Article
Medicine, Research & Experimental
Yarong Liu, Aiwei Song, Hongfei Wu, Yin Sun, Min Dai
Summary: Paeonol induces autophagy in VSMCs by activating the III class PI3K/Beclin-1 signaling pathway, ultimately inhibiting VSMCs apoptosis.
Review
Biotechnology & Applied Microbiology
Laura Locatelli, Sara Castiglioni, Jeanette A. M. Maier
Summary: This review article discusses the effects of space environment on the human vasculature and the adaptive responses activated in such conditions. The study suggests that oxidative stress and mitochondrial dysfunction might be mediators of vascular alterations in space. Understanding the cellular and molecular mechanisms involved in these adaptive processes could provide insights for designing proper countermeasures for space exploration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jiayan Liu, Tao Mi, Zhaoxia Zhang, Liming Jin, Maoxian Li, Chenghao Zhanghuang, Mujie Li, Jinkui Wang, Xin Wu, Zhaoying Wang, Xiaojun Tan, Zhang Wang, Dawei He
Summary: Malignant rhabdoid tumor of the kidney (MRTK) has a poor prognosis and is unresponsive to radiotherapy and chemotherapy. In this study, BKM120 was identified as a potential therapeutic agent for MRTK by inhibiting the PI3K/Akt signaling pathway to induce cell apoptosis and cycle arrest. Both in vitro and in vivo experiments confirmed the inhibitory effects of BKM120 on MRTK.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wangsheng Jiang, Wenfeng Ruan, Zhengqiang Wang
Summary: This study found that Dendrobium officinale polysaccharide (DOP) can alleviate vascular calcification in patients with chronic kidney disease (CKD) by suppressing inflammation and apoptosis through the activation of heme oxygenase-1 (HMOX-1). These results provide a promising treatment approach for vascular calcification in CKD.
Article
Biochemistry & Molecular Biology
Zhou Cai, Xin He, Shuai Liu, Yang Bai, Baihong Pan, Kemin Wu
Summary: NR6A1 is involved in promoting VSMC apoptosis in atherosclerosis by activating RIPK3 and caspases, while LUBAC inhibits NR6A1 expression and attenuates caspase activity, thereby preventing VSMC apoptosis.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Craig K. Docherty, Anastasiya Strembitska, Christa P. Baker, Fiona F. Schmidt, Kieran Reay, John R. Mercer
Summary: This study reveals the important role of the antiageing protein Klotho in atherosclerotic plaques, improving vascular smooth muscle cell phenotype and mediating energetic switching, which delays the consequences of plaque rupture and enhances cell survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Shubhnita Singh, Ariane Bruder-Nascimento, Eric J. Belin de Chantemele, Thiago Bruder-Nascimento
Summary: The study demonstrates that CCL5 activates Nox1 in the vasculature, leading to vascular injury likely via NFkB and Erk1/2 pathways. CCR5 antagonists and Nox1 inhibitors are suggested as potential compounds to reduce cardiovascular risk associated with medical procedures and vascular diseases.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Christine Veith, Ipek Varturk-Ozcan, Magdalena Wujak, Stefan Hadzic, Cheng-Yu Wu, Fenja Knoepp, Simone Kraut, Aleksandar Petrovic, Marija Gredic, Oleg Pak, Monika Brosien, Marie Heimbrodt, Jochen Wilhelm, Friederike C. Weisel, Kathrin Malkmus, Katharina Schaefer, Henning Gall, Khodr Tello, Djuro Kosanovic, Akylbek Sydykov, Akpay Sarybaev, Andreas Guenther, Ralf P. Brandes, Werner Seeger, Friedrich Grimminger, Hossein A. Ghofrani, Ralph T. Schermuly, Grazyna Kwapiszewska, Natascha Sommer, Norbert Weissmann
Summary: This study provides evidence for the involvement of SPARC in the pathogenesis of human PH and chronic hypoxia-induced PH in mice, most likely by affecting vascular cell function.
Article
Biochemistry & Molecular Biology
Jia-feng Tang, Guo-li Li, Tao Zhang, Yu-mei Du, Shi-ying Huang, Jian-hua Ran, Jing Li, Di-long Chen
Summary: In this study, it was found that HHT effectively inhibits the proliferation of melanoma cells by inducing DNA damage, apoptosis, and cell cycle arrest. Both in vitro and in vivo experiments confirmed the inhibitory effect of HHT on melanoma, providing evidence for its potential as an anti-melanoma agent.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Cardiac & Cardiovascular Systems
Yong Wang, Yiming Xu, Siyuan Yan, Kaixiang Cao, Xianqiu Zeng, Yaqi Zhou, Zhiping Liu, Qiuhua Yang, Yue Pan, Xiaoling Wang, Detlev Boison, Yunchao Su, Xuejun Jiang, Vijay S. Patel, David Fulton, Neal L. Weintraub, Yuqing Huo
Summary: The study reveals a novel mechanism by which ADK promotes VSMC proliferation via inducing aberrant DNA hypermethylation, down-regulating KLF4 expression and promoting neointima formation. The findings suggest the possibility of targeting ADK as an epigenetic modulator to combat vascular injury.
