Article
Chemistry, Medicinal
Yuanyuan Zhong, Bin Wang, Wenjing Chen, Hongying Zhang, Jing Sun, Jingcheng Dong
Summary: This study investigated the effectiveness and mechanisms of action of modified Bu-Shen-Yi-Qi decoction (MBSYQ) in the treatment of osteoporosis associated with chronic obstructive pulmonary disease (COPD). The results showed that MBSYQ improved lung pathology and bone loss, and activated the MAPK and PI3K/AKT pathways while improving oxygen metabolism. This suggests that MBSYQ has potential for prevention and treatment of COPD-related osteoporosis.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Plant Sciences
Lu Zhang, Ling-Ling Wang, Hao Zeng, Bin Li, Hua Yang, Guang-Ji Wang, Ping Li
Summary: The study found that long-term CDDP treatment has prolonged and stable efficacy against AMI. Compared with short-term treatment, it specifically regulates purine and taurine and hypotaurine metabolism and systematically corrects metabolic disorders.
Article
Clinical Neurology
Yap-Hang Chan, C. Mary Schooling, Jie Zhao, Shiu-Lun Au Yeung, Jo Jo Hai, G. Neil Thomas, Kar-Keung Cheng, Chao-Qiang Jiang, Yuen-Kwun Wong, Ka-Wing Au, Clara S. Tang, Chloe Y. Y. Cheung, Aimin Xu, Pak-Chung Sham, Tai-Hing Lam, Karen Siu-Ling Lam, Hung-Fat Tse
Summary: The study demonstrated through Mendelian randomization that vitamin D has a protective effect on the recurrence of ischemic vascular events in individuals with prior ischemic stroke or myocardial infarction. The genetic risk score predicted improved event-free survival from recurrent ischemic stroke or MI, supporting a causal relationship between genetically predicted lower vitamin D levels and the recurrence of ischemic vascular events.
Article
Cardiac & Cardiovascular Systems
Han Fu, Linrui Wang, Shuo Ying, Zhicheng Zhao, Peng Zhang
Summary: This study aimed to investigate the effectiveness of Compound Danshen dripping pills (CDDP) in preventing contrast-induced nephropathy (CIN) after coronary stent implantation. The study enrolled 411 patients who received CDDP and hydration therapy or hydration only. The results showed that the CIN incidence was significantly lower in the CDDP group. Inflammatory response and oxidative stress may play a significant role in the mechanism of CDDP.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Zhe Liang, Qi Chen, Ruiqi Wei, Chenyao Ma, Xuehui Zhang, Xue Chen, Fang Fang, Quanming Zhao
Summary: Alirocumab is not cost-effective in the general MI population in China at its current discounted price, but shows potential health benefits in patients with polyvascular disease in three vascular beds. Reducing the annual cost of alirocumab may improve its cost-effectiveness.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Aihua Liu, Jing Sun, Sagun Tiwari, John Wong, Honglin Wang, Dongxu Tang, Zhenxiang Han
Summary: This study aimed to evaluate the therapeutic efficacy of Bu-Shen-Yi-Qi granule (BSYQG) in the neurovascular unit (NVU) and its mechanism of action on thrombin expression in a cerebral ischemic/reperfusion (I/R) model. The results showed that BSYQG significantly reduced neuronal apoptosis and thrombin expression in the NVU after I/R injury. These findings provide a foundation for further research on the treatment of ischemic stroke.
Article
Plant Sciences
Jingjing Qin, Tulake Wuniqiemu, Ying Wei, Fangzhou Teng, Jie Cui, Jing Sun, La Yi, Weifeng Tang, Xueyi Zhu, Weifang Xu, Jingcheng Dong
Summary: This study evaluated the therapeutic efficacy of JWBSYQF in an asthma mouse model and identified the targeted proteins and functional pathways associated with its treatment.
