Article
Chemistry, Medicinal
Wen Xu, Jiaying Li, Dongli Li, Junfeng Tan, Hang Ma, Yu Mu, Yan Wen, Lishe Gan, Xueshi Huang, Liya Li
Summary: Clinacanthus nutans, a medicinal herb consumed traditionally in Asia, has been found to contain compounds with potential anticancer and antifungal activities. The cycloartane triterpenoids and megastigmanes isolated from C. nutans showed moderate anti-proliferative effects and induced apoptosis in HepG2 cells, as well as enhanced the anti-Candida albicans activity of amphotericin B. These findings provide insight into the relationship between the chemical constituents of C. nutans and its health beneficial effects, supporting further pharmaceutical applications of this medicinal plant.
Article
Environmental Sciences
Noor Zafirah Ismail, Salwani Md Saad, Ismail Abiola Adebayo, Zaleha Md Toha, Rafedah Abas, Nur Nadhirah Mohamad Zain, Hasni Arsad
Summary: This study found that Clinacanthus nutans dichloromethane fraction (SF2) extract can induce apoptosis in MCF7 cells through both intrinsic and extrinsic pathways. SF2 extract significantly inhibited MCF7 cell proliferation and upregulated the expression of P53, BAX, BID, caspase-8, caspase-9, and caspase-3, while downregulating the expression of BCL2. This suggests that SF2 extract has the potential to be effective against breast cancer.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Food Science & Technology
Martin Samuel Hernandez-Zazueta, Joel Said Garcia-Romo, Luis Noguera-Artiaga, Ivan Luzardo-Ocampo, Angel Antonio Carbonell-Barrachina, Pablo Taboada-Antelo, Rocio Campos-Vega, Ema Carina Rosas-Burgos, Maria Guadalupe Burboa-Zazueta, Josafat Marina Ezquerra-Brauer, Juan Manuel Martinez-Soto, Hisila del Carmen Santacruz-Ortega, Armando Burgos-Hernandez
Summary: O. vulgaris ink, particularly the dichloromethane extract, demonstrates potential health benefits such as antimutagenic, cytoprotective, and antiproliferative effects on human cancer cell lines. The discovery of a novel compound in the purified fractions highlights the promising bioactivity of understudied marine natural products like OI, which may have implications for cancer prevention and treatment. Further research is needed to explore the mechanisms and health benefits of OI at different levels of investigation.
JOURNAL OF FOOD SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Weng Kit Ban, Isabel Lim Fong, Heng Yen Khong, Joyce Hui Yie Phung
Summary: Clinacanthus nutans and Strobilanthes crispus have multiple beneficial properties, including antimicrobial and wound healing activities. Strobilanthes crispus exhibits superior antimicrobial and wound healing activities.
Article
Biochemistry & Molecular Biology
Katerina Spyridopoulou, Sotiris Kyriakou, Angeliki Nomikou, Angelos Roupas, Antreas Ermogenous, Katerina Karamanoli, Daniela Moyankova, Dimitar Djilianov, Alex Galanis, Mihalis I. Panayiotidis, Aglaia Pappa
Summary: This study extracted aqueous and ethanolic extracts from the leaves of the Balkan endemic plant Haberlea rhodopensis, finding that the ethanolic extract exhibited stronger inhibitory effects on human cancer cells and contained more antioxidant compounds, demonstrating potential anticancer properties.
Article
Biochemistry & Molecular Biology
Kai Song Ng, Sheri-Ann Tan, Chui Yin Bok, Khye Er Loh, Intan Safinar Ismail, Chen Son Yue, Chui Fung Loke
Summary: Antioxidants, particularly from Clinacanthus nutans leaves, show potential in preventing liver cancer in NAFLD patients. The study identified strong radical scavenging and reducing power properties in CNL compared to CNS, with the presence of specific metabolites contributing to antioxidant and hepatoprotective abilities. HepG2 cell model further supported the effectiveness of CNL in reducing ROS levels and protecting liver cells from oxidative stress.
