期刊
EUROSURVEILLANCE
卷 18, 期 50, 页码 38-45出版社
EUR CENTRE DIS PREVENTION & CONTROL
DOI: 10.2807/1560-7917.ES2013.18.50.20657
关键词
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资金
- National Grand Program on Key Infectious Disease Control [2012ZX10001-006, 2013ZX10001-002]
- China Ministry of Health
- 973 National Key Basic Research Project [2012CB519005]
- Ministry of Science and Technology of PRC
- Area of Excellence Scheme of the University Grants Committee, Hong Kong Special Administrative Region [AoE/M-12/96]
The novel avian influenza A(H7N9) infection has recently emerged to cause severe respiratory illness in China. The objectives of this study were to define the kinetics of the antibody responses in patients with influenza A(H7N9) disease and to correlate these kinetics with clinical outcome. Serial serum samples were obtained at intervals of three to four days from 18 patients with virologically confirmed A(H7N9) disease in Shanghai. We determined the kinetics of the haemagglutination inhibition (HI) and A(H7H9) pseudo-type neutralisation antibody (Nab) responses and correlated these with clinical outcomes. Most patients had robust serological responses by both HI and Nab tests. Taking into account censoring due to time of testing and death, the median time from onset of illness to Nab titre >= 1:40 was 14 days (95% confidence interval (CI): 11-18 days) in the fatal cases and 10.5 days (95% CI: 7-12) in the survivors (p=0.003). The two groups did not differ in initial Nab titres, but the rate of increase in Nab titres was significantly faster for survivors by approximately 10-fold per 15 days (p=0.007). Early and rapid induction of Nab was correlated significantly with better clinical outcome.
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