Article
Biochemistry & Molecular Biology
Dong-Jun Lee, Ji-Weon Choi, Ji-Nam Kang, Si-Myung Lee, Gyu-Hwang Park, Chang-Kug Kim
Summary: In this study, a chromosome-scale genome assembly of Platycodon grandiflorum was reported, providing insights into its molecular basis. The genome of P. grandiflorum consists of nine pseudo-chromosomes with a high proportion of repeat sequences, and the expansion of the beta-amylin gene family related to triterpenoid saponin biosynthesis was also identified. This research contributes to the understanding of genome evolution in P. grandiflorum and facilitates genomic-assisted breeding for the production of important components.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Linlin Jiang, Hui Niu, Yuan Chen, Xing Li, Yulian Zhao, Chunhong Zhang, Minhui Li
Summary: Through chemical analysis and quality evaluation of Platycodon grandiflorum from different producing areas, a basis for quality control was provided. In addition, the anti-inflammatory and anti-cancer activities of P. grandiflorum extract under different links were studied, as well as the transfer efficiency of its active components. The results showed that vertical coordination improved the traceability system and regulation of the supply chains.
SCIENTIFIC REPORTS
(2023)
Article
Veterinary Sciences
Yuxiao Xing, Lumei Wang, Guanlong Xu, Shuhua Guo, Meihua Zhang, Guodong Cheng, Yongxia Liu, Jianzhu Liu
Summary: The study showed that PGPSt can reduce PRV replication and inhibit PRV-induced autophagy. Additionally, PGPSt inhibits PRV replication by restoring the Akt/mTOR signaling pathway suppressed by PRV infection. These findings provide insights for the development of antiviral drugs.
RESEARCH IN VETERINARY SCIENCE
(2021)
Article
Plant Sciences
Xinglong Su, Fei Meng, Yingying Liu, Weimin Jiang, Zhaojian Wang, Liping Wu, Xiaohu Guo, Xiaoyan Yao, Jing Wu, Zongping Sun, Liangping Zha, Shuangying Gui, Daiyin Peng, Shihai Xing
Summary: This study identified a beta-glucosidase in Platycodon grandiflorus that can convert platycoside E to platycodin D. The expression level of the enzyme was higher at night than during the day and was regulated by light. These findings are important for further studying the biosynthesis and metabolism regulation of triterpenoid saponins in P. grandiflorus.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Integrative & Complementary Medicine
Qiong Shen, Xiao-Meng Wei, Jun-Nan Hu, Ming-Han Li, Ke Li, Si-Min Qi, Xiang-Xiang Liu, Zi Wang, Wei Li, Ying-Ping Wang
Summary: The study found that saponins from the roots of Platycodon grandiflorum have a protective effect on intestinal injury induced by cisplatin in mice. They can restore the damaged intestinal mucosal oxidative system, improve the loosened junctions of small intestinal villi, mitigate the apoptotic effects caused by cisplatin exposure, and prevent ER stress-induced apoptosis by restoring the activity of the PERK-eIF2 alpha-ATF4 signal transduction pathway.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Zhe Wang, Chunhai Li, Xi He, Kang Xu, Zhipeng Xue, Ting Wang, Zhenshang Xu, Xinli Liu
Summary: The fermented Platycodon grandiflorum root broth showed significant therapeutic effects on ulcerative colitis in mice by regulating inflammatory factors, macrophage polarization, and tight junction protein expression in intestinal epithelial cells. Additionally, it was demonstrated that the broth inhibited the NF-kappa B signaling pathway and NLRP3 inflammasomes by activating AMPK and reducing pro-inflammatory cytokines release.
Article
Multidisciplinary Sciences
Xinglong Su, Yingying Liu, Lu Han, Zhaojian Wang, Mengyang Cao, Liping Wu, Weimin Jiang, Fei Meng, Xiaohu Guo, Nianjun Yu, Shuangying Gui, Shihai Xing, Daiyin Peng
Summary: Platycodin D and platycoside E are two triterpenoid saponins in Platycodon grandiflorus, with distinct differences in content within calli and plant organs. Studies also indicate the potential presence of enzymes converting platycoside E to platycodin D in P. grandiflorus. This research contributes to understanding the biosynthesis of triterpenoid saponins in the plant.