Article
Biochemistry & Molecular Biology
Manel Ouerfelli, Isidoro Meton, Idoia Codina-Torrella, Maria Pilar Almajano
Summary: Anthyllis vulneraria extracts are rich in phenolic compounds, exhibit potent radical scavenging activity, and demonstrate antitumor effects against various cancer cell lines.
Article
Multidisciplinary Sciences
Micaela Giani, Yoel Genaro Montoyo-Pujol, Gloria Peiro, Rosa Maria Martinez-Espinosa
Summary: Oxidative stress is linked to neoplasia, but antioxidants can help prevent it. In this study, the cytotoxic effect of BRCE from Haloferax mediterranei on breast cancer cell lines was evaluated. The results showed that BRCE selectively affected breast cancer cells, particularly triple-negative subtypes, and also had an impact on cell size.
SCIENTIFIC REPORTS
(2023)
Article
Agricultural Engineering
Kogilavanee Devasvaran, Batoul Alallam, Vuanghao Lim
Summary: This study aimed to evaluate the optimal method for extracting crude polysaccharides from Clinacanthus nutans leaves (CNP) as natural antioxidants. Five different extraction methods were compared, and the alkaline and ultrasound-assisted methods were found to be the most effective, with the highest extraction yield and antioxidant properties. The total phenolic content (TPC) was directly related to antioxidant activity, with the freeze-thaw method showing the highest TPC. The extraction method played a significant role in determining the antioxidant properties of CNP extracts. These findings have implications for the food industry, which has a high demand for natural antioxidants for food preservation and enhancement.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Integrative & Complementary Medicine
Nur Mazidah Haji Noor Mohamed, Vuanghao Lim, Rafeezul Mohamed, Ida Shazrina Ismail
Summary: C. nutans extracts have immunomodulatory effects on macrophage cellular response, downregulating pro-inflammatory cytokine production and stimulating phagocytic function.
JOURNAL OF HERBAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Fariza Juliana Nordin, Lishantini Pearanpan, Kok Meng Chan, Endang Kumolosasi, Yoke Keong Yong, Khozirah Shaari, Nor Fadilah Rajab
Summary: Clinacanthus nutans (CN) extracts did not show cytotoxic effects on MDA-MB-231 and THP-1 cells, but exhibited potential in ameliorating chronic inflammation in the tumor microenvironment of breast cancer. Further studies are needed to fully understand the underlying mechanisms of CN in cooling the inflamed TME in breast cancer.
Article
Biochemistry & Molecular Biology
Esra Eroglu Ozkan, Mehmet Fatih Seyhan, Ozlem Kurt Sirin, Tugba Yilmaz- Ozden, Ezgi Ersoy, Seda Damla Hatipoglu Cakmar, Ahmet Ceyhan Goren, Hulya Yilmaz Aydogan, Oguz Ozturk
Summary: This study evaluated the antioxidant and cytotoxic effects of eight commercially valuable pomegranate cultivars from Turkey on breast cancer cells. The extract from cultivar P7 demonstrated the strongest cytotoxic activity against MCF-7 breast cancer cell lines. These cultivars have potential to be used as natural antioxidant and anticancer agents.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Zaleha Md Toha, Nor Hasyimah Haron, Nik Nur Syazni Nik Mohamed Kamal, Melati Khairuddean, Hasni Arsad
Summary: The study showed that different solvent extracts of C. nutans leaves have antiproliferative and survival effects on breast cancer cells, with dichloromethane extract exhibiting the strongest antiproliferative properties. Furthermore, CNDCM extract significantly induced apoptosis in different cell cycle phases.
FUTURE JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Lei Xiong, Na Deng, Bisheng Zheng, Tong Li, Rui Hai Liu
Summary: The study found that Lycium ruthenicum Murr. (LRM) exhibited stronger antioxidant activity compared to Lycium barbarum L. (LB), while LB showed weaker induction of cell apoptosis. Both varieties activated the proliferation-related p53 signaling pathway, but LB had a weaker antiproliferative effect. This suggests that LRM and LB may have different potential in managing cancer cell proliferation and improving human health.
