Article
Environmental Sciences
Kuang-Chi Lai, Fu-Shin Chueh, Yi-Shih Ma, Yu-Cheng Chou, Jaw-Chyun Chen, Ching-Lung Liao, Yi-Ping Huang, Shu-Fen Peng
Summary: This study aimed to investigate the apoptotic effects of the combination of IRI and PEITC on human colon cancer HCT 116 cells in vitro. The results showed that the combination treatment reduced viable cell number and induced higher levels of cell apoptosis compared to IRI or PEITC alone. The combination treatment also increased levels of reactive oxygen species (ROS) and calcium ions (Ca2+), and higher caspase activities. Additionally, the combination treatment induced higher levels of ER stress, mitochondria, and caspase-associated proteins.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Klaudyna Krause, Agnieszka Pyrczak-Felczykowska, Monika Karczewska, Magdalena Narajczyk, Anna Herman-Antosiewicz, Agnieszka Szalewska-Palasz, Dariusz Nowicki
Summary: Plant-derived phytoncides, isothiocyanates, have shown promising antibacterial potential against Vibrio cholerae, inhibiting bacterial growth, reducing toxicity, and inducing global stress response, suggesting they could be considered as effective antibacterial agents in V. cholerae infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Taolan Zhang, Weijuan Zhang, Meng Hao
Summary: PEITC, a compound derived from cruciferous vegetables, has been found to inhibit BCSC-like properties by epigenetic reactivation of CDH1. This discovery suggests a novel method to eradicate BCSCs from breast cancer patients.
Review
Biochemistry & Molecular Biology
Pinghan Wang, Fangyi Long, Hong Lin, Ting Wang
Summary: Breast cancer, accounting for 11.7% of all newly diagnosed cancer cases, has become the leading cause of cancer worldwide. Naturally occurring dietary phytochemical compounds, such as curcumin and resveratrol, are considered promising agents for breast cancer prevention. Nuclear factor erythroid 2-related factor 2 (Nrf2) plays a key regulatory role in suppressing the accumulation of carcinogens, and its modulation by dietary phytochemicals appears to be a promising approach for breast cancer prevention.
Article
Oncology
Yaxun Jia, Min Wang, Xiaolin Sang, Pixu Liu, Jingchun Gao, Kui Jiang, Hailing Cheng
Summary: This study demonstrates that oxidative stress sensitizes HGSOC cells to PARPi BMN 673 and that the combination of PEITC and BMN 673 enhances cytotoxic effects through ROS-mediated mechanisms. The PEITC/BMN 673 combination significantly inhibits the growth of HGSOC and cervical cancer, suggesting a potential novel therapeutic strategy for these cancers.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jui-Feng Lin, Chih-Wen Chi, Yu-Chuen Huang, Tung-Hu Tsai, Yu-Jen Chen
Summary: In this study, the anti-cancer effects of 6-MITC and its derivatives on chronic myelogenous leukemia cells were examined. It was found that they can induce cell death through suppressing the cell cycle and inducing autophagy and aberrant mitosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Robyn Broad, Stacey J. Jones, Melina C. Teske, Laura M. Wastall, Andrew M. Hanby, James L. Thorne, Thomas A. Hughes
Summary: CAFs induce activation of IFN signaling in claudin-low TNBCs, leading to chemoresistance. High expression of IFN beta 1 (CAFs) or MX1 (tumour cells) correlates with reduced survival after chemotherapy, especially in claudin-low subtype tumors.