Article
Cardiac & Cardiovascular Systems
Anete Kaldal, Serena Tonstad, Jarle Jortveit
Summary: In the field of secondary prevention of cardiovascular events, long-term hospital-based follow-up has shown improvement in composite endpoint-free survival compared to follow-up at primary health care, but did not reduce all-cause mortality significantly. Some important risk factors remain unaddressed despite the beneficial effects on blood pressure and LDL-cholesterol disappearing after annual consultations ceased.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Medicine, General & Internal
Ju Hyeon Kim, Jung-Joon Cha, Subin Lim, Jungseok An, Mi-Na Kim, Soon Jun Hong, Hyung Joon Joo, Jae Hyoung Park, Cheol Woong Yu, Do-Sun Lim, Kyeongmin Byeon, Sang-Wook Kim, Eun-Seok Shin, Kwang Soo Cha, Jei Keon Chae, Youngkeun Ahn, Myung Ho Jeong, Tae Hoon Ahn
Summary: This study aimed to investigate recurrent adverse events in post-myocardial infarction patients. The results showed that achieving target LDL-C levels in acute myocardial infarction patients was associated with a lower incidence and reduced hazard of recurrent clinical events, highlighting the need to improve LDL-C level management in real-world settings.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biophysics
Dillon J. Dzikowicz, Mary G. Carey
Summary: In the United States, approximately 720,000 adults experience myocardial infarction (MI) annually. The 12-lead electrocardiogram (ECG) is crucial for classifying MI. ST-segment elevation on the 12-lead ECG is present in about 30% of MIs and is classified as STEMI that urgently requires intervention. However, the remaining 70% of MIs, called NSTEMI, lack ST-segment elevation and exhibit various changes on the 12-lead ECG. Among NSTEMI cases, 33% actually have occlusion of the culprit artery, leading to similar myocardial damage and worse outcomes compared to NSTEMI without occlusion.
PHYSIOLOGICAL MEASUREMENT
(2023)
Article
Cardiac & Cardiovascular Systems
Adam C. Livori, Zanfina Ademi, Jenni Ilomaki, Derk Pol, Jedidiah Morton, J. Simon Bell
Summary: There is no clinically significant relationship between remoteness and the use of secondary prevention medications among myocardial infarction patients in Victoria, Australia.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Integrative & Complementary Medicine
Yu-jie Wu, Bo Deng, Si-bo Wang, Rui Qiao, Xi-wen Zhang, Yuan Lu, Li Wang, Shun-zhong Gu, Yu-qing Zhang, Kai-qiao Li, Zong-liang Yu, Li-xing Wu, Sheng-biao Zhao, Shuang-lin Zhou, Yang Yang, Lian-sheng Wang
Summary: This study aims to evaluate the efficacy and safety of CDDP in improving ventricular remodeling and cardiac function after AAMI.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Clara K. Chow, Harry Klimis, Aravinda Thiagalingam, Julie Redfern, Graham S. Hillis, David Brieger, John Atherton, Ravinay Bhindi, Derek P. Chew, Nicholas Collins, Michael Andrew Fitzpatrick, Craig Juergens, Nadarajah Kangaharan, Andrew Maiorana, Michele McGrady, Rohan Poulter, Pratap Shetty, Jonathon Waites, Christian Hamilton Craig, Peter Thompson, Sandrine Stepien, Amy Von Huben, Anthony Rodgers
Summary: A text message-based program did not improve medication adherence after acute coronary syndrome, but had small effects on lifestyle risk factors.
Article
Integrative & Complementary Medicine
Yuanyuan Zhong, Lingli Hu, Wenjing Chen, Bin Wang, Jing Sun, Jingcheng Dong
Summary: The study identified common therapeutic targets for asthma and IPF, with many overlapping proteins falling into the same statistically significant GO terms. The active ingredients of BSYQ decoction were found to regulate common pathological processes in asthma and IPF, such as inflammation response, cytokine production, leukocyte differentiation, and oxygen level response.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
Article
Cardiac & Cardiovascular Systems
Annette Marie Maznyczka, Peter McCartney, Patrycja Duklas, Margaret McEntegart, Keith G. Oldroyd, John P. Greenwood, Douglas Muir, Saqib Chowdhary, Anthony H. Gershlick, Clare Appleby, Hany Eteiba, James Cotton, Andrew Wragg, Nick Curzen, R. Campbell Tait, Peter MacFarlane, Paul Welsh, Naveed Sattar, Mark C. Petrie, Ian Ford, Keith A. A. Fox, Alex McConnachie, Colin Berry
Summary: This study evaluated the effects of intracoronary alteplase on persistently impaired culprit artery flow during primary percutaneous coronary intervention. The results showed that in patients with TIMI flow <= 2 pre-drug, alteplase was associated with increased risk of microvascular obstruction and myocardial hemorrhage.