Article
Biochemistry & Molecular Biology
Feng Qin, Cai Yi Wang, Chun-Gu Wang, Yao Chen, Jin-Jun Li, Mei-Shan Li, Yan-Kui Zhu, Sang Kook Lee, Heng-Shan Wang
Summary: Several previously unknown alkaloids were isolated from Zanthoxylum nitidum, a plant with potential medicinal properties. One of these alkaloids showed significant anti-cancer activity by inhibiting proliferation and migration of cancer cells.
Article
Agriculture, Multidisciplinary
Eng Huan Hau, Soek Sin Teh, Siok Koon Yeo, Siau Hui Mah
Summary: The study explored the physicochemical and functional properties of protein hydrolysates from oil palm leaves, finding that PH extracted with 8% Alcalase exhibited superior functional properties and could serve as an alternative plant protein in the food industry.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Chemistry, Applied
Harrison Lik Nang Lau, Yi Shen Tee, Mieow Kee Chan, Soek Sin Teh
Summary: This study found that refining palm-pressed mesocarp fiber oil with 0.05 wt.% of phosphoric acid through wet degumming can reduce phosphorus and free fatty acid content while retaining key phytonutrients. Therefore, this method provides a new resource of nutritious oil.
JOURNAL OF OLEO SCIENCE
(2022)
Article
Food Science & Technology
Azka Ainun Nisaa, Chern-Ein Oon, Sasidharan Sreenivasan, Venugopal Balakrishnan, Jun Jie Tan, Cindy Shuan-Ju Teh, Salina Sany, Svetoslav Dimitrov Todorov, Guoxia Liu, Yong-Ha Park, Min-Tze Liong
Summary: The aim of this study was to investigate the immunological and antimicrobial properties of breast milk in pregnant women with or without vaginal yeast infections. The study found that concentrations of IL-10, IgA, IgM, IgG, EGF, and TGF-alpha were similar in both groups. However, breast milk from women in the W-group who were below 31 years old had a higher concentration of EGF compared to the WO-group. Additionally, breast milk from the WO-group exhibited higher anti-Candida properties. Correlation analysis showed that the concentration of TGF-alpha in breast milk positively correlated with the concentrations of IL-10 and IgA in the W-group. These findings suggest that while breast milk from women with vaginal infections during pregnancy may not hinder Candida growth, other immuno-modulatory bioactives may compensate for this protective effect.
FOOD SCIENCE AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Medicinal
Ka Woong Wong, Soek Sin Teh, Kung Pui Law, Intan Safinar Ismail, Kohei Sato, Nobuyuki Mase, Siau Hui Mah
Summary: Oxidative stress and inflammation are critical in the development of various diseases. In this study, novel compounds with strong antioxidant and anti-inflammatory properties were synthesized, and a specific substituent was found to play a key role in their activities. Compound 4b was identified as a potential lead compound for further drug development.
ARCHIV DER PHARMAZIE
(2023)
Review
Chemistry, Medicinal
Mansab Ali Saleemi, Noorfatimah Yahaya, Nur Nadhirah Mohamad Zain, Muggundha Raoov, Yoke Keong Yong, Nurul Shahfiza Noor, Vuanghao Lim
Summary: The development of new antibiotics is urgently needed to combat bacterial resistance. Cannabis extracts containing cannabinoids have potential antimicrobial properties, and combination therapy with different antibiotics may result in synergistic effects and broad-spectrum activity.
Article
Chemistry, Applied
Vincentsia Vienna Vanessa, Soek Sin Teh, Kok Wai Lam, Siau Hui Mah
Summary: This study synthesized 1,3-dihydroxyxanthone and its derivatives with different groups at C3 position, and investigated their inhibition of AChE activity. Some of these derivatives showed strong inhibitory activity, and molecular docking study revealed their binding mechanism with AChE. These derivatives have the potential to be developed as lead compounds for Alzheimer's disease drugs.
