Article
Cell Biology
Chunwei Jiao, Hao Yun, Huijia Liang, Xiaodong Lian, Shunxian Li, Jiaming Chen, Javeria Qadir, Burton B. Yang, Yizhen Xie
Summary: The study showed that Ganoderma lucidum spore oil (GLSO) significantly promoted cell proliferation and burn wound healing, potentially through the TRPV1/SMAD signaling pathway.
Article
Polymer Science
Wei-Lun Qiu, Wei-Hung Hsu, Shu-Ming Tsao, Ai-Jung Tseng, Zhi-Hu Lin, Wei-Jyun Hua, Hsin Yeh, Tzu-En Lin, Chien-Chang Chen, Li-Sheng Chen, Tung-Yi Lin
Summary: The study investigated the effects of WSG, a polysaccharide from Ganoderma lucidum, in combination with cisplatin on lung cancer treatment. It found that WSG enhanced the inhibitory effect of cisplatin on tumor growth and metastasis in mice, as well as increased their survival rate. Additionally, WSG reduced the cytotoxic effects of cisplatin on macrophages and normal lung fibroblasts.
Article
Plant Sciences
Wenshuai Wang, Yaohan Zhang, Zhiying Wang, Jianjun Zhang, Le Jia
Summary: This study investigated the protective effects of Ganoderma lucidum polysaccharides (GLP) on high-fat diet-induced hyperlipidemia and explored the underlying mechanism. The results showed that GLP decreased body weight gain, reduced lipid levels, alleviated tissue injury, and improved oxidative stress and inflammation response. GLP also modulated bile acids synthesis, lipid regulatory factors, and promoted reverse cholesterol transport.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
M. A. Oke, F. J. Afolabi, O. O. Oyeleke, T. A. Kilani, A. R. Adeosun, A. A. Olanbiwoninu, E. A. Adebayo
Summary: Ganoderma lucidum, also known as Lingzhi, is a medicinal mushroom used in traditional medicine for various health benefits. It contains a wide range of bioactive compounds, including triterpenoids and polysaccharides, which have been shown to possess numerous pharmacological activities. Studies have demonstrated the potential of Ganoderma lucidum in disease prevention and treatment, leading to the development of various formulations and products.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Applied
Shaodan Chen, Xiaoying Guan, Tianqiao Yong, Xiong Gao, Chun Xiao, Yizhen Xie, Diling Chen, Huiping Hu, Qingping Wu
Summary: In this study, Ganoderma lucidum crude polysaccharide (GLP) was found to have a protective effect on liver damage caused by restraint stress in mice by improving oxidative status. Two polysaccharides, including a neutral beta-glucan (GLPB2) and an acidic beta-glucan (GLPC2), were purified from GLP. GLPC2 exhibited a stronger hepatoprotective effect compared to GLPB2. The findings provide a theoretical basis for the potential application of G. lucidum polysaccharides as hepatoprotective agents in the food and pharmaceutical industry.
Article
Biochemistry & Molecular Biology
Jiaqi Jiao, Tianqiao Yong, Longhua Huang, Shaodan Chen, Chun Xiao, Qingping Wu, Huiping Hu, Yizhen Xie, Xiangmin Li, Yuancao Liu, Manjun Cai, Ruifang Zhang, Ting Xie, Rongjie Liu
Summary: In this paper, we revealed the hypoglycemic effect of Ganoderma lucidium polysaccharide F31, which showed efficacies between 45 and 54%, approaching that of liraglutide (52%). F31 reduced body weight gains and food intakes, protected kidney function, promoted apoptosis in epididymal fat, and induced early apoptosis in 3 T3-L1 preadipocyte cells. Molecular docking showed a possible cross-talk between kidney and epididymal fat through the glycerophosphorylcholine-Bax axis. Overall, F31 alleviated hyperglycemia through kidney protection and adipocyte apoptosis in db/db mice, providing novel insights into the hypoglycemic activity of polysaccharides.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Fatma Kubra Tombulturk, Zeynep Gizem Todurga-Seven, Onder Huseyinbas, Sibel Ozyazgan, Turgut Ulutin, Gonul Kanigur-Sultuybek
Summary: The research found that topical application of metformin accelerates wound healing by suppressing NF-kappa B p65 activity and diminishing the expression of MMP2 and MMP9. Diabetic wounds treated with metformin healed even faster than those in the control group that mimicked standard wound healing.
