has made doctors hesitant to support their use. This article provides general pharmacological principles for a small selection of chemicals used in a medical setting to offer guidance for their use.
INTERNAL MEDICINE JOURNAL
(2022)
Review
Medicine, General & Internal
Julien Dubreucq, Astrid M. Kamperman, Nadia Al-Maach, Wichor M. Bramer, Francisca Pacheco, Ana Ganho-Avila, Mijke Lambregtse-van den Berg
Summary: This study aims to conduct an umbrella review of SRs and MAs to assess the association between CATs and reduction of depressive symptoms during pregnancy or after childbirth.
Review
Integrative & Complementary Medicine
Tae-Hun Kim, Sae-Rom Jeon, Jung Won Kang, Sunoh Kwon
Summary: The present study conducted a bibliometric analysis to identify studies on complementary and alternative medicine (CAM) interventions for long COVID and provide an overview of the research status. The analysis revealed that there are few studies published about the use of CAM for long COVID and long-term management for COVID-19 survivors. More original studies, including randomized controlled trials and systematic reviews, are needed to support the evidence for their use in the management of long COVID.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Review
Medicine, General & Internal
Sandeep Arora, Pankaj Das, Gulhima Arora
Summary: Combining different therapies for psoriasis, including newer and conventional agents, based on evidence from literature can improve efficacy and reduce toxicity of higher dosages, providing therapeutic guidelines for better management of the disease.
FRONTIERS IN MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Carlos Moreno, Christopher Haynie, Abigail Cheever, K. Scott Weber
Summary: This article reviews recent advancements in chimeric antigen receptor (CAR) therapies, including modified CARs and CARs applied to different immune cell types. In addition, the application of CAR technology in treating other diseases and conditions is also discussed.
Review
Psychiatry
Jeremy Y. Ng, Archit Jain
Summary: This study evaluated the quantity and quality of CAM recommendations in clinical practice guidelines for the treatment and management of anxiety disorders. The findings suggest a need to improve the quality of CAM recommendations in anxiety CPGs.
PSYCHIATRY RESEARCH
(2022)
Review
Dermatology
Leonel Hidalgo, Cristobal Saldias-Fuentes, Karina Carrasco, Allan C. Halpern, Jun J. Mao, Cristian Navarrete-Dechent
Summary: Complementary and alternative medicine (CAM) is widely used by skin cancer patients, with self-administration rates reaching up to 40%-50% in melanoma. Phytochemicals, particularly Curcumin, have shown promising in vitro efficacy against skin cancer, but there is a lack of human clinical trials supporting CAM effectiveness in skin cancer treatment.
DERMATOLOGIC THERAPY
(2022)
Article
Psychiatry
Fei-Yi Zhao, Peijie Xu, Zhen Zheng, Russell Conduit, Yan Xu, Li-Ping Yue, Hui-Ru Wang, Yan-Mei Wang, Yuan-Xin Li, Chun-Yan Li, Wen-Jing Zhang, Qiang-Qiang Fu, Gerard A. Kennedy
Summary: Background: Complementary and Alternative Medicine (CAM) may be an attractive option for treating depression. Methods: This scientometric analysis examined global research on using CAM for depression treatment and identified hotspots and frontiers. Results: A total of 1,710 publications were analyzed, showing an increasing trend in annual publications. The USA was the leading research center, and most research collaboration was limited within the same country, institution, or research team. The Journal of Alternative and Complementary Medicine was the most productive periodical. Acupuncture and body-mind techniques were the most researched CAM therapies. Inflammation, rating scale, and psychological stress were the recent trending topics. Conclusion: Evidence-based CAM treatment for depression is gaining global attention, with body-mind techniques and acupuncture as research hotspots and emerging trends. Future research may focus on investigating the mechanisms of CAM treatments in reducing depression, particularly in terms of psychological stress and inflammation levels.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Clinical Neurology
Isabelle V. Weld-Blundell, Lisa Grech, Yvonne C. Learmonth, Claudia H. Marck
Summary: Management of multiple sclerosis involves clinical interventions and self-management strategies. Existing guidelines and consensus statements have limitations in guiding lifestyle modifications and complementary therapies. More guidelines specifically for people with multiple sclerosis and improved implementation resources are needed.
