Article
Clinical Neurology
Kaiyin He, Tianying Pang, Hao Huang
Summary: This study aimed to explore the relationship between depressive symptoms and body mass index (BMI). The findings suggest a U-shaped relationship between depression and BMI, but this relationship was not found among non-Hispanic blacks. More research is needed to confirm the relationship between weight and depression, as well as the causal relationship between them.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Aline Maria M. Ciciliati, Izabela Ono Adriazola, Daniela Souza Farias-Itao, Carlos Augusto Pasqualucci, Renata Elaine Paraizo Leite, Ricardo Nitrini, Lea T. Grinberg, Wilson Jacob-Filho, Claudia Kimie Suemoto
Summary: A study on deceased individuals who underwent autopsy examination showed an association between BMI and moderate to severe dementia in late life, but no clear associations with less advanced dementia stages were found.
FRONTIERS IN NEUROLOGY
(2021)
Article
Endocrinology & Metabolism
Ya Zhang, Jian Pu
Summary: This study found a positive relationship between obesity and bone mineral density (BMD) in individuals over the age of 50. It also identified a saturation value for BMI and BMD, suggesting that maintaining a moderate BMI level (around 24.3 kg/m(2)) would result in optimal BMD in older adults.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Andrea Maugeri, Roberta Magnano San Lio, Maria Clara La Rosa, Giuliana Giunta, Marco Panella, Antonio Cianci, Maria Anna Teresa Caruso, Antonella Agodi, Martina Barchitta
Summary: Inadequate gestational weight gain could affect fetal health and is associated with DNA telomere length.
Article
Multidisciplinary Sciences
Jaeyu Park, Myeongcheol Lee, Hojae Lee, Hyeon Jin Kim, Rosie Kwon, Hwi Yang, Seung Won Lee, Sunyoung Kim, Masoud Rahmati, Ai Koyanagi, Lee Smith, Min Seo Kim, Louis Jacob, Guillermo Felipe Lopez Sanchez, Dragioti Elena, Jae Il Shin, Sang Youl Rhee, Myung Chul Yoo, Dong Keon Yon
Summary: This study analyzed the temporal trend of rheumatoid arthritis (RA) and osteoarthritis (OA) in South Korean adults from 1998 to 2021, including the COVID-19 pandemic period. The prevalence of RA and OA showed a steady decrease, but there was a slight increase after the onset of the COVID-19 pandemic. Vulnerable groups, including older adults, urban residents, and those with higher education, showed higher odds ratios for OA.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Yunsoo Soh, Chang Won Won
Summary: The study examined the relationship between body composition and frailty in community-dwelling elderly Koreans, revealing gender differences with frailty in females associated with fat-related body composition and in males with fat-free mass.
Article
Medicine, Research & Experimental
Jiacheng Wang, Yi Zheng, Yawen Wang, Chengjun Zhang, Yanfeng Jiang, Chen Suo, Mei Cui, Tiejun Zhang, Xingdong Chen, Kelin Xu
Summary: This study investigated the association between lifetime body mass index (BMI) trajectories and bone loss. The results showed that rapid and excess weight gain during adulthood is associated with a higher risk of osteoporosis, but this association varies by skeletal sites. Maintaining stable overweight and obesity at an early stage may have potentially beneficial effects on bone health.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Peripheral Vascular Disease
Yang Wang, Jie Wang, Xiao-Wei Zheng, Ming-Fei Du, Xi Zhang, Chao Chu, Dan Wang, Yue-Yuan Liao, Qiong Ma, Hao Jia, Gui-Lin Hu, Yu Yan, Yue Sun, Chen Chen, Xiao-Yu Zhang, Hao Li, Ting Zou, Ze-Jiaxin Niu, Zi-Yue Man, Lan Wang, Wen-Jing Luo, Guan-Ji Wu, Yu-Ming Kang, John Chang, Christian Delles, Yao Lu, Jian-Jun Mu
Summary: This study found that the accumulation of individual cardiovascular risk factors from childhood to midlife was associated with vascular aging in midlife. Persistent increase and accumulation of cardiovascular risk factors were associated with arterial stiffness and thickening of arterial walls in midlife.