MOLECULAR BIOLOGY REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Fang Kou, Yunfei Ge, Weihao Wang, Yuxia Mei, Longkui Cao, Xuetuan Wei, Hang Xiao, Xian Wu
Summary: Ganoderma lucidum polysaccharides have unique functional properties and various processing technologies have been used to improve their yield and utilization. This review summarizes the structure and health benefits of G. lucidum polysaccharides, and discusses factors that may affect their quality, including chemical modifications. These modifications improve the physicochemical characteristics and utilization of G. lucidum polysaccharides, making them more stable and suitable for encapsulating active substances. Ultimately, G. lucidum polysaccharide-based nanoparticles are designed to deliver functional ingredients for better health-promoting effects.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Organic
Zhiyuan Chen, Guozhi Xiao
Summary: The highly branched tetradecasaccharide repeating unit and shorter sequences of GLSWA-1 from Ganoderma lucidum, which possess immune-enhancing activities, were prepared using a one-pot glycan assembly strategy that features orthogonal one-pot glycosylation, one-pot assembly of oligosaccharides, and modular and convergent [4+5+5] assembly of the highly branched tetradecasaccharide.
Article
Biochemistry & Molecular Biology
Fabia Judice Marques Viroel, Leticia Favara Laurino, Erika Leao Ajala Caetano, Angela Faustino Jozala, Sara Rosicler Vieira Spim, Thaisa Borim Pickler, Michelle Klein Sercundes, Marcela C. Gomes, Alessandre Hataka, Denise Grotto, Marli Gerenutti
Summary: The consumption of Ganoderma lucidum, a type of mushroom, has positive effects on gestational diabetes mellitus (GDM) and maternal-fetal health. Ganoderma lucidum contains various bioactive compounds that can regulate blood glucose and be used in anti-cancer therapy.
Article
Plant Sciences
Eva Sanchez-Hernandez, Ana Teixeira, Catarina Pereira, Adriana Cruz, Jesus Martin-Gil, Rui Oliveira, Pablo Martin-Ramos
Summary: This study investigated the chemical composition of an ammonia extract from Ganoderma lucidum and its potential as an antimicrobial. The extract contained several chemical compounds, and when conjugated with chitosan oligomers, it showed enhanced antimicrobial activity against plant pathogens. These findings suggest that the extract could be a valuable resource for protecting oak trees.
Article
Multidisciplinary Sciences
He Li, Yawei Du, Hanrui Ji, Yanan Yang, Changchang Xu, Qiaodan Li, Longkai Ran, Chongming Wu, Qile Zhou, Shengxian Wu
Summary: The adenosine extract from Ganoderma lucidum (AEGL) was found to have lipid-lowering effects on hyperlipidemic mice, significantly reducing serum cholesterol and triglyceride levels, improving hepatic steatosis without causing liver or kidney damage. Regulating the expression and acetylation/crotonylation of proteins involved in the PPAR signaling pathway may be one of the potential mechanisms behind the lipid-lowering effects of AEGL.
