Article
Pharmacology & Pharmacy
Michelle Whirl-Carrillo, Rachel Huddart, Li Gong, Katrin Sangkuhl, Caroline F. Thorn, Ryan Whaley, Teri E. Klein
Summary: Clinical annotations in PharmGKB summarize the association between variant-drug pairs and are assigned a level of evidence. To ensure consistency and transparency, a scoring system has been developed to automate LOE assignment. This system improves the quality and reliability of clinical annotations.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Veterinary Sciences
Jan M. Sargeant, Marnie L. Brennan, Annette M. O'Connor
Summary: Clinical decisions should be based on the best evidence, and primary research results are an important part of that evidence. There are three approaches to evaluating internal validity: assessing bias potential based on study designs, evaluating key study design features associated with bias potential, and judging whether study design elements may result in biased results. Assessing bias risk is the least assumptive approach and should be used when possible. However, not all study designs have bias risk instruments, so it may be necessary to incorporate bias risk questions into existing quality assessment instruments.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Education & Educational Research
Ivan Buljan, Matko Marusic, Ruzica Tokalic, Marin Vidak, Tina Poklepovic Pericic, Darko Hren, Ana Marusic
Summary: The study aimed to assess EBM knowledge at higher and lower cognitive levels by creating a knowledge test (SPLIT instrument). Results showed that experts in advanced fields performed better than students in EBM topics of study design and sources of evidence.
BMC MEDICAL EDUCATION
(2021)
Review
Medicine, General & Internal
Liqing Huang, Junru Hong, Yang Wang
Summary: Traditional Chinese medicine (TCM) has been shown to be effective in improving non-motor symptoms, especially depression, and quality of life in patients with Parkinson disease.
Article
Health Care Sciences & Services
Braden O'Neill, Jacob Ferguson, Lauren Dalueg, Abban Yusuf, Abirami Kirubarajan, Taryn Lloyd, Eisi Mollanji, Navindra Persaud
Summary: Since the legalization of medical cannabis in Canada in 2013, medical cannabis prescription has become common, but the evidence cited by cannabis clinics to support its effectiveness is of low quality and the potential harms are rarely discussed.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Economics
Stefano DellaVigna, Elizabeth Linos
Summary: Nudge interventions have been widely implemented in both academic studies and government units. However, there are significant differences in the impact of nudges between these two settings. This study compares data from 126 randomized controlled trials (RCTs) conducted by Nudge Units and academic journals, and identifies three factors contributing to the differences: statistical power, characteristics of the interventions, and selective publication. The findings suggest that selective publication and low statistical power are the major contributors to the disparities, while variation in nudge characteristics explains the remaining differences.
Article
Otorhinolaryngology
Jennifer A. Silver, Marco Mascarella, George Tali, Rickul Varshney, Marc A. Tewfik, Bobby A. Tajudeen, Joseph S. Schwartz
Summary: Over the past decade, the number of RSBS publications and high-quality RSBS publications have significantly increased. Despite the increase in high-quality studies, they still only represent a minority of total RSBS research.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Engineering, Biomedical
Kai Zhang, Bin Ma, Kaiyan Hu, Bo Yuan, Xin Sun, Xu Song, Zhonglan Tang, Hai Lin, Xiangdong Zhu, Yufeng Zheng, Andres J. Garcia, Antonios G. Mikos, James M. Anderson, Xingdong Zhang
Summary: This article proposes the concept and methodology of evidence-based biomaterials research, highlighting its origin, key information, application steps, as well as the opportunities and challenges in this field.
BIOACTIVE MATERIALS
(2022)
Article
Multidisciplinary Sciences
Jiayu Liu, Jiqi Zheng, Xintian Cai, Dongdong Wu, Chengliang Yin
Summary: This study investigates whether ChatGPT can respond in accordance with evidence-based medicine in neurosurgery. The results show that GPT-3.5's ability is comparable to neurosurgeons with low seniority, while GPT-4.0's ability is comparable to neurosurgeons with high seniority. Future upgrades could enhance ChatGPT's performance and abilities.
Article
Engineering, Biomedical
Jonathan Espiritu, Mostafa Berangi, Christina Yiannakou, Eduarda Silva, Roberto Francischello, Andre Kuehne, Thoralf Niendorf, Soeren Koenneker, Regine Willumeit-Romer, Jan-Marten Seitz
Summary: This study found that the metallic artefacts produced by Mg-based implants in MRI decreased as the implant material degraded, and outperformed the Ti equivalent in all experiments. The worst-case imaging scenario was determined to be when the imaging plane was selected to be perpendicular to the implant axis.
