Article
Veterinary Sciences
Lakshi A. Dayarathne, Sachithra S. Ranaweera, Premkumar Natraj, Priyanka Rajan, Young Jae Lee, Chang-Hoon Han
Summary: The study revealed that naringenin and naringin inhibit adipogenesis by modulating the expression levels of genes related to lipid metabolism, increasing phosphorylation of AMPK and ACC. These flavonoids have the potential to normalize lipid metabolism-related gene expression levels, demonstrating their anti-adipogenic effects.
JOURNAL OF VETERINARY SCIENCE
(2021)
Article
Agriculture, Multidisciplinary
Md Shamim Rahman, Inseok Kang, Youri Lee, Md Ahasun Habib, Byeong Jo Choi, Jong Soon Kang, Doo-Sang Park, Yong-Sik Kim
Summary: The study demonstrates the role of Bifidobacterium longum subsp. infantis YB0411 in inhibiting adipogenesis by reducing triglyceride accumulation and related gene expression, lowering levels of autophagic markers, and exerting anti-obesity effects through AMP-activated protein kinase. YB supplementation also significantly reduced body weight and fat accretion in mice with high-fat-diet-induced obesity.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Wei Zhao, Jiahui Yang, Xianghong Xie, Chunmei Li, Weihong Zhang, Enhui Chen, Yanfang Guo, Li Yan, Fude Fang, Hong Yao, Xiaojun Liu
Summary: In this study, MX69, an MDM2 inhibitor, was found to promote body weight and white adipose tissue weight in high-fat diet-induced obesity (DIO) mice. MX69 had no effects on glucose tolerance and insulin sensitivity. Additionally, MX69 treatment reduced adipocyte size and fat deposition in adipose tissue and inhibited preadipocyte differentiation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Nutrition & Dietetics
Rawan Nehme, Arthur Chervet, Caroline Decombat, Lucie Longechamp, Adrien Rossary, Rebecca Boutin, Amandine Rousset, Francois Senejoux, Caroline Vachias, Celine Auxenfans, Didier Fraisse, Jean-Baptiste Guyon, Edith Filaire, Jean-Yves Berthon, Mona Diab-Assaf, Laetitia Delort, Florence Caldefie-Chezet
Summary: Polyphenols and flavonoids in Rooibos tea can reduce obesity and inflammation by reducing ROS production and pro-inflammatory cytokine secretion, inhibiting macrophage polarization, and decreasing lipid accumulation and adipogenesis.
Article
Multidisciplinary Sciences
Isabell Kaczmarek, Isabel Wower, Katja Ettig, Christina Katharina Kuhn, Robert Kraft, Kathrin Landgraf, Antje Koerner, Torsten Schoeneberg, Susanne Horn, Doreen Thor
Summary: This study established an interactive public database, FATTLAS, for improved access and analysis of RNA-seq data of mouse and human adipose tissue. Highly expressed and differentially regulated GPCRs were identified by extracting the GPCRome of non-obese and obese individuals. Four receptors (GPR146, MRGPRF, FZD5, PTGER2) were analyzed for their functions in a (pre)adipocyte cell model.
Article
Endocrinology & Metabolism
Ann A. Coulter, Frank L. Greenway, Dachuan Zhang, Sujoy Ghosh, Cathryn R. Coulter, Sarah L. James, Yanlin He, Luke A. Cusimano, Candida J. Rebello
Summary: Naringenin, an activator found in citrus fruits, has beneficial effects on thermogenesis and insulin sensitivity. Our study investigated if carotenoids can enhance the metabolic effects of naringenin on adipocytes. Results showed that beta-carotene acts synergistically with naringenin to improve thermogenesis and glucose metabolism genes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hyeon-Ji Kang, Byong-Keol Min, Won-Il Choi, Jae-Han Jeon, Dong Wook Kim, Sungmi Park, Yun-Kyung Lee, Hwa-jin Kim, Ju-Eun Byeon, Younghoon Go, Hye Jin Ham, Yong Hyun Jeon, Mi-Jin Kim, Jung Yi Lee, Adam R. Wende, Sung Hee Choi, Robert A. Harris, In-Kyu Lee
Summary: The study revealed that PDK1 and PDK2 are novel regulators of adipogenesis and play critical roles in obesity, with deficiencies offering protection against diet-induced obesity in mice. The enzymes play important roles in the development and growth of fat cells, suggesting that targeting PDK enzymes could be a potential approach to combat obesity.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Article
Cell Biology
Gwan-Jun Lee, Youn Ju Kim, Bongju Park, Sujin Yim, Chansang Park, Hyunsoo Roh, Yunwon Moon, Je Kyung Seong, Hyunsung Park
Summary: This study found that adipocytes are primarily responsible for the increase in Wnt5a levels in obesity. Adipocytes in subcutaneous white adipose tissues are more sensitive to high-fat diet and have a positive correlation between cell size and Wnt5a levels. YAP and TAZ activity responds to mechanical changes in hypertrophic adipocytes to promote Wnt5a expression.