Article
Biochemistry & Molecular Biology
Chiara Migone, Noemi Scacciati, Brunella Grassiri, Marinella De Leo, Alessandra Braca, Dario Puppi, Ylenia Zambito, Anna Maria Piras
Summary: Jellyfishes are considered as a potential resource in the food, pharmaceutical and biomedical industries. In this study, jellyfish skin polysaccharides (JSP) with glycosaminoglycan (GAG) features were extracted and evaluated for their potential as wound healing promoters and antioxidants. The results showed that the JSPs were effective in promoting scratch repair and protecting cells from oxidative stress. These GAG-like polysaccharides have potential applications in biomedical skin treatments and as pharmaceutical excipients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Mohamadmahdi Samandari, Fariba Aghabaglou, Kristo Nuutila, Hossein Derakhshandeh, Yuteng Zhang, Yori Endo, Seth Harris, Lindsay Barnum, Craig Kreikemeier-Bower, Elmira Arab-Tehrany, Nicholas A. Peppas, Indranil Sinha, Ali Tamayol
Summary: Insufficient vascularization is a major obstacle to normal wound healing, but delivery of angiogenic factors like VEGF can modestly improve healing. Specialty delivery systems, such as MNAs and LJIs, play a crucial role in controlling drug distribution and enhancing wound healing. The effectiveness of these delivery systems has been confirmed both in vitro and in vivo, showing enhanced angiogenesis and accelerated wound healing.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Pharmacology & Pharmacy
Darija Cor Andrejc, Zeljko Knez, Masa Knez Marevci
Summary: Ganoderma lucidum is a medicinal mushroom with various biologically active compounds that have antioxidant, antitumor, anti-inflammatory properties.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Nurul Anisa Mat Yunan, Tan Yee Shin, Vikineswary Sabaratnam
Summary: This study demonstrated the utilization of lignocellulolytic enzymes from spent mushroom substrate for the hydrolysis of palm oil mill effluent, leading to the production of biohydrogen gas. Enzyme activities and productivities were analyzed, and optimized conditions resulted in high reducing sugar yield and biohydrogen gas production. The results show that enzymes from spent mushroom substrate can effectively hydrolyze POME, showcasing their potential for environmental remediation in the palm oil industry.
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Food Science & Technology
Kian Aun Chang, Han Ni Kow, Tzia-E Tan, Kiat Liang Tan, Lye Yee Chew, Yun Ping Neo, Vikineswary Sabaratnam
Summary: This study evaluated the effect of different cooking methods on the phenolic acids and antioxidant activity in Hericium erinaceus, with stir-frying demonstrating the best retention of gallic acid and receiving the most favorable sensory response.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Oncology
Meng-Fei Lau, Kek-Heng Chua, Vikineswary Sabaratnam, Umah Rani Kuppusamy
Summary: The study revealed that fractions from Ganoderma neo-japonicum have therapeutic potential in managing hyperglycemia-associated colorectal cancer (CRC). The hexane and chloroform fractions stimulated NO production and induced cell cycle arrest, with the apoptotic effects of hexane fraction being dependent on glucose levels. Overall, the fractions show promising effects in treating CRC associated with high glucose levels.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2022)
Article
Chemistry, Medicinal
Nor Athirah Kamaliah Ahmad Tarmizi, Naufal Kushairi, Chia Wei Phan, Vikineswary Sabaratnam, Murali Naidu, Pamela David
Summary: This study found that beta-glucan-rich Pleurotus pulmonarius (beta gPp) can alleviate the impact of high-fat diet on mouse neurobehavior and hippocampus, as well as promote hippocampus development in maternal mice and their male offspring.
JOURNAL OF MEDICINAL FOOD
(2022)
Article
Agricultural Engineering
Win Yee Lim, Eric Wei Chiang Chan, Chia Wei Phan, Chen Wai Wong
Summary: This study developed a stable formulation using flaxseed oil and partially purified extract from Hibiscus tiliaceus, and evaluated its physicochemical properties, microbial quality, storage stability, safety, and bioactivities. The results showed that the formulation had significant whitening effects and maintained good quality during storage.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Integrative & Complementary Medicine
Win Yee Lim, Eric Wei Chiang Chan, Chia Wei Phan, Chen Wai Wong
Summary: The study found that friedelin isolated from Hibiscus tiliaceus leaves has the ability to inhibit tyrosinase and melanogenesis. This is the first report of friedelin exhibiting these effects in vitro and in cells, as well as its synergy with minor compounds from the same fraction.
EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE
(2022)
Article
Food Science & Technology
Chuan Xiong, Yu Zhu, Qiang Luo, Chia Wei Phan, Yujie Huo, Ping Li, Qiang Li, Xin Jin, Wenli Huang
Summary: Oxidative stress is a leading cause of Parkinson's disease, and a novel peptide (LRP) extracted from Lignosus rhinocerotis has been found to have neuroprotective effects. LRP improves cell viability, enhances the activity of antioxidative enzymes, reduces oxidative damage, inhibits cell apoptosis, and decreases the activation of Parkinson's disease-related proteins.
