Article
Multidisciplinary Sciences
Ngoc Minh Luu, Thi Tra Bui, Thi Phuong Thao Tran, Thi Huyen Trang Nguyen, Jin-Kyoung Oh
Summary: The study aimed to identify latent classes based on lifestyle behavior trajectories and investigate their association with cancer risk. The research found that only a small percentage of participants maintained a long-term healthy lifestyle, highlighting the importance of linking behavior combinations to cancer prevention.
SCIENTIFIC REPORTS
(2023)
Article
Biology
Anna Kankaanpaeae, Asko Tolvanen, Aino Heikkinen, Jaakko Kaprio, Miina Ollikainen, Elina Sillanpaeae
Summary: This study found that an unhealthy lifestyle during adolescence is associated with accelerated biological aging in young adulthood, which may be explained by genetic factors.
Article
Anesthesiology
Anne-Priscille Trouvin, Nadine Attal, Serge Perrot
Summary: It is important to analyze the lifestyle factors in patients with chronic pain without stigmatization. Some lifestyle factors, such as alcohol consumption, smoking, cannabis use, or psychostimulant intake, are harmful to patients, while physical activity and a balanced diet are considered beneficial, but require effort on the part of patients.
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Article
Multidisciplinary Sciences
Miaw Yn Jane Ling, Norfazilah Ahmad, Muhammad Fadhli Mohd Yusoff, Kuang Hock Lim
Summary: This study found that the prevalence of current e-cigarette use among in-school adolescents in West Malaysia was 9.1%, and it was significantly associated with male gender, older age, Malay ethnicity, schooling in urban area, current smoking, current alcohol use, current drug use, having parents that are not married and living together, and parental tobacco product use. There were significant interactions between these factors.
Article
Oncology
Jonviea D. Chamberlain, Sebastien Nussle, Laurence Chapatte, Cassandre Kinnaer, Dusan Petrovic, Sylvain Pradervand, Murielle Bochud, Sarah E. Harris, Janie Corley, Simon R. Cox, Semira Gonseth Nussle
Summary: This study identified and validated novel epigenetic signatures of tobacco and alcohol consumption, which were found to be highly correlated with self-reported exposure status and associated with long-term health outcomes. Epigenetic signatures of lifestyle exposures may help reduce measurement issues and biases, and could potentially assist in risk stratification for early-stage targeted interventions.
CLINICAL EPIGENETICS
(2022)
Article
Genetics & Heredity
Mahmoud Amiri Roudbar, Seyedeh Fatemeh Mousavi, Siavash Salek Ardestani, Fernando Brito Lopes, Mehdi Momen, Daniel Gianola, Hasan Khatib
Summary: The use of DNA methylation markers to predict chronological age and aging rate was studied, revealing that un-adjusted methylation data provided higher prediction accuracy. Reducing the number of predictors improved predictive power. Distinct global methylation patterns and widespread epigenetic drift were observed.
G3-GENES GENOMES GENETICS
(2021)
Article
Oncology
Drew R. Nannini, Yinan Zheng, Brian T. Joyce, Tao Gao, Lei Liu, David R. Jacobs, Pamela Schreiner, Chunyu Liu, Steve Horvath, Ake T. Lu, Kristine Yaffe, Stephen Sidney, Philip Greenland, Donald M. Lloyd-Jones, Lifang Hou
Summary: The study found that cumulative and recent marijuana use are associated with age-related epigenetic changes that are related to lifespan, and these associations may be modified by alcohol consumption.
CLINICAL EPIGENETICS
(2022)
Article
Oncology
Antonio Di Meglio, Arnauld S. Gbenou, Elise Martin, Barbara Pistilli, Jennifer A. Ligibel, Tracy E. Crane, Jean-Daniel Flaysakier, Etienne Minvielle, Laurence Vanlemmens, Charles Guenancia, Olivier Rigal, Marion Fournier, Patrick Soulie, Marie-Ange Mouret-Reynier, Carole Tarpin, Florence Boiffard, Sophie Guillermet, Sibille Everhard, Anne-Laure Martin, Sylvie Giacchetti, Thierry Petit, Florence Dalenc, Philippe Rouanet, Antoine Arnaud, Fabrice Andre, Ines Vaz-Luis
Summary: This study assessed the prevalence and risk factors of unhealthy behaviors among survivors of early-stage breast cancer. Most women were adherent to healthy lifestyle behaviors at diagnosis, but a significant subset showed nonadherence, with these unhealthy behaviors tending to persist over time. The study will inform more targeted interventions to promote optimal health.
