期刊
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
卷 2011, 期 -, 页码 1-8出版社
HINDAWI LTD
DOI: 10.1155/2011/539356
关键词
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资金
- Ministry of Science, Technology and Innovation, Malaysia (MOSTI) [SF 12-02-03-2015]
- University of Malaya [PS269/2008C, PS244/2009C]
Water extract of Lentinus squarrosulus mycelia was analysed for nutritional content, antioxidant capacity, and antiulcer ability. The extract contains high protein (57.6 g/100 g) and low total fat (0.5 g/100 g) and is rich in magnesium (0.4 g/100 g), potassium (3.8 g/100 g), vitamins B1 (1.42mg/100 g), and B3 (194.29 mg/100 g) with total phenolic content of 39.16 mg/100 g. The cupric reducing antioxidant capacity and 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity of the extract were A(450) of 0.20 perpendicular to 0.03 at 0.5mg/ml and IC50 of 14.29 mg/ml, respectively. Oral feeding of L. squarrosulus extract (250 mg/kg) offered significant gastric mucosal protection of Sprague-Dawley rats compared to cimetidine (50 mg/kg). The ulcer healing rate of ulcerated rats after 24, 48, and 72 hours of treatment was 82%, 90%, and 100%, respectively. The IL-1 beta level in the serum and the NF-kappa B level in the tissues indicate that the healing potential was associated with attenuation of proinflammatory cytokines.
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