CELL DEATH & DISEASE
(2022)
Article
Biotechnology & Applied Microbiology
Shuaipeng Zhu, Binbin Zhang, Tingqi Zhu, Dongxue Wang, Cong Liu, Yixuan Liu, Yuehua He, Wenjie Liang, Wenting Li, Ruili Han, Donghua Li, Fengbin Yan, Yadong Tian, Guoxi Li, Xiangtao Kang, Zhuanjian Li, Ruirui Jiang, Guirong Sun
Summary: miR-128-3p inhibits intramuscular adipocyte differentiation in chickens by downregulating FDPS. The study provides a theoretical basis for the study of lipid metabolism and identifies a potential target for molecular breeding to improve meat quality.
Article
Endocrinology & Metabolism
Innocence Harvey, Jacqueline M. Stephens
Summary: This study found that Artemisia scoparia extract (SCO) can attenuate glucocorticoid-induced lipolysis independently of glucocorticoid receptor (GR) activity.
Article
Medicine, Research & Experimental
Benjarat Janson, Janjira Prasomthong, Wachirawadee Malakul, Tantip Boonsong, Sakara Tunsophon
Summary: This study demonstrated that roselle extract can reduce body weight, food intake, lipid profiles, inflammatory cytokines, lipid peroxidation, serum leptin, insulin, and duodenal glucose absorption, while significantly increasing glucose uptake of adipose tissue and muscle compared to a high-fat diet group. Roselle can prevent lipid accumulation by suppressing differentiation of 3T3-L1 adipocyte through downregulating adipogenic gene expression, providing an alternative approach for preventing obesity-related insulin resistance.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Pere Bibiloni, Catalina A. Pomar, Andreu Palou, Juana Sanchez, Francisca Serra
Summary: Elevated miR-222 levels are linked to metabolic syndrome, insulin resistance, and diabetes. Rats fed an obesogenic diet during lactation have higher miR-222 content in breast milk, leading to increased body fat mass and impaired insulin sensitivity in their offspring. Transfection experiments with miR-222 mimics or inhibitors on 3T3-L1 preadipocytes reveal that miR-222 plays a role in pathways related to insulin signaling, lipid metabolism, and adipogenesis.
Article
Biochemical Research Methods
Nina Compera, Scott Atwell, Johannes Wirth, Christine von Toerne, Stefanie M. Hauck, Matthias Meier
Summary: This study developed a microfluidic chip platform to simulate adipose tissue in vitro and revealed the differences in adipocytes under low/high glucose conditions using proteomics analysis. This in vitro model can be used to investigate the molecular and functional mechanisms of adipose tissue under normal and pathological conditions.
Article
Pharmacology & Pharmacy
Ji Young Je, Jae Eun Park, Youngwan Seo, Ji Sook Han
Summary: This study demonstrated that HM-chromanone extracted from Portulaca oleracea L. inhibits adipocyte differentiation and adipogenesis in 3T3-L1 cells by regulating adipogenic transcription factors and activating AMPK. The results suggest that HM-chromanone may be a potential anti-adipogenesis agent that targets adipogenic transcription factors.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Antonio Casado-Diaz, Angel Rodriguez-Ramos, Barbara Torrecillas-Baena, Gabriel Dorado, Jose Manuel Quesada-Gomez, Maria Angeles Galvez-Moreno
Summary: Study found that phloretin can inhibit human adipogenesis by increasing beta-catenin and inducing apoptosis in adipocytes during late differentiation. This suggests the potential of phloretin-rich foods for clinical use and regenerative-medicine applications to combat obesity and prevent bone-marrow adiposity.