BRITISH JOURNAL OF CANCER
(2021)
Article
Immunology
Xinxin Xu, Zhiqiang Han, Yetian Ruan, Min Liu, Guangxu Cao, Chao Li, Fang Li
Summary: This study investigated the impact of HPV16 integration on chromosome structure and gene expression in cervical cells. The results showed significant genomic variation and differential gene expression in the integrated chromosome, affecting topologically associated domain boundaries and tumor suppressor gene expression. This research provides valuable insights into the structural changes induced by HPV16 integration and its role in tumorigenesis, contributing to the understanding of the cervical carcinogenic mechanism.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Qi-cheng Zhang, Yong-mei Qian, Ying-hui Ren, Meng-meng Chen, Li-min Cao, Si-jia Zheng, Bing-bing Li, Min Wang, Xiang Wu, Ke Xu
Summary: In this study, the researchers investigated the molecular mechanisms underlying the inhibitory effects of isothiocyanates (ITCs) on cancer cell metastasis. They found that phenethyl isothiocyanate (PEITC) dose-dependently inhibited the cell viability, invasion, and migration of non-small cell lung cancer (NSCLC) cells. PEITC treatment also increased m(6)A methylation levels and inhibited the expression of the m(6)A demethylase fat mass and obesity-associated protein (FTO) in NSCLC cells. Knockdown of FTO increased m(6)A methylation and impaired the invasion and migration abilities of NSCLC cells in vitro, as well as enhanced the inhibition of PEITC on tumor growth in vivo. On the other hand, overexpression of FTO promoted NSCLC cell migration and mitigated the inhibitory effect of PEITC on migration. Furthermore, they found that FTO regulated the mRNA m(6)A modification of a transcriptional co-repressor Transducin-Like Enhancer of split-1 (TLE1) and further affected its stability and expression. The study suggests that ITCs inhibit lung cancer cell metastasis by targeting m(6)A methylation.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Multidisciplinary Sciences
Paulina Wigner, Krzysztof Zielinski, Magdalena Labieniec-Watala, Agnieszka Marczak, Marzena Szwed
Summary: The DOX-Tf conjugate as a drug delivery system exhibits higher cytotoxicity in human breast adenocarcinoma cells, especially in triple-negative breast cancer cells. Our findings also suggest that the functionality of cellular antioxidant systems and expression levels of estrogen receptors in breast cancer cells may influence the sensitivity to DOX-Tf conjugate.
SCIENTIFIC REPORTS
(2021)
Article
Plant Sciences
Ji Min Shin, Eunbi Lim, Yoon Shin Cho, Chu Won Nho
Summary: PEITC may have the potential to prevent or delay colorectal cancer growth by inhibiting the properties of CSCs, especially clonogenicity and the expression of pluripotent factors. RNA-sequencing results demonstrated that PEITC pre-treatment significantly suppressed genes related to inflammatory, immune responses, and chemokine-related signaling.
Article
Biochemistry & Molecular Biology
Carolina Alonso-Gonzalez, Cristina Gonzalez-Abalde, Javier Menendez-Menendez, Alicia Gonzalez-Gonzalez, Virginia Alvarez-Garcia, Alicia Gonzalez-Cabeza, Carlos Martinez-Campa, Samuel Cos
Summary: Radiation therapy is a crucial part of cancer treatment, but it has adverse effects. Melatonin, as an adjuvant molecule, can limit damage to normal tissues and enhance the efficacy of radiation therapy in breast cancer. This study revealed that melatonin can potentiate the anti-proliferative effect of radiation, modulate gene and microRNA expression, and enhance the inhibition of cancer growth. Melatonin shows promise as both a radiosensitizer and radioprotector in breast cancer treatment.
Article
Biochemistry & Molecular Biology
Inho Bae, Taeyu Grace Kim, Taeyeon Kim, Dohoon Kim, Doug-Hoon Kim, Jaewon Jo, Young-Ju Lee, Young-Il Jeong
Summary: This study aimed to synthesize ChitoPEITC nanophotosensitizers and demonstrate their potential in Ce6 uptake, ROS production, and PDT efficacy. The results showed that ChitoPEITC nanophotosensitizers exhibited superior performance compared to free Ce6 in various aspects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Nisreen Faizo, Chandrakala Aluganti Narasimhulu, Anna Forsman, Shibu Yooseph, Sampath Parthasarathy
Summary: The study utilized RNA sequencing to investigate the impact of exposure to peroxidized linoleic acid on cellular processes, uncovering alterations in lipid metabolic pathways, detoxification mechanisms, and suppression of oxidative phosphorylation. These findings provide insights into the effects of 13-HPODE on cellular processes and propose potential therapeutic strategies for LOOH-related pathologies.
Article
Biology
Peter Quicke, Yilin Sun, Mar Arias-Garcia, Melina Beykou, Corey D. Acker, Mustafa B. A. Djamgoz, Chris Bakal, Amanda J. Foust
Summary: Voltage imaging and machine learning techniques have revealed that human breast cancer cells exhibit voltage fluctuations which are not present in non-tumorigenic breast cells. This discovery sheds light on the bioelectric properties of cancer processes. Cancer cells have a depolarized resting membrane potential (V-m) and express active ionic conductances, which directly affect their pathophysiological behavior. By analyzing the V-m fluctuations using machine learning algorithms, researchers have identified four classes of breast cancer cells based on their Dynamic Electrical Signatures (DESs), ranging from noisy to blinking/waving.
COMMUNICATIONS BIOLOGY
(2022)