Correction
Cell Biology
Ning Kang, Jun-feng Jian, Shi-jie Cao, Qiang Zhang, Yi-wei Mao, Yi-yuan Huang, Yan-fei Peng, Feng Qiu, Xiu-mei Gao
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Danni Wang, Jiaming Guo, Xin Chai, Jing Yang, Yuefei Wang, Xiumei Gao
Summary: This study focused on the dynamic variations of compounds in Psoralea corylifolia during its growth, storage, and treatment by different temperatures. It successfully established a method for the simultaneous determination of nine compounds and identified the characteristics of compounds' variation in different parts of the plant. The results demonstrated that compounds' transformation arising from the growth, processing, and storage of Psoralea corylifolia are critical factors to ensure the quality of Fructus Psoraleae.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Plant Sciences
Hui Na Cao, Jing Ya Ruan, Yu Han, Wei Zhao, Ying Zhang, Chang Gao, Hong Hua Wu, Lin Ma, Xiu Mei Gao, Yi Zhang, Tao Wang
Summary: The flavonoid glycosides from A. wilsonii seeds exhibit anti-inflammatory effects by inhibiting the release of nitric oxide through multiple signaling pathways.
Article
Biochemical Research Methods
Dongxue Zhao, Meiyu Liu, He Sun, Xiaoyan Xu, Simiao Wang, Hongda Wang, Xue Li, Meiting Jiang, Boxue Chen, Yuying Zhao, Xiumei Gao, Wenzhi Yang
Summary: Addressing chemical complexity is crucial in various research fields. The integration of multidimensional chromatography and mass spectrometry enables comprehensive characterization of herbal metabolites. In this study, a three-dimensional liquid chromatography system combined with quadrupole time-of-flight mass spectrometry was used to fully characterize the metabolome of two Astragalus species. By utilizing an in-house library and reference standards, a total of 513 compounds from the Astragalus species were identified. This approach allows for in-depth characterization of herbal metabolites.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Plant Sciences
Xiaoyan Qin, Qiu Wei, Ran An, Yun Yang, Mingqi Cai, Xiaoling Han, Haoping Mao, Xiumei Gao
Summary: This study investigates the anti-osteoporotic effects of an ethanol extract of FLL in ovariectomized mice and explores the underlying mechanism. The results show that FLL prevents bone loss and improves bone microstructure by modulating bone and fat balance, suggesting its potential as a therapeutic agent for postmenopausal osteoporosis.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Cell Biology
Jingyu Ni, Hao Zhang, Xiaodan Wang, Zhihao Liu, Tong Nie, Lan Li, Jing Su, Yan Zhu, Chuanrui Ma, Yuting Huang, Jingyuan Mao, Xiumei Gao, Guanwei Fan
Summary: This study reveals that 2-hydroxyisobutyrylation is an essential protein translational modification that regulates the activity of the pyruvate dehydrogenase complex (PDHc) and has an impact on cardiac hypertrophy. Ginsenoside Rg3 can reduce 2-hydroxyisobutyrylation levels and restore PDH activity by inhibiting the activity of P300, suggesting a potential therapeutic effect for reversing myocardial hypertrophy.
CELL DEATH & DISEASE
(2022)
Article
Pharmacology & Pharmacy
Zhihao Liu, Xiaozhi Liu, Li Liu, Ying Wang, Jie Zheng, Lan Li, Sheng Li, Han Zhang, Jingyu Ni, Chuanrui Ma, Xiumei Gao, Xiyun Bian, Guanwei Fan
Summary: SUMOylation is a dynamic post-translational modification that maintains cardiac function and protects against hypertrophic response in the heart. The role of SUMO1 in myocardial infarction (MI) and the molecular details of heart cell responses to SUMO1 deficiency were investigated in this study. SUMO1 knockout worsened systolic dysfunction and infarct size after myocardial injury, and its loss promoted proliferation of endothelial cell subsets with angiogenic potential.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2023)
Article
Pharmacology & Pharmacy
Bin Lv, Jinhe Guo, Yaodong Du, Yang Chen, Xin Zhao, Bin Yu, Jiarui Liu, Tianyi Cui, Haoping Mao, Xiaoying Wang, Xiumei Gao
Summary: Respiratory diseases, such as acute lung injury (ALI), have become a global health problem. The excessive activation and recruitment of immunocytes in the lungs, as well as the release of cytokines, are considered the primary causes of ALI. However, the cellular mechanisms involved in ALI remain unknown. Therefore, new therapeutic strategies need to be developed to control inflammation and prevent the worsening of ALI.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Plant Sciences