Article
Gastroenterology & Hepatology
Kali Zhou, Tiffany Lim, Jennifer L. L. Dodge, Norah A. A. Terrault, Lynne R. R. Wilkens, V. Wendy Setiawan
Summary: Lifestyle factors are closely associated with the risk of hepatocellular carcinoma (HCC). Modifying adverse lifestyle behaviors, particularly coffee intake, can have a substantial impact on the burden of HCC in diverse populations.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Neurosciences
Tabea Schoeler, Jessie Baldwin, Andrea Allegrini, Wikus Barkhuizen, Andrew McQuillin, Nicola Pirastu, Zoltan Kutalik, Jean-Baptiste Pingault
Summary: A common genetic liability was found to contribute to the co-occurrence of nicotine, alcohol, and cannabis consumption. Genetic correlations among 6 measures of substance dependence and frequency of use were analyzed, leading to the identification of 42 genetic variants related to substance involvement. These findings provide insights into the genetic architecture underlying the use of common psychoactive substances.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Mst Sabrina Moonajilin, Md Khalid Ibne Kamal, Firoj al Mamun, Mariam Binte Safiq, Ismail Hosen, Md Dilshad Manzar, Mohammed A. Mamun
Summary: This study investigated the prevalence of substance use and its associated risk factors among Bangladeshi high school-going adolescents. The current substance use risk factors identified include being male, not being from a science academic background, having less family influence, irregular teeth brushing, smartphone use, longer smartphone usage, and late-night sleeping. Modifiable risk factors may be targeted to develop prevention programs for managing substance abuse in Bangladeshi adolescents.
Article
Public, Environmental & Occupational Health
Charlotte Dieteren, Igna Bonfrer
Summary: This study quantifies the prevalence and socioeconomic inequalities in lifestyle risk factors in LMICs, highlighting that tobacco and alcohol use are concentrated among the poor, while overweight is concentrated among the better-off. The associations between the share of GDP spent on health and the socioeconomical distribution of lifestyle factors are multidirectional, emphasizing the importance of tailored interventions towards specific high-risk populations in LMICs.
Article
Oncology
Elia J. Mmbaga, Beatrice P. Mushi, Katrina Deardorff, William Mgisha, Larry O. Akoko, Alan Paciorek, Robert A. Hiatt, Geoffrey C. Buckle, Julius Mwaiselage, Li Zhang, Katherine Van Loon
Summary: In Tanzania, low International Wealth Index, smoking, household second-hand smoke exposure, daily intake of spicy chilies and salted foods were associated with an increased risk of ESCC, while daily consumption of raw greens, fruit, and smoked fish was protective. Permanent residence in the Central, Northern-Lake, or Southern Highlands zones of Tanzania compared with the Eastern zone was associated with an increased risk of ESCC.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Cell Biology
Kara N. Fitzgerald, Tish Campbell, Suzanne Makarem, Romilly Hodges
Summary: This case series reports on the effects of a methylation-supportive diet and lifestyle program on DNA methylation and biological aging in six women. The program, which lasted 8 weeks, included guidance on diet, sleep, exercise, relaxation, as well as the use of probiotics and phytonutrients, and nutritional coaching. Analysis of blood samples revealed that five out of six participants experienced a reduction in biological age ranging from 1.22 to 11.01 years after the intervention. The mean biological age of the participants also showed a statistically significant decrease after the program, with an average reduction of 4.60 years.
Article
Substance Abuse
Goranka Radmilovic, Valentina Matijevic, Danijel Mikulic, Danijela Rasic Markota, Asija Rota Ceprnja, Valentina Matijevi
Summary: Our study aims to explore a new approach for smoking cessation by analyzing body composition differences between smokers and non-smokers. The study found that smokers have higher fat tissue percentages and estimated biological ages compared to non-smokers.
TOBACCO INDUCED DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Allan Andersen, Rachel Reimer, Kelsey Dawes, Ashley Becker, Natasha Hutchens, Shelly Miller, Meesha Dogan, Brandon Hundley, James A. Mills, Jeffrey D. Long, Robert Philibert
Summary: This study found that DNA methylation status at cg05575921 can distinguish exposure to tobacco smoke from non-combusted sources of nicotine, such as e-cigarettes and smokeless tobacco. Additionally, propylene glycol levels were not reliable in distinguishing user groups. The combination of methylomic and metabolite profiling may allow for accurate classification of the use status of different nicotine-containing products.
Article
Biochemistry & Molecular Biology
Steven R. H. Beach, Mei Ling Ong, Man-Kit Lei, Sierra E. Carter, Ronald L. Simons, Frederick X. Gibbons, Robert A. Philibert
Summary: The methylation of FKBP5 is associated with accelerated DNA methylation ageing and predicts poorer cardiovascular health among young and middle-aged Black Americans. Exposure to community danger may influence FKBP5 methylation levels, which in turn affects accelerated ageing and cardiometabolic risk.
Article
Gerontology
Ronald L. Simons, Mei Ling Ong, Man-Kit Lei, Eric Klopack, Mark Berg, Yue Zhang, Robert Philibert, Steven S. R. Beach
Summary: This study examined how childhood instability, adult adversity, and lifestyle predict accelerated GrimAge and PoAm. The results showed that childhood instability, adult financial hardship, and smoking were significant predictors of both clocks.