Letter
Medicine, General & Internal
David A. Gorelick
Summary: This comprehensive review of human adipose tissue fails to mention the role of the endocannabinoid system in fat metabolism. The endogenous cannabinoids and their receptors, found in both white and brown fat, have been recognized as key players in adipose tissue metabolism. Rimonabant, an inverse agonist of cannabinoid receptor type 1, has shown promising effects as a therapeutic target for obesity, dyslipidemia, and insulin resistance, although its clinical use was discontinued due to neuropsychiatric side effects.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Endocrinology & Metabolism
Ryusei Ohno, Hidehiro Kaneko, Kensuke Ueno, Hiroyuki Aoki, Akira Okada, Kentaro Kamiya, Yuta Suzuki, Satoshi Matsuoka, Katsuhito Fujiu, Norifumi Takeda, Taisuke Jo, Junya Ako, Hiroyuki Morita, Koichi Node, Hideo Yasunaga, Issei Komuro
Summary: This retrospective observational cohort study found that the risk of developing diabetes mellitus significantly increased when BMI exceeded approximately 20 to 21 kg/m(2). Participants with an increase in BMI of 5.0% or more had a relative risk of 1.33 for developing diabetes, while those with a decrease in BMI of 5.0% or more had a relative risk of 0.82. Furthermore, individuals classified as normal weight, overweight, and obese reduced their risk of developing diabetes when they reduced their BMI, while underweight individuals had an increased risk.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Clinical Neurology
Lei Zhang, Kezhi Liu, Jun Li, Yaling Li
Summary: This study found a positive correlation between blood cadmium levels and depression in American adults, while no significant correlations were observed between depression and blood levels of lead, selenium, and manganese. Higher cadmium concentrations were associated with a greater risk of depression in individuals with different body mass indices, and the risk gradually increased with increasing BMI, but was lowest among obese individuals.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Nutrition & Dietetics
Yun Zhang, Caixia Tan, Wenfu Tan
Summary: This study investigated whether BMI mediates the relationship between SES and lumbar BMD. The results showed that BMI partially mediated the association between SES and BMD, but this association may be largely mediated by factors other than BMI.
FRONTIERS IN NUTRITION
(2023)
Article
Pharmacology & Pharmacy
Masato Takase, Tomohiro Nakamura, Naho Tsuchiya, Mana Kogure, Fumi Itabashi, Akira Narita, Takumi Hirata, Naoki Nakaya, Yohei Hamanaka, Junichi Sugawara, Kichiya Suzuki, Nobuo Fuse, Akira Uruno, Eiichi N. Kodama, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa
Summary: This study found that a higher body fat percentage is associated with hypertension, even in non-obese individuals. Reducing both FMI and FFMI may play an important role in preventing hypertension. However, the relationship between FFMI and hypertension in the lowest FMI group might be weak for men.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2021)
Article
Endocrinology & Metabolism
Chaoran Liu, Keith Yu-Kin Cheng, Xin Tong, Wing-Hoi Cheung, Simon Kwoon-Ho Chow, Sheung Wai Law, Ronald Man Yeung Wong
Summary: This study aimed to explore the relationship between obesity and sarcopenia, and the optimal proportion of fat and muscle for old individuals. The results showed that obesity was a risk factor for sarcopenia, and there was a positive correlation between muscle mass and fat mass. It was recommended that older females should have a body fat percentage between 26.0-34.6%, while older males should have a body fat percentage below 23.9% to prevent sarcopenia.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Geriatrics & Gerontology
Hyun-E Yeom, Young-Joo Kim
Summary: The study found that depressive symptoms were associated with cognitive decline both directly and indirectly through reduced BMI. However, the indirect relationship between depressive symptoms and cognitive function through BMI was observed only in men or individuals older than 70 years.