SCIENTIFIC REPORTS
(2021)
Article
Food Science & Technology
Shan Shan, Yi Xiong, Mengyao Liu, Deyong Zeng, Chen Song, Denis Baranenko, Dayou Cheng, Weihong Lu
Summary: A novel polysaccharide fraction named PGPIV-1-a was isolated from Platycodon grandiflorum in this study, showing neutral heteropolysaccharide properties and biological activities. PGPIV-1-a was found to stimulate cell proliferation, enhance phagocytic capacity, and induce the secretion of inflammatory cytokines.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Elodie Beaumont, Vincent Larochette, Laurence Preisser, Charline Miot, Pascale Pignon, Simon Blanchard, Bjorn-Thore Hansen, Jonathan Dauve, Caroline Poli, Minna M. Poranen, Patricia Lamourette, Marc Plaisance, Alain Morel, Helmut Fickenscher, Pascale Jeannin, Philippe Roingeard, Yves Delneste
Summary: IL-26 plays a crucial role in protecting against HCV infection in the liver of patients with chronic hepatitis C, exerting direct antiviral activity by inhibiting viral replication and interfering with RNA polymerase activity.
JOURNAL OF HEPATOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yong-Kyoung Kim, Ramaraj Sathasivam, Yeon Bok Kim, Jae Kwang Kim, Sang Un Park
Summary: The study focused on the expressed sequence tag (EST) library of the methyl jasmonate (MeJA)-treated hairy root of Platycodon grandiflorum, identifying and characterizing four genes related to the terpenoid biosynthetic pathway (TBP). Phylogenetic analysis and pairwise identity matrix revealed the close relationship of these genes to those of other higher plants, with distinct expression patterns in different organs.
Review
Virology
Hui-Chun Li, Chee-Hing Yang, Shih-Yen Lo
Summary: Hepatitis C virus (HCV) infection can lead to the development of chronic liver diseases and other extra-hepatic diseases. HCV relies on host cells for replication and can manipulate host cellular factors to facilitate its replication. Dysregulation of cellular factors, including microRNAs (miRNAs), has been observed during HCV infection. These dysregulated miRNAs can directly or indirectly modulate HCV replication and induce liver diseases. Some dysregulated miRNAs have been identified as biomarkers for the detection of HCV infection and related diseases. This review provides a summary of the identified miRNAs involved in HCV replication and pathogenesis, with a focus on recent developments.
Article
Biochemistry & Molecular Biology
Tai Young Kim, Sangeun Jeon, Youngho Jang, Lizaveta Gotina, Joungha Won, Yeon Ha Ju, Sunpil Kim, Minwoo Wendy Jang, Woojin Won, Mingu Gordon Park, Ae Nim Pae, Sunkyu Han, Seungtaek Kim, C. Justin Lee
Summary: The study shows that platycodin D (PD) effectively blocks SARS-CoV-2 infection routes by preventing membrane fusion through cholesterol redistribution, suggesting a potent natural product for preventing or treating COVID-19.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Editorial Material
Biology
Altaira D. Dearborn, Ashish Kumar, Joseph Marcotrigiano
Summary: A domain in the ORF1 polyprotein of the hepatitis E virus, previously believed to be a protease, is actually a zinc-binding domain.
Article
Microbiology
Rosario Sabariegos, Laura Albentosa-Gonzalez, Blanca Palmero, Pilar Clemente-Casares, Eugenio Ramirez, Carlos Garcia-Crespo, Isabel Gallego, Ana Isabel de avila, Celia Perales, Esteban Domingo, Antonio Mas
Summary: This study identified specific amino acids of the NS5B protein phosphorylated by cellular kinases, which may affect HCV RNA polymerase activity and lead to viral inactivation. Results from RNA transfection experiments with mutant viruses showed that T53E/A and S282E/A mutations had an impact on viral titers.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Linyao Yang, Jiangchao Du, Rongtao Li, Fei Yu, Jindong Zhong
Summary: Seven new triterpenoid saponins, Bodiniosides S-Y, were isolated from the n-BuOH extract of the aerial parts of Elsholtzia bodinieri. Compounds 2 and 5 showed moderate anti-influenza activities against the A/WSN/33/2009 (H1N1) virus.