FOOD SCIENCE & NUTRITION
(2023)
Review
Geriatrics & Gerontology
Yasaaswini Apparoo, Chia Wei Phan, Umah Rani Kuppusamy, Vikneswary Sabaratnam
Summary: Healthy ageing is crucial for lifespan quality. An antioxidant-rich diet and ergothioneine (EGT) can help prevent age-related diseases and improve health.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Food Science & Technology
Weiyi Chu, Chia Wei Phan, Seng Joe Lim, Abdul Salam Babji
Summary: Edible bird's nest (EBN) has been found to be beneficial against neurodegenerative diseases, with antioxidative, anti-inflammatory, and anti-apoptotic properties that preserve and repair neuronal cells.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Ethics
Wan Ping Ng, Khong Yun Pang, Pei Boon Ooi, Chia Wei Phan
Summary: This study investigated the knowledge, awareness, and acceptance of research misconduct among Pharmacy academics and students in Malaysia. A cross-sectional study using an online questionnaire was conducted with 393 participants. The findings suggest that awareness of terminologies regarding research misconduct is positively related to perceived research misconduct, while acceptance of unethical practices in research is negatively correlated. However, knowledge and awareness of research misconduct do not significantly predict perceived research misconduct. The study highlights the need for further research to explore other factors contributing to research misconduct among Pharmacy academics and students in Malaysia.
JOURNAL OF ACADEMIC ETHICS
(2023)
Review
Dentistry, Oral Surgery & Medicine
Yoon Xuan Liew, Kathreena Kadir, Chia Wei Phan, Kok Hoong Leong, Thomas George Kallarakkal, Wanninayake Mudiyanselage Tilakaratne
Summary: This study systematically reviewed the potential of salivary biomarkers as diagnostic tools for oral squamous cell carcinoma and oral leukoplakia. Most studies suggest that single or multiple salivary biomarkers have the potential to serve as accurate diagnostic tools for these diseases, but further validation and the establishment of standardized saliva collection methods are needed.
Review
Ethics
Teong Win Zee, Mohammad Firdaus Bin Abdul Aziz, Phan Chia Wei
Summary: This study aims to explore the development of human genomics research in Malaysia in relation to ethical issues. The researchers and research ethics committee members expressed concerns over the absence of a clear ethical and regulatory framework at the national level, but the study suggests that international guidelines and training can help ensure the ethical development of genomics research.
DEVELOPING WORLD BIOETHICS
(2023)
Article
Information Science & Library Science
Siau-Ting Keng, Pei -Boon Ooi, Khong-Yun Pang, Chia -Wei Phan
Summary: As scholarly communication increasingly moves online, it is necessary to improve evaluation methods of research impact. Limited studies have focused on the familiarity and usage of research metrics among academics. This study investigated the relationship between awareness, familiarity, and usage of research metrics among academics in Malaysia, finding that familiarity is the only predictor associated with usage.
MALAYSIAN JOURNAL OF LIBRARY & INFORMATION SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Jason Kar Seng Tang, Chia Wei Phan, Yee Shin Tan, Vikineswary Sabaratnam, Jaya Seelan Sathiya Seelan, Mohamad Hasnul Bolhassan
Summary: This study assessed the most significant publications and trends in the field of mushroom poisoning research. The United States was found to be the largest contributor, while China emerged as a leader in recent years.
INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS
(2022)
Article
Parasitology
W. X. Ang, S. Sarasvathy, U. R. Kuppusamy, V Sabaratnam, S. H. Tan, K. T. Wong, D. Perera, K. C. Ong
Summary: Hand, foot and mouth disease (HFMD) is a highly contagious viral disease that predominantly affects children under 5 years old, caused by enteroviruses. A medicinal mushroom called Ganoderma neo-japonicum Imazeki (GNJI) has shown broad-spectrum antiviral activity against enteroviruses that cause HFMD, potentially serving as a candidate for the development of antiviral drugs targeting HFMD.
TROPICAL BIOMEDICINE
(2021)