CARDIOVASCULAR RESEARCH
(2021)
Article
Hematology
Yanan Guo, Zhihan Tang, Binjie Yan, Hao Yin, Shi Tai, Juan Peng, Yuting Cui, Yu Gui, Darrell Belke, Shenghua Zhou, Xi-Long Zheng
Summary: This study reveals the direct effects of PCSK9 on vascular smooth muscle cells and highlights its significance in degenerative vascular diseases.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Transplantation
Aoran Huang, Tianhua Xu, Xiaomei Lu, Ling Ma, Haiying Ma, Yanqiu Yu, Li Yao
Summary: This study found that Shh inhibits the development of vascular calcification by interacting with Gli2 and promoting the degradation of Runx2. Therefore, Shh may be a novel potential target for the treatment of vascular calcification.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Biochemistry & Molecular Biology
Fangyuan Jia, Rui Ji, Gang Qiao, Zhigang Sun, Xiaosan Chen, Zhidong Zhang
Summary: Recent studies have shown that bitter taste receptors play a role in regulating various cellular processes. This study found that the bitter taste receptor activator amarogentin (AMA) can inhibit the proliferation and migration of vascular smooth muscle cells (VSMCs) by activating the AMPK signaling pathway, thereby attenuating neointimal hyperplasia. This highlights the potential of AMA as a new drug candidate for the treatment of neointimal hyperplasia.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Ioana Alesutan, Trang T. D. Luong, Nadeshda Schelski, Jaber Masyout, Susanne Hille, Markus P. Schneider, Delyth Graham, Daniel Zickler, Nicolas Verheyen, Misael Estepa, Andreas Pasch, Winfried Maerz, Andreas Tomaschitz, Stefan Pilz, Norbert Frey, Florian Lang, Christian Delles, Oliver J. Mueller, Burkert Pieske, Kai-Uwe Eckardt, Juergen Scherberich, Jakob Voelkl
Summary: The study found that uromodulin can reduce vascular calcification in CKD patients, possibly by interfering with cytokine-dependent pro-calcific signaling pathways. In CKD, decreased levels and carbamylation of uromodulin may contribute to vascular pathology.
CARDIOVASCULAR RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Hong-yu Zhong, Chong Yuan, Xiao-lin Liu, Qian-qian Wang, Xiao Li, Ya-chao Zhao, Xuan Li, Dong-dong Liu, Teng-fei Zheng, Mei Zhang
Summary: This study reveals that mechanical stretch downregulates EZH2 through the YAP-TEAD1 pathway, thereby aggravating smooth muscle cell apoptosis and vascular remodeling.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2022)
Review
Nanoscience & Nanotechnology
Heshu Sulaiman Rahman, Hemn Hassan Othman, Nahidah Ibrahim Hammadi, Swee Keong Yeap, Kawa Mohammad Amin, Nozlena Abdul Samad, Noorjahan Banu Alitheen
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2020)
Article
Integrative & Complementary Medicine
Nur Sumirah Mohd Dom, Nurshieren Yahaya, Zainah Adam, Nik Mohd Afizan Nik Abd Rahman, Muhajir Hamid
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2020)
Article
Biology
Zhi Xiong Chong, Swee Keong Yeap, Wan Yong Ho
Summary: miRNAs play important roles in regulating the response of breast cancer cells to radiotherapy, with some miRNAs playing key roles in mediating radio-responses.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
F. H. Tan, J. C. Kong, J. F. Ng, N. B. Alitheen, C. L. Wong, C. Y. Yong, K. W. Lee
Summary: The study successfully displayed a 10-residue peptide on the surface of TYMVcHis(6) VLPs, showing high stability under different pH and temperature conditions, and the ability to reassemble into VLPs after chemical denaturation.
JOURNAL OF APPLIED MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Swee Keong Yeap, Norlaily Mohd Ali, Muhammad Nadeem Akhtar, Nursyamirah Abd Razak, Zhi Xiong Chong, Wan Yong Ho, Lily Boo, Seema Zareen, Tonni Agustiono Kurniawan, Ram Avtar, Stephanie Y. L. Ng, Alan Han Kiat Ong, Noorjahan Banu Alitheen
Summary: BHMC exhibits selective cytotoxic effects on ER positive MCF-7 cells, promoting G2/M cell cycle arrest and apoptosis. It involves dysregulation of various miRNAs such as miR-3195, miR-30a-3p, miR-6813-5p, and miR-6132, as well as downregulation of tumor-promoting genes like VEGF and SNAIL in MCF-7 cells.
Review
Multidisciplinary Sciences
Zhi Xiong Chong, Swee Keong Yeap, Wan Yong Ho
Summary: Transfection is a powerful method used to insert foreign nucleic acids into eukaryotic cells, enabling the study of normal cellular processes, disease mechanisms, and gene therapy effects. This review compares different transfection methods, nucleic acid types, controls, and efficiency assessment approaches, providing researchers with options for choosing the appropriate transfection strategy for their experimental goals.