ACTA NEUROLOGICA SCANDINAVICA
(2022)
Review
Pharmacology & Pharmacy
Victoria A. Nazarova, Aleksandr V. Sokolov, Vladimir N. Chubarev, Vadim V. Tarasov, Helgi B. Schioeth
Summary: This analytical review provides a quantitative overview of the existing pharmacological and non-pharmacological methods of ADHD treatments investigated in clinical trials during 1999-2021. Non-pharmacological therapies, including behavioral options and devices, were the focus of the majority of studies, while pharmacological treatments accounted for a smaller proportion. The most common drug classes were central nervous system stimulants, selective noradrenaline reuptake inhibitors, and alpha2 adrenergic receptor agonists.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Anesthesiology
Patric Bialas, Claudia Boettge-Wolpers, Mary-Ann Fitzcharles, Sven Gottschling, Dieter Konietzke, Stephanie Juckenhoefel, Albrecht Madlinger, Patrick Welsch, Winfried Haeuser
Summary: There are concerns about the development of cannabis use disorder (CUD) in patients using medical cannabis for chronic pain. The current diagnostic criteria for CUD may not accurately identify patients using cannabis for therapeutic reasons. Alternative strategies are needed to determine the true prevalence of CUD in chronic pain patients treated with medical cannabis. In a study conducted in three German pain centers, the prevalence of CUD in chronic pain patients prescribed medical cannabis was assessed using anonymous questionnaires.
Article
Neurosciences
Luisa Kress, Nadine Egenolf, Claudia Sommer, Nurcan Uceyler
Summary: This study found higher gene expression of the anti-inflammatory cytokines IL-2, IL-8, and TNF in white blood cells of patients with SFN compared to healthy controls. The combination of these three cytokines had high diagnostic accuracy. Furthermore, female patients showed higher gene expression levels of IL-8 and TNF. IL-2 gene expression was negatively correlated with current pain intensity, and IL-10 gene expression differed between different types of pain.
Article
Clinical Neurology
Luise Appeltshauser, Helena Junghof, Julia Messinger, Janis Linke, Axel Haarmann, Ilya Ayzenberg, Panoraia Baka, Johannes Dorst, Anna L. Fisse, Thomas Grueter, Valerie Hauschildt, Alexander Joerk, Frank Leypoldt, Mathias Maeurer, Edgar Meinl, Sebastian Michels, Jeremias Motte, Kalliopi Pitarokoili, Mark Stettner, Carmen Villmann, Marc Weihrauch, Gabriel S. Welte, Inga Zerr, Katrin G. Heinze, Claudia Sommer, Kathrin Doppler
Summary: Autoimmune neuropathy associated with antibodies against pan-neurofascin is a new subtype of nodo-paranodopathy that is associated with high morbidity and mortality. The underlying pathology and long-term prognosis of this condition are not well understood. Understanding the pathogenic mechanism of this disease may have direct implications for its treatment.
Article
Clinical Neurology
Marie Madlener, Christine Strippel, Franziska S. Thaler, Kathrin Doppler, Klaus P. Wandinger, Jan Lewerenz, Marius Ringelstein, Rosa Roessling, Til Menge, Jonathan Wickel, Christoph Kellingshaus, Sigrid Mues, Andrea Kraft, Andreas Linsa, Simone C. Tauber, Florian Then Berg, Stefan T. Gerner, Asterios Paliantonis, Alexander Finke, Josef Priller, Ingo Schirotzek, Marie Suesse, Kurt W. Suehs, Christian Urbanek, Makbule Senel, Claudia Sommer, Tania Kuempfel, Harald Pruess, Gereon R. Fink, Frank Leypoldt, Nico Melzer, Michael P. Malter
Summary: This study investigated 101 patients with suspected autoimmune neurological syndromes (AINS) associated with glutamic acid decarboxylase (GAD) antibodies. The results showed that immunotherapy had moderate effectiveness in these patients, and serum GAD antibody levels and intrathecal GAD antibody synthesis did not predict clinical characteristics or treatment outcomes.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Article
Endocrinology & Metabolism
Jonas Muentze, Kolja Lau, Markus Cybulla, Eva Brand, Tereza Cairns, Lora Lorenz, Nurcan Ueceyler, Claudia Sommer, Christoph Wanner, Peter Nordbeck
Summary: This study investigated therapy adherence and patient-reported outcomes in Fabry disease patients receiving migalastat treatment. The results showed that almost all patients demonstrated high therapy adherence, and there was improvement in pain and physical limitations during the treatment.
MOLECULAR GENETICS AND METABOLISM
(2023)
Article
Rheumatology
Ana Margarida Pinto, Rinie Geenen, Tor D. Wager, Mark A. Lumley, Winfried Hauser, Eva Kosek, Jacob N. Ablin, Kirstine Amris, Jaime Branco, Dan Buskila, Joao Castelhano, Miguel Castelo-Branco, Leslie J. Crofford, Mary-Ann Fitzcharles, Marina Lopez-Sola, Mariana Luis, Tiago Reis Marques, Philip J. Mease, Filipe Palavra, Jamie L. Rhudy, Lucina Q. Uddin, Paula Castilho, Johannes W. G. Jacobs, Jose A. P. da Silva
Summary: This article presents a new model called FITSS (Fibromyalgia: Imbalance of Threat and Soothing Systems), which proposes that an imbalance in emotion regulation, specifically an overactive 'threat' system and underactive 'soothing' system, may contribute to the development of fibromyalgia. This model provides a new perspective for future research and may stimulate the discovery of novel therapeutic interventions.