JOURNAL OF AGING AND HEALTH
(2022)
Article
Psychology, Clinical
Man-Kit Lei, Gene H. Brody, Steven R. H. Beach
Summary: The study showed that a family-based program designed for rural Black youth can improve self-control, reduce substance use, and decrease biological aging. This has positive effects on young adult health behavior and ultimately lowers mortality risk.
Article
Psychology, Clinical
Man-Kit Lei, Mark T. Berg, Ronald L. Simons, Steven R. H. Beach
Summary: This study measures early adversity using an innovative method and proposes indirect pathways through which childhood and adolescent adversity influence adult health via psychosocial maladjustment. The results show that early social environmental experiences, especially parenting, financial stress, and racial discrimination, are associated with adult health profiles among Black Americans.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Environmental Sciences
Steven R. H. Beach, Eric T. Klopack, Sierra E. Carter, Robert A. Philibert, Ronald L. Simons, Frederick X. Gibbons, Mei Ling Ong, Meg Gerrard, Man-Kit Lei
Summary: In a study of 685 late middle-aged Black adults, the changes in both loneliness and per capita income were found to be associated with accelerated aging. The study also revealed that the average pace of change increased with age.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Genetics & Heredity
Steven R. H. Beach, Mei Ling Ong, Frederick X. Gibbons, Meg Gerrard, Man-Kit Lei, Kelsey Dawes, Robert A. Philibert
Summary: Excessive alcohol consumption is associated with epigenetic aging, but self-report measures may not accurately reflect this association. Newly developed non-self-report indices provide a more accurate and effective assessment of the contribution of excessive alcohol consumption to accelerated epigenetic aging.
Article
Psychology, Clinical
Man-Kit Lei, Steven R. H. Beach
Summary: This study examines the relationship between supportive couple functioning, neighborhood disadvantage, and accelerated aging, and finds that enhancing couple functioning can mitigate the negative effects of neighborhood disadvantage on aging.
Article
Genetics & Heredity
Jeffrey D. D. Long, Michael P. Gehlsen, Joanna Moody, Gracie Weeks, Robert Philibert
Summary: We analyzed data from the National Lung Screening Trial (NLST) to determine the predictive ability of gender, body mass index (BMI), marital status, and race on smoking behavior, with emphasis on gender interactions. The final selected variables for the prediction model were BMI, gender, BMI by gender, age, divorced (vs. married), education, and race.
Article
Education & Educational Research
Joseph C. Hermanowicz, Man-Kit Lei
Summary: This article examines the differences in authorship patterns between sole authorship and coauthorship based on the stratification of academic institutions. The study reveals significant organizational differences in publishing multi-authored work in fields where sole authorship is more prevalent, after considering demographic characteristics and research methods.
STUDIES IN HIGHER EDUCATION
(2023)
Article
Genetics & Heredity
Ronald L. Simons, Mei Ling Ong, Man-Kit Lei, Steven R. H. Beach, Yue Zhang, Robert Philibert, Michelle M. Mielke
Summary: A recent study developed a new epigenetic measure of aging using human cortex tissue called cortical clock (CC). This CC outperformed existing blood-based epigenetic clocks in predicting brain age and neurological degeneration. The study also found that loneliness and BDNFm were robust predictors of accelerated CC-Bd, suggesting a link between brain health and overall aging of the organism.
Article
Genetics & Heredity
Robert Philibert, Joanna Moody, Willem Philibert, Meeshanthini V. Dogan, Eric A. Hoffman
Summary: Coronary heart disease (CHD) is a major cause of death worldwide, but current diagnostic tools like coronary computed tomography angiography (CCTA) aren't suitable for monitoring treatment response. We recently introduced an artificial intelligence-guided genetic-epigenetic test for CHD, which involves six assays to determine DNA methylation in CHD-related pathways. In a study on 39 subjects undergoing a 90-day smoking cessation intervention, we found that changes in DNA methylation related to smoking intensity were associated with the recovery of CHD-related methylation markers. Methylation-based approaches could be a scalable method for assessing the effectiveness of CHD interventions, and further research on the response of these epigenetic measures to other forms of CHD treatment is needed.
Article
Criminology & Penology
Thomas L. McNulty, Paul E. Bellair, ManKit (Karlo) Lei
Summary: Research on racial invariance in neighborhood violence focuses on concentrated disadvantage but has limitations due to restricted distribution. This study examines the role of spatial polarization of disadvantage and affluence in explaining racial differences in violence when few extremely poor, white neighborhoods are available for comparison. Results from analyzing Atlanta neighborhoods reveal that the index of concentration at the extremes (ICE) fully explains the higher violence rates in black and mixed-race neighborhoods compared to white neighborhoods. The expected effects of the ICE index on violent crime across different racial neighborhoods are also supported.
