Article
Rheumatology
George Athanasios Karpouzas, Bianca Papotti, Sarah Ormseth, Marcella Palumbo, Elizabeth Hernandez, Maria Pia Adorni, Francesca Zimetti, Matthew Budoff, Nicoletta Ronda
Summary: Cholesterol loading capacity (CLC) is associated with coronary atherosclerosis presence, burden, and cardiovascular risk in patients with rheumatoid arthritis (RA). It is particularly linked to high-risk low attenuation and obstructive plaques in non-users of biologic disease-modifying antirheumatic drugs (bDMARD).
Review
Pharmacology & Pharmacy
Cecilia Nalli, Jessica Galli, Daniele Lini, Angela Merlini, Silvia Piantoni, Maria Grazia Lazzaroni, Victoria Bitsadze, Jamilya Khizroeva, Sonia Zatti, Laura Andreoli, Elisa Fazzi, Franco Franceschini, Alexander Makatsariya, Yehuda Shoenfeld, Angela Tincani
Summary: The management of reproductive issues in women with inflammatory arthritis has evolved with the availability of biologic agents, leading to discussions about medication use during pregnancy and breastfeeding. While controlling maternal disease with safe drugs is crucial for the health of both the mother and the baby, concerns remain about the potential impact on the fetus.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Monika Czokolyova, Attila Hamar, Anita Pusztai, Gabor Tajti, Edit Vegh, Zsofia Petho, Nora Bodnar, Agnes Horvath, Boglarka Soos, Szilvia Szamosi, Anita Szentpeteri, Ildiko Seres, Mariann Harangi, Gyorgy Paragh, Gyorgy Kerekes, Levente Bodoki, Andrea Domjan, Katalin Hodosi, Tamas Seres, Gyorgy Panyi, Zoltan Szekanecz, Gabriella Szucs
Summary: The study found that tofacitinib treatment had balanced effects on lipids and other metabolic markers in patients with rheumatoid arthritis (RA). Various correlations were observed between lipids, clinical markers, and vascular pathophysiology in relation to tofacitinib treatment. Complex assessment of these factors could be used in clinical practice to monitor cardiovascular status and treatment response in RA patients.
Article
Nanoscience & Nanotechnology
Jiayao Lyu, Lujun Wang, Xiaosheng Bai, Xingjie Du, Jun Wei, Jianxin Wang, Yan Lin, Zhenyu Chen, Zhongbing Liu, Jianming Wu, Zhirong Zhong
Summary: This study successfully loaded methotrexate (MTX) into nanoparticles of human serum albumin modified with mannose for targeted drug delivery to neutrophils, reducing toxicity and showing significant anti-inflammatory, antiangiogenic, and anti-arthritic effects in experimental models. The nanoparticles prolonged the in vivo circulation of MTX and accumulated mainly in arthritic joints, indicating their potential as a useful drug delivery system for rheumatoid arthritis.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Chemistry, Medicinal
Muhammad Bilal, Maimoona Qindeel, Leonardo Vieira Nunes, Marco Thulio Saviatto Duarte, Luiz Fernando Romanholo Ferreira, Renato Nery Soriano, Hafiz M. N. Iqbal
Summary: Rheumatoid arthritis is a common worldwide public health concern with traditional treatments having toxic and side effects, leading researchers to explore marine-derived biologically active compounds as potential alternatives. These compounds show anti-inflammatory and antioxidant properties, offering a new and safe source for drug development against RA.