Review
Pathology
Zhi Xiong Chong, Winnie Pui Pui Liew, Hui Kian Ong, Chean Yeah Yong, Chong Seng Shit, Wan Yong Ho, Stephanie Y. L. Ng, Swee Keong Yeap
Summary: MERS-CoV and SARS-CoV-2 are two common betacoronaviruses, with MERS-CoV causing sporadic transmission and SARS-CoV-2 causing a global pandemic. Different diagnostic methods such as clinical evaluation, laboratory diagnosis, and radiological diagnosis can be used to screen and confirm infections of these coronaviruses.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Review
Food Science & Technology
Nor Farahin Azizi, Muganti Rajah Kumar, Swee Keong Yeap, Janna Ong Abdullah, Melati Khalid, Abdul Rahman Omar, Mohd Azuraidi Osman, Sharifah Alawieyah Syed Mortadza, Noorjahan Banu Alitheen
Summary: Kefir is a fermented beverage rich in probiotics that offer various nutraceutical benefits, leading to a growing global interest. Due to its potential nutritional advantages, kefir and similar products have a promising future in commercialization.
Article
Chemistry, Medicinal
Muhammad Nazirul Mubin Aziz, Nurul Fattin Che Rahim, Yazmin Hussin, Swee Keong Yeap, Mas Jaffri Masarudin, Nurul Elyani Mohamad, Muhammad Nadeem Akhtar, Mohd Azuraidi Osman, Yoke Kqueen Cheah, Noorjahan Banu Alitheen
Summary: Osteosarcoma is a life-threatening bone tumor with poor prognosis in children, prompting the search for safer and more effective treatments. Natural compounds like curcumin have pharmacological advantages but poor cellular uptake. The synthetic curcumin analog DK1 shows potential as an anti-metastatic and anti-angiogenic agent.
Article
Integrative & Complementary Medicine
Wan Yong Ho, Sok Sian Liew, Swee Keong Yeap, Noorjahan Banu Alitheen
Summary: The combined treatment of E. scaber and tamoxifen showed synergistic cytotoxicity in MCTS, reducing drug resistance in estrogen receptor-positive breast cancer. The treatment induced apoptosis, cell cycle arrest, and mitochondrial membrane potential depolarization. Additionally, it upregulated proapoptotic gene expression and downregulated prosurvival gene expression.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Noorshafadzilah Talib, Nurul Elyani Mohamad, Swee Keong Yeap, Chai Ling Ho, Mas Jaffri Masarudin, Suraini Abd-Aziz, Mira Nadiah Mohd Izham, Muganti Rajah Kumar, Yazmin Hussin, Noorjahan Banu Alitheen
Summary: This study evaluated the anti-diabetic potential of the isolated L. paracasei from Malaysian water kefir grains and found that it alleviated T2DM by regulating gene expression, suggesting its potential as a dietary supplement for T2DM.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Multidisciplinary Sciences
Previnaa Sundrarajoo, Sugumaran Manickam, Nur Fatihah Mohd Yusoff, Noorjahan Banu Mohammed Alitheen, Parameswari Namasivayam
Summary: This study conducted histological analysis on the underexplored plant species Glycosmis perakensis from the Rutaceae family, highlighting important anatomical features of its leaves and stems. The findings will serve as a valuable tool for future plant identification.
MALAYSIAN JOURNAL OF FUNDAMENTAL AND APPLIED SCIENCES
(2022)
Article
Materials Science, Biomaterials
Raja Vadivelu, Navid Kashaninejad, Mohammad Reza Nikmaneshi, Rubina Rahaman Khadim, Seyedeh Sarah Salehi, Naveen Chintala Ramulu, Yasuyuki Sakai, Masaki Nishikawa, Bahar Firoozabadi, Nam-Trung Nguyen
Summary: A functional sessile LM system for long-term 3D cell culture is developed by embedding LM with agarose gel to reduce evaporation. Comprehensive mathematical modeling, numerical simulations, and experimental investigations show that the platform acts as a moisture absorption system to control evaporation, extending the life span of LMs. The presence of agarose significantly contributes to minimizing evaporation and improving the viability of the harvested multicellular spheroids.
Article
Integrative & Complementary Medicine
Muganti Rajah Kumar, Swee Keong Yeap, Nurul Elyani Mohamad, Janna Ong Abdullah, Mas Jaffri Masarudin, Melati Khalid, Adam Thean Chor Leow, Noorjahan Banu Alitheen
Summary: This study investigated the microbial composition and bioactive compounds of water kefir fermented in Malaysia, showing Lactobacillus hilgardii as the most abundant species. Toxicity analysis on BALB/c mice administered with kefir water showed no adverse effects, and antioxidant assays demonstrated enhanced SOD and FRAP activities.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2021)
Review
Biochemical Research Methods
Chin Hong Ooi, Raja Vadivelu, Jing Jin, Kamalalayam Rajan Sreejith, Pradip Singha, Nhat-Khuong Nguyen, Nam-Trung Nguyen
Summary: This paper presents the latest discoveries in the physics of liquid marbles and their practical applications, covering fundamental properties, synthesis techniques, manipulation methods, and applications in chemical and biological reactors. It also provides insights into the future development of liquid marble-based digital microfluidics.