Yang Liu, Rui Shao, Tongchuan Suo, Junjie Zhu, Erwei Liu, Yajing Wang, Lin Miao, Xiumei Gao
Summary: In this study, the effect of DZQE on inflammation-related benign prostatic hyperplasia (BPH) was investigated. The results showed that DZQE can significantly inhibit prostate enlargement and decrease the inflammation index. Furthermore, DZQE was found to suppress inflammation-associated BPH by regulating the ERK1/2 signal through its active components, Tan IIA and Ba.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Microbiology
Xinqin Zhong, Yucui Zhao, Lu Huang, Jiarui Liu, Kaiyue Wang, Xiumei Gao, Xin Zhao, Xiaoying Wang
Summary: In this study, it was demonstrated that L. johnsonii protects cardiac function, delays cardiac pathology, and improves gut barrier integrity by remodeling the gut microbiome. The beneficial effects of L. johnsonii on cardiac function post-AMI were abrogated by microbiome dysbiosis caused by antibiotics. The enrichment of L. johnsonii reshapes the gut microbiome by increasing the abundance of Muribaculaceae, Lactobacillus, and decreasing Romboutsia, Clostridia UCG-014, which are correlated with cardiac traits and serum metabolic biomarkers.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Lan Li, Jiasong Cao, Sheng Li, Tianyi Cui, Jingyu Ni, Han Zhang, Yan Zhu, Jingyuan Mao, Xiumei Gao, Adam C. Midgley, Meifeng Zhu, Guanwei Fan
Summary: Tissue-resident cardiac macrophage subsets play important roles in cardiac tissue inflammation and repair after acute myocardial infarction (AMI). CC chemokine receptor 2 (CCR2)-expressing macrophages recruit circulating monocytes to infarcted myocardium and promote inflammation. However, small extracellular vesicles (sEV) derived from CCR2 macrophages, which resemble M2-polarized macrophages, have anti-inflammatory effects and contribute to cardiac repair.
Article
Chemistry, Medicinal
Yuxing Huang, Erwei Liu, Xuhua Huang, Jia Hao, Siyuan Hu, Xiumei Gao
Summary: The study investigated the pharmacokinetic properties of Eucommia ulmoides and Psoralea corylifolia in rats. It was found that the combined administration of the two herbs could affect the exposure of the main components of Eucommia ulmoides extract in rats due to altered intestinal absorption. This research provides guidance for the simultaneous clinical administration of Eucommia ulmoides and Psoralea corylifolia.
CHINESE HERBAL MEDICINES
(2023)
Article
Biochemical Research Methods
Xiaoyan Xu, Meiting Jiang, Xiaohang Li, Yu Wang, Meiyu Liu, Hongda Wang, Yueguang Mi, Boxue Chen, Xiumei Gao, Wenzhi Yang
Summary: We propose the concept of a three-dimensional characteristic chromatogram (3D CC) and use it to authenticate various ginseng products through online comprehensive two-dimensional liquid chromatography (LC x LC) technology. By analyzing the stereo peaks and shade depth in the 3D CC, it is feasible to identify and distinguish different ginseng species and Chinese patent medicines. This provides a practical solution for the accurate identification of easily confused traditional Chinese medicines (TCMs).
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Plant Sciences
Benyu Liu, Shiming Fang, Kun Zhou, Lulu Ma, Yaling Shi, Yuefei Wang, Xiumei Gao
Summary: This study aimed to reveal the hepatotoxicity distinction of coumarin-related compounds from glycosides to aglycones in Fructus Psoraleae (FP) and elucidate their potential mechanism. The results showed that P, IP, FA, and IFA were identified as hepatotoxic compounds, while their glycosides were almost non-hepatotoxic. The conversion from glycosides to aglycones played an essential role in FP-induced hepatotoxicity.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Integrative & Complementary Medicine
Xiumei Gao, Chenyan Wang, Yong Ni, Huiling Zhang
Summary: This study aimed to observe the clinical efficacy of acupuncture along fascia, meridians, and nerves combined with ultrasound-guided nerve blockage in the treatment of postherpetic neuralgia. The results showed that the combination treatment was more effective than ultrasound-guided nerve blockage alone.
JOURNAL OF TRADITIONAL CHINESE MEDICINE
(2023)