BIOACTIVE MATERIALS
(2022)
Article
Multidisciplinary Sciences
Eman Alefishat, Anan S. Jarab, Suhaib Muflih, Abdel Wahab Aqeel
Summary: The attitudes of community pharmacists towards practice-based research (PBR) have an impact on their utilization of current best evidence in pharmacy practice. This study highlights the importance of supporting and promoting PBR among community pharmacists to enhance their utilization of the best evidence in their everyday practice.
Article
Health Care Sciences & Services
Xiuxia Li, Yanfei Li, Kangle Guo, Nan Chen, Xudong Cui, Zhenggang Bai, Yaolong Chen, Kehu Yang
Summary: This study evaluated randomized controlled trials (RCTs) in the social sciences published in China, finding issues with reporting quality and risk of bias in the majority of studies, particularly needing improvement in methods and results reporting.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2022)
Article
Rheumatology
Walter P. Maksymowych, Robert G. W. Lambert, Liron Caplan, Filip E. van den Bosch, Mikkel ostergaard
Summary: The current RCT design does not fully utilize MRI to select nr-axSpA patients who best demonstrate differences in clinical response rates between active drug and placebo therapies. Future studies should incorporate revised patient inclusion criteria based on expanded MRI evaluation and data-driven definitions of a positive MRI to improve discrimination between therapies.
NATURE REVIEWS RHEUMATOLOGY
(2022)
Review
Medicine, General & Internal
Tsz Yuen Au, Chanika Assavarittirong
Summary: Antimicrobial resistance (AMR) poses a significant challenge in various fields. Bacteriophage therapy, which involves infecting bacteria with a virus, has shown promise in treating AMR. However, limited clinical trials have been conducted, and further research is needed to determine the efficacy and dosage of specific bacteriophage strains.
POSTGRADUATE MEDICAL JOURNAL
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lei Zhang, Liu-qing Yang, Li Wen, Sheng-qing Lv, Jun-hao Hu, Qing-rui Li, Jian-ping Xu, Ru-fu Xu, Dong Zhang
Summary: The study investigated the performance of multi-parametric magnetic resonance imaging (MRI) for glioma grading, and found that normalized relative cerebral blood flow (rCBV), mean kurtosis (MK), and water molecular diffusion heterogeneity index (alpha) were the most accurate parameters for assessing glioma grading. Multiparametric MRI can increase the accuracy of glioma grading.
ACADEMIC RADIOLOGY
(2021)
Editorial Material
Health Care Sciences & Services
Vance W. Berger, Diana Knoll
EVALUATION & THE HEALTH PROFESSIONS
(2011)
Article
Health Care Sciences & Services
P. Cristian Gugiu, Mihaiela Ristei Gugiu
EVALUATION & THE HEALTH PROFESSIONS
(2011)
Article
Health Care Sciences & Services
Cristian Gugiu, Chris L. S. Coryn, Brooks Applegate
JOURNAL OF EVALUATION IN CLINICAL PRACTICE
(2010)
Article
Education, Scientific Disciplines
Yang Shi, P. Cristian Gugiu, Remle P. Crowe, David P. Way
TEACHING AND LEARNING IN MEDICINE
(2019)
Editorial Material
Health Care Sciences & Services
Paul Cristian Gugiu
Summary: The use of public surveys in healthcare policy decision making, as proposed by Kaplan and Baron-Epel, may have negative consequences such as disregarding the needs of minority groups, reducing critical services, and promoting fringe group agendas.
EVALUATION & THE HEALTH PROFESSIONS
(2021)
Article
Health Care Sciences & Services
P. Cristian Gugiu, Damon Drew, Ela Polek
Summary: This paper evaluated the factor structure of existing coping instruments and found that most studies did not follow current psychometric recommendations. The conflicting results suggest a need for improvement in future validation studies.
EVALUATION & THE HEALTH PROFESSIONS
(2022)
Article
Family Studies
P. Cristian Gugiu, Mihaiela Ristei Gugiu, Michael Barnes, Belinda Gimbert, Megan Sanders
JOURNAL OF CHILD AND FAMILY STUDIES
(2019)
Article
Psychology, Educational
Daniel M. Huber, Eric M. Sauer, Adam J. Mrdjenovich, P. Cristian Gugiu
TRAINING AND EDUCATION IN PROFESSIONAL PSYCHOLOGY
(2010)
Article
Social Sciences, Interdisciplinary
P. Cristian Gugiu, Lifiana Rodriguez-Campos
EVALUATION AND PROGRAM PLANNING
(2007)