Article
Immunology
Enrico Brunetta, Giacomo Ramponi, Marco Folci, Maria De Santis, Emanuela Morenghi, Elena Vanni, Elena Bredi, Raffaello Furlan, Claudio Angelini, Carlo Selmi
Summary: This study found that serum pANCA and cANCA are independent negative prognostic factors in patients with concurrent autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Congqi Hu, Zhao Dai, Jia Xu, Lianyu Zhao, Yanping Xu, Meilin Li, Jiahui Yu, Lu Zhang, Hui Deng, Lijuan Liu, Mingying Zhang, Jiarong Huang, Linping Wu, Guangxing Chen
Summary: This study identified the serum marker ORM1 as a significant differential expression between normal and RA patient samples, positively correlated with disease activity, offering a new perspective for future research on RA.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Andreas Kerschbaumer, Nina Maria Stimakovits, Josef S. Smolen, Tijen Stefanova, Eva Chwala, Daniel Aletaha
Summary: The study aims to investigate whether treatment effects of pharmaceutical compounds compared with placebo controls are systematically different to the effects of the same compounds compared with active treatment controls in rheumatoid arthritis (RA) clinical trials. Using mixed-model logistic regression, the researchers found that placebo controlled trials lead to smaller effect sizes of active compounds compared to head-to-head trials. The difference may be explained by potential nocebo effects in placebo-controlled settings.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Immunology
Di Wu, Yehao Luo, Tong Li, Xinyi Zhao, Ting Lv, Gang Fang, Peiqi Ou, Hongyi Li, Xiaofan Luo, An Huang, Yuzhou Pang
Summary: Rheumatoid arthritis (RA), as a systemic autoimmune disease, not only damages joints but also other tissues and organs. Severe complications of RA are closely associated with the prognosis and increased mortality of patients. This article summarizes the incidence, pathogenesis, clinical features, and treatment methods of serious complications of RA, providing a reference for clinicians to manage RA complications effectively.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Yan Zhu, Tianjiao Zhao, Min Liu, Shuya Wang, Saili Liu, Yunrong Yang, Yuqi Yang, Yayun Nan, Qiong Huang, Kelong Ai
Summary: Rheumatoid arthritis (RA) is a disease with a significant medical burden and a tumor-like microenvironment. Traditional anti-inflammatory therapies are hindered by the buffer barrier of the RA microenvironment, while nanomaterials offer a potential solution by interfering with multiple pathogenic factors and achieving precise treatment. Recent advances in nanomaterials have greatly improved the therapeutic effect and reduced side effects in RA treatment.
Article
Immunology
Jiahui Yu, Congqi Hu, Zhao Dai, Jia Xu, Lu Zhang, Hui Deng, Yanping Xu, Lianyu Zhao, Meilin Li, Lijuan Liu, Mingying Zhang, Jiarong Huang, Linping Wu, Guangxing Chen
Summary: This study identified potential biomarkers associated with disease activity and treatment response in rheumatoid arthritis (RA) using liquid chromatography-tandem mass spectrometry (LC-MS/MS) proteomic analysis. The results showed that serum DPP4 concentration significantly increased after RA treatment and was inversely correlated with disease activity indicators. These findings suggest that serum DPP4 may be a potential biomarker for assessing disease activity and treatment response in RA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Kaja Kasarello, Iwona Koehling, Anna Kosowska, Katarzyna Pucia, Anna Lukasik, Agnieszka Cudnoch-Jedrzejewska, Leszek Paczek, Urszula Zielenkiewicz, Piotr Zielenkiewicz
Summary: Cross-kingdom gene expression regulation by xenomiRs, particularly from plants, has been found to have potential scientific significance. In this study, miR172a derived from Brassica oleracea was shown to decrease the levels of FAN protein in human and mouse cells. Furthermore, treatment with miR172a was found to mitigate inflammation in a mouse model of rheumatoid arthritis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Samantha Rodriguez-Muguruza, Antonio Altuna-Coy, Veronica Arreaza-Gil, Marina Mendieta-Homs, Sonia Castro-Oreiro, Maria Jose Poveda-Elices, Nuria del Castillo-Pinol, Ramon Fontova-Garrofe, Matilde R. Chacon
Summary: This study identified new serum biomarkers for ERA using metabolomics and constructed a biomarker panel composed of glyceric acid, lactic acid, and 3-hydroxisovaleric acid, which shows potential for improving the early clinical diagnosis of RA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Jill Hahn, Nancy R. Cook, Erik K. Alexander, Sonia Friedman, Joseph Walter, Vadim Bubes, Gregory Kotler, I-Min Lee, JoAnn E. Manson, Karen H. Costenbader
Summary: Vitamin D supplementation for five years, with or without omega 3 fatty acids, reduced autoimmune disease by 22%, while omega 3 fatty acid supplementation with or without vitamin D reduced the autoimmune disease rate by 15% (not statistically significant). Both treatment arms showed larger effects than the reference arm (vitamin D placebo and omega 3 fatty acid placebo).