NATURAL PRODUCT RESEARCH
(2023)
Article
Plant Sciences
Natalie Vivien Gunter, Soek Sin Teh, Ibrahim Jantan, Carlos Leonardo Cespedes-Acuna, Siau Hui Mah
Summary: Cancers such as breast, colon, and lung cancers have shown alarming increases in the number of new diagnoses and mortality rates. Non-specific toxicity limits the use of current chemotherapy drugs, necessitating the development of new agents such as xanthones. Prenylated xanthones have demonstrated cytotoxic activity against cancer cells and potential as anticancer drugs, but further studies are required to establish their effectiveness and safety.
PHYTOCHEMISTRY REVIEWS
(2023)
Article
Energy & Fuels
Eng Huan Hau, Soek Sin Teh, Siok Koon Yeo, Bee Lin Chua, Amorn Owatworakit, Jianbo Xiao, Siau Hui Mah
Summary: Protein hydrolysate extracted from oil palm leaves exhibits good physicochemical and functional properties, making it a potential functional food for improving nutritional value and food properties.
BIOMASS CONVERSION AND BIOREFINERY
(2022)
Correction
Energy & Fuels
Eng Huan Hau, Soek Sin Teh, Siok Koon Yeo, Bee Lin Chua, Amorn Owatworakit, Jianbo Xiao, Siau Hui Mah
BIOMASS CONVERSION AND BIOREFINERY
(2023)
Article
Biochemistry & Molecular Biology
Tharani Subarmaniam, Rusydatul Nabila Mahmad Rusli, Kokila Vani Perumal, Yoke Keong Yong, Siti Hadizah, Fezah Othman, Khaled Salem, Nurul Husna Shafie, Rosnani Hasham, Khoo Boon Yin, Khairul Kamilah Abdul Kadir, Hasnah Bahari, Zainul Amiruddin Zakaria
Summary: This study examines the chemopreventive impact of Andrographis paniculata ethanolic extract (APEE) against high-fat diet and 1,2-dimethylhydrazine-induced colon cancer in rats. The results show that APEE improves the dysplastic state of the colon tissue and reduces aberrant crypt foci, while also having anti-obesity and anti-cancer potential.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Ain Nabila Syahira Shamsol Azman, Jun Jie Tan, Muhammad Nazrul Hakim Abdullah, Hasnah Bahari, Vuanghao Lim, Yoke Keong Yong
Summary: This study utilized network pharmacology to assess the potential pharmacological effects of bioactive compounds in Tualang honey on atherosclerosis. The results showed that 6 compounds in Tualang honey had potential therapeutic effects on atherosclerosis, supporting its use as a promising treatment for the disease.
Article
Food Science & Technology
Azka Ainun Nisaa, Chern-Ein Oon, Sasidharan Sreenivasan, Venugopal Balakrishnan, Deepa Rajendran, Jun-Jie Tan, Fatin Fazrina Roslan, Svetoslav Dimitrov Todorov, Woo-Sik Jeong, Feiyan Zhao, Nur Syafiqah Mohamad Nasir, Zakuan Zainy Deris, Heping Zhang, Yong-Ha Park, Guoxia Liu, Min-Tze Liong
Summary: We compared the microbiota profiles of breast milk from women with and without vaginal yeast infection during pregnancy. Breast milk from women with vaginal yeast infection exhibited higher alpha diversity across different taxonomic levels. The composition of breast milk from the two groups showed marginal differences at certain taxonomic levels. Our findings suggest that vaginal infection during pregnancy may affect breast milk composition, but it may not pose a threat to infant growth and development.
PREVENTIVE NUTRITION AND FOOD SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Li Wen Pang, Sharina Hamzah, Sui Ling Janet Tan, Siau Hui Mah, Hui Yin Yow
Summary: Xanthones are natural compounds with potential neuroprotective effects on Alzheimer's disease (AD). This study aimed to review the effects and mechanisms of xanthones in cell culture and animal studies, revealing their roles in AD. The results showed that xanthones exhibited anti-cholinesterase activity, neuroprotective effects, and reduced neuronal inflammation. They also modulated signaling pathways and suppressed endoplasmic reticulum stress. However, there is still limited understanding of the underlying mechanisms of xanthones in AD. Further studies are needed to explore their full potential.
NEUROCHEMICAL RESEARCH
(2023)