NATURE REVIEWS RHEUMATOLOGY
(2023)
Letter
Cardiac & Cardiovascular Systems
Caroline Morbach, Aikaterini Papagianni, Sandra Ihne-Schubert, Vladimir Cejka, Maximilian Steinhardt, Georg Fette, Melissa Held, Andreas Geier, Hermann Einsele, Stefan Frantz, Stefan Knop, Claudia Sommer, Stefan Stoerk
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Editorial Material
Clinical Neurology
Didier Leys, Claudia Sommer, Paul Boon
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Patricia Garcia-Fernandez, Colette Reinhold, Nurcan Ueceyler, Claudia Sommer
Summary: Polyneuropathy (PNP) refers to diseases of the peripheral nervous system, with 50% of cases presenting with neuropathic pain. Certain types of PNP show pain restricted to the distal leg skin, indicating a local regulatory process leading to pain. This study suggests that a pro-inflammatory pathway mediated by NF-κB may contribute to pain development in patients with painful PNP. Our findings support the hypothesis of local inflammatory processes involved in pain in PNP, and suggest disrupted anti-inflammatory pathways in inflammatory PNP involving TRPV1 and SIRT1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Nadine Cebulla, Daniel Schirmer, Eva Runau, Leon Flamm, Sonja Gommersbach, Helena Stengel, Xiang Zhou, Hermann Einsele, Ann-Kristin Reinhold, Bruno Rogalla von Bieberstein, Daniel Zeller, Heike Rittner, K. Martin Kortuem, Claudia Sommer
Summary: This study aimed to evaluate the relationship between serum levels of neurofilament light chain (NfL) and the characteristics of BTZ-induced peripheral neuropathy (BIPN). The study found that both patients with ongoing BTZ treatment and patients with previous BTZ treatment had higher serum NfL levels compared to controls, and patients with ongoing BTZ treatment had higher NfL levels than patients with past treatment. Serum NfL levels correlated with electrophysiological measures of axonal damage in the group with ongoing BTZ treatment.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Anastasia Kuzkina, Celine Panzer, Aline Seger, Daniela Schmitt, Jonas Roessle, Sebastian R. Schreglmann, Henrike Knacke, Elena Salabasidou, Antonia Kohl, Elisabeth Sittig, Michael Barbe, Daniela Berg, Jens Volkmann, Claudia Sommer, Wolfgang H. Oertel, Eva Schaeffer, Michael Sommerauer, Annette Janzen, Kathrin Doppler
Summary: The study assessed the use of RT-QuIC method to detect alpha-synuclein aggregation in skin biopsy samples of iRBD patients. It was found that 97.4% of iRBD patients, 87.2% of PD patients, and 13% of controls showed aggregation of alpha-synuclein. RT-QuIC was more sensitive but less specific compared to immunohistochemistry.
MOVEMENT DISORDERS
(2023)
Article
Multidisciplinary Sciences
Jacob N. N. Ablin, Erez Lang, Merav Catalogna, Valerie Aloush, Amir Hadanny, Keren Doenyas-Barak, Shachar Finci, Nir Polak, Gregory Fishlev, Calanit Korin, Rachel Yehudit Tzidky, Oshra Meir Genuth, Shai Efrati
Summary: This study investigated the utility of Hyperbaric Oxygen therapy (HBOT) for fibromyalgia triggered by traumatic brain injury (TBI). The results showed that HBOT significantly reduced pain symptoms, improved quality of life and pain thresholds, and increased brain activity in frontal and parietal regions associated with executive function and emotional processing.
Article
Medicine, General & Internal
Einat Ritter, Eden Shusterman, Lior Prozan, Orli Kehat, Ahuva Weiss Meilik, Oren Shibolet, Jacob Nadav Ablin
Summary: Liver test abnormalities are common in patients with COVID-19 and seasonal respiratory viruses, and are associated with poor clinical outcome. Hepatocellular injury has the greatest prognostic significance 48 h after admission. Failure of liver functions to improve or worsen after 48 h is strongly associated with increased risk of death or ventilation in RSV, COVID-19, and influenza patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Clinical Neurology
Claudia Sommer
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Anesthesiology
Claudia Sommer, Margarita Calvo, Fernando Cervero, John D. Loeser
Summary: The International Association for the Study of Pain has made important contributions to the understanding and treatment of pain through various activities and is committed to reducing the burden of pain worldwide.