BMJ-BRITISH MEDICAL JOURNAL
(2022)
Review
Pharmacology & Pharmacy
Parastou Rahimizadeh, Zahra Rezaieyazdi, Faezeh Behzadi, Abbas Hajizade, Sung In Lim
Summary: Rheumatoid arthritis is a chronic inflammatory autoimmune disease with a prevalence of around 5 per 1000 people, and nanotechnology has emerged as a significant player in efficacious disease management, with applications in joint replacement, photothermal therapy, photodynamic therapy, diagnosis, and treatment monitoring.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Public, Environmental & Occupational Health
Nicole M. Wedick, Yunsheng Ma, Barbara C. Olendzki, Elizabeth Procter-Gray, Jie Cheng, Kevin J. Kane, Ira S. Ockene, Sherry L. Pagoto, Thomas G. Land, Wenjun Li
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2015)
Article
Medicine, General & Internal
Yunsheng Ma, Barbara C. Olendzki, Jinsong Wang, Gioia M. Persuitte, Wenjun Li, Hua Fang, Philip A. Merriam, Nicole M. Wedick, Ira S. Ockene, Annie L. Culver, Kristin L. Schneider, Gin-Fei Olendzki, James Carmody, Tingjian Ge, Zhiying Zhang, Sherry L. Pagoto
ANNALS OF INTERNAL MEDICINE
(2015)
Article
Nutrition & Dietetics
Barbara C. Olendzki, Elizabeth Procter-Gray, Nicole M. Wedick, Vijayalakshmi Patil, Hua Zheng, Kevin Kane, Thomas Land, Wenjun Li
JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
(2015)
Article
Obstetrics & Gynecology
Tiffany A. Moore Simas, Silvia Corvera, Mary M. Lee, NingNing Zhang, Katherine Leung, Barbara Olendzki, Bruce Barton, Milagros C. Rosal
BMC PREGNANCY AND CHILDBIRTH
(2015)
Article
Geriatrics & Gerontology
B. Olendzki, E. Procter-Gray, M. F. Magee, G. Youssef, K. Kane, L. Churchill, J. Ockene, W. Li
JOURNAL OF NUTRITION HEALTH & AGING
(2017)
Article
Geriatrics & Gerontology
W. Li, G. Youssef, E. Procter-Gray, B. Olendzki, T. Cornish, R. Hayes, L. Churchill, K. Kane, K. Brown, M. F. Magee
JOURNAL OF NUTRITION HEALTH & AGING
(2017)
Article
Education & Educational Research
Lori Pbert, Susan Druker, Bruce Barton, Kristin L. Schneider, Barbara Olendzki, Mary A. Gapinski, Stephen Kurtz, Stavroula Osganian
JOURNAL OF SCHOOL HEALTH
(2016)
Article
Pediatrics
Lori Pbert, Susan Druker, Bruce Barton, Barbara Olendzki, Victoria Andersen, Gioia Persuitte, Jennifer Bram, Stephen Kurtz, E. Michael Powers, Sybil Crawford, Alan C. Geller
Article
Nutrition & Dietetics
Lijuan Zhang, Sherry Pagoto, Christine May, Barbara Olendzki, Katherine L. Tucker, Carolina Ruiz, Yu Cao, Yunsheng Ma
EUROPEAN JOURNAL OF NUTRITION
(2018)
Article
Medicine, Research & Experimental
Judith K. Ockene, Karen M. Ashe, Rashelle B. Hayes, Linda C. Churchill, Sybil L. Crawford, Alan C. Geller, Denise Jolicoeur, Barbara C. Olendzki, Maria Theresa Basco, Jyothi A. Pendharkar, Kristi J. Ferguson, Thomas P. Guck, Katherine L. Margo, Catherine A. Okuliar, Monica A. Shaw, Taraneh Soleymani, Diane D. Stadler, Sarita S. Warrier, Lori Pbert
CONTEMPORARY CLINICAL TRIALS
(2018)
Article
Nutrition & Dietetics
Lijuan Zhang, Sherry Pagoto, Barbara Olendzki, Gioia Persuitte, Linda Churchill, Jessica Oleski, Yunsheng Ma
Article
Gastroenterology & Hepatology
Barbara Olendzki, Vanni Bucci, Caitlin Cawley, Rene Maserati, Margaret McManus, Effie Olednzki, Camilla Madziar, David Chiang, Doyle Ward, Randall Pellish, Christine Foley, Shakti Bhattarai, Beth A. McCormick, Ana Maldonado-Contreras
Summary: This study aims to investigate the impact of specific foods on the intestinal microbiome in patients with IBD and explore the interactions between diet and immunity to provide personalized nutrition guidance for IBD patients with dysbiosis-related conditions.
Article
Health Care Sciences & Services
Paula Gardiner, Lisa McGonigal, Ariel Villa, Lara C. Kovell, Pallavi Rohela, Andrew Cauley, Diana Rinker, Barbara Olendzki
Summary: The feasibility of using OWL-H and TKMGVs in a low-income population with hypertension was evaluated. Results showed that 88% of participants completed the study, with an average age of 57.
JMIR FORMATIVE RESEARCH
(2022)
Article
Health Care Sciences & Services
Elizabeth Procter-Gray, Barbara Olendzki, Kevin Kane, Linda Churchill, Rashelle B. Hayes, Annabella Aguirre, Hyung-joo Kang, Wenjun Li
AIMS PUBLIC HEALTH
(2017)
Meeting Abstract
Gerontology
W. Li, E. Procter-Gray, K. Kane, L. C. Churchill, J. Cheng, H. Kang, J. Ockene, B